CN102920760A - Production process of water-soluble acanthopanax leaf full powder - Google Patents
Production process of water-soluble acanthopanax leaf full powder Download PDFInfo
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- CN102920760A CN102920760A CN2012104802587A CN201210480258A CN102920760A CN 102920760 A CN102920760 A CN 102920760A CN 2012104802587 A CN2012104802587 A CN 2012104802587A CN 201210480258 A CN201210480258 A CN 201210480258A CN 102920760 A CN102920760 A CN 102920760A
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Abstract
The invention discloses a production process of water-soluble acanthopanax leaf full powder. The production process is characterized in that acanthopanax leaves are cleaned and smashed, water is used to extract water-soluble components of the acanthopanax leaves, after filtration, ethanol of certain concentration is used to extract liposoluble components of the acanthopanax leaves, water extract and ethanol extract are respectively obtained through concentrating and drying of the two extracting solution, the water extract and the ethanol extract are mixed according to a certain proportion, the particle size are improved, and auxiliary materials are added as required to obtain water-soluble acanthopanax leaf powder. The powder can be used independently or together with other materials. The powder provided by the invention has the characteristics of small particle size, good water solubility, high oral absorbability, high utilization efficiency, high yield rate, low cost and facilitation in industrialization.
Description
Technical field
The present invention relates to a kind of production technology of water solublity powder body, particularly a kind of production technology with water solublity powder body of alimentary health-care function.
Background technology
Radix Et Caulis Acanthopanacis Senticosi [Acanthopanax senticocus (Rupr.et Maxim.) Harms] is Araliaceae (Araliaceae) [1-4].It is one of the northern area of China medical material commonly used.The leaf of Radix Et Caulis Acanthopanacis Senticosi, flower, fruit, root, rhizome all can be used as medicine, acrid in the mouth, little hardship, slightly warm in nature.Returning spleen, kidney, heart channel, is the strong medicine that consolidates simply.To modern, through medical research, Radix Et Caulis Acanthopanacis Senticosi is for the metabolism of regulating body, and enhancing body has more significantly effect for the resistance of disease, is very typically to consolidate simply strong medicine.Through clinical and practice, confirmed that it has effects such as " invigorating the liver and kidney, wind-damp dispelling, strengthening bone and muscle, blood circulation and promoting silt, stomach invigorating diuresis ".Along with people are deeply continuous for Radix Et Caulis Acanthopanacis Senticosi research, the multiple effective active composition in the Folium Acanthopanacis Senticosi constantly is developed, and what wherein content was maximum is flavone compound, secondly also has the multiple compositions that remarkable effect is arranged for medical aspect such as saponins.Contain the various active composition in the Folium Acanthopanacis Senticosi, the pharmacologically active of significant effective is arranged for various diseases, for the clinical medicine aspect larger DEVELOPMENT PROSPECT is arranged.Research for Radix Et Caulis Acanthopanacis Senticosi helps protection of resources.Along with the continuous research to Radix Et Caulis Acanthopanacis Senticosi, its active component and pharmacological research be also constantly deeply, for the further developmental research of Radix Et Caulis Acanthopanacis Senticosi provides certain basis.But it is water insoluble that Folium Acanthopanacis Senticosi is directly used, and is not easy to be directly used in clinical.Its blade Chang Zuowei tea soaks and is absorption of human body, such result is difficult to utilize fully the blade resource finally to cause the wasting of resources, and not only guaranteed efficient utilization of resource by the water solublity Folium Acanthopanacis Senticosi powder body of this method preparation, and powder body good water solubility, the bioavailability of preparation are high and toxic and side effects also reduces greatly, for Folium Acanthopanacis Senticosi is efficiently utilized, have pollution-freely with the water solublity Folium Acanthopanacis Senticosi powder body of the method preparation, cost is low, yield is high, easily the advantage of industrialization.
