CN102908707A - Hui medicine oxygen mask and matched medical oxygen medicated pad as well as preparation method of medicated pad - Google Patents
Hui medicine oxygen mask and matched medical oxygen medicated pad as well as preparation method of medicated pad Download PDFInfo
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Abstract
The invention discloses a Hui medicine oxygen mask and a matched medical oxygen medicated pad for preventing cardiovascular and cerebrovascular diseases and a preparation method of the medicated pad. The medical oxygen mask comprises a plastic mask, a Y-shaped connection pipe, a filter box, an I-shaped connection pipe, a medical oxygen box and an oxygen connection pipe which are sequentially connected together, wherein a medical oxygen mouth is formed on the plastic mask; one end of the medical oxygen mouth is inlaid in the plastic mask, and the other end of the medical oxygen mouth is connected with the Y-shaped connection pipe. According to the invention, through the application of Hui medicine oxygen intake technology, the function of oxygen therapy can be achieved, the volatile components and active factors of a Hui fragrant medicine directly act on the focus through being absorbed by schneiderian membrane, so that the effects that multiple targets are activated and multiple systems are involved to treat the focus are exerted; and the clinical practice shows that the method has the advantages of high efficacy, no side effects, no pains and the like, and is fast to act, safe, convenient.
Description
Technical field
The invention belongs to the national medicine technical field, particularly relate to a kind of time medical medicine oxygen mask for the control cardiovascular and cerebrovascular disease and matching used medicine oxygen medicated cushion and preparation method thereof.
Background technology
Cardiovascular and cerebrovascular disease is one of the commonly encountered diseases of China and even global human and frequently-occurring disease, has " four height " characteristics such as high prevalence, high case fatality rate, high disability rate, high relapse rate, has brought white elephant for society and family.Along with progress, amblent air temperature and the human life style's of China aged's increase, society change, its M ﹠ M is year by year ascendant trend, and the initial age of falling ill more greatly shifted to an earlier date, the serious harm mankind's life is with healthy.
The medicine of control cardiovascular and cerebrovascular disease is main mainly with injection and oral formulations at present, medicine need to be by the first pass effect of liver stomach mostly, because the Chinese medicine macromolecular drug is difficult to pass through blood brain barrier, seriously affected the drug effect performance of medicine, secondly, the expense of all Western medicine, Chinese medicine is also soaring constantly, so that the situation of Expensive and hard to visit doctors fundamentally is difficult to alleviate.Therefore, seek and develop a kind of letter, just, test, honest and clean national medicine characteristic therapy control cardiovascular and cerebrovascular disease, have undoubtedly great strategic importance and social meaning.
China Hui ethnic group medicine is an important component part of Chinese traditional medicine, have distinct Hui ethnic group's medicine cultural traits, especially aspect the preventing and treating of cardio-cerebral diseases, Hui ethnic group's medicine not only has long and brilliant history, more has the opinion of science to administer opinion and abundant treatment experience.Return the doctor to etiology and pathogenesis and the pathological change of cardiovascular and cerebrovascular disease may be summarized to be " yin-Yang, abnormal ascent-descent between clear YANG and turbid YIN; cause the distribution imbalance of quaternary, four property, four liquid; and cause that expectorant is turbid, stagnation of blood stasis in brain through the brain network; the brain body is stranded for evil; must not QI and blood moisten foster; weak to having under one's command of hundred arteries and veins, body key, consciousness and motion, and be that abnormal state of mind, body key are obstructed, consciousness reach (or) syndrome caused by wind pathogen disease among the dyskinesia etc. ".China returns medicine control heart and brain disease and emphasizes with regulating YIN and YANG, and balance quaternary four property four liquid are rule for the treatment of, and kind take causing resuscitation with aromatic drugs, eliminating phlegm and removing dampness, the Li Mai that stimulates the menstrual flow as main, route of administration is especially paid attention to the method for nose administration.
Summary of the invention
The present invention just is being based on and is putting back medical ancient books and records in order---" Huihui Formularies " kind theory and proved recipe with nose administration control cardiovascular and cerebrovascular disease, in conjunction with modern pharmacology knowledge, excavation and summary through long-term medical practice, invented a kind of in order to prevent and treat the medical medicine oxygen mask that returns of cardiovascular and cerebrovascular disease, this face shield is aromatics to be returned medicine combine with oxygen, with oxygen as carrier, form medicine oxygen, suck from the mouth and nose atomizing, thereby reach the blood oxygen that increases sharply, the content of medicine, effectively improve brain, the tissue metabolism of the heart and blood supply, the oxygen supply situation, and then effectively prevent and treat a kind of time medical therapy of cardiovascular and cerebrovascular vessel.
Another object of the present invention provides and the matching used medicine oxygen of above-mentioned medicine oxygen mask medicated cushion.
Another purpose of the present invention provides the preparation method of above-mentioned medicine oxygen medicated cushion.
The technical scheme of taking for achieving the above object is:
A kind of medical medicine oxygen mask that returns for the control cardiovascular and cerebrovascular disease, it is characterized in that being formed by the plastic mask that is connected in turn, Y-shaped connection tube, filter cartridge, I font connection tube, medicine oxygen medicine box and oxygen connecting tube, medicine oxygen mouth is installed on the described plastic mask, this medicine oxygen mouth one end is embedded in plastic mask, and the other end is connected with the Y-shaped connection tube.
Have several air-vents on the described plastic mask.
