CN102988912A

CN102988912A - Oral liquid for treating chronic superficial gastritis, and preparation method thereof

Info

Publication number: CN102988912A
Application number: CN 201110275235
Authority: CN
Inventors: 董根荣
Original assignee: Individual
Current assignee: Individual
Priority date: 2011-09-16
Filing date: 2011-09-16
Publication date: 2013-03-27

Abstract

The invention relates to an oral liquid for treating chronic superficial gastritis, and a preparation method of the oral liquid; and the oral liquid is prepared by orange peel, ginger and the like. Compared with the prior art, the oral liquid disclosed by the invention is simple in compatibility of medicines, convenient to take and good in treatment effect, and provides the reasonable and feasible preparation method.

Description

A kind of oral liquid for the treatment of chronic superficial gastritis and preparation method thereof

Technical field: the present invention is a kind of oral liquid for the treatment of chronic superficial gastritis and preparation method thereof, belongs to the technical field of medicine.

Technical background: chronic superficial gastritis is a kind of chronic gastric mucosa shallow inflammation, and it is one type the most common in the chronic gastritis, accounts for 50%～85% of whole chronic gastritiss in gastroscopy.The onset peak age of primary disease is 31～50 years old, and the male falls ill more than the women.Doctor trained in Western medicine thinks that its pathogenic factor differs, can be because being addicted to drink, drinking espresso, or because of bile reflux, or cause because of helicobacter pylori infections etc.The patient can have indigestion symptom in various degree, and epigastric discomfort after the feed has a dull ache, and can accompany belch, feel sick, pantothenic acid, idol has vomiting, general symptom is slight, have in addition non-evident sympton, can when gastroscopy, find.Basic lesion is the epithelial cell degeneration, and inflammatory cell infiltration in little recessed epithelial proliferation and the lamina propria can be seen the intestinal epithelial metaplasia of superficial epithelium and little recessed epithelium sometimes, does not accompany the minimizing of intrinsic body of gland.Diseased region is often obvious with gastric antrum, mostly is diffusivity, and gastroscopy is gastric mucosa congestion, edema and petechial hemorrhage and rotten to the corn or with yellow-white mucus exudate.At present the domestic depth by the inflammatory cell infiltration mucous layer with primary disease be divided into gently, in, weigh three degree.All infiltration mucosa shallow-layers are slight; In relating to 1/3 for moderate; Surpassing mucous layer is severe.Because most of superficial gastritis patients lack clinical symptoms, the patient is not too noted and ignore treatment.Some patients were often has epigastrium feeling of distension and oppression, belch, acid regurgitation, loss of appetite, or irregular upper abdomen dull pain, many performances such as food postemphasis.Chronic superficial gastritis is through the recovery from illness for the treatment of multipotency; If lose in treatment, then can further develop, intrinsic body of gland destroys because of inflammation and reduces, and chronic superficial gastritis can be converted into atrophic gastritis.During chronic atrophic gastritis, gastric mucosa atrophy and to be replaced by the epithelial cell of intestinal be that intestinalization is given birth to; Inflammation continue to develop, and then Growth of Cells is not true to type, and becomes between namely; Even hyperplasia and carcinogenesis.

Because chronic superficial gastritis is a kind of chronic disease, treatment time is longer, and some patients are easily recurrence also.To the ill medication after clarifying a diagnosis, and to adhere to medication, general treatment time is 4-8 week.Doctor trained in Western medicine mostly is symptomatic treatment to the treatment of primary disease.As protect gastric mucosa, and reduce gastric acid secretion, promote gastrointestinal peristalsis, suppress helicobacter pylori infections etc., the long-term taking Western medicine can produce drug dependence and toxic and side effects.So the pharmacology intestinal transfers the stomach sedative drugs prescriptions to be cured in the general employing of clinical treatment, avoids the long-term taking Western medicine to produce drug dependence and toxic and side effects, is the first-selection of clinical treatment superficial gastritis.

Chinese medicine is attributed to this disease the category of gastric abscess, painful abdominal mass, regurgitation, vomiting etc., and its etiology and pathogenesis mainly is that taste are impaired, abnormal ascending-descending of QI, cold and heat are tied mutually, middle burnt painful abdominal mass resistance, or the depression of liver-QI perverse and unreasonable manner is violated due to the stomach clinical hyperactive liver-QI attacking the stomach card, weakness of the spleen and stomach, the stomach-Yin virtual loss card etc. of being divided into.Wherein hyperactive liver-QI attacking the stomach card is common, and clinical manifestation is gastral cavilty distension pain, pain and two sides of body, and full vexed discomfort more so, is met the not Shu Ze aggravation of feelings will after the food, doublely sees nausea and vomiting, and the belch acid regurgitation vows that gas then relaxes sighing frequently, dimly pale tongue, white and thin fur, stringy pulse.The Therapeutic Principle is dispersing the stagnated liver-QI for regulating the stomach, the irritability resolving depression.

