CN103251868A - Kidney-clearing particles for treating chronic renal failure and preparation method thereof - Google Patents
Kidney-clearing particles for treating chronic renal failure and preparation method thereof Download PDFInfo
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Abstract
The invention provides kidney-clearing particles for treating chronic renal failure. The kidney-clearing particles are prepared from the following effective components by weight parts: 2-4 parts of heydyotis, 2-4 parts of Salvia miltiorrhiza, 1-3 parts of virgate wormwood herb, 1-3 parts of motherwort, 1-2 parts of coix seeds, 0.5-1.5 parts of coptis, 0.5-1.5 parts of cardamom seed, 0.5-1.5 parts of hyacinth bean, 0.5-1.5 parts of polyporus, 0.5-1.5 parts of oriental waterplantain rhizome, 0.5-1.5 parts of Plantago depressa Willd, and 0.4-1.2 parts of raw rheum officinale. The invention can effectively clear away heat and eliminate dampeness, and promote blood circulation to remove blood stasis, thereby realizing treatment for the chronic renal failure.
Description
Technical field
The present invention relates to a kind of clear kidney granule for the treatment of chronic renal failure, relate in particular to and a kind ofly have the clearing away heat and eliminating dampness clear kidney granule for the treatment of chronic renal failure of effect of invigorating blood circulation, and relate to its preparation method.
Background technology
Chronic renal failure (chronic renal failure, CRF) course of disease is progressive development, but in a certain stage of the course of disease, because inducements such as infection, hypertension, metabolic acidosis, electrolyte disturbances, rapid deterioration can appear in renal function in a short time.Even serious threat patient life.This renal function worsens, and as timely treatment, often has certain reversibility, even returns to premalignant renal function level fully.Therefore, control increases the weight of factor, prevents that renal function from sharply worsening is one of main intervention content of early metaphase CRF (being equivalent to chronic kidney disease 3,4 phases).Proceed to end stage renal failure (ESRD) stage from early metaphase CRF, modern medicine does not still have effective measures and delays this process.
We find that damp-heat syndrome is the main TCM Syndrome Type that CRF sharply increases the weight of the patient at the past clinical observation.CRF patient is deficiency of spleen and stomach usually, insufficiency of vital energy and blood, again because feeling the heresy of wind, six climate exopathogens such as cold, wet again, the unable fight of body and rapidly by heat-transformation in the table people is harmonious with the heresy of turbid damp in the body and leads to damp and hotly, causes the state of an illness sharply to increase the weight of, this moment is damp and hot, both being the cause of disease, is again by the excess syndrome due to the pathological product, and blood stasis runs through the chronic kidney disease generation and develops from start to finish.And the medicine of in the past intervening chronic renal failure there is no specific aim treatment CRF and sharply increases the weight of process, can not give prominence to and embody this base therapy principle of clearing away heat and eliminating dampness blood stasis dispelling.
Summary of the invention
The object of the present invention is to provide a kind of clear kidney granule for the treatment of chronic renal failure and preparation method thereof, it is clearing away heat and eliminating dampness, blood circulation promoting and blood stasis dispelling effectively, thereby realizes the treatment to chronic renal failure, solves the problem in the above-mentioned background technology.
For achieving the above object, the present invention is by the following technical solutions:
A kind of clear kidney granule for the treatment of chronic renal failure, the preparation of employing raw material of Chinese medicine, its active component is as follows by weight: 2～4 parts of Herba Hedyotidis Diffusaes, 2～4 parts of Radix Salviae Miltiorrhizaes, 1～3 part of Herba Artemisiae Scopariae, 1～3 part of Herba Leonuri, 1～2 part of Semen Coicis, 0.5～1.5 part of Rhizoma Coptidis, 0.5～1.5 part of Semen Vignae Cylindricae KOUREN, 0.5～1.5 part of the Rhizoma Atractylodis Macrocephalae, 0.5～1.5 part in Seem Lablab Album, 0.5～1.5 part of Polyporus, 0.5～1.5 part in Poria, 0.5～1.5 part of Rhizoma Alismatis, 0.5～1.5 part of Herba Plantaginis, 0.4～1.2 part of Radix Et Rhizoma Rhei.