Described filter cartridge is comprised of filter cartridge shell and the middle sponge filter bed at two ends.
Accompany active carbon in the described sponge filter bed.
Described medicine oxygen medicine box is comprised of the upper box shell that cooperatively interacts into box body and lower box shell and the medicine oxygen medicated cushion that is placed in the box body.
Nearly bottom around the described upper box shell inboard is provided with stopper in the medicine box shell, is provided with the sliding gear of lower medicine box shell internal lock around the nearly upper limb in the lower box shell outside, and the sliding gear of stopper and lower medicine box shell internal lock matches in the described upper medicine box shell.
A kind of medicine oxygen medicated cushion that supports the use on above-mentioned medicine oxygen mask is characterized in that containing in this medicine oxygen medicated cushion the medicine of following weight proportioning:
Resina Ferulae 1～3 weight portion;
Styrax 1～2 weight portion;
Benzoinum 1 weight portion;
Flos Caryophylli 1～3 weight portion;
Lignum Santali Albi 1～2 weight portion;
Aloe 1～3 weight portion.
The preparation method of above-mentioned medicine oxygen medicated cushion, its processing step is: at first Resina Ferulae, Styrax, Benzoinum, Flos Caryophylli, Lignum Santali Albi and Aloe are cleaned respectively, dry, then be mixed in proportion, pulverize after mixing, cross 80 mesh sieves, make medicamental pulverata, for subsequent use behind the ultraviolet radiation sterilization; Get the medicamental pulverata of 3 grams, fill in medical non-woven fabrics ventilative, antiallergic and make in the bag, namely make medicine oxygen medicated cushion after the sealing.
Medication theoretical foundation of the present invention is:
1. Resina Ferulae
Resina Ferulae is resin and the root of Umbelliferae Ferula sinkiangensis K.M.Shen.Be distributed in Central Asia and Iran and Afghan, China only has the Xinjiang growth." Huihui Formularies " be called the Sa Jibie crossbow only, be the transliteration of Arabic.Its gas of " Bencao Jingshu " meaning Resina Ferulae is smelly strong different normal, therefore kind extremely parasites is specially warded off bad odor; Suffering is walked and is not kept, Wen Tong and manageing it, thus can removing food stagnancy, sharp all keys, dirt eliminating is disliked also." book on Chinese herbal medicine converge with speech " record Resina Ferulae be eliminate indigestion, induced abortion, parasite killing medicine also.Its gas is hot strong and smelly.People from unit with its enter with foodstuff among, can ward off all poison of all brutish fish Testudinis raw meat meat or fish; Tang Materia Medica claims its master to kill all small worms, the gas of deodorizing, and broken disease is long-pending, lower bad odor; " Japan hanako materia medica " put down in writing it and controlled the biography corpse, broken disease addiction ...The medication experience of national medicine is thought its suffering, temperature; During function is closed, relieving spasm to stop pain, the cold expelling of regulating the flow of vital energy, relaxing muscles and tendons and activating QI and blood in the collateral, removing blood stasis to reduce swelling, wind dispelling cold expelling, sedation and analgesia, cure mainly infantile convulsion, the stagnation of QI of twitching, have a guilty conscience, traumatic injury, blood stasis are made painful, apoplexy etc.
Hui ethnic group medical science doctor thinks the people because the variation of many liquid matter and cause phlegmatic temperament in the body, thereby hinders blood vessels, and brain is not through capable and send out and be hemiplegia, all diseases of facial hemiparalysis, can dirt eliminating dislike (phlegmatic temperament) because of Resina Ferulae, acrid in the mouth is walked and do not kept, and is warm in nature then logical and can manage it, therefore energy dredging the meridian, and sharp all keys.And the Yuan Dynasty is Hui ethnic group's medicine culture in central plain of China the most prosperous period, and first people enters it in foodstuff, because it can ward off all poison of all brutish fish Testudinis raw meat meat or fish, thereby reaches the purpose of disease preventing and treating, does not get rid of the impact that is back that medicine is cultural.
By to finding after the research of pertinent literature in recent years, the pharmacological action of Resina Ferulae mainly contains: anti-allergic effects, obviously suppress uterine myometrium amount, antiinflammatory action, to the effect of cyclic nucleotide in cell, blood plasma and the tissue, can play 6 aspects such as the effect that increases the rhythm of the heart and antibacterial insecticidal action to heart.The contained volatile oil of Resina Ferulae, resin and natural gum etc., the detumescence of regulating the flow of vital energy is arranged, invigorate blood circulation disappear tired, eliminate the phlegm and the effect of excitor nerve.
