CN102973583A - Compound gentamicin sulphate composition for treating poultry diarrhea and preparation method thereof - Google Patents
Compound gentamicin sulphate composition for treating poultry diarrhea and preparation method thereof Download PDFInfo
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- CN102973583A CN102973583A CN2012105162338A CN201210516233A CN102973583A CN 102973583 A CN102973583 A CN 102973583A CN 2012105162338 A CN2012105162338 A CN 2012105162338A CN 201210516233 A CN201210516233 A CN 201210516233A CN 102973583 A CN102973583 A CN 102973583A
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Abstract
The invention relates to a compound gentamicin sulphate composition for treating poultry diarrhea. The compound gentamicin sulphate composition is characterized by being prepared by mixing the following components by weight part: 5-10 parts of gentamicin sulphate, 10-15 parts of ciprofloxacin, 10-20 parts of berberine hydrochloride, 5-9 parts of trimethoprim Lactate salt and 46-70 parts of glucosum anhydricum. The compound gentamicin sulphate composition has the beneficial effects of reasonable formula, simple preparation, extremely obvious curative effect and special effect on the treatment of poultry diarrhea through clinical proving.
Description
Technical field
The present invention relates to treat the compound gentamicine sulphate composition and method of making the same of poultry diarrhoea, belong to the animal field of medicaments, particularly a kind of compound gentamicine sulphate composition and method of making the same that is specifically designed to treatment poultry diarrhoea.
Background technology
Poultry diarrhoea mainly is a kind of more serious disease that is caused by pathogenic bacterias such as escherichia coli and Salmonellas.Long-term serious diarrhoea can make the forfeiture of poultry body large quantity of moisture, salt and alkaline matter, and in various degree dehydration, salt deficiency and acidosis occur, the blood contracting that thickens, thus affect the normal circulation of body fluid, finally cause heart failure and cause death.The less sickness rate of poultry age in days is higher, and case fatality rate is also higher, is generally between the 10%-40%.Primary disease all can occur throughout the year, is one of principal disease of harm poultry farming.
This kind disease almost spreads all over all poultry farming countries of the world, is widely distributed.At present, treat the most frequently used antimicrobial product of this disease, because prescription is unreasonable, produce easily drug resistance, it is not fine causing clinical effectiveness.
Therefore researching and developing a kind of chemical sproof specific medicament of difficult generation for the treatment of poultry diarrhoea is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, a kind of reasonable recipe, simple, the difficult compound gentamicine sulphate composition and method of making the same that produces chemical sproof effective treatment poultry diarrhoea of preparation are provided.
Implementation of the present invention is as follows for achieving the above object: a kind of compound gentamicine sulphate compositions for the treatment of poultry diarrhoea, by following component by weight mixed preparing form: gentamycin sulfate 5-10 part, ciprofloxacin 10-15 part, berberine hydrochloride 10-20 part, lactic acid trimethoprim 5-9 part, anhydrous glucose 46-70 part.
Described various component optimum ratio amount is: 7.5 parts of gentamycin sulfate, 12.5 parts of ciprofloxacins, 15 parts of berberine hydrochloride, 7 parts of lactic acid trimethoprims, 58 parts of anhydrous glucose.
A kind of preparation method for the treatment of the compound gentamicine sulphate compositions of poultry diarrhoea, carry out as follows:
(1) takes by weighing by weight gentamycin sulfate 5-10 part, ciprofloxacin 10-15 part and anhydrous glucose 15-25 part, mix 5-10 minute to even;
(2) take by weighing by weight berberine hydrochloride 10-20 part, lactic acid trimethoprim 5-9 part, anhydrous glucose 15-29 part, mix 5-10 minute to even;
(3) merge the mixture and residue anhydrous glucose that above-mentioned (1), (2) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Gentamycin sulfate: white or off-white powder, easily molten in water, be the aminoglycosides broad ectrum antibiotic, multiple gram-negative bacteria and positive bacteria all had antibacterial and bactericidal action, oral absorption is poor, is mainly used in clinically the responsive microbial intestinal infection such as escherichia coli, dysentery bacterium, Salmonella and bacillary dysentery etc.
