CN102961566A - Navel compressing agent for treating irritable bowel syndrome - Google Patents
Navel compressing agent for treating irritable bowel syndrome Download PDFInfo
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Abstract
The invention discloses a navel compressing agent for treating irritable bowel syndrome so as to solve the treatment problem of irritable bowel syndrome. The navel compressing agent is characterized by being processed from the following traditional Chinese medicines serving as raw materials in the formula in parts by weight: 6-10 parts of crinite uraria, 8-15 parts of spatholobus stem, 8-15 parts of semen thlaspi, 6-10 parts of Perilla root, 6-10 parts of betula luminifera bark, 8-15 parts of herb of paniculate spot flower, 6-10 parts of Allium caelureum, 8-15 parts of pangolin and 3-6 parts of Gorgon euryale seed. Clinical experiments prove that the navel compressing agent disclosed by the invention has the characteristics of good treatment effect on irritable bowel syndrome and high security, and is worthy of being clinically applied and popularized.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to treat the deposited umbilicus agent of irritable bowel syndrome.
Background technology
Irritable bowel syndrome (irritable bowel syndrome, IBS), claim again irritable bowel syndrome, refer to one group of clinical syndrome that comprises the performances such as stomachache, abdominal distention, bowl evacuation habit change and the stool character is unusual, Mucous Stool, the organic disease that can cause these symptoms is got rid of in sustainable existence or repeatedly outbreak on inspection.Primary disease is modal a kind of functional intestinal tract disease, carries out questionnaire survey the general population, has IBS symptom America and Europe to be reported as 10% ~ 20%, and one group in China Beijing is reported as 8.7%.The patient is in the majority with the young and the middle aged, and First episode is rare after 50 years old, the about 1:2 of M-F.Irritable bowel syndrome roughly has two types: constipation type and diarrhea-type.The cause of disease of IBS is still not clear, and can not find any anatomical reason.Emotional factor, diet, medicine or hormone all can inspire or increase the weight of the gastrointestinal movement of this high-tension.Some patient has anxiety neurosis; Especially phobia, grow up depression and somatization obstacle.Yet, stress with not always symptoms accompanied outbreak and repeatedly of emotional disturbance.Some IBS patient's performance has a kind of acquired unusual pathology behavior that has, such as, they tend to spiritual puzzlement is expressed as gastral main suit, normally stomachache.
Based on this, the treatment of irritable bowel syndrome only is symptomatic treatment, as using gastrointestinal antispasmodic medicine (anticholinergic agent) treatment stomachache, uses the treatment diarrhoea such as absorption diarrhea such as dioctahedral smectite, medicinal charcoal, and the constipation type patient is taken the circumstances into consideration to use cathartic etc.Symptomatic treatment can solve for the moment problem, but in the course of time, being used alternatingly of antidiarrheal, catharsis medicine more increased the weight of gastrointestinal motility disorders.
The integrally-regulated doctor trained in Western medicine that is better than of the traditional Chinese medical science, for the patient who repeatedly shows effect, western medical treatment is difficult to control seizure frequency, then resorts to Chinese traditional treatment more.At present, the Chinese traditional treatment of IBS is mainly started with from solving " incoordination between the liver and spleen ", thinks that the primary disease pathogenesis is that disorder of emotion causes irritability stasis more, and incoordination between the liver and spleen causes the intestinal functional activity of QI being not smooth, and intestinal internal organs conduction mistake department produces pain and rushes down symptom.But inventor's clinical empirical summary for many years finds that the reason of this irritable bowel syndrome is not simple owing to hyperactive liver-QI attacking the spleen, but clearly relevant with sufferer body constitution, namely the hypersensitivity with intestinal smooth is relevant.So should control through opinion from liver,spleen,kidney three, and large intestine and lung phase the exterior and the interior, also will fully take into account respectful the falling of lung qi and lack of proper care on the impact of large intestine mechanism of qi, simple soothing liver and strengthening spleen is only relatively good to a part of patient's effect, for the high quick patient treatment poor effect of intestinal smooth.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, and the deposited umbilicus agent of the sure treatment irritable bowel syndrome of a kind of curative effect is provided.