2. Benzoinum
Benzoinum is a kind of of Styracaceae (Styracaceae) plant, is distributed in subtropical and tropical zones, and China mainly is distributed in the Northwest.It is gained the name is to secrete resinoid because its trunk is injured, belongs to the aromatic and inducing resuscitation medicine.The traditional Chinese medical science is thought the Benzoinum fragrant odour, be good at walking to alter, take the refreshment of having one's ideas straightened out as main effect, and can blood-activating and qi-promoting, the effect such as endogenous wind stopping is relieving convulsion.Its hot flavor enters heart channel, and the effect trend is floating for rising, be used for the treatment of at present cerebral ischemia the rule for the treatment of be embodied in the aspects such as the refreshment of having one's ideas straightened out, benefiting QI for activating blood circulation, liver and kidney tonifying, eleminating phlegm and freeing channels more.According to the literature, its chemical composition is mainly lignanoids, mushrooms and fragrant volatility constituents.Modern experimental zoology studies show that; to different cerebral ischemia animal models; Benzoinum to neural protective effect be by reduce cerebral edema, improve cerebral tissue damage, promote the approach such as microcirculation to realize, its mechanism of action with suppress the neurotoxicity due to inflammatory cytokine release, antioxidation, the energy metabolism of raising cerebral tissue, the antagonism many factors and the inhibitory action of neuronal apoptosis etc. had some relations.The people such as Liu Yude research thinks that aromatic drug mainly may be to have walked women's head-ornaments by the vim and vigour that the property that its fragrance is walked string is drawn all medicines and body to reach therapeutic effect in the effect for the treatment of encephalopathy, therefore its purpose is tying-in, rather than treats; And Benzoinum is hot and walk string, and it is floating that the effect trend rises, reach on all medicines in head therefore can lead, and promote medicine rapidly by blood brain barrier, and through focus performance therapeutical effect.
3. Aloe
Aloe is the perennial meat herbaceous plant of Liliaceae Aloe, has the effects such as removing heat from the liver, relieving constipation, and traditional medicine is mainly used in treating the hot constipation of intestinal, beauty treatment etc.Yang Daqing research is found to contain a large amount of 1-Hydroxy-1,2,3-propanetricarboxylic acid. calcium in the Aloe, it has significant heart tonifying, promotion and improves the effects such as blood circulation, vessel softening wall, blood fat reducing and expansion blood capillary, a large amount of SOD that it contains and catalase etc. have the effect of very strong removing superoxide radical, therefore Aloe has significant blood circulation promoting and the therapeutic effect that alleviates the heart burden.The materials such as the carotene in the discovery Aloes such as Tang Jianhong, superoxide dismutase (SOD), catalase and cysteine all can be removed the superoxide radical in the body significantly, and the blood vessel injury that is caused by lipid peroxidation is had good protective effect.Li Jianchun etc. are by the zoopery discovery, and Aloe can obviously reduce the content of lipid peroxide in the blood to the rabbit arterial hardening model of high fat diet foundation, dwindles the area of atheromatous plaque.
4. Flos Caryophylli
Record in " Kaibao Bencao ": " acrid in the mouth, temperature, nontoxic." enter stomach, spleen, kidney channel ". the Decoction and Material Medica " ": lunar, bright, the shaoyin channel of foot sun of starting with. " " Thunder God is concocted property of medicine solution ": " enter lung, spleen, stomach, kidney four warps." " book on Chinese herbal medicine is newly organized ": " and Flos Caryophylli has female, male dividing, and in fact cures the disease without dividing each other. acrid in the mouth, and temperature, pure sun is nontoxic. enter kidney, stomach two warps, walk again lunar lungs.”。
Contain 46 kinds of volatile compounds in the Flos Caryophylli, wherein the Flos Caryophylli fruit always identifies 41 kinds, identifies 30 kinds in the Flos Caryophylli alabastrum.
Its pharmacological action has: antibacterial action, anti-inducing with antitumaous effect, antioxidation with to the effect of digestive system.
5. Styrax
Styrax (styrax) forms through processing and refining for the balsam that the trunk of Hamamelidaceae Plants Styrax tree (Liquidambar orientalis Mill.) oozes out, and resin part resin ester class and Resin Acid form.Styrax main constituent cinnamic acid is by suppressing the thromboxane synthetase effect, thereby make (the phospholipase A2 of thromboxane A in the blood plasma, TXA) level reduces, simultaneously to prostacyclin (prostacyclin, be called for short PGI2) not impact of level, reach anti-platelet aggregation and anti thrombotic action.Styrax all belongs to blood-activating stasis-removing kind Chinese medicine.According to modern pharmacology research, blood-activating stasis-removing kind Chinese medicine generally has common pharmacological action more: coronary artery dilator and blood vessel, increase blood flow, and anti-myocardial ischemia improves the heavy degeneration of blood, anticoagulation, antithrombotic formation and platelet aggregation etc.
6. Lignum Santali Albi
Lignum Santali Albi is the trunk heartwood of Santalaceae plant Lignum Santali Albi Santalum album L., has the effect of the warming middle-JIAO of regulating the flow of vital energy, appetizing pain relieving.Leaf of Lignum Santali Albi and twig general flavone content thereof are quite high, have zest and can promote energy expenditure, appetite-suppressing, raising metabolism and heat production etc.
Design theory of the present invention is according to being:
The present invention reaches " mouth and nose lead in brain " scheduling theory according to time medicine " brain the master always feel ", " brain is that hundred feeling pulse are always former ", and the prescription that the opinion that absorbs back medicine is controlled the contained nose administration recipe of classics-" Huihui Formularies " control brain heart illness selects the medicine experience, a kind of time medical uniqueness therapy device of developing.Its treatment mechanism is three therapeutic methods of traditional Chinese medicine unification: namely
1. oxygen therapy makes brain, the heart, the quick oxygen supply of lung, and metabolism is increased, and improves the cell function of brain, the heart, lung.
2. incense drug therapy, abnormal smells from the patient fragrance makes the people in high spirits first, is in a cheerful frame of mind; Then be rich in multiple volatile oil in addition, the multiple pharmacological effect such as the cranial nerve of stimulation, expansion cardiovascular and cerebrovascular vessel are arranged; Can see through fast in addition the effect of blood brain barrier; Have simultaneously certain sterilization or bacteriostasis.