Preferably, the preferable weight portion of described active component is counted: 3 parts of Herba Hedyotidis Diffusaes, 3 parts of Radix Salviae Miltiorrhizaes, 2 parts of Herba Artemisiae Scopariaes, 2 parts of Herba Leonuris, 1.5 parts of Semen Coiciss, 1 part of Rhizoma Coptidis, 1 part of Semen Vignae Cylindricae KOUREN, 1 part of the Rhizoma Atractylodis Macrocephalae, 1 part in Seem Lablab Album, 1 part of Polyporus, 1 part in Poria, 1 part of Rhizoma Alismatis, 1 part of Herba Plantaginis, 0.8 part of Radix Et Rhizoma Rhei.
A kind of preparation method for the treatment of the clear kidney granule of chronic renal failure may further comprise the steps:
(1) gets 2～4 parts of Herba Hedyotidis Diffusaes, 2～4 parts of Radix Salviae Miltiorrhizaes, 1～3 part of Herba Artemisiae Scopariae, 1～3 part of Herba Leonuri, 1～2 part of Semen Coicis, 0.5～1.5 part of Rhizoma Coptidis, 0.5～1.5 part of Semen Vignae Cylindricae KOUREN, 0.5～1.5 part of the Rhizoma Atractylodis Macrocephalae, 0.5～1.5 part in Seem Lablab Album, 0.5～1.5 part of Polyporus, 0.5～1.5 part in Poria, 0.5～1.5 part of Rhizoma Alismatis, 0.5～1.5 part of Herba Plantaginis, 0.4～1.2 part of Radix Et Rhizoma Rhei, decoct with water and extract merge extractive liquid, three times;
(2) with the extracting liquid filtering that obtains in the step (1), staticly settle, draw supernatant;
(3) with the supernatant concentrating under reduced pressure that obtains in the step (2), obtain concentrated solution;
(4) concentrated solution that obtains in the step (3) is added dextrin and do bed material, spray drying is granulated, and granulate obtains kidney finished granule clearly.
As a kind of improvement, in the described step (1), 3 parts of Herba Hedyotidis Diffusaes, 3 parts of Radix Salviae Miltiorrhizaes, 2 parts of Herba Artemisiae Scopariaes, 2 parts of Herba Leonuris, 1.5 parts of Semen Coiciss, 1 part of Rhizoma Coptidis, 1 part of Semen Vignae Cylindricae KOUREN, 1 part of the Rhizoma Atractylodis Macrocephalae, 1 part in Seem Lablab Album, 1 part of Polyporus, 1 part in Poria, 1 part of Rhizoma Alismatis, 1 part of Herba Plantaginis, 0.8 part of Radix Et Rhizoma Rhei.
As a kind of improvement, in the described step (2), the time that staticly settles is 48h.
As a kind of improvement, in the described step (3), being evaporated to relative proportion is 1.10 (that is: concentrated solution is 1.10: 1 with the ratio of the density of supernatant).
As a kind of improvement, in the described step (4), spray-dired temperature≤80 ℃.
As a kind of improvement, in the described step (4), in the granulate process, top sieve adopts 10 orders, and following sieve adopts 60 orders.
Active component of the present invention is Herba Hedyotidis Diffusae, Radix Salviae Miltiorrhizae, Herba Artemisiae Scopariae, Herba Leonuri, Semen Coicis, Rhizoma Coptidis, Semen Vignae Cylindricae KOUREN, the Rhizoma Atractylodis Macrocephalae, Seem Lablab Album, Polyporus, Poria, Rhizoma Alismatis, Herba Plantaginis, Radix Et Rhizoma Rhei, and further be made into kidney granule clearly, has clearing away heat and eliminating dampness blood stasis dispelling effect, and change by dosage form and can avoid the different curative effect differences that cause with method of the mode of boiling medicine, keep the stability of curative effect; It is easy to carry simultaneously also to be conducive to the patient, is easy to take, and has increased the compliance of patient treatment.Take a broad view of the concrete compatibility characteristics of full side and have five: 1. clearing heat and expelling damp, three warmers Tonghua.Existing a surname is led to part of the body cavity above the diaphragm housing the heart and lungs breast lung qi machine, and the Semen Vignae Cylindricae KOUREN of saturating removing dampness heresy has the product of burnt wet Sheng in the dampness of being amusing heat clearing away, the balance again, and pungent drugs can disperse and bitter drugs can descend is transferred smooth important department such as Radix Et Rhizoma Rhei, Rhizoma Coptidis etc., elimination of pathogens through purgation and diuresis, the pivot of the spleen and stomach regulating lifting.Poria, Polyporus, Rhizoma Alismatis, Herba Plantaginis five equilibrium Xuanhua that disappears, the light diuresis that oozes both can make three warmers fill the air and ly wetly be able to go from bladder, can make the gas of haze turbid damp both disappear back and pathogenic heat from saturating again, and yang-energy must be logical.2. wetting belongs to YIN pathogen, the deep viscous of its property, and the easiest obstruction mechanism of qi, Fructus Amomi Rotundus large usage quantity in the side, in the hope of the removing dampness circulation of qi promoting, then humidifying gasifies.3. smart product with the blood circulation promoting and blood stasis dispelling diuretic make damp and hot blood stasis and change, and hold concurrently and the reason of lead to " prolonged illness must the stasis of blood " is adopted.4. clearing up internal heat by using drugs of bitter in taste and cold in nature is not forgotten the spleen invigorating warming middle-JIAO, to keep away the suspicion that the ice volt is difficult to resolve; The light tonneau that oozes is not forgotten in the warm-dryness syndrome damp eliminating, in case help thermal burn the moon.5. we's demonstrating fully of " symptomatic treatment in acute condition, radical treatment in chronic case " just do not forgotten simultaneously the rule for the treatment of of " treating both the principal and secondary aspects of a disease " again.