Summary of the invention
A kind of production technology of water solublity Folium Acanthopanacis Senticosi powder body, take Folium Acanthopanacis Senticosi as raw material, after Folium Acanthopanacis Senticosi cleaned and pulverize, use water soluble ingredient in the water extraction Folium Acanthopanacis Senticosi, filter, filtering residue uses liposoluble constituent in the certain density ethanol extraction Folium Acanthopanacis Senticosi, two kinds of extracting solution are carried out obtaining respectively behind the concentrate drying water extract and the alcohol extract of Folium Acanthopanacis Senticosi, water extract and alcohol extract carry out the particle diameter transformation after mixing with certain proportion, and add as required the adjuvant preparation and become water solublity Folium Acanthopanacis Senticosi powder body.This powder body can use separately also can carry out composite use as required.Advantage of the present invention:
1 technological process of the present invention is simple, easy and simple to handle, and production cost is low, and favorable reproducibility is easy to be amplified to industrialization production.
The Folium Acanthopanacis Senticosi diameter of particle of 2 gained of the present invention is little, good water solubility, oral absorption utilization rate are high.
Raw water soluble components and liposoluble constituent ratio contained in the Folium Acanthopanacis Senticosi water solublity powder body of 3 gained of the present invention are adjustable.
4 product organic solvent-frees of the present invention are residual, reclaim solvent and obtain recycling, environmentally friendly.
Specific embodiments
After the Folium Acanthopanacis Senticosi raw material sieved roguing, water cleaned, and according to its granular is processed, the particle diameter after the processing is 1 μ m –, 10 μ m.
Water soluble ingredient content is as foundation in the raw material, obtain the raw water extracting solution according to the water soluble ingredient of solid-liquid ratio 1:1 – 1:10 in take water as solvent extraction raw material (powder), determine to extract temperature according to the stability of water-soluble biological bioactive molecule wherein, generally between 25 ℃ to 100 ℃; Extraction time is 1 – 4 times, and extraction time is 0.5 – 4 hours.
Liposoluble constituent content in the raw material and polarity thereof are as foundation, obtain the feed ethanol extracting solution according to solid-liquid ratio 1:1 – 1:10 take 50% –, 100% ethanol as the liposoluble constituent in the solvent extraction residue, determine to extract temperature according to the stability of fat-soluble biological bioactive molecule wherein, generally between 25 ℃ to 85 ℃; Complexity according to wherein contained fat-soluble biological bioactive molecule extraction is determined extraction time and each extraction time, and extraction time is 1 – 4 times, and extraction time is 0.5 – 4 hours.
Raw water extracting solution and ethanol extract are carried out respectively negative pressure concentrated, obtain raw water and extract concentrated solution and ethanol extraction concentrated solution, solvent carries out recycling.
According to bioactive molecule stability in the concentrated solution, choice for use lyophilization, constant temperature aeration-drying or spray drying are carried out the desolventizing dried to water extraction concentrated solution and ethanol extraction concentrated solution, obtain raw water extract and ethanol extraction.
Take the ratio of water extraction rate and ethanol extraction rate and wherein the content of bioactive molecule as foundation, water extract and ethanol extraction proportionally 50:1 – 1:1 mix, use high speed disintegrator, ball mill or vibration pulverizer that it is carried out the particle diameter transformation after mixing, make its particle diameter reach 100nm – 10 μ m.According to the standby demand of water soluble powder system, add one or more adjuvants in adjuvant mannitol, water soluble starch, alpha-cyclodextrin, beta-schardinger dextrin-, gamma-cyclodextrin, the carboxymethyl cellulose etc., to increase water solublity and the dispersibility of powder body.The production technology of 1 one kinds of water solublity Folium Acanthopanacis Senticosi full price powder body, it is characterized in that: after Folium Acanthopanacis Senticosi is cleaned and pulverizes, use water soluble ingredient in the water extraction Folium Acanthopanacis Senticosi, filter, filtering residue uses liposoluble constituent in the certain density ethanol extraction Folium Acanthopanacis Senticosi, two kinds of extracting solution are carried out obtaining respectively behind the concentrate drying water extract and the alcohol extract of Folium Acanthopanacis Senticosi, water extract and alcohol extract carry out the particle diameter transformation after mixing with certain proportion, and add as required the adjuvant preparation and become water solublity Folium Acanthopanacis Senticosi powder body.This powder body can use separately also can carry out composite use as required.
The production technology of described a kind of water solublity powder body is characterized in that, Folium Acanthopanacis Senticosi cleans and pulverizes before extracting, and particle size range is 1 μ m –, 10 μ m after pulverizing.
