CN102908501A - Traditional Chinese medicine composition for treating hyperthyroidism and preparation method and use method thereof - Google Patents
Traditional Chinese medicine composition for treating hyperthyroidism and preparation method and use method thereof Download PDFInfo
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Abstract
A traditional Chinese medicine composition for treating hyperthyroidism and a preparation method and a use method thereof resolve the problem that the existing traditional Chinese medicine for treating hyperthyroidism does not have common adaptability and is not favorable for industrial production. The composition comprises the following raw materials as effective components: 15-60 parts of astragalus mongholicus, 15-50 parts of radix scrophulariae, 15-60 parts of oyster, 15-50 parts of thunberg fritillary bulb and 10-60 parts of selfheal. The composition changes composition ratio of the raw material medicine according to difference of clinical symptoms of hyperthyroidism, thereby being suitable for the front stage, the middle stage and the later stage of the hyperthyroidism. The composition adopts the start point design- response surface method to optimize process parameter extracted from the effective components of the raw material medicine. The traditional Chinese medicine composition is based on heteropathy in the whole generation and development processes of the disease and has the advantages of being quick, good and high in treatment effect, small in side effect, convenient to take and the like. The disease is not apt to reappear by means of the composition.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method thereof and using method.
Background technology
Hyperthyroidism (Hyperthyroidism, be called for short hyperthyroidism) be a kind of metabolic disease, mean that Different types of etiopathogenises causes thyroid function to strengthen, a kind of clinical syndrome due to thyroid hormone secretion is too much, its feature has thyromegaly, basal metabolism increase and autonomic nervous system not normal.Its cause of disease has multiple, and the most common with Graves sick (GD), GD claims again diffuse toxic goiter.The hyperthyroidism sickness rate is up to 2%-3%, the women significantly occurred frequently (4-6: 1), the age occurred frequently is in 20-50 year, serious threat human life and health and affected quality of life of people, so the research of the treatment of hyperthyroidism more and more causes people's attention.
Modern study thinks that hyperthyroidism is on hereditary basis, because the stressors such as infection, psychic trauma are brought out, due to suppressor T cell (Ts cell) functional defect, still lack at present etiotropic effective treatment, mainly contain clinically antithyroid drug, operation,
131Several modes such as I radiation therapy, but certain contraindication and side effect are all arranged, antithyroid drug mainly contains Thiourea and imidazoles, treatment time will keep 1 ~ 2 year at least, and cure rate only has 40%, and relapse rate is up to 50%-60%, and side effect is larger, and the operative treatment some patients were is difficult to accept
131The I radiation therapy easily causes the infringement of irreversibility thyroid, and above Therapeutic Method does not all reach desirable therapeutic effect, and therefore, the method for seeking and develop the treatment hyperthyroidism that side effect is little, therapeutic effect is stable becomes current urgent problem.
The traditional Chinese medical science thinks that the morbidity of hyperthyroidism is relevant with internal injury caused by excess of seven emotions and physical factors.It is relevant with the depressed grade of being worried that " General Treatise on the Cause and Symptoms of Diseases " proposes " wart "." facing the case of disease guide " said: " restless susceptible to get angry, gas fire knot wart ".Stimulate as Etiological take the plain body deficiency of YIN, feelings will.The wrong track of hyperthyroidism clinical manifestation is complicated, tcm clinical practice also has various ways to the differentiation of symptoms and signs for classification of syndrome of hyperthyroidism, take active stage typing as (1) pathogenic wind toxic liver-fire, on attack the eyes type, controlling should soothing the liver pathogenic fire purging, heat-clearing and toxic substances removing.(2) stagnation of liver-QI with deficiency of the spleen, phlegm retention is gathered type, and controlling should soothing liver and strengthening spleen, diuretic reduces phlegm.(3) hyperactivity of fire caused by deficiency of YIN, stagnation of QI phlegm stagnation type is controlled suitable nourishing YIN to lower pathogenic fire, promoting the circulation of QI and reducing phlegm.Take the nonmobile phase typing as (1) deficiency of both QI and YIN, expectorant stasis of blood accumulation type, controlling should supplementing QI and nourishing YIN, dissipating phlegm and removing blood stasis.(2) yang-energy virtual loss, expectorant stasis of blood accumulation type: control suitable warming YANG and invigorating QI, dissipating phlegm and removing blood stasis.Also have the scholar to adopt Local Differentiation of Syndromes and the integral syndrome differentiation treatment primary disease that combines, Local Differentiation of Syndromes is divided into two types: (1) expectorant knot blood stasis type, control take dissipating phlegm and removing blood stasis as main the circulation of qi promoting hard masses softening and resolving of holding concurrently; (2) stagnation of QI causing phlegm retention type is controlled with the soothing liver-QI promoting QI circulation for relieving depression, the hard masses softening and resolving of holding concurrently.Integral syndrome differentiation divides four types: (1) syndrome of spleen-deficiency, work as invigorating spleen to remove dampness; (2) stagnation of liver-QI hyperactivity of fire card is when clearing away liver-fire, soothing liver-QI yin nourishing; (3) yin deficiency syndrome, suitable nourishing the liver and kidney; (4) syndrome of heat in the stomach is controlled and is worked as clearing stomach and purging heat.Adopt corresponding treatment rule treatment hyperthyroidism to obtain preferably curative effect according to different method of syndrome differentiation clinically, yet the course of disease of hyperthyroidism is long and clinical manifestation is intricate, syndrome is along with also phase co-conversion of the variation of the state of an illness, therefore, therefore a kind of method of syndrome differentiation can not run through the treatment overall process of whole hyperthyroidism, and it is imperative to seek and develop a kind of Therapeutic Method with general applicability.