The technical scheme that the present invention solves its technical problem is: a kind of deposited umbilicus agent for the treatment of irritable bowel syndrome, it is characterized in that being processed by plurality of Chinese, its composition of raw materials and weight proportion are: 6 ~ 10 parts of Herba Urariae crinitae, 8 ~ 15 parts of 8 ~ 15 parts of ， Semen thlaspis of Caulis Spatholobi, 6 ~ 10 parts of Radix Perillae, 6 ~ 10 parts of Cortex Betulae Luminiferaes, 8 ~ 15 parts of Herba Spilanthis Acmellae, 6 ~ 10 parts of blue Jacob's ladders, 8 ~ 15 parts of Squama Maniss, 3 ~ 6 parts of Semen Euryaless.
Its optimum weight proportioning is: 8 parts of Herba Urariae crinitae, 10 parts of 10 parts of ， Semen thlaspis of Caulis Spatholobi, 8 parts of Radix Perillae, 8 parts of Cortex Betulae Luminiferaes, 10 parts of Herba Spilanthis Acmellae, 8 parts of blue Jacob's ladders, 10 parts of Squama Maniss, 5 parts of Semen Euryaless.
Wherein said: Herba Urariae crinitae, penetrate the herb of Uraria crinita (T.) Desv. for leguminous plant cat tail.Nature and flavor are sweet; Little hardship; Flat.GUIXIN; Lung; Liver Channel.But merit clearing away lung-heat to relieve cough; The dissipating blood stasis hemostasis.
Caulis Spatholobi is the rattan of leguminous plant spatholobus suberectus, Mucuna birdwoodiana, fragrant flower Moghania fluminalis(C. B. Clarke) Li rattan or bright leaf Moghania fluminalis(C. B. Clarke) Li rattan etc.Nature and flavor are bitter, sweet, temperature.Return liver, kidney channel.Merit can be enriched blood, and invigorates blood circulation collateral dredging.
Semen thlaspis, Cruciferae herba thlaspis genus plant Herba Thlaspis Thlaspi arvense L. seed.Nature and flavor are hot, bitter, tepor.Expelling wind and removing dampness, and stomach and alleviating pain.
Radix Perillae, be labiate Folium Perillae Perilla frutescens (L.) Britt., wild Folium Perillae Var. Crispa (Thunb.) Hand.-Mazz., P.frutescens (L.) Britt. and common perilla Var. Acuta (Thunb.) Kudo, the root of P. Frutescens (L.) Britt. and the old stem of nearly root.Acrid in the mouth, warm in nature, nontoxic.Acrid in the mouth; Warm in nature.Return lung; Spleen channel.But merit expelling wind and cold; Lowering the adverse-rising QI and dispelling phlegm; With in antiabortive.
Cortex Betulae Luminiferae is Betulaceae betula luminifera Betula luminifera H. Win Herba Spilanthis Acmellae. bark.Nature and flavor are sweet; Hot; Slightly warm in nature.But merit damp eliminating cold expelling; Disappear stagnate and in, detoxifcation.
Herba Spilanthis Acmellae is the herb of feverfew Herba Cancriniae lasiocarpae Spilanthes paniculata Wall.ex DC..Acrid in the mouth; Bitter; Slightly warm in nature.Return lung; Liver; Large intestine channel.But merit relieving cough and asthma; Detoxification and promoting urination; Reducing swelling and alleviating pain.
Blue Jacob's ladder is for the blue Jacob's ladder Allium of Liliaceae cyaneum Regel, with all herbal medicine.Nature and flavor are hot, temperature.But the merit dispersing wind-cold activates yang, stomach invigorating.
Squama Manis is the scute of Manidae animal Squama Manis Manis pentadactyla Linnaeus.Nature and flavor are salty, are slightly cold.Return liver, stomach warp.The merit stimulating milk secretion of can stimulating the menstrual flow, detumescence and apocenosis, expel wind to dredge collateral.