The production technology of described a kind of water solublity Folium Acanthopanacis Senticosi powder body is characterized in that, water soluble ingredient extracting method parameter: the extraction solvent is water, solid-liquid ratio is 1:1 – 1:10, extract 100 ℃ of temperature 25 –, each extraction time is 0.5 – 4 hours, and extraction time is 1 – 4 times.
The production technology of described a kind of water solublity Folium Acanthopanacis Senticosi powder body, it is characterized in that, liposoluble constituent extracting method parameter: extracting solvent is 50% –, 100% ethanol water, solid-liquid ratio is 1:0.5 – 1:50, extract 75 ℃ of temperature 25 –, each extraction time is 0.5 – 4 hours, and extraction time is 1 – 4 times.
The production technology of described a kind of water solublity Folium Acanthopanacis Senticosi powder body is characterized in that, the concentrated mode of extracting solution is that negative pressure is concentrated, reclaims solvent and carries out recyclingly, extracts the concentrated solution drying mode and be a kind of in constant temperature aeration-drying, spray drying and the lyophilization.
The production technology of described a kind of water solublity Folium Acanthopanacis Senticosi powder body is characterized in that, water extract and alcohol extract carry out mixing manufacture water solublity powder body according to the ratio of 1:1 – 10:1, contain water soluble ingredient and liposoluble constituent in this powder body.
The production technology of described a kind of water solublity Folium Acanthopanacis Senticosi powder body is characterized in that, the mixture to water extract and alcohol extract in the powder body preparation process carries out the particle diameter transformation, and particle diameter is 100nm – 10 μ m after transforming.
The production technology of described a kind of water solublity Folium Acanthopanacis Senticosi powder body, it is characterized in that, add adjuvant in the powder body preparation process according to demand, supplementary product kind comprises one or more in mannitol, water soluble starch, alpha-cyclodextrin, beta-schardinger dextrin-, gamma-cyclodextrin, the carboxymethyl cellulose etc.
The production technology of described a kind of water solublity Folium Acanthopanacis Senticosi powder body, the use of this water solublity powder body are that single powder body uses or composite the use.
Specific embodiment
Example 1:
After the roguing of Radix Et Caulis Acanthopanacis Senticosi material screening, water cleans, and uses pulverizer that it is crushed to particle diameter 1 – 5mm.
Obtain the Radix Et Caulis Acanthopanacis Senticosi aqueous extract according to the water soluble ingredient of solid-liquid ratio 1:4 in take water as the solvent extraction Radix Et Caulis Acanthopanacis Senticosi, extracting parameter is 100 ℃ of temperature, and extraction time is 2 times, and each extraction time is 1.5 hours.
Obtain the Radix Et Caulis Acanthopanacis Senticosi ethanol extract according to the liposoluble constituent of solid-liquid ratio 1:4 in take 80% ethanol as solvent extraction Radix Et Caulis Acanthopanacis Senticosi residue, extracting parameter is 65 ℃ of temperature, and extraction time is 2 times, and each extraction time is 1 hour.
Radix Et Caulis Acanthopanacis Senticosi aqueous extract and ethanol extract are carried out respectively negative pressure concentrated, obtain Radix Et Caulis Acanthopanacis Senticosi water extraction concentrated solution and ethanol extraction concentrated solution, solvent carries out recycling.
Adopt constant temperature aeration-drying (temperature is 75 ℃) that water extraction concentrated solution and ethanol extraction concentrated solution are carried out the desolventizing dried, obtain Radix Et Caulis Acanthopanacis Senticosi water extract and ethanol extraction.
Radix Et Caulis Acanthopanacis Senticosi water extract and ethanol extraction proportionally 4:1 mix, and add 50% mannitol according to weight ratio, use high speed disintegrator and vibration pulverizer that it is carried out the particle diameter transformation behind the mix homogeneously, making its particle diameter is 1 μ m, obtains water solublity Radix Et Caulis Acanthopanacis Senticosi powder body.
