CN102977089B - 一种高纯度头孢地尼抗菌素7-位侧链合成关键原料的制备方法 - Google Patents
一种高纯度头孢地尼抗菌素7-位侧链合成关键原料的制备方法 Download PDFInfo
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- CN102977089B CN102977089B CN201210519221.0A CN201210519221A CN102977089B CN 102977089 B CN102977089 B CN 102977089B CN 201210519221 A CN201210519221 A CN 201210519221A CN 102977089 B CN102977089 B CN 102977089B
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- thiazolyl
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- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
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CN201210519221.0A CN102977089B (zh) | 2012-12-06 | 2012-12-06 | 一种高纯度头孢地尼抗菌素7-位侧链合成关键原料的制备方法 |
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CN102977089A CN102977089A (zh) | 2013-03-20 |
CN102977089B true CN102977089B (zh) | 2015-01-14 |
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CN113214186A (zh) * | 2021-05-18 | 2021-08-06 | 山东昌邑四方医药化工有限公司 | 头孢地尼活性酯的精制方法 |
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CN102659713A (zh) * | 2012-05-07 | 2012-09-12 | 山东金城柯瑞化学有限公司 | 头孢地尼侧链酸活性酯的制备方法 |
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WO2011029596A1 (en) * | 2009-09-11 | 2011-03-17 | Lonza Ltd | Process for preparing 2-aminothiazol-4-yl-acetic acid derivates |
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CN102659713A (zh) * | 2012-05-07 | 2012-09-12 | 山东金城柯瑞化学有限公司 | 头孢地尼侧链酸活性酯的制备方法 |
Non-Patent Citations (3)
Title |
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Elisabeth Defoßa,等.."Synthesis of HR 916 K: An Efficient Route to the Pure Diastereomers of the 1-(Pivaloy1oxy)ethyl Esters of Cephalosporins".《Liebigs Annalen》.1996,第1996卷(第11期),1743-1749. * |
H Kamachi,等.."Improved synthesis of an ester-type prodrug, 1-acetoxyethyl 7-[(Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-3-[(Z)-1-propenyl]-3-cephem-4-carboxylate (BMY-28271)".《The Journal of antibiotics》.1990,(第12期),1564-1572. * |
朱阳,等.."(Z)-2-(2-氨基噻唑-4-基)-2-三苯甲氧基亚胺基乙酸合成的改进".《中国医药工业杂志》.1997,第28卷(第6期),270-271. * |
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