It is as follows that Chinese medicine preparation of the present invention is respectively formed the pharmacological action of medicine:
(1) Radix Et Rhizoma Rhei: bitter in the mouth, cold, have the effect of heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.Clinical research finds that Radix Et Rhizoma Rhei can partly be removed the metabolic waste in CRF patient's digestive tract, improves the barrier function of gastrointestinal mucosal, stops serum endotoxin (ETX) to go into blood, and the ETX level descends and makes nitric oxide enzyme (NOS) reduced activity, reduces so NO produces; Can reduce simultaneously the level of serum BUN and Scr.
(2) Radix Salviae Miltiorrhizae: bitter in the mouth, be slightly cold, have the effect that promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, relieving restlessness are calmed the nerves.Clinical research finds that Radix Salviae Miltiorrhizae obviously suppresses the apoptosis of renal cells that Aristolochic Acid causes, and can obviously protect renal cells; Can obviously improve the rat anemia state, reduce Scr, reduce the discharge of 24h urine protein, the chronic Aristolochic Acid renal damage rat model due to the Caulis Aristolochiae Manshuriensis extractum is had certain kidney protective effect; Can reduce CRF patients serum IL-6, TNF content, have the effect of renal function protecting.
(3) Herba Leonuri: acrid in the mouth, hardship, be slightly cold, have the effect of promoting blood flow to regulate menstruation, inducing diuresis to remove edema, heat-clearing and toxic substances removing.Clinical research finds, Herba Leonuri has played the active protection effect to kidney in caused the developing of rat acute renal failure (ARF) by gentamycin, may can improve hemodynamics in the kidney with it, increase renal blood flow; Protection cell submicroscopic structure is mitochondrial function particularly, stablize lysosome membrane etc. and acts on relevant.
(4) Rhizoma Coptidis: bitter in the mouth, cold, have the effect of heat clearing and damp drying, eliminating fire and detoxication.Rhizoma Coptidis total alkaloids can reduce the blood glucose of artificial diabetes nephropathy (DN) rat, improves renal function.
(5) Herba Hedyotidis Diffusae: bitter in the mouth, sweet, cold, have heat-clearing and toxic substances removing, effect that dampness removing is treating stranguria.Its pharmacological action can stimulate the reticuloendothelial system hypertrophy in vivo, and enhancing antibody forms, and skein cell, leukocytic phagocytic activity are strengthened, thereby reaches the purpose of anti-inflammation.Clinical research finds that Herba Hedyotidis Diffusae has better elimination albuminuria, effects such as renal function protecting.
(6) Fructus Amomi Rotundus: acrid in the mouth, temperature has the effect of removing dampness circulation of qi promoting, warming middle-JIAO to arrest vomiting.Its pharmacological action can promote gastric secretion, promotes gastrointestinal peristalsis, prevents enteral abnormal fermentation, dispels gastrointestinal pneumatosis, thus good fragrant digestion promoting function is arranged, and can preventing or arresting vomiting.Modern pharmacological research is thought Fructus Amomi Rotundus treatment CRF patient can obviously correct the digestive functional disturbance state, remarkable appetite strengthening, and can effectively control infection, thus promote toxin to eliminate, effectively mitigate the disease improves clinical symptoms.