For the chronic superficial gastritis patient due to the hyperactive liver-QI attacking the stomach, develop a kind of safe and effective, the thing that the little medicine of side effect has just become people to be badly in need of solving.

Summary of the invention: the object of the invention is to: a kind of oral liquid for the treatment of chronic superficial gastritis and preparation method thereof is provided; The present invention is directed to prior art, Rhizoma Zingiberis Recens, Pericarpium Citri tangerinae etc. is made oral liquid, not only taking convenience, and craft science is reasonable, can better keep effective ingredient, and therapeutical effect is good, extensive market.

The present invention consists of like this: calculate according to components by weight percent, it is to be made by Rhizoma Zingiberis Recens 10～30g, Pericarpium Citri tangerinae 10～30g, Vascular aurantii 10～30g, Folium Citri tangerinae 10～30g.Specifically: calculate according to components by weight percent, it is to be made by Rhizoma Zingiberis Recens 20g, Pericarpium Citri tangerinae 20g, Vascular aurantii 20g, Folium Citri tangerinae 20g.The preparation method of the oral liquid of described treatment chronic superficial gastritis: get Rhizoma Zingiberis Recens, Pericarpium Citri tangerinae, Vascular aurantii, Folium Citri tangerinae, clean, decoct with water 1-3 time, each 0.5-2 hour, collecting decoction filtered, filtrate is concentrated, leaves standstill 12-36 hour, filters, filtrate is an amount of with sucrose, boils to make dissolving, adds water, stir evenly, cold preservation 12-36 hour, filter, embedding, sterilization, and get final product.Specifically: get Rhizoma Zingiberis Recens, Pericarpium Citri tangerinae, Vascular aurantii, Folium Citri tangerinae, clean, decoct with water 2 times, each 0.5 hour, collecting decoction filtered, filtrate is concentrated, leaves standstill 24 hours, filters, and filtrate is an amount of with sucrose, boils to make dissolving, adds water, stir evenly, cold preservation 24 hours filters, embedding, and sterilization, and get final product.

We's Therapeutic Principle is dispersing the stagnated liver-QI for regulating the stomach, the irritability resolving depression.The hot warm bitter in the mouth of Pericarpium Citri tangerinae, Vascular aurantii, Folium Citri tangerinae, hardship can be let out can be dry, hot can fall apart, the temperature energy with, can suit to the damaged by excess of seven emotions person." medicine origin " record Pericarpium Citri tangerinae energy QI invigorating adds Pericarpium Citri Reticulatae Viride and reduces by half, and removes the gas that stagnates, and pushes away Chen Zhixin.If tonifying the spleen and stomach does not go whitely, the gas if reason stagnates in the heart removes bag." curing mainly secret wanting " cloud: the toil QI invigorating, sharp lung has then tonifying the lung of Radix Glycyrrhizae, without then eliminating the pathogens from the lung." daily book on Chinese herbal medicine " record Pericarpium Citri tangerinae can fall apart and can rush down, and can temperature can mend the diaphragm gas that can disappear, the saliva that reduces phlegm, and spleen antitussive, logical five types of stranguria.The effect of frying in shallow oil drink is felt sick in middle wine vomiting.The Compendium of Material Medica cloud: hardship can be rushed down can be dry, hot can fall apart, the temperature energy with.It controls all kinds of diseases and ailments, always gets its wet merit of making an uproar of regulating the flow of vital energy, and then mends with tonic, then rushes down with cathartic, then rises with Hydrargyri Oxydum Rubrum, then falls with falling medicine.Spleen is the mother of vigour, and lung is to take the photograph Qi Zhi Yue, therefore Pericarpium Citri tangerinae is two medicines through edema caused by disorder of QI, but with joining city's reinforcing and reducing lifting also.

The netted grain of the outer white of Fructus Citri tangerinae flesh is termed " Vascular aurantii " usually." it is former that book on Chinese herbal medicine is asked " puts down in writing its meridian dredging, has a respite, and reduces phlegm, and dry stomach goes dirty, and blood vessels.The leaf of the multiple Fructus Citri tangerinae classes such as the leaf of Folium Citri tangerinae rutaceae orange Citrus reticulata Blanco or Zhu's Fructus Citri tangerinae,, can adopt at any time, dry or using fresh herb." book on Chinese herbal medicine converge with speech " record " Folium Citri tangerinae, soothing the liver, loose contrary gas, decide hypochondriac pain medicine also.Press the Dan Xi speech.This medicine is bitter and puckery flavor altogether, and its gas is hot fragrant, and the general character temperature is loose.All sick blood agglomeration are depressed, and the sputum fire is contrary, and disease is hypochondriac pain, is acute mastitis, is beriberi, is toxic swelling, are the diseases such as the contrary gas of chest and diaphragm, or smash the juice drink, or get slag and apply ointment or plaster, and invariably answer hands to obtain effect." we are particularly suitable to the double cold person of the chronic superficial gastritis stagnation of QI for Rhizoma Zingiberis Recens, the power of enhancing warming stomach for dispelling cold.