Semen Euryales is the dry mature kernal of nymphaeaceae plant Gorgon euryale Euryale ferox Salisb..Nature and flavor are sweet, puckery, and are flat.Return spleen, kidney channel.But the merit supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, damp eliminating leukorrhagia stopping.
Composition principle: the rule for the treatment of of the Chinese medicine of irritable bowel syndrome employing is started with from solving " incoordination between the liver and spleen " mostly clinically now, think that the primary disease pathogenesis is that disorder of emotion causes irritability stasis, incoordination between the liver and spleen causes the intestinal functional activity of QI being not smooth more, intestinal internal organs conduction mistake department produces pain and rushes down symptom.But inventor's clinical empirical summary for many years finds that the reason of this irritable bowel syndrome is not simple owing to hyperactive liver-QI attacking the spleen, but clearly relevant with sufferer body constitution, namely the hypersensitivity with intestinal smooth is relevant.So should control through opinion from liver,spleen,kidney three, and large intestine and lung phase the exterior and the interior, also will fully take into account respectful the falling of lung qi and lack of proper care on the impact of large intestine mechanism of qi, simple soothing liver and strengthening spleen is only relatively good to a part of patient's effect, for the high quick patient treatment poor effect of intestinal smooth.
The present invention has following characteristics compared with the prior art.
1, cooperate with Herba Urariae crinitae, Caulis Spatholobi He Semen thlaspis: " function cures mainly record " clearing away lung-heat to relieve cough in the hurdle to Herba Urariae crinitae in the Chinese pharmacopoeia; The dissipating blood stasis hemostasis "; but inventor's clinical experience shows; the lung and the large intestine being interior-exteriorly related; Herba Urariae crinitae is applied to the deposited umbilicus of IBS patient promoting blood circulation to remove obstruction in the collateral; the regulating the flow of Qi and the middle Jiao effect, cooperates the promoting blood circulation to remove obstruction in the collateral of enriching blood of Caulis Spatholobi, dehumidifying and the stomach and alleviating pain of Semen thlaspis, can effectively alleviate the high excitation state of IBS Intestinal Mucosal Injury in Patients Undergoing smooth muscle; alleviate enterospasm, recover original digestive tract power; We are not that medicine take promoting QI circulation for relieving depression is as core, but the blood medicine is better than the gas medicine, its reason just is that purpose is to regulate smooth muscle function, and the blood medicine is not selected simple blood circulation promoting medicine, such as Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra etc., mainly be Herba Urariae crinitae, Caulis Spatholobi also have collateral dredging except invigorating blood circulation merit, enter Liver and kidney lung meridian conditioning intestinal blood fortune machine.
2, Herba Spilanthis Acmellae is returned lung; Liver; Large intestine channel.But merit relieving cough and asthma; Detoxification and promoting urination; Reducing swelling and alleviating pain.The mechanism of IBS intestinal hypersensitivity is also indefinite, and inventor's clinical research finds that adding Herba Spilanthis Acmellae in prescription has special effect, and its effect may be relevant with alleviation intestinal immune stress state.
3, the Radix Perillae sending down the abnormal ascending QI and in, Cortex Betulae Luminiferae disappear stagnate and in, the stomach invigorating that activates yang of blue Jacob's ladder, the inventor studies show that, add specifically regulating intestinal canal mechanism of qi of this three herbal medicine, and other digestive tract power regulating drugs can not reach this effect, so infer that its action pathway is irrelevant with the increase enterokinesia.
4, this drug regimen does not use the medicine of the promotion topical remedy Transdermal absorption commonly used such as Borneolum Syntheticum, Herba Menthae, its reason is that often zest is larger for the medicine of above-mentioned short Transdermal absorption, the good Qie of the drug diffusion that this prescription is selected Semen thlaspis contains potassium myronate, after the enzyme effect, produce mustard oil, this kind material enters in the abdominal tissues by applying the umbilicus form easily, accelerates drug effect and occurs; And it is active to add the in love product of Squama Manis flesh and blood, and the effect of short drug diffusion is also arranged.