(7) Poria, Polyporus, Semen Coicis, Rhizoma Alismatis: mostly be sweet light cold and cool or flat product, it is descending that the property of medicine is tending towards, and it is wet to ooze diuretic, and so unimpeded urine is can clearing away damp-heat from lower-JIAO.Modern pharmacological research thinks that the mechanism of action of this type of Drug therapy CRF comprises: 1. diuresis.Wherein Polyporus, Rhizoma Alismatis diuresis are stronger.Its diuresis can be realized by following approach: suppress renal tubules to the heavily absorption of electrolyte and water, as Polyporus, Rhizoma Alismatis; Activate the Na+-K+-ATP enzymatic activity, as Poria, Rhizoma Alismatis; Act on Plasma Atrial Natriuretic Peptide (ANP), as the Rhizoma Alismatis mice ANP content that can obviously raise; The aldosterone receptor antagonist effect is as Poria.2. strengthen immunization.Poria can improve mouse T lymphocyte breeder reaction and IL-2 activity, promotes macrophage phagocytosis of mice; Polyporusum bellatus can strengthen the humoral immunization function, promotes the B cell mitogen to generate antibody, improves lymhocyte transformation rate; Semen Coicis can strengthen humoral immunization, promotes macrophage to produce justacrine IL-1.
(8) Herba Artemisiae Scopariae, Herba Plantaginis: for bitter or sweet cold product, have the effect of clearing away heat-damp and promoting diuresis, be applicable to the obvious person of damp-heat syndrome.Herba Artemisiae Scopariae, Herba Plantaginis energy clearing away heat-damp and promoting diuresis, obvious person has better curative effect to damp-heat syndrome.
(9) Seem Lablab Album: sweet in the mouth, slightly warm in nature has the effect of strengthening the spleen and nourishing the stomach, expelling summer-heat and damp, tonify deficiency antidiarrheal.Pharmacological research is found to strengthen the lymphocytic activity of T, improves the immunologic function of cell.Clinical discovery its can swelling diuretic, eliminate urine protein etc.
(10) Rhizoma Atractylodis Macrocephalae: bitter in the mouth, warm in nature, have the spleen strengthening and damp drying effect.Pharmacological research finds that it has effects such as diuresis, immunomodulating, enhancing hemopoietic function, antioxidation, slow down aging, adjustment gastrointestinal motility function, can improve the Patients with Chronic Renal Disease symptom.
The present invention is through a series of clinical and experimentation, found that Chinese medicine preparation treatment chronic renal failure of the present invention has following mechanism of action: 1. clear kidney granule can significantly improve chronic renal failure (chronic renal failure, CRF) sharply increase the weight of damp-heat syndrome patient's clinical symptoms, as limbs be stranded heavy, lack of appetite is indigestion and loss of appetite, distension and fullness in the abdomen, nausea and vomiting, dry mouth with bitter taste, mouthful in symptom such as sticky, reduce the tcm syndrome integration; 2. by reducing patients serum's creatinine (Scr), blood urea nitrogen (BUN), parathyroid hormone (PTH) and urine protein quantitation (24h Upro), effectively alleviate renal damage, improve renal function; 3. raise by reducing the multiple inflammatory factor level of patient, as blood serum tumor necrosis factor-alpha (TNF-α), soluble tumor necrosis factor receptor I (sTNFR I), IL-10, IL-8, IL-18 etc., thus suppress kidney inflammation proliferation response; 4. by reducing blood plasma palatelet-selectin (CD62P), iuntercellular adhesion molecule-1 (ICAM-1), serum endothelin (ET) level, rising serum levels of nitric oxide (NO) level alleviates vascular endothelial injury, reduces the generation of microthrombus; 5. by reducing plasma viscosity, thromboxane B2 (TXB2), rising 6-ketone-PGF1 (6-keto-PGF1 α) level is improved the pathological state of hemorheology and blood stasis; 6. by rising OKT3, OKT4, OKT4/OKT8 level, adjust t lymphocyte subset group disorder, improve the patient immune function; 7. by reduce serum super quick-c reactive protein (hs-CRP), homocysteine (Hcy) level, alleviate the little inflammatory conditions of kidney; 8. by reducing serum laminin (LN) and collagen protein IV (CV-IV) level, reduce glomerule inner cell epimatrix content.