And existing treatment hyperthyroidism Chinese medicinal components is more, is unfavorable for suitability for industrialized production.
Summary of the invention
The objective of the invention is not have general applicability and be unfavorable for the problem of suitability for industrialized production in order to solve existing treatment hyperthyroidism Chinese medicine, and a kind of Chinese medicine composition for the treatment of hyperthyroidism and preparation method thereof and using method are provided.
A kind of Chinese medicine composition for the treatment of hyperthyroidism of the present invention, the raw material of making effective ingredient by following weight portion is: 15 ~ 60 parts the Radix Astragali, 15 ~ 50 parts Radix Scrophulariae, 15 ~ 60 parts Concha Ostreae, 15 ~ 50 parts Bulbus Fritillariae Thunbergii and 10 ~ 60 parts Spica Prunellae.
A kind of using method for the treatment of the Chinese medicine composition of hyperthyroidism of the present invention, its using method is carried out according to the following steps:
One, at the Chinese medicine composition A that adopts the treatment hyperthyroidism early stage of hyperthyroidism, dosage is 20 ~ 30 parts the Radix Astragali, 25 ~ 35 parts Radix Scrophulariae, 15 ~ 25 parts Concha Ostreae, 15 ~ 25 parts Bulbus Fritillariae Thunbergii and 40 ~ 60 parts Spica Prunellae;
Two, adopt the Chinese medicine composition B that treats hyperthyroidism, 20 ~ 30 parts the Radix Astragali, 20 ~ 30 parts Radix Scrophulariae, 40 ~ 60 parts Concha Ostreae, 25 ~ 35 parts Bulbus Fritillariae Thunbergii and 15 ~ 25 parts Spica Prunellae in the mid-term of hyperthyroidism;
Three, adopt the Chinese medicine composition C for the treatment of hyperthyroidism in the later stage of hyperthyroidism, dosage is 40 ~ 60 parts the Radix Astragali, 25 ~ 35 parts Radix Scrophulariae, 20 ~ 30 parts Concha Ostreae, 20 ~ 30 parts Bulbus Fritillariae Thunbergii and 15 ~ 25 parts Spica Prunellae.
A kind of method for the treatment of the Chinese medicine composition of hyperthyroidism of the present invention, carry out according to following steps:
One, takes by weighing by weight 15 ~ 60 parts the Radix Astragali, 15 ~ 50 parts Radix Scrophulariae, 15 ~ 60 parts Concha Ostreae, 15 ~ 50 parts Bulbus Fritillariae Thunbergii and 10 ~ 60 parts Spica Prunellae;
Two, cross 100 mesh sieves after each component that step 1 is taken by weighing is pulverized, the water that the component after sieve adds 12 ~ 14 times of quality soaks 70 ~ 80min, heating and refluxing extraction 2 times, each reflux, extract, 1.1 ~ 1.3h collects extracting solution and filters, and being concentrated into relative density is 1.15 ~ 1.20g/cm
3Clear paste, be 65 ℃ ~ 75 ℃ in temperature, carry out vacuum drying under the condition of pressure for-0.08MPa ~ 0.1MPa, namely get the Chinese medicine composition for the treatment of hyperthyroidism.
The present invention comprises following beneficial effect:
The present invention is on the basis of summing up lot of documents report and clinical treatment experience, proposition is carried out Coryza Treated by Syndrome Differentiation with the pattern of syndrome variation of hyperthyroidism morbidity different times, think that the hyperthyroidism pathogenesis is deficiency in origin and excess in superficiality, deficiency of both QI and YIN is basis of pathogenesis, and fire stagnation, expectorant coagulate, blood stasis is the mark of pathogenesis.Hyperthyroidism their early stage: take hepatic and renal YIN deficiency, hyperactivity of fire caused by deficiency of YIN as main; Hyperthyroidism many simulataneous insufficiency and excessive in morbidity mid-term, the moon loses with fire, expectorant, the stasis of blood and deposits, and take reality as main; Hyperthyroidism is fallen ill the later stage: cannot not accumulate in the course of time loose because of fire, expectorant, stasis of blood heresy and more consume the moon of feeling frustrated, become again the time of deficiency of both QI and YIN, take void as the main and folder excess pathogen of can holding concurrently.Disease type according to hyperthyroidism morbidity different times adopts supplementing QI and nourishing YIN Liver-Clearing Powder connection to be the treatment rule, lays particular stress on to some extent to reach the purpose for the treatment of hyperthyroidism according to its different times medication rule.