3. anapnotherapy, the mouth and nose administration without the first-pass effect of liver stomach, directly enters the body circulation, can significantly increase the drug utilization degree.
The present invention can reach the effect of oxygen therapy by the application of returning medicine medicine oxygen suction technology, can make go back to again the volatile ingredient of medicated incense medicine and the through sick institute of absorption that active factors passes through nasal mucosa, play back the many target spots of medicine and activate the effect that multisystem participates in the treatment focus, clinical trial shows, effect is remarkable.
The present invention mainly is adapted to cerebral apoplexy sequela, cerebral infarction, cerebral embolism, dementia, Parkinson's disease, heart infarction, the coronary heart disease of cardio-cerebrovascular disorder, and angina pectoris is dizzy, and the insomnia of mental disease is demonstrate,proved, depression is demonstrate,proved etc.; The hyperlipemia of subhealth state class, obesity, easy catching a cold, chronic fatigue syndrome etc. also there is obvious preventive and therapeutic effect.Clinical practice proves, that this method has is rapid-action, curative effect is high, safe and simple, have no side effect, the painless advantage of waiting bitterly for.
Medical medicine oxygen mask is used for the treatment of the clinical trial process of cardiovascular and cerebrovascular disease to the below for the present invention returns:
One. return medical medicine oxygen therapy treatment cerebral infarction reconvalescent 120 routine clinical observations
1 clinical data
1.1 the physical data all cases derives from First People's Hospital, Yinchuan City and goes back to medical encephalopathy section's outpatient service and ward, all meets the case choice criteria.The patient successively adopts the table of random number method to be divided into 2 groups according to being admitted to hospital, and treatment is removed the case that comes off after finishing.Treatment group 120 examples, male 69 examples wherein, women 51 examples; 62.82 years old mean age; The course of disease 15～172 days.Matched group 118 examples, male 66 examples, women 52 examples; 61.68 years old mean age; The course of disease 18～168 days.2 groups of sexes, age, Staging of course of disease and western medicine aspects etc. are learned processing by statistics, and there was no significant difference (P〉0.05), have comparability.
1.2 " the TCM diagnosis efficacy assessment standard " of diagnostic criteria tcm diagnosis standard reference Society of Internal Medicine of All-China Association of Traditional Chinese Medicine revision in 1986." all kinds of cerebrovascular disease diagnosis main points " of the Western medicine diagnose standard reference Chinese Medical Association whole nation the 4th cerebrovascular academic conference revision.
1.3 inclusive criteria meets above-mentioned diagnostic criteria and signs Informed Consent Form.
1.4 exclusion standard is transient ischemic attack or hemorrhagic apoplexy and Combination apoplexy person 1..2. affect treatment by Chinese herbs person with degree of depth stupor, the hematemesis that occurs together etc., confirm on inspection by the reasons such as the cerebral tumor, cerebral trauma, cerebral parasitosis, the dysbolismus person that causes the cerebral embolism.3. more than 70 years old, gestation or women breast-feeding their children, those who are allergic to this drug.4. be associated with the serious primary disease such as liver, kidney, hemopoietic system and hormonal system, insane.5. all inclusive criterias that do not meet, not in accordance with regulations medication can't be judged that curative effect or data are not congruent to affect the treatment or safety judgement person.
2 methods
2.1 Therapeutic Method
Treatment group:
(1) operational approach: will return medical medicine oxygen medicated core and be filled in the disposable nebulizer medicine box, and connect nebulizer to the medical oxygen cylinder seam, ventilation checks the conduit seal; Oxygen catheter is connected in face shield, and the per os snuffing enters, and oxygen flow is 1.5L/min, and each respiratory time is 30 minutes, and 1 time on the 1st, 10 times was 1 course for the treatment of, treats observation index after 3 courses for the treatment of.
(2) Primary Care: give anticoagulant (the oral aspirin enteric coatel tablets, 100mg, 1 time 1,1 time on the 1st), nutrition cranial nerve medicine (oryzanol tablets, 100mg, 1 time 4,3 times on the one), 10 times was 1 course for the treatment of, treated observation index after 3 courses for the treatment of.
Matched group:
(1) Therapeutic Method: simple low discharge oxygen Inhalation in Treating, oxygen flow is 1.5L/min, and each respiratory time is 30 minutes, and 1 time on the 1st, 10 times was 1 course for the treatment of, treated observation index after 3 courses for the treatment of.
(2) Primary Care is the same.
2.2 observation index
(1) neurological functional deficit scoring: with reference to Chinese Medical Association's the 4th cerebrovascular academic conference Cerebral Apoplexy Nerve Function defect degree standards of grading in the whole nation
[2]Compare two groups of patient treatments front and back neurological deficits score.
(2) SOD, MDA detect: (build up bio-engineering research institute available from Nanjing, lot number: 20040716) illustrate and carry out by test kit.
2.3 statistical method adopts SPSS10.0 for Windows statistical software to carry out data analysis, adopts the t check.
3 results
3.1 neurological deficits score relatively sees Table 1 before and after 2 groups of patient treatments.
Neurological deficits score relatively before and after 2 groups of patient treatments of table 1
| Group | n | Before the treatment | After the treatment |
| Treatment group | 120 | 34.41±6.57 | 15.97±5.45 * △ |
| Matched group | 118 | 33.23±5.42 | 20.43±4.57 * |
Relatively front with the treatment of this group
*P＜0.05,
*P＜0.01; With comparison △ P＜0.05 (lower same) after the treatment of control group.