Show that by above-mentioned clear kidney granule with clearing away heat and eliminating dampness blood stasis dispelling effect can pass through number of ways, effectively alleviate CRF acute exacerbation damp-heat syndrome patient clinical symptoms, protect residual renal function, delay the progress that renal function goes down.
Model case:
Case one: pay certain, the woman, 44 years old, because of " urinate repeatedly uncomfortable 1 year surplus, find serum creatinine raise 1 year surplus " go to a doctor in my section on October 22nd, 2009, disease is seen: soreness of waist lumbago, lassitude and weak is afraid of cold, poor appetite, the retch of feeling sick, frequent micturition, urgent micturition, dysurea; Blood pressure 130/76mmHg, 36.7 ℃ of body temperature, two kidneys district tapping pain, bilateral rib ridge point, costolumbar point tenderness (±), bilateral ureter conduct district does not have tenderness; Light red tongue, yellow and greasy fur, deep-thready pulse.Routine urinalysis: protein 1+, leukocyte 2+, erythrocyte 1+; Serum creatinine 371umol/l (48-133), blood urea nitrogen 18.79mmol/l; B ultrasonic: the slightly little and diffuse lesion of two kidneys.Western medicine diagnose " chronic renal failure (4 phases of CKD), urinary tract infection, hypertension ", tcm diagnosis is " chronic kidney hypofunction (deficiency of spleen and stomach, dampness and heat stasis) ".Control with strengthening spleen, tonifying kidney the clearing away heat and eliminating dampness blood stasis dispelling.Give clearly 1 bag of tid * 14 of kidney granule day, doxycycline 0.1g bid * 14 days.Take medicine after two weeks, symptoms such as patient's soreness of waist lumbago, the discomfort of urinating are clearly better, and routine urinalysis shows leukocyte 2-5/HP, and erythrocyte 0-3/HP, protein-.Satisfy the doxycycline of stopping using, continue to take kidney granule clearly.December in 2009 check on the 30th serum creatinine 238.3umol/l (normal reference value 48-133umol/l), blood urea nitrogen 13.79mmol/l, the patient does not have significant discomfort.
Case two: revive certain, the woman, 62 years old, to go to a doctor in February, 2010 because of " the weak poor appetite of carrying out property 5 years increases the weight of January ", disease is seen: shallow complexion, weak poor appetite, soreness of the waist and knees, dry mouth with bitter taste, the urine yellow skin still can be measured nocturia 2-3 time, big dry stool is few, the difference of sleeping dreaminess, light red tongue, yellow fur, thready pulse.Urine protein 1+, serum creatinine 625umol/l, blood urea nitrogen 27.42mmol/l.Suffer from acute nephritis in the time of surplus in the of 10 year old, previously hypertension, hyperuricemia medical history.Western medicine diagnose: chronic renal failure (5 phases of CKD), tcm diagnosis: chronic kidney hypofunction (deficiency of spleen and stomach, dampness and heat stasis).With strengthening spleen, tonifying kidney, clearing away heat and eliminating dampness, dissipating stasis and purging turbidity are method in the treatment, give clearly 1 bag of tid * 14 of kidney granule day; Doctor trained in Western medicine gives the Plendil blood pressure lowering, and the calcium that is very replenished the calcium, sodium bicarbonate entangles acid.The patient takes medicine and sees that symptoms such as weak, dry mouth with bitter taste, loose stool obviously improve a little soreness of the waist and knees after a week.The further consultation patient tells indigestion and loss of appetite, sleep improvement after January, and the soreness of the waist and knees sense disappears, and checks serum creatinine 450umol/l, blood urea nitrogen 20.17mmol/l in April, 2010.
Case three: shut out certain, the woman, 59 years old, go to a doctor because of " find serum creatinine raise 2 years surplus ", seek medical advice in my institute in 2010-6-6, disease is seen: xerostomia, weak, lumbago, receive sleep can, urine can, constipation with dry stool, light red tongue is dark, yellow and thin fur, deep-thready pulse; Serum creatinine 265umol/l, urine protein 3+.Western medicine diagnose: 1. chronic renal failure (CKD4 phase), 2. chronic glomerulonephritis; Tcm diagnosis: chronic kidney hypofunction (deficiency of spleen and stomach, dampness and heat stasis).The traditional Chinese medical science is method with the clearing away heat and eliminating dampness blood stasis dispelling, and it is day oral to give clearly 1 bag of tid * 14 of kidney granule.The further consultation patient tells the soreness of waist, xerostomia, weak alleviating after January, and stool is normal, and the clear kidney granule of clothes continues.2010-10-21 patient's symptom when examining has not had obvious alleviation, check serum creatinine 205umol/l, urine protein 2+.Adhere to outpatient service tracking treatment, period in a medicine is not seen the significant discomfort sense.