Ciprofloxacin: light yellow crystalline powder, soluble in water, fluoroquinolone antibacterial agent has broad-spectrum antibacterial action, and oral absorption is good.Be applicable to the responsive microbial respiratory system such as escherichia coli, Salmonella, urinary system and intestinal infection etc.This product and other antibiotic be without cross resistance, and be still responsive to this product to beta-lactam, aminoglycoside, sulfonamides Resistant strain.
Berberine hydrochloride: yellow acicular crystal, water-soluble, has a broad antifungal spectrum all has multiple gram positive bacteria and negative bacterium and to kill or inhibitory action.This product oral absorption is poor, clinical intestinal infection and the bacillary dysentery etc. of being mainly used in.This product and penicillin, streptomycin etc. are without cross resistance.
The lactic acid trimethoprim: white or off-white color crystalline powder, water-soluble, have the notable synergistic effect during with sulfa drugs and other antibacterial coupling, can increase by ten effects to decades of times.Do not use separately, generally use by 1: 5 ratio, can treat fowl and raise bacillary dysentery that escherichia coli, Salmonella etc. cause, enteritis, respiratory tract infection etc., also can be used for the control of coccidiosis of domestic fowls.
More than all medicines according to antimicrobial susceptibility experimental result compatible combination, the paathogenic factor for poultry diarrhoea has good clinical effectiveness.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Cost is low, is difficult for producing drug resistance, curative effect highly significant.The present invention optimizes this three kinds of medicines, and they is formed according to optimum ratio according to antimicrobial susceptibility experimental result compatible combination, and clinical practice proves that treatment poultry diarrhoea is had specially good effect.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1
A kind of compound gentamicine sulphate composition and method of making the same for the treatment of poultry diarrhoea: carry out as follows: (every part by 10g)
(1) takes by weighing by weight 100 parts of 50 parts of gentamycin sulfate, ciprofloxacin and 150 parts of anhydrous glucose, mixes 5-10 minute to even;
(2) take by weighing by weight 100 parts of berberine hydrochloride, 50 parts of lactic acid trimethoprims, 150 parts of anhydrous glucose, mix 5-10 minute to even;
(3) merge the mixture and residue anhydrous glucose that above-mentioned (1), (2) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of compound gentamicine sulphate composition and method of making the same for the treatment of poultry diarrhoea: carry out as follows: (every part by 10g)
(1) takes by weighing by weight 125 parts of 75 parts of gentamycin sulfate, ciprofloxacin and 200 parts of anhydrous glucose, mixes 5-10 minute to even;
(2) take by weighing by weight 150 parts of berberine hydrochloride, 70 parts of lactic acid trimethoprims, 220 parts of anhydrous glucose, mix 5-10 minute to even;
(3) merge the mixture and residue anhydrous glucose that above-mentioned (1), (2) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of compound gentamicine sulphate composition and method of making the same for the treatment of poultry diarrhoea: carry out as follows: (every part by 10g)
(1) takes by weighing by weight 150 parts of 100 parts of gentamycin sulfate, ciprofloxacin and 25 parts of anhydrous glucose, mixes 5-10 minute to even;
(2) take by weighing by weight 200 parts of berberine hydrochloride, 90 parts of lactic acid trimethoprims, 290 parts of anhydrous glucose, mix 5-10 minute to even;
(3) merge the mixture and residue anhydrous glucose that above-mentioned (1), (2) step make, continue to mix 10-15 minute to even.
Clinical trial:
The clinical experiment animal selects 15 ages in days, body weight between 0.5kg-0.7kg, and Laboratory Diagnosed is the ill broiler of salmonellosis of chicken.Ill chicken isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 30 every group, 3 groups of feeding environments are identical, and experimental period was carried out 5 days altogether; The blank group is left intact, and the medicine matched group uses treatment with " dysentery is clear " by specification; Present composition group is with the ill poultry of product feeding of the present invention etc., and a day dose is: by the every 100g drinking-water of the present invention 300kg, every day 2-3 time, be used in conjunction 3-5 day; Reach the purpose for the treatment of disease after oral by gastrointestinal absorption.Result's (testing the 5th day) when following table is the experiment end.