5, Semen Euryales spleen reinforcing antidiarrheal, the medicine that takes stopgap measures for astringent therapy; This prescription does not use Pericarpium Granati, the Radix Pulsatillae, terminalia flesh, Fructus Mume, the too fast medicine of the one class astringent therapy such as Halloysitum Rubrum, its reason is that such medicine only plays astriction, but the high excitation state of intestinal still exists, use this class medicine after, IBS patient can produce the more than result of stomachache on the contrary; And in we, Semen Euryales dosage is significantly less than the dosage of pharmacopeia record, and its reason is that the effect of this medicine in we is not simple antidiarrheal, and only provides a kind of trend of convergence.
6, the deposited umbilicus agent raw material consumption of the present invention is groped to sum up to draw through the inventor in a large number, and each raw material consumption is for all to have preferably curative effect in the following weight parts scope.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, the crude drug weight proportion: Herba Urariae crinitae 6g, Caulis Spatholobi 8g ， Semen thlaspis 8g, Radix Perillae 6g, Cortex Betulae Luminiferae 6g, Herba Spilanthis Acmellae 8g, blue Jacob's ladder 6g, Squama Manis 8g, Semen Euryales 3g.
Embodiment 2, the crude drug weight proportion: Herba Urariae crinitae 10g, Caulis Spatholobi 15g ， Semen thlaspis 15g, Radix Perillae 10g, Cortex Betulae Luminiferae 10g, Herba Spilanthis Acmellae 15g, blue Jacob's ladder 10g, Squama Manis 15g, Semen Euryales 6g.
Embodiment 3, the crude drug weight proportion: Herba Urariae crinitae 8g, Caulis Spatholobi 10g ， Semen thlaspis 10g, Radix Perillae 8g, Cortex Betulae Luminiferae 8g, Herba Spilanthis Acmellae 10g, blue Jacob's ladder 8g, Squama Manis 10g, Semen Euryales 5g.
During use, Chinese medicine Herba Urariae crinitae of the present invention, Caulis Spatholobi, Semen thlaspis, Radix Perillae, Cortex Betulae Luminiferae, Herba Spilanthis Acmellae, blue Jacob's ladder, Semen Euryales and Squama Manis are decocted with water twice, the merging filtrate post-heating is condensed into extractum or thick paste, and minute morning and evening compress is in IBS patient's umbilical part.
Effective combination of above-mentioned deposited umbilicus agent is coordinated mutually, can effectively reach the purpose for the treatment of irritable bowel syndrome, and side effect is less.The above results is the clinical data sufficient proof, and interrelated data is as follows, and wherein the deposited umbilicus agent of research is used and is the crude drug weight proportion among the embodiment 3.
1 object and method.
1.1 object: be in January, 2010 ~ 2012 year JIUYUE irritable bowel syndrome 62 examples, the patient all meets the irritable bowel syndrome diagnostic criteria, gets rid of the possibility of other diarrhoea.Lab testing: just antibacterial culturing all (-), leukocyte counts is normal.Wherein, male 39 examples, women 23 examples.Be divided at random matched group 31 example and treatment group 31 examples, two groups of patients are at the aspect comparing difference not statistically significants such as age, sex, the course of disease, typing (P〉0.05).Diagnostic criteria is as the criterion with the IBS clinical diagnosis reference standard that China in 1986 formulates: 1. be chief complaint with stomachache, abdominal distention, diarrhoea or constipation, with general nervous symptoms (symptom continue or repeatedly above 3 months); 2. ordinary circumstance is good, and without becoming thin and generating heat, system's health check-up is only found; 3. repeatedly stool routine and cultivation (at least 3 times) are all negative, and the excrement occult blood test is negative; 4. the x-ray barium enema checks without positive and finds, or colon has excitation sign; 5. the motion of colon mirror some patients were is hyperfunction, without obviously mucosa is unusual, and the histological examination normal; 6. blood, routine urinalysis are normal, and erythrocyte sedimentation rate is normal; 7. without parasite medical histories such as dysentery, schistosomicide, therapeutic trial is invalid.