Claims (9)
1. the production technology of a water solublity Folium Acanthopanacis Senticosi full price powder body, it is characterized in that: after Folium Acanthopanacis Senticosi is cleaned and pulverizes, use water soluble ingredient in the water extraction Folium Acanthopanacis Senticosi, filter, filtering residue uses liposoluble constituent in the certain density ethanol extraction Folium Acanthopanacis Senticosi, two kinds of extracting solution are carried out obtaining respectively behind the concentrate drying water extract and the alcohol extract of Folium Acanthopanacis Senticosi, water extract and alcohol extract carry out the particle diameter transformation after mixing with certain proportion, and add as required the adjuvant preparation and become water solublity Folium Acanthopanacis Senticosi powder body.This powder body can use separately also can carry out composite use as required.
2. according to the production technology of a kind of water solublity powder body claimed in claim 1, it is characterized in that, Folium Acanthopanacis Senticosi cleans and pulverizes before extracting, and particle size range is 1 μ m –, 10 μ m after pulverizing.
3. according to the production technology of a kind of water solublity Folium Acanthopanacis Senticosi powder body claimed in claim 1, it is characterized in that, water soluble ingredient extracting method parameter: the extraction solvent is water, solid-liquid ratio is 1:1 – 1:10, extract 100 ℃ of temperature 25 –, each extraction time is 0.5 – 4 hours, and extraction time is 1 – 4 times.
4. according to the production technology of a kind of water solublity Folium Acanthopanacis Senticosi powder body claimed in claim 1, it is characterized in that, liposoluble constituent extracting method parameter: extracting solvent is 50% –, 100% ethanol water, solid-liquid ratio is 1:0.5 – 1:50, extract 75 ℃ of temperature 25 –, each extraction time is 0.5 – 4 hours, and extraction time is 1 – 4 times.
5. according to the production technology of a kind of water solublity Folium Acanthopanacis Senticosi powder body claimed in claim 1, it is characterized in that, the concentrated mode of extracting solution is that negative pressure is concentrated, reclaims solvent and carries out recyclingly, extracts the concentrated solution drying mode and be a kind of in constant temperature aeration-drying, spray drying and the lyophilization.
6. according to the production technology of a kind of water solublity Folium Acanthopanacis Senticosi powder body claimed in claim 1, it is characterized in that, water extract and alcohol extract carry out mixing manufacture water solublity powder body according to the ratio of 1:1 – 10:1, contain water soluble ingredient and liposoluble constituent in this powder body.
7. according to the production technology of a kind of water solublity Folium Acanthopanacis Senticosi powder body claimed in claim 1, it is characterized in that, the mixture to water extract and alcohol extract in the powder body preparation process carries out the particle diameter transformation, and particle diameter is 100nm – 10 μ m after transforming.
8. according to the production technology of a kind of water solublity Folium Acanthopanacis Senticosi powder body claimed in claim 1, it is characterized in that, add adjuvant in the powder body preparation process according to demand, supplementary product kind comprises one or more in mannitol, water soluble starch, alpha-cyclodextrin, beta-schardinger dextrin-, gamma-cyclodextrin, the carboxymethyl cellulose etc.
9. according to the production technology of a kind of water solublity Folium Acanthopanacis Senticosi powder body claimed in claim 1, the use of this water solublity powder body is that single powder body uses or composite the use.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012104802587A CN102920760A (en) | 2012-11-23 | 2012-11-23 | Production process of water-soluble acanthopanax leaf full powder |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012104802587A CN102920760A (en) | 2012-11-23 | 2012-11-23 | Production process of water-soluble acanthopanax leaf full powder |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113318137A (en) * | 2021-06-25 | 2021-08-31 | 东北林业大学 | Preparation method of water-soluble acanthopanax powder capsule |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1133176A (en) * | 1995-04-11 | 1996-10-16 | 宋士岳 | Preparation process for acunthopanax senticosus powder injection |
| CN102579531A (en) * | 2012-02-20 | 2012-07-18 | 山东大学威海分校 | Acanthopanax leaf extract having antioxidation |
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- 2012-11-23 CN CN2012104802587A patent/CN102920760A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1133176A (en) * | 1995-04-11 | 1996-10-16 | 宋士岳 | Preparation process for acunthopanax senticosus powder injection |
| CN102579531A (en) * | 2012-02-20 | 2012-07-18 | 山东大学威海分校 | Acanthopanax leaf extract having antioxidation |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113318137A (en) * | 2021-06-25 | 2021-08-31 | 东北林业大学 | Preparation method of water-soluble acanthopanax powder capsule |
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Application publication date: 20130213 |