3.2 SOD variation active, MDA content sees Table 2 before and after 2 groups of treatments.
The variation of SOD activity, MDA content before and after 2 groups of patient treatments of table 2
4. brief summary
By this clinical observation, to return medical medicine oxygen therapy and can obviously improve ATCI reconvalescent function of nervous system, curative effect is better than matched group.After ATCI occurs, the cerebral tissue of hypoxic-ischemic produces more free radical by approach such as xanthine oxidase system, arachidonic acid-epoxidase system and mitochondrions " univalent leak ", make body oxygen-derived free radicals defense mechanism activity decreased, cause a large amount of free radicals to generate, brain inner lipid peroxidation is strengthened, cause cell membrane and blood-brain barrier damage, cause the biomembrane cracking, protein denaturation, enzymatic activity forfeiture, cranial nerve cell death or apoptosis.Therefore the toxic action of free radical has been considered to one of key pathology link of cerebral ischemia infringement.Originally studies show that, return the medical medicine oxygen therapy ATCI reconvalescent activity of SOD in serum that can significantly raise, reduce MDA content, illustrate back that medical medicine oxygen therapy can improve the mechanism of action of ATCI reconvalescent function of nervous system relevant with anti-oxidative damage.
Two. return medical medicine oxygen therapy treatment vasospasm aypnia 58 examples
1 clinical data
1.1 case is included in and exclusion standard
Inclusive criteria: 1. meet " Chinese Spirit Obstacles classification and diagnostic criteria " the 3rd edition (CCMD-3) insomnia diagnosis; 2. without the drug dependence history; 3. get rid of mental disorder and physical disease institute induced insomnia; 4. transcranial Doppler sonography detects prompting vasospasm.
1.2 physical data: 98 patients all derive from August, 2009-2011 year First People's Hospital, December Yinchuan City department of Chinese medicine outpatient service.Half randomized is divided into two groups, treatment group 58 examples, male 20 examples, women 38 examples; 18～53 years old age, 39.6 years old mean age.Matched group 40 examples, male 18 examples, women 22 examples, 21～58 years old age, 40.5 years old mean age; Two groups of Genders, age, TCD check results are learned by statistics the equal not statistically significant of processing (p＜0.05) and are had comparability.
1.3 Therapeutic Method:
Treatment group
Operational approach: will return medical medicine oxygen medicated core and be filled in the disposable nebulizer medicine box, and connect nebulizer to the medical oxygen cylinder seam, ventilation checks the conduit seal; Oxygen catheter is connected in face shield, and the per os snuffing enters, and oxygen flow is 1.5L/min, and each respiratory time is 30 minutes, and 1 time on the 1st, 10 times was 1 course for the treatment of, treats observation index after 3 courses for the treatment of.
Matched group
Give 1 bag of oral blood-nourishing and brain-refreshing granules (Tianjin Tasly Pharmaceutical Co., Ltd's production) 1 time, 3 times on the one.10 days is a course for the treatment of.
2 observation of curative effect
2.1 curative effect judging standard
With reference to " new Chinese medicine guideline of clinical investigations " relevant criterion, detect judgement according to patient's symptom and TCD index, cure: the insomnia primary symptom disappears, and it is normal that TCD detects vertebra basilar artery blood flow rate; Produce effects: insomnia obviously improves, the life that can work, and TCD detects index improvement; Effectively: insomnia slightly is improved; Invalid: doing well,improving is not obvious, and TCD detects prompting vertebra basilar artery blood flow rate and speeds.
2.2 clinical efficacy
2 groups of curative effects of table 1 are (example) relatively
| Group | n | Cure | Effectively | Take a turn for the better | Invalid | Total effective rate/% |
| Treatment group | 58 | 16 | 25 | 11 | 6 | 89.6 |
| Matched group | 40 | 6 | 12 | 9 | 13 | 67.5 |
χ
2=81.05，P<0.05。
3 brief summaries
Modern experimentation proves, suffers from for a long time brain diseases, can cause cranial nerve cell ischemia, anoxia in various degree, so that the partial nerve cell is in inhibitory state, and especially the neurocyte of damaged zone has lost normal propagation function, and the physiological reflex arc is destroyed.Return medical medicine oxygen therapy and have blood vessel dilating, establishment side is propped up Circulation rapidly, to guarantee the blood supply in disease damage district, helps the cortex cell of damaged to finish its function, and hypnotic improves brain electrical acti.
Three. return the clinical research of medical medicine oxygen anapnotherapy treatment vascular dementia
1 data and method
Physical data derives from the patient that medical encephalopathy section and Neurology Clinic and ward are gone back to by First People's Hospital, Yinchuan City, all meet Chinese Chinese medicine association gerontology and can formulate " diagnostic criteria of senile dementia ", have memory, computing power or disorientation, obvious emotion changes and personality disorder occur, and the course of disease is more than 6 months.Be divided into matched group and observation group by admission number Dan Shuan, observation group's 72 examples, male 42 examples, women 30 examples, year at age (68.0 ± 7.8); The course of disease (1.0 ± 0.4) year; Its dementia degree, slight 35 examples, moderate 23 examples, severe 14 examples.Matched group 51 examples, women 21 examples of man's 30 examples, age (67.0 ± 6.9) year; The course of disease (1.0 ± 0.4) year; Its dementia degree, slight 25 examples, moderate 16 examples, severe 10 examples.Two groups of above-mentioned data compare, no significant difference (all P〉0.05).