The Concha Ostreae, Bulbus Fritillariae Thunbergii, Spica Prunellae that the present invention is preferred has the Radix Astragali, Radix Scrophulariae and an effect of liver heat removing eliminating stagnation of supplementing QI and nourishing YIN effect totally 5 flavor Chinese medicines forms compound recipes;
At the hyperthyroidism their early stage, be main pathogenesis for hepatic and renal YIN deficiency, hyperactivity of fire caused by deficiency of YIN, adopt the Chinese medicine composition A for the treatment of hyperthyroidism, namely reuse Spica Prunellae, the monarch drug that act as that has removing fire from the liver, Disperse hepatic depression because its bitter cold is heavier, ministerial drug Radix Scrophulariae YIN nourishing and the production of body fluid promoting, assistant helps ministerial drug Radix Scrophulariae YIN nourishing and the production of body fluid promoting with Radix Astragali QI invigorating, makes medicine Concha Ostreae, Bulbus Fritillariae Thunbergii Disperse hepatic depression jointly reach therapeutic purposes;
Fall ill mid-term in hyperthyroidism, many simulataneous insufficiency and excessive, the moon loses with fire, expectorant, the stasis of blood and deposits, and take reality as main, adopt the Chinese medicine composition B for the treatment of hyperthyroidism, namely reusing the pent-up of Concha Ostreae salty in the mouth softening the hard mass is monarch drug, ministerial drug Bulbus Fritillariae Thunbergii softening and eliminating sputum, assistant is with Radix Scrophulariae and Radix Astragali supplementing QI and nourishing YIN, Spica Prunellae removing fire from the liver, Disperse hepatic depression, but so and inducting the medicines into affected channel for making medicine;
In the hyperthyroidism morbidity later stage, then because of fire, expectorant, stasis of blood heresy cannot not accumulated in the course of time loose and is more consumed the moon of feeling frustrated, become again the time of deficiency of both QI and YIN, take void as the main and folder excess pathogen of can holding concurrently, adopt the Chinese medicine composition C for the treatment of hyperthyroidism, take the Radix Astragali as monarch drug, focus on QI invigorating, tonify without causing stagnation, ministerial drug Radix Scrophulariae principal drug assistance Radix Astragali boosting qi and nourishing yin promotes the production of body fluid, the loose phlegm-fire pent-up of can detoxifying again, Concha Ostreae salty in the mouth hard masses softening and resolving in the side, the Bulbus Fritillariae Thunbergii Disperse hepatic depression that reduces phlegm, both are that adjuvant drug is to help the power of Radix Scrophulariae Disperse hepatic depression altogether, the Spica Prunellae bitter cold is heavier, removing fire from the liver, Disperse hepatic depression, but so and inducting the medicines into affected channel for making medicine, all medicines share, and play altogether the QI invigorating YIN nourishing, the liver heat removing pathogenic fire reducing, the merit of dissipating phlegm and resolving masses;
According to the concrete pattern of syndrome of hyperthyroidism morbidity different times, disease reaches the purpose for the treatment of hyperthyroidism in conjunction with reusing different medicines.
The specific embodiment
Technical solution of the present invention is not limited to the following cited specific embodiment, also comprises the combination in any between each specific embodiment.
The specific embodiment one: a kind of Chinese medicine composition for the treatment of hyperthyroidism of present embodiment, the raw material of making effective ingredient by following weight portion is: 15 ~ 60 parts the Radix Astragali, 15 ~ 50 parts Radix Scrophulariae, 15 ~ 60 parts Concha Ostreae, 15 ~ 50 parts Bulbus Fritillariae Thunbergii and 10 ~ 60 parts Spica Prunellae.
Present embodiment is on the basis of summing up lot of documents report and clinical treatment experience, proposition is carried out Coryza Treated by Syndrome Differentiation with the pattern of syndrome variation of hyperthyroidism morbidity different times, think that the hyperthyroidism pathogenesis is deficiency in origin and excess in superficiality, deficiency of both QI and YIN is basis of pathogenesis, and fire stagnation, expectorant coagulate, blood stasis is the mark of pathogenesis.Hyperthyroidism their early stage: take hepatic and renal YIN deficiency, hyperactivity of fire caused by deficiency of YIN as main; Hyperthyroidism many simulataneous insufficiency and excessive in morbidity mid-term, the moon loses with fire, expectorant, the stasis of blood and deposits, and take reality as main; Hyperthyroidism is fallen ill the later stage: cannot not accumulate in the course of time loose because of fire, expectorant, stasis of blood heresy and more consume the moon of feeling frustrated, become again the time of deficiency of both QI and YIN, take void as the main and folder excess pathogen of can holding concurrently.Disease type according to hyperthyroidism morbidity different times adopts supplementing QI and nourishing YIN Liver-Clearing Powder connection to be the treatment rule, lays particular stress on to some extent to reach the purpose for the treatment of hyperthyroidism according to its different times medication rule.