Table is the field applicable cases contrast of the present invention and other medicines treatment salmonellosis of chicken:
| Numbering | Group | Mortality rate % | Cure rate % | Symptom rate % is arranged during end |
| I | The blank group | 13.3 | 53.4 | 33.3 |
| II | Dysentery is organized clearly | 6.7 | 76.4 | 16.7 |
| III | Present composition group | 3.3 | 90.0 | 6.7 |
This clinical effectiveness statistical analysis, present composition group is being compared difference extremely significantly (P＜0.01) with " dysentery is clear " group aspect the cure rate.
The detailed description that above-mentioned compound gentamicine sulphate composition and method of making the same of this treatment poultry being suffered from diarrhoea with reference to embodiment carries out; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (3)
1. compound gentamicine sulphate compositions for the treatment of poultry diarrhoea, it is characterized in that by following component by weight mixed preparing form: gentamycin sulfate 5-10 part, ciprofloxacin 10-15 part, berberine hydrochloride 10-20 part, lactic acid trimethoprim 5-9 part, anhydrous glucose 46-70 part.
2. the compound gentamicine sulphate compositions for the treatment of according to claim 1 poultry diarrhoea, it is characterized in that by following component by weight mixed preparing form: 7.5 parts of gentamycin sulfate, 12.5 parts of ciprofloxacins, 15 parts of berberine hydrochloride, 7 parts of lactic acid trimethoprims, 58 parts of anhydrous glucose.
3. the preparation method of the compound gentamicine sulphate compositions of a treatment according to claim 1 and 2 poultry diarrhoea is characterized in that carrying out as follows:
(1) takes by weighing by weight gentamycin sulfate 5-10 part, ciprofloxacin 10-15 part and anhydrous glucose 15-25 part, mix 5-10 minute to even;
(2) take by weighing by weight berberine hydrochloride 10-20 part, lactic acid trimethoprim 5-9 part, anhydrous glucose 15-29 part, mix 5-10 minute to even;
(3) merge the mixture and residue anhydrous glucose that above-mentioned (1), (2) step make, continue to mix 10-15 minute to even.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210516233.8A CN102973583B (en) | 2012-11-22 | 2012-11-22 | Compound gentamicin sulphate composition for treating poultry diarrhea and preparation method thereof |
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| CN201210516233.8A CN102973583B (en) | 2012-11-22 | 2012-11-22 | Compound gentamicin sulphate composition for treating poultry diarrhea and preparation method thereof |
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| CN102973583A true CN102973583A (en) | 2013-03-20 |
| CN102973583B CN102973583B (en) | 2014-11-12 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109331034A (en) * | 2018-12-20 | 2019-02-15 | 江苏卓和药业有限公司 | A kind of pharmaceutical composition for treating diarrhea |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1536987A (en) * | 2001-02-19 | 2004-10-13 | 株式会社Lg生命科学 | Sustained-release suspension of ceftiofur hydrochloride |
| CN101467999A (en) * | 2007-12-25 | 2009-07-01 | 郑州后羿制药有限公司 | Compound preparation of berberine hydrochloride |
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- 2012-11-22 CN CN201210516233.8A patent/CN102973583B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1536987A (en) * | 2001-02-19 | 2004-10-13 | 株式会社Lg生命科学 | Sustained-release suspension of ceftiofur hydrochloride |
| CN101467999A (en) * | 2007-12-25 | 2009-07-01 | 郑州后羿制药有限公司 | Compound preparation of berberine hydrochloride |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109331034A (en) * | 2018-12-20 | 2019-02-15 | 江苏卓和药业有限公司 | A kind of pharmaceutical composition for treating diarrhea |
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