1.2 method
1.2.1 Therapeutic Method
Treatment group:
(1) operational approach: will return medical medicine oxygen medicated core and be filled in the disposable nebulizer medicine box, and connect nebulizer to the medical oxygen cylinder seam, ventilation checks the conduit seal; Oxygen catheter is connected in face shield, and the per os snuffing enters, and oxygen flow is 1.5L/min, and each respiratory time is 30 minutes, and 1 time on the 1st, 10 times was 1 course for the treatment of, treats observation index after 3 courses for the treatment of.
(2) oral vitamin E 0.1g, 3 times/d, piracetam 0.8g, 3 times/d, 10 is 1 course for the treatment of, treats observation index after 3 courses for the treatment of.
Matched group: oral vitamin E 0.1g, 3 times/d, piracetam 0.8g, 3 times/d, 10 is 1 course for the treatment of, treats observation index after 3 courses for the treatment of.
1.2.2 evaluation side:
1. two groups of patients all detect erythrocyte superoxide dismutase (SOD) activity before treatment and after treating 3 courses for the treatment of, blood plasma lipid peroxidation (LPO), triglyceride (TG), serum cholesterol (TCH), high density lipoprotein (HDL).
2. Chang Gu river dementia is revised scale detected value, mild dementia 22～29 minutes, moderate 14～21 minutes, severe 6～13 minutes, utmost point severe 0～5 minute before and after the record treatment.
3. criterion of therapeutical effect:
Conscious, directed sound, answer a question correct, be quick on the draw, take care of oneself, can carry out the mass society activity, the Chang Gu river is dull-witted revises the scale scoring increases before the treatment〉8 be divided into produce effects;
The main spirits symptom weakens to some extent or partly disappears, and life is self-care substantially, and answering a question is in the main true, but bradykinesia, intelligence and personality still have partial impairment, and the Chang Gu river dementia modification scale scoring front increase by 5～8 for the treatment of is divided into effective;
Cardinal symptom has development without change or the state of an illness, can't take care of oneself, answer a question incorrect, and mental dementia, it is invalid that front＜5 minutes persons of increasing are treated in the scoring of the dull-witted modification in Chang Gu river scale.
1.2.3 statistical method:
Data represent with-x ± s, and measurement data adopts the t check, and enumeration data adopts χ 2.
2 results
2.1 TCH, TG, HDL, SOD, LPO are relatively before and after two groups of patient.See Table 1
TCH, TG, HDL, SOD, LPO are relatively before and after the table 1 liang group patient
Relatively front with treatment
*P＜0.05
*P＜0.01; Compare △ P＜0.01 with matched group
Revise the scale scoring relatively 2.2 the Chang Gu river is dull-witted before and after two groups of treatments.See Table 2.
The scoring of the dull-witted modification in Chang Gu river scale relatively divides before and after the table 2 liang group treatment,
With front relatively * P＜0.01 for the treatment of, compare △ P＜0.05 with matched group
2.3 two groups of patient's curative effects relatively see Table 3.
Table 3 liang group patient's curative effect comparative example (%)
| Group | The example number | Produce effects | Effectively | Invalid | Total effective rate |
| Matched group | 51 | 5(9.80) | 26(50.98) | 20(39.22) | 60.78 |
| Treatment group | 72 | 16(22.22) | 37(51.39) | 19(26.39) | 73.61 * |
Compare with matched group
*P＜0.05
3 brief summaries
The demonstration of this therapeutic outcome, TCH, TG, HDL, SOD, LPO compare before and after two groups of patient, P＜0.05, P＜0.01, difference has significant, illustrates that western medicine and time medical medicine oxygen Inhalation in Treating vascular dementia all are improved the effect of These parameters.After the treatment treatment group and matched group relatively TCH, TG descend more significantly, HDL, SOD increase, LPO content minimizing (P＜0.01), show back medical medicine oxygen anapnotherapy than the Western medicine therapy more superior aspect the defying age index.The Chang Gu river is dull-witted after two groups of treatments revises scale scoring and curative effect relatively, and all P＜0.05 also point out back medical medicine oxygen low discharge suction curative effect to be better than matched group.Return medical theory and think, " brain the master always feel ", " receiving tangible in invisible ", " logical invisible in tangible ".Namely think body key, internal organs, hundred arteries and veins, the vital essence on the brain supervisor whole body, consciousness and the motion of anima.Think that people's various sensations and internal organs organ all only are " each is departments to some extent ", only brain can have total feel effect of having each organ under one's command.If the brains virtual loss then must be the inexorable trend in the body aging process, and the turbid illiteracy key of expectorant, obstruction of collaterals by blood stasis, disorder of movement of QI are only the key point of vascular dementia.
Return medical medicine oxygen medicated cushion compound recipe and be rich in volatile oil, can suck with low discharge oxygen, the ratio that medicine is absorbed in vivo improves.Return medical medicine oxygen and suck the effect that to bring into play oxygen removing free radical, thereby improve microcirculation, improve brain chronic hypoxia state.Experiment shows, return medical medicine oxygen volatile oil in the low discharge oxygen supply after 30 minutes, the less loss rate is (93.54 ± 2.23) % (tests 5 batches 25 times get average), almost can overflow fully under by the effect of low discharge oxygen therefore return the volatile oil of medical medicine oxygen compound recipe, wherein not get rid of the possibility that other volatile oil component can be overflowed in the lump.3 examples have the sneeze phenomenon among the 72 routine patients when medicine oxygen sucks first; 5 routine main suit flavour of a drug are unpleasant, feel sick; 30min pale complexion after 1 example sucks, (eliminating hypoglycemia) is in a cold sweat.Above patient without unusual, finishes the course for the treatment of after being interrupted suction.Have no hematuria and hepatic and renal function is affected.