The specific embodiment two: what present embodiment and the specific embodiment one were different is: the raw material of making effective ingredient by following weight portion is: 20 ~ 30 parts the Radix Astragali, 25 ~ 35 parts Radix Scrophulariae, 15 ~ 25 parts Concha Ostreae, 15 ~ 25 parts Bulbus Fritillariae Thunbergii and 40 ~ 60 parts Spica Prunellae.Other is identical with the specific embodiment one.
The specific embodiment three: what present embodiment was different from the specific embodiment one or two is: the raw material of making effective ingredient by following weight portion is: 20 ~ 30 parts the Radix Astragali, 20 ~ 30 parts Radix Scrophulariae, 40 ~ 60 parts Concha Ostreae, 25 ~ 35 parts Bulbus Fritillariae Thunbergii and 15 ~ 25 parts Spica Prunellae.Other is identical with the specific embodiment one or two.
The specific embodiment four: what present embodiment was different from one of specific embodiment one to three is: the raw material of making effective ingredient by following weight portion is: 40 ~ 60 parts the Radix Astragali, 25 ~ 35 parts Radix Scrophulariae, 20 ~ 30 parts Concha Ostreae, 20 ~ 30 parts Bulbus Fritillariae Thunbergii and 15 ~ 25 parts Spica Prunellae.Other is identical with one of specific embodiment one to three.
The specific embodiment five: a kind of using method for the treatment of the Chinese medicine composition of hyperthyroidism of present embodiment, its using method is carried out according to the following steps:
One, at the Chinese medicine composition A that adopts the treatment hyperthyroidism early stage of hyperthyroidism, dosage is 20 ~ 30 parts the Radix Astragali, 25 ~ 35 parts Radix Scrophulariae, 15 ~ 25 parts Concha Ostreae, 15 ~ 25 parts Bulbus Fritillariae Thunbergii and 40 ~ 60 parts Spica Prunellae;
Two, adopt the Chinese medicine composition B that treats hyperthyroidism, 20 ~ 30 parts the Radix Astragali, 20 ~ 30 parts Radix Scrophulariae, 40 ~ 60 parts Concha Ostreae, 25 ~ 35 parts Bulbus Fritillariae Thunbergii and 15 ~ 25 parts Spica Prunellae in the mid-term of hyperthyroidism;
Three, adopt the Chinese medicine composition C for the treatment of hyperthyroidism in the later stage of hyperthyroidism, dosage is 40 ~ 60 parts the Radix Astragali, 25 ~ 35 parts Radix Scrophulariae, 20 ~ 30 parts Concha Ostreae, 20 ~ 30 parts Bulbus Fritillariae Thunbergii and 15 ~ 25 parts Spica Prunellae.
Use administration time and the administration number of times of present embodiment treatment hyperthyroidism to decide according to clinical concrete treatment situation.Be excessive noxious heat the early stage of the described hyperthyroidism of present embodiment, and excess pathogen is main; Be that poison is contained cloudy the wound mid-term of hyperthyroidism, and deficiency and excess is held concurrently assorted; The later stage of hyperthyroidism is deficiency of both vital energy and Yin, exogenous pathogen is main, inferior by stages method referring to " Wang Yongyan; Zhang Tian; Li Dichen. clinical Chinese Internal Medicine (descending) [M]. Beijing: Beijing Publishing House, 1994.2050. " and " Yi Fayin, Wu Aihua. giving consideration to both the incidental and fundamental opinion is controlled hyperthyroidism [J]. Hunan College of Traditional Chinese Medicine's journal; 2003,23 (3) 27-33. " described in by stages method.
Present embodiment is on the basis of summing up lot of documents report and clinical treatment experience, proposition is carried out Coryza Treated by Syndrome Differentiation with the pattern of syndrome variation of hyperthyroidism morbidity different times, think that the hyperthyroidism pathogenesis is deficiency in origin and excess in superficiality, deficiency of both QI and YIN is basis of pathogenesis, and fire stagnation, expectorant coagulate, blood stasis is the mark of pathogenesis.Hyperthyroidism their early stage: take hepatic and renal YIN deficiency, hyperactivity of fire caused by deficiency of YIN as main; Hyperthyroidism many simulataneous insufficiency and excessive in morbidity mid-term, the moon loses with fire, expectorant, the stasis of blood and deposits, and take reality as main; Hyperthyroidism is fallen ill the later stage: cannot not accumulate in the course of time loose because of fire, expectorant, stasis of blood heresy and more consume the moon of feeling frustrated, become again the time of deficiency of both QI and YIN, take void as the main and folder excess pathogen of can holding concurrently.Disease type according to hyperthyroidism morbidity different times adopts supplementing QI and nourishing YIN Liver-Clearing Powder connection to be the treatment rule, lays particular stress on to some extent to reach the purpose for the treatment of hyperthyroidism according to its different times medication rule.