1.2 method: matched group is taked symptomatic treatment, uses Semen daturae tablet treatment stomachache, uses dioctahedral smectite treatment diarrhoea, and the constipation type patient is taken the circumstances into consideration to use phenolphthalein tablet.Treatment group adopts the applying Chinese medicine to the umbilicus agent treatment of the embodiment of the invention 3 gained, is 14d the course for the treatment of.
1.3 safety evaluatio: all carry out blood, urine, stool routine before and after the medication, liver, renal function detect.
1.4 statistical analysis: carry out statistical analysis with SPSS 13.0, P＜0.05 expression has significant.
2 results.
2.1 relapse rate in the constipation type patient 3m: matched group constipation type patient 6 examples, relapse rate 100% is all recurred in the interior constipation of 3m after the treatment.Treatment group constipation type patient 7 examples, 1 routine recurrent constipation in the 3m after the treatment, relapse rate 14.28%.Treatment group obviously is better than matched group, and difference has statistical significance (P＜0.01).
2.2 diarrhea-type patient stool frequency changes: matched group diarrhea-type patient 25 examples, 5.31 ± 2.34 times/d of times of defecation before the treatment, 3.34 ± 1.63 times/d behind the 3d after the treatment.Treatment group diarrhea-type patient 24 examples, 5.54 ± 1.94 times/d of times of defecation before the treatment, 1.86 ± 1.43 times/d behind the 3d after the treatment.The minimizing for the treatment of group times of defecation obviously is better than matched group, and difference has statistical significance (P＜0.05).
2.3 relapse rate in the diarrhea-type patient 3m: the interior relapse rate 76.00%(19/25 of 3m after the treatment of control group).Treatment group relapse rate 41.67%(10/24).Treatment group obviously is better than matched group, and difference has statistical significance (P＜0.05).
2.4 untoward reaction: patient's vital sign (blood pressure, heart rate, body temperature, breathing), physical examination and routine urinalysis Non Apparent Abnormality during treating.
3. conclusion.
The prompting of this result of study, the present invention treats irritable bowel syndrome and has good effect and the higher characteristics of safety, and clinic is used, is promoted.
Claims (2)
1. deposited umbilicus agent for the treatment of irritable bowel syndrome, it is characterized in that being processed by plurality of Chinese, its composition of raw materials and weight proportion are: 6 ~ 10 parts of Herba Urariae crinitae, 8 ~ 15 parts of 8 ~ 15 parts of ， Semen thlaspis of Caulis Spatholobi, 6 ~ 10 parts of Radix Perillae, 6 ~ 10 parts of Cortex Betulae Luminiferaes, 8 ~ 15 parts of Herba Spilanthis Acmellae, 6 ~ 10 parts of blue Jacob's ladders, 8 ~ 15 parts of Squama Maniss, 3 ~ 6 parts of Semen Euryaless.
2. a kind of deposited umbilicus agent for the treatment of irritable bowel syndrome according to claim 1 is characterized in that its weight proportion is: 8 parts of Herba Urariae crinitae, 10 parts of 10 parts of ， Semen thlaspis of Caulis Spatholobi, 8 parts of Radix Perillae, 8 parts of Cortex Betulae Luminiferaes, 10 parts of Herba Spilanthis Acmellae, 8 parts of blue Jacob's ladders, 10 parts of Squama Maniss, 5 parts of Semen Euryaless.
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| CN101961479A (en) * | 2010-04-27 | 2011-02-02 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating bellyache and preparation method thereof |
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| CN103861040A (en) * | 2014-03-21 | 2014-06-18 | 郑秀芬 | Medicament for treating renal colic and preparation method thereof |
| CN103861040B (en) * | 2014-03-21 | 2016-03-30 | 李华 | A kind of medicine and preparation method for the treatment of renal colic |
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