Compared with prior art, compatibility can produce Synergistic between this product medicine, the chronic superficial gastritis patient who causes for hyperactive liver-QI attacking the stomach specially.Pharmacological evaluation has been investigated the preventive and therapeutic effect of this product to rat experiment chronic superficial gastritis.The method that adopts be to 6 months ten HP bacterium liquid of rat ethanol+sodium deoxycholate gavage repeatedly (inferior/week * 4 times) empty clothes complex factors such as (ig) cause the sick mould of animal chronic superficial gastritis, drug effect is observed in simultaneously (ig) administration.Experimental result show this product high, in two dosage, have obvious anti-gastric mucosa HP and infect and alleviate the preventive and therapeutic effect of rat chronic active superficial gastritis pathological change.Experiment conclusion: this product has the effect of control chronic active superficial gastritis.

Concrete embodiment:

Embodiments of the invention 1: Rhizoma Zingiberis Recens 20g, Pericarpium Citri tangerinae 20g, Vascular aurantii 20g, Folium Citri tangerinae 20g

Get Rhizoma Zingiberis Recens, Pericarpium Citri tangerinae, Vascular aurantii, Folium Citri tangerinae, clean, decoct with water 2 times, each 0.5 hour, collecting decoction filtered, filtrate is concentrated, leaves standstill 24 hours, filters, and filtrate is an amount of with sucrose, boils to make dissolving, adds water, stir evenly, cold preservation 24 hours filters, embedding, and sterilization, and get final product.This product oral, every day 2 times, each 10ml.

Embodiments of the invention 2: Rhizoma Zingiberis Recens 10g, Pericarpium Citri tangerinae 30g, Vascular aurantii 10, Folium Citri tangerinae 30g

Get Rhizoma Zingiberis Recens, Pericarpium Citri tangerinae, Vascular aurantii, Folium Citri tangerinae, clean, decoct with water 0.5 hour, decocting liquid filters, and filtrate is concentrated, leaves standstill 12 hours, filters, and filtrate is an amount of with sucrose, boils to make dissolving, adds water, stirs evenly, and cold preservation 12 hours filters, embedding, and sterilization, and get final product.

Embodiments of the invention 3: Rhizoma Zingiberis Recens 30g, Pericarpium Citri tangerinae 10g, Vascular aurantii 30g, Folium Citri tangerinae 10g

Get Rhizoma Zingiberis Recens, Pericarpium Citri tangerinae, Vascular aurantii, Folium Citri tangerinae, clean, decoct with water 3 times, each 2 hours, collecting decoction filtered, and filtrate is concentrated, leaves standstill 36 hours, filters, and filtrate is an amount of with sucrose, boils to make dissolving, adds water, stirs evenly, and cold preservation 36 hours filters, embedding, and sterilization, and get final product.

Claims

1. oral liquid for the treatment of chronic superficial gastritis is characterized in that: calculate according to components by weight percent, it is to be made by Rhizoma Zingiberis Recens 10～30g, Pericarpium Citri tangerinae 10～30g, Vascular aurantii 10～30g, Folium Citri tangerinae 10～30g.

2. according to the oral liquid for the treatment of chronic superficial gastritis claimed in claim 1, it is characterized in that: calculate according to components by weight percent, it is to be made by Rhizoma Zingiberis Recens 20g, Pericarpium Citri tangerinae 20g, Vascular aurantii 20g, Folium Citri tangerinae 20g.

3. according to the preparation method of the oral liquid of claim 1 or 2 described treatment chronic superficial gastritiss, it is characterized in that: get Rhizoma Zingiberis Recens, Pericarpium Citri tangerinae, Vascular aurantii, Folium Citri tangerinae, clean, decoct with water 1-3 time, each 0.5-2 hour, collecting decoction filtered, filtrate is concentrated, leaves standstill 12-36 hour, filters, filtrate is an amount of with sucrose, boils to make dissolving, adds water, stir evenly, cold preservation 12-36 hour, filter, embedding, sterilization, and get final product.

4. according to the preparation method of the oral liquid for the treatment of chronic superficial gastritis claimed in claim 3, it is characterized in that: get Rhizoma Zingiberis Recens, Pericarpium Citri tangerinae, Vascular aurantii, Folium Citri tangerinae, clean, decoct with water 2 times, each 0.5 hour, collecting decoction filtered, filtrate is concentrated, leaves standstill 24 hours, filters, filtrate is an amount of with sucrose, boils to make dissolving, adds water, stir evenly, cold preservation 24 hours filters, embedding, sterilization, and get final product.