The Concha Ostreae, Bulbus Fritillariae Thunbergii, Spica Prunellae that present embodiment is preferred has the Radix Astragali, Radix Scrophulariae and an effect of liver heat removing eliminating stagnation of supplementing QI and nourishing YIN effect totally 5 flavor Chinese medicines forms compound recipes;
At the hyperthyroidism their early stage, be main pathogenesis for hepatic and renal YIN deficiency, hyperactivity of fire caused by deficiency of YIN, adopt the Chinese medicine composition A for the treatment of hyperthyroidism, namely reuse Spica Prunellae, the monarch drug that act as that has removing fire from the liver, Disperse hepatic depression because its bitter cold is heavier, ministerial drug Radix Scrophulariae YIN nourishing and the production of body fluid promoting, assistant helps ministerial drug Radix Scrophulariae YIN nourishing and the production of body fluid promoting with Radix Astragali QI invigorating, makes medicine Concha Ostreae, Bulbus Fritillariae Thunbergii Disperse hepatic depression jointly reach therapeutic purposes;
Fall ill mid-term in hyperthyroidism, many simulataneous insufficiency and excessive, the moon loses with fire, expectorant, the stasis of blood and deposits, and take reality as main, adopt the Chinese medicine composition B for the treatment of hyperthyroidism, namely reusing the pent-up of Concha Ostreae salty in the mouth softening the hard mass is monarch drug, ministerial drug Bulbus Fritillariae Thunbergii softening and eliminating sputum, assistant is with Radix Scrophulariae and Radix Astragali supplementing QI and nourishing YIN, Spica Prunellae removing fire from the liver, Disperse hepatic depression, but so and inducting the medicines into affected channel for making medicine;
In the hyperthyroidism morbidity later stage, then because of fire, expectorant, stasis of blood heresy cannot not accumulated in the course of time loose and is more consumed the moon of feeling frustrated, become again the time of deficiency of both QI and YIN, take void as the main and folder excess pathogen of can holding concurrently, adopt the Chinese medicine composition C for the treatment of hyperthyroidism, take the Radix Astragali as monarch drug, focus on QI invigorating, tonify without causing stagnation, ministerial drug Radix Scrophulariae principal drug assistance Radix Astragali boosting qi and nourishing yin promotes the production of body fluid, the loose phlegm-fire pent-up of can detoxifying again, Concha Ostreae salty in the mouth hard masses softening and resolving in the side, the Bulbus Fritillariae Thunbergii Disperse hepatic depression that reduces phlegm, both are that adjuvant drug is to help the power of Radix Scrophulariae Disperse hepatic depression altogether, the Spica Prunellae bitter cold is heavier, removing fire from the liver, Disperse hepatic depression, but so and inducting the medicines into affected channel for making medicine, all medicines share, and play altogether the QI invigorating YIN nourishing, the liver heat removing pathogenic fire reducing, the merit of dissipating phlegm and resolving masses;
According to the concrete pattern of syndrome of hyperthyroidism morbidity different times, disease reaches the purpose for the treatment of hyperthyroidism in conjunction with reusing different medicines.
The specific embodiment six: a kind of method for the treatment of the Chinese medicine composition of hyperthyroidism of present embodiment, carry out according to following steps:
One, takes by weighing by weight 15 ~ 60 parts the Radix Astragali, 15 ~ 50 parts Radix Scrophulariae, 15 ~ 60 parts Concha Ostreae, 15 ~ 50 parts Bulbus Fritillariae Thunbergii and 10 ~ 60 parts Spica Prunellae;
Two, cross 100 mesh sieves after each component that step 1 is taken by weighing is pulverized, the water that the component after sieve adds 12 ~ 14 times of quality soaks 70 ~ 80min, heating and refluxing extraction 2 times, each reflux, extract, 1.1 ~ 1.3h collects extracting solution and filters, and being concentrated into relative density is 1.15 ~ 1.20g/cm
3Clear paste, be 65 ℃ ~ 75 ℃ in temperature, carry out vacuum drying under the condition of pressure for-0.08MPa ~ 0.1MPa, namely get the Chinese medicine composition for the treatment of hyperthyroidism.
The Chinese medicine composition of the treatment hyperthyroidism of present embodiment can add corresponding adjuvant and make the watered pill, granule capsule and tablet.