Description of drawings
Fig. 1 is the structural representation sketch that the present invention returns medical medicine oxygen mask;
Fig. 2 is the structural representation sketch of plastic mask among the present invention;
Fig. 3 is the structural representation sketch of filter cartridge among the present invention;
Fig. 4 is the structural representation sketch of Chinese medicine oxygen medicine box of the present invention.
The specific embodiment
The medical medicine oxygen mask that returns for the control cardiovascular and cerebrovascular disease of the present invention is comprised of the plastic mask 1 that is connected in turn, Y-shaped connection tube 2, filter cartridge 3, I font connection tube 4, medicine oxygen medicine box 5 and oxygen connecting tube 6.
Medicine oxygen mouth 7 is installed on the described plastic mask 1, and these medicine oxygen mouth 7 one ends are embedded in plastic mask, and the other end is connected with Y-shaped connection tube 2.The other end of oxygen connecting tube 6 is connected with apparatus of oxygen supply, and oxygen is sent into the nostril by the medicine oxygen mouth 7 on oxygen connecting tube 6, medicine oxygen medicine box 5, I font connection tube 4, filter cartridge 3, Y-shaped connection tube 2, the plastic mask 1 successively.
Have several air-vents 8 on the described plastic mask 1, and face shield two middle side part outer rims there are degree of tightness with holes 16, have elastic cord to connect, play the effect of fixed visors.
Described filter cartridge 3 is comprised of filter cartridge shell 9 and the middle sponge filter bed 10 at two ends, and the filter cartridge shell 9 at two ends cooperates the formation box body, and sponge filter bed 10 is placed in the box body, accompanies active carbon in the sponge filter bed 10.
Described medicine oxygen medicine box 5 is comprised of the upper box shell 11 that cooperatively interacts into box body and lower box shell 12 and the medicine oxygen medicated cushion 13 that is placed in the box body, nearly bottom around described upper box shell 11 inboards is provided with stopper 14 in the medicine box shell, be provided with the sliding gear 15 of lower medicine box shell internal lock around the nearly upper limb in lower box shell 12 outsides, the sliding gear 15 of stopper 14 and lower medicine box shell internal lock matches, locks in the described upper medicine box shell.Medicine oxygen medicated cushion 13 is placed in the box body of box shell 11 and lower box shell 12 compositions.
Embodiment 1
Prepare the crude drug of the medicine oxygen medicated cushion on the medicine oxygen mask according to the following weight proportioning:
Resina Ferulae 1kg; Styrax 1kg; Benzoinum 1kg; Flos Caryophylli 1kg; Lignum Santali Albi 1kg; Aloe 1kg.
Preparation method: at first Resina Ferulae, Styrax, Benzoinum, Flos Caryophylli, Lignum Santali Albi and Aloe are cleaned respectively, dry, then be mixed in proportion, pulverize after mixing, cross 80 mesh sieves, make medicamental pulverata, for subsequent use behind the ultraviolet radiation sterilization; Get the medicamental pulverata of 3 grams, fill in medical non-woven fabrics ventilative, antiallergic and make in the bag, namely make medicine oxygen medicated cushion after the sealing.
Prepare the crude drug of the medicine oxygen medicated cushion on the medicine oxygen mask according to the following weight proportioning:
Resina Ferulae 3kg; Styrax 2kg; Benzoinum 1kg; Flos Caryophylli 1kg; Lignum Santali Albi 2kg; Aloe 2kg.
Preparation method is with embodiment 1.
Embodiment 3
Prepare the crude drug of the medicine oxygen medicated cushion on the medicine oxygen mask according to the following weight proportioning:
Resina Ferulae 3kg; Styrax 1kg; Benzoinum 1kg; Flos Caryophylli 3kg; Lignum Santali Albi 1kg; Aloe 3kg.
Preparation method is with embodiment 1.
Prepare the crude drug of the medicine oxygen medicated cushion on the medicine oxygen mask according to the following weight proportioning:
Resina Ferulae 2kg; Styrax 2kg; Benzoinum 1kg; Flos Caryophylli 2kg; Lignum Santali Albi 2kg; Aloe 1kg.
Preparation method is with embodiment 1.
Using method:
1 will return medical medicine oxygen medicated cushion correctly is positioned in the medicine oxygen medicine box of breathing mask, connects oxygen tank, must carefully check the pipeline seal before sucking, and prevents that oxygen from exosmosing, and record.
2 oxygen flows are decided to be 1～2L/min.
Slowly air-breathing during 3 treatment, slightly stop a moment, in order to absorption, exhale and use nose, slowly spue.
4 treatment times, each 30min, every day 1～2 time, 10 days was 1 course for the treatment of.
In 5 whens treatment, accomplished 1 people, 1 face shield, and medicine oxygen medicated core uses and changed in 1 day 1, sucks complete rear oxygen absorption mask every day and use flushing with clean water, dry for subsequent usely, and oxygen uptake pipeline cleaning, disinfecting process are carried out cleaning-sterilizing, prevent cross infection.