Present embodiment is on the basis of summing up lot of documents report and clinical treatment experience, proposition is carried out Coryza Treated by Syndrome Differentiation with the pattern of syndrome variation of hyperthyroidism morbidity different times, think that the hyperthyroidism pathogenesis is deficiency in origin and excess in superficiality, deficiency of both QI and YIN is basis of pathogenesis, and fire stagnation, expectorant coagulate, blood stasis is the mark of pathogenesis.Hyperthyroidism their early stage: take hepatic and renal YIN deficiency, hyperactivity of fire caused by deficiency of YIN as main; Hyperthyroidism many simulataneous insufficiency and excessive in morbidity mid-term, the moon loses with fire, expectorant, the stasis of blood and deposits, and take reality as main; Hyperthyroidism is fallen ill the later stage: cannot not accumulate in the course of time loose because of fire, expectorant, stasis of blood heresy and more consume the moon of feeling frustrated, become again the time of deficiency of both QI and YIN, take void as the main and folder excess pathogen of can holding concurrently.Disease type according to hyperthyroidism morbidity different times adopts supplementing QI and nourishing YIN Liver-Clearing Powder connection to be the treatment rule, lays particular stress on to some extent to reach the purpose for the treatment of hyperthyroidism according to its different times medication rule.
The Concha Ostreae, Bulbus Fritillariae Thunbergii, Spica Prunellae that present embodiment is preferred has the Radix Astragali, Radix Scrophulariae and an effect of liver heat removing eliminating stagnation of supplementing QI and nourishing YIN effect totally 5 flavor Chinese medicines forms compound recipes;
At the hyperthyroidism their early stage, be main pathogenesis for hepatic and renal YIN deficiency, hyperactivity of fire caused by deficiency of YIN, adopt the Chinese medicine composition A for the treatment of hyperthyroidism, namely reuse Spica Prunellae, the monarch drug that act as that has removing fire from the liver, Disperse hepatic depression because its bitter cold is heavier, ministerial drug Radix Scrophulariae YIN nourishing and the production of body fluid promoting, assistant helps ministerial drug Radix Scrophulariae YIN nourishing and the production of body fluid promoting with Radix Astragali QI invigorating, makes medicine Concha Ostreae, Bulbus Fritillariae Thunbergii Disperse hepatic depression jointly reach therapeutic purposes;
Fall ill mid-term in hyperthyroidism, many simulataneous insufficiency and excessive, the moon loses with fire, expectorant, the stasis of blood and deposits, and take reality as main, adopt the Chinese medicine composition B for the treatment of hyperthyroidism, namely reusing the pent-up of Concha Ostreae salty in the mouth softening the hard mass is monarch drug, ministerial drug Bulbus Fritillariae Thunbergii softening and eliminating sputum, assistant is with Radix Scrophulariae and Radix Astragali supplementing QI and nourishing YIN, Spica Prunellae removing fire from the liver, Disperse hepatic depression, but so and inducting the medicines into affected channel for making medicine;
In the hyperthyroidism morbidity later stage, then because of fire, expectorant, stasis of blood heresy cannot not accumulated in the course of time loose and is more consumed the moon of feeling frustrated, become again the time of deficiency of both QI and YIN, take void as the main and folder excess pathogen of can holding concurrently, adopt the Chinese medicine composition C for the treatment of hyperthyroidism, take the Radix Astragali as monarch drug, focus on QI invigorating, tonify without causing stagnation, ministerial drug Radix Scrophulariae principal drug assistance Radix Astragali boosting qi and nourishing yin promotes the production of body fluid, the loose phlegm-fire pent-up of can detoxifying again, Concha Ostreae salty in the mouth hard masses softening and resolving in the side, the Bulbus Fritillariae Thunbergii Disperse hepatic depression that reduces phlegm, both are that adjuvant drug is to help the power of Radix Scrophulariae Disperse hepatic depression altogether, the Spica Prunellae bitter cold is heavier, removing fire from the liver, Disperse hepatic depression, but so and inducting the medicines into affected channel for making medicine, all medicines share, and play altogether the QI invigorating YIN nourishing, the liver heat removing pathogenic fire reducing, the merit of dissipating phlegm and resolving masses;
According to the concrete pattern of syndrome of hyperthyroidism morbidity different times, disease reaches the purpose for the treatment of hyperthyroidism in conjunction with reusing different medicines.
The specific embodiment seven: what present embodiment and the specific embodiment six were different is: the relative density described in the step 2 is measured under 60 ℃ ~ 70 ℃ temperature.Other is identical with the specific embodiment six.
By following verification experimental verification beneficial effect of the present invention:
This test be a kind of Chinese medicine composition its preparation method for the treatment of hyperthyroidism, comprising:
One, takes by weighing the Radix Astragali of 50g, the Radix Scrophulariae of 30g, the Concha Ostreae of 25g, the Bulbus Fritillariae Thunbergii of 25g and the Spica Prunellae of 20g;
Two, after pulverizing, each component that step 1 is taken by weighing crosses 100 mesh sieves, does the component after sieving add? the water of times quality soaks 74.4min, heating and refluxing extraction 2 times, each 1.2h collects extracting solution and filters, and relative density is 1.18g/cm when being concentrated into 60 ~ 70 ℃ of mensuration
3Clear paste, be 70 ℃ in temperature, carry out vacuum drying under the condition of pressure for-0.09MPa, namely get the Chinese medicine composition for the treatment of hyperthyroidism.
The Chinese medicine composition of the treatment hyperthyroidism of this test can add corresponding adjuvant and make the watered pill, granule, capsule and tablet.
This test is to adopt the excellent optimum extraction process of getting of punctate opacity of the cornea design-response surface method to extract.
The Chinese medicine composition of the treatment hyperthyroidism of this test can be made into the watered pill or adds the agent of corresponding adjuvant granulation, capsule and tablet.
The Chinese medicine composition of the treatment hyperthyroidism that this test is obtained carries out pharmacodynamic experiment:
Experimental technique: claim quality status stamp with 60 Wistar rats, be divided at random Normal group, Hyperthyroid Model group, western medicine group and high, medium and low dosage Chinese medicine composition group, 10 every group.Except normal group, all the other 5 groups of rats gavage Euthyrox (levothyroxine sodium) by 75ug/100g and carry out modeling every days, meter 21d.Rose in the 8th day, give simultaneously high, medium and low dosage Chinese medicine composition group rat every day respectively by 10.8g crude drug/kg, 5.4g crude drug/kg, 2.7g crude drug/kg gavage, the western medicine group rat gavages propylthiouracil by 20.25mg/100g every day, and normal group such as gavages at the capacity normal saline.Each is organized rat and claims weekly weight 1 time, adjusts drug dose according to weight.And observation weight and outward appearance behavior variation, behind the 21d, each is organized rat limosis and claims weight, the carotid artery sacrificed by exsanguination, get blood system from serum, use respectively serum measured by radioimmunoassay FT3, FT4, T3, T4 content, measure serum TSH content with the immune radiating method, detect leukocyte, neutrophilic granulocyte sum, get rat thyroid, adrenal tissue's weighing calculating organ coefficient.
The Chinese medicine composition of the treatment hyperthyroidism that the crude drug that above-mentioned high, medium and low dosage Chinese medicine composition group gives prepares for this test.
Experimental result: it is many that Hyperthyroid Model group rat experiment began to occur dysphoria, frequent activity, amount of drinking water on the 5th day; Moist in the mouse cage, Excreta increases; When finishing to experiment, majority has chattering, all obviously becomes thin, and hair is matt.The phenomenons such as other each treatment group rats action is unable, irritated, irritability all have alleviating in various degree, and weight reduces degree and slightly reduces than the model group rat, drying in the cage, and Excreta is less.
Each organizes rat blood serum T3, T4, FT3, FT4, the TSH measurement result is as shown in table 1, as shown in Table 1, compare with Normal group, Hyperthyroid Model group serum T 3, T4, FT3, FT4 value significantly raise, the serum TSH value significantly reduces, and illustrates that the rat experiment Hyperthyroid Model is successfully established.Compare with the Hyperthyroid Model group, the serum T 3 of each treatment group, T4, FT3, FT4 all significantly reduce, and wherein, middle and high dosage Chinese medicine composition group is more remarkable; Each treatment group serum TSH all significantly raises, and wherein, middle and high dosage Chinese medicine composition group has very significant difference, and the prompting Chinese medicine composition has good lifting TSH effect, and has certain proportional relation between this effect and the dosage.
Each organizes rat leukocyte and neutrophilic granulocyte sum measured value is as shown in table 2, as shown in Table 2, each organ coefficient of organizing rat thyroid, adrenal tissue significantly reduces, leukocyte, neutrophilic granulocyte sum significantly raise than Hyperthyroid Model group, this point is better than treating the western medicine group, has reduced that the neutrophilic granulocyte deficiency disease appears in the patient in treatment and the probability of causing danger.Wherein, each organizes rat thyroid and adrenal tissue's organ coefficient measurement result is as shown in table 3, and the overall assessment Chinese medicine composition has preferably therapeutical effect for hyperthyroidism.
Table 1 is respectively organized rat blood serum T3, T4, FT3, FT4, TSH measurement result
Annotate: compare * P＜0.01 with the blank group; Compare #P＜0.01, △ P＜0.05 with model group
Table 2 is respectively organized rat leukocyte and neutrophilic granulocyte sum measured value
Annotate: compare * P＜0.05 with the blank group; Compare #P＜0.05 with model group
Table 3 is respectively organized rat thyroid and adrenal tissue's organ coefficient measurement result
Annotate: compare * P＜0.05 with the blank group; Compare #P＜0.05 with model group
In sum, the Chinese medicine composition of the treatment hyperthyroidism of this test is in the constant situation of ingredients, change according to the umber of medicine, change each other proportion of medicine (monarch, minister, help and make), and the early, middle, late stage of applicable hyperthyroidism plays good therapeutic effect.