Should accomplish fire prevention, grease proofing, shockproof, explosion-proof in the 6 medicine oxygen suction processes.
Claims (8)
1. one kind is returned medical medicine oxygen mask, it is characterized in that being formed by the plastic mask that is connected in turn (1), Y-shaped connection tube (2), filter cartridge (3), I font connection tube (4), medicine oxygen medicine box (5) and oxygen connecting tube (6), medicine oxygen mouth (7) is installed on the described plastic mask (1), these medicine oxygen mouth (7) one ends are embedded in plastic mask (1), and the other end is connected with Y-shaped connection tube (2).
2. according to claimed in claim 1 time medical medicine oxygen mask, it is characterized in that: have several air-vents (8) on the described plastic mask (1).
3. according to claimed in claim 1 time medical medicine oxygen mask, it is characterized in that: described filter cartridge (3) is comprised of filter cartridge shell (9) and the middle sponge filter bed (10) at two ends.
4. according to claimed in claim 3 time medical medicine oxygen mask, it is characterized in that: accompany active carbon in the described sponge filter bed (10).
5. according to claimed in claim 1 time medical medicine oxygen mask, it is characterized in that: described medicine oxygen medicine box (5) is comprised of the upper box shell (11) that cooperatively interacts into box body and lower box shell (12) and the medicine oxygen medicated cushion (13) that is placed in the box body.
6. according to claimed in claim 5 time medical medicine oxygen mask, it is characterized in that: the inboard nearly bottom all around of described upper box shell (11) is provided with stopper (14) in the medicine box shell, be provided with the sliding gear of lower medicine box shell internal lock (15) around the nearly upper limb in lower box shell (12) outside, the sliding gear of stopper (14) and lower medicine box shell internal lock (15) matches in the described upper medicine box shell.
7. medicine oxygen medicated cushion that supports the use on the described medicine oxygen mask of claim 1 is characterized in that containing in this medicine oxygen medicated cushion the medicine of following weight proportioning:
Resina Ferulae 1～3 weight portion;
Styrax 1～2 weight portion;
Benzoinum 1 weight portion;
Flos Caryophylli 1～3 weight portion;
Lignum Santali Albi 1～2 weight portion;
Aloe 1～3 weight portion.
8. the preparation method of a medicine oxygen medicated cushion as claimed in claim 7, its processing step is: at first Resina Ferulae, Styrax, Benzoinum, Flos Caryophylli, Lignum Santali Albi and Aloe are cleaned respectively, dry, then be mixed in proportion, pulverize after mixing, cross 80 mesh sieves, make medicamental pulverata, for subsequent use behind the ultraviolet radiation sterilization; Get the medicamental pulverata of 3 grams, fill in medical non-woven fabrics ventilative, antiallergic and make in the bag, namely make medicine oxygen medicated cushion after the sealing.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210404165.6A CN102908707B (en) | 2012-10-23 | 2012-10-23 | Hui medicine oxygen mask and matched medical oxygen medicated pad as well as preparation method of medicated pad |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210404165.6A CN102908707B (en) | 2012-10-23 | 2012-10-23 | Hui medicine oxygen mask and matched medical oxygen medicated pad as well as preparation method of medicated pad |
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| CN102908707A true CN102908707A (en) | 2013-02-06 |
| CN102908707B CN102908707B (en) | 2015-04-15 |
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|---|---|---|---|---|
| US4938209A (en) * | 1989-01-12 | 1990-07-03 | Fry William J | Mask for a nebulizer |
| CN2140766Y (en) * | 1992-09-19 | 1993-08-25 | 丁贤良 | Multi-functional health respirator |
| EP0579384A1 (en) * | 1992-07-16 | 1994-01-19 | Smiths Industries Public Limited Company | Tubing and humidification systems |
| CN2171368Y (en) * | 1993-09-09 | 1994-07-13 | 妥福军 | Two-purpose face guard with atomizing and oxygen feed |
| US20050247316A1 (en) * | 2003-05-01 | 2005-11-10 | Orr Joseph A | Apparatus and techniques for reducing the effects of general anesthetics |
| CN201171841Y (en) * | 2008-03-25 | 2008-12-31 | 修志红 | Simple aerosol inhalation device special for brake patient |
| CN102284150A (en) * | 2011-09-08 | 2011-12-21 | 陈春松 | Multifunctional wet-type protective respirator |
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Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4938209A (en) * | 1989-01-12 | 1990-07-03 | Fry William J | Mask for a nebulizer |
| EP0579384A1 (en) * | 1992-07-16 | 1994-01-19 | Smiths Industries Public Limited Company | Tubing and humidification systems |
| CN2140766Y (en) * | 1992-09-19 | 1993-08-25 | 丁贤良 | Multi-functional health respirator |
| CN2171368Y (en) * | 1993-09-09 | 1994-07-13 | 妥福军 | Two-purpose face guard with atomizing and oxygen feed |
| US20050247316A1 (en) * | 2003-05-01 | 2005-11-10 | Orr Joseph A | Apparatus and techniques for reducing the effects of general anesthetics |
| CN201171841Y (en) * | 2008-03-25 | 2008-12-31 | 修志红 | Simple aerosol inhalation device special for brake patient |
| CN102284150A (en) * | 2011-09-08 | 2011-12-21 | 陈春松 | Multifunctional wet-type protective respirator |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102908707B (en) | 2015-04-15 |
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