Claims (7)
1. a Chinese medicine composition for the treatment of hyperthyroidism is characterized in that, the raw material of making effective ingredient by following weight portion is: 15 ~ 60 parts the Radix Astragali, 15 ~ 50 parts Radix Scrophulariae, 15 ~ 60 parts Concha Ostreae, 15 ~ 50 parts Bulbus Fritillariae Thunbergii and 10 ~ 60 parts Spica Prunellae.
2. a kind of Chinese medicine composition for the treatment of hyperthyroidism according to claim 1, it is characterized in that the raw material of making effective ingredient by following weight portion is: 20 ~ 30 parts the Radix Astragali, 25 ~ 35 parts Radix Scrophulariae, 15 ~ 25 parts Concha Ostreae, 15 ~ 25 parts Bulbus Fritillariae Thunbergii and 40 ~ 60 parts Spica Prunellae.
3. a kind of Chinese medicine composition for the treatment of hyperthyroidism according to claim 1, it is characterized in that the raw material of making effective ingredient by following weight portion is: 20 ~ 30 parts the Radix Astragali, 20 ~ 30 parts Radix Scrophulariae, 40 ~ 60 parts Concha Ostreae, 25 ~ 35 parts Bulbus Fritillariae Thunbergii and 15 ~ 25 parts Spica Prunellae.
4. a kind of Chinese medicine composition for the treatment of hyperthyroidism according to claim 1, it is characterized in that the raw material of making effective ingredient by following weight portion is: 40 ~ 60 parts the Radix Astragali, 25 ~ 35 parts Radix Scrophulariae, 20 ~ 30 parts Concha Ostreae, 20 ~ 30 parts Bulbus Fritillariae Thunbergii and 15 ~ 25 parts Spica Prunellae.
5. a kind of using method for the treatment of the Chinese medicine composition of hyperthyroidism as claimed in claim 1 is characterized in that, the using method of the Chinese medicine composition for the treatment of hyperthyroidism is carried out according to the following steps:
One, at the Chinese medicine composition A that adopts the treatment hyperthyroidism early stage of hyperthyroidism, dosage is 20 ~ 30 parts the Radix Astragali, 25 ~ 35 parts Radix Scrophulariae, 15 ~ 25 parts Concha Ostreae, 15 ~ 25 parts Bulbus Fritillariae Thunbergii and 40 ~ 60 parts Spica Prunellae;
Two, adopt the Chinese medicine composition B that treats hyperthyroidism, 20 ~ 30 parts the Radix Astragali, 20 ~ 30 parts Radix Scrophulariae, 40 ~ 60 parts Concha Ostreae, 25 ~ 35 parts Bulbus Fritillariae Thunbergii and 15 ~ 25 parts Spica Prunellae in the mid-term of hyperthyroidism;
Three, adopt the Chinese medicine composition C for the treatment of hyperthyroidism in the later stage of hyperthyroidism, dosage is 40 ~ 60 parts the Radix Astragali, 25 ~ 35 parts Radix Scrophulariae, 20 ~ 30 parts Concha Ostreae, 20 ~ 30 parts Bulbus Fritillariae Thunbergii and 15 ~ 25 parts Spica Prunellae.
6. preparation is characterized in that such as claim 1,2,3 or 4 described a kind of methods for the treatment of the Chinese medicine composition of hyperthyroidism described a kind of preparation method for the treatment of the Chinese medicine composition of hyperthyroidism is carried out according to following steps:
One, takes by weighing by weight 15 ~ 60 parts the Radix Astragali, 15 ~ 50 parts Radix Scrophulariae, 15 ~ 60 parts Concha Ostreae, 15 ~ 50 parts Bulbus Fritillariae Thunbergii and 10 ~ 60 parts Spica Prunellae;
Two, cross 100 mesh sieves after each component that step 1 is taken by weighing is pulverized, the water that the component after sieve adds 12 ~ 14 times of quality soaks 70 ~ 80min, heating and refluxing extraction 2 times, each reflux, extract, 1.1 ~ 1.3h collects extracting solution and filters, and being concentrated into relative density is 1.15 ~ 1.20g/cm
3Clear paste, be 65 ℃ ~ 75 ℃ in temperature, carry out vacuum drying under the condition of pressure for-0.08MPa ~ 0.1MPa, namely get the Chinese medicine composition for the treatment of hyperthyroidism.
7. a kind of preparation method for the treatment of the Chinese medicine composition of hyperthyroidism according to claim 6 is characterized in that, the relative density described in the step 2 is measured under 60 ℃ ~ 70 ℃ temperature.
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