Beneficial effect:
Chinese medicine preparation of the present invention has the clearing away heat and eliminating dampness effect of invigorating blood circulation, and be used for the treatment of chronic renal failure and sharply increase the weight of damp-heat syndrome, towards molten decoction being taken warmly, every day 3 times, each 1 bag (10 gram), laxativeness may appear in part patient, does not see other serious side effects.This medicine can effectively alleviate the clinical symptoms that chronic renal failure sharply increases the weight of the damp-heat syndrome patient, reduces serum creatinine and blood urea nitrogen, reduces urinary protein excretion; Improve patient's malnutrition, improve immunologic function, alleviate the little inflammatory conditions of kidney; Improve hemorheology, alleviate vascular endothelial injury; Reduce glomerule inner cell epimatrix content etc., thereby can protect residual renal function, delay the progress of renal fibrosis.
The specific embodiment
For technological means, creation characteristic that the present invention is realized, reach purpose and effect is easy to understand, below in conjunction with specific embodiment, further set forth the present invention.
Embodiment 1
A kind of clear kidney granule for the treatment of chronic renal failure, the preparation of employing raw material of Chinese medicine, its active component is as follows by weight: 2 parts of Herba Hedyotidis Diffusaes, 2 parts of Radix Salviae Miltiorrhizaes, 1 part of Herba Artemisiae Scopariae, 1 part of Herba Leonuri, 2 parts of Semen Coiciss, 1.5 parts of Rhizoma Coptidis, 1.5 parts of Semen Vignae Cylindricae KOUREN, 0.5 part of the Rhizoma Atractylodis Macrocephalae, 1 part in Seem Lablab Album, 1.5 parts of Polyporus, 1.5 parts in Poria, 0.5 part of Rhizoma Alismatis, 1 part of Herba Plantaginis, 0.7 part of Radix Et Rhizoma Rhei.
A kind of preparation method for the treatment of the clear kidney granule of chronic renal failure may further comprise the steps:
(1) gets 2 parts of Herba Hedyotidis Diffusaes, 2 parts of Radix Salviae Miltiorrhizaes, 1 part of Herba Artemisiae Scopariae, 1 part of Herba Leonuri, 2 parts of Semen Coiciss, 1.5 parts of Rhizoma Coptidis, 1.5 parts of Semen Vignae Cylindricae KOUREN, 0.5 part of the Rhizoma Atractylodis Macrocephalae, 1 part in Seem Lablab Album, 1.5 parts of Polyporus, 1.5 parts in Poria, 0.5 part of Rhizoma Alismatis, 1 part of Herba Plantaginis, 0.7 part of Radix Et Rhizoma Rhei, decoct with water and extract three times, extract the water that adds in 10 times of amounts of drug weight for the first time, decoct 1.5h, the water that adds in 8 times of amounts of drug weight is extracted in second and third time, decoct 1h, merge extractive liquid;
(2) with the extracting liquid filtering that obtains in the step (1), staticly settle 48h, draw supernatant;
(3) supernatant that obtains in the step (2) is evaporated to relative proportion 1.10, obtains concentrated solution;
(4) concentrated solution that obtains in the step (3) is added dextrin and do bed material, in 70 ℃ of following spray dryinges of temperature, granulate, granulate (top sieve adopts 10 orders, and following sieve adopts 60 orders) obtains kidney finished granule clearly.
Embodiment 2
A kind of clear kidney granule for the treatment of chronic renal failure, the preparation of employing raw material of Chinese medicine, its active component is as follows by weight: 3 parts of Herba Hedyotidis Diffusaes, 3 parts of Radix Salviae Miltiorrhizaes, 2 parts of Herba Artemisiae Scopariaes, 2 parts of Herba Leonuris, 1.5 parts of Semen Coiciss, 1 part of Rhizoma Coptidis, 1 part of Semen Vignae Cylindricae KOUREN, 1 part of the Rhizoma Atractylodis Macrocephalae, 1 part in Seem Lablab Album, 1 part of Polyporus, 1 part in Poria, 1 part of Rhizoma Alismatis, 1 part of Herba Plantaginis, 0.8 part of Radix Et Rhizoma Rhei.
A kind of preparation method for the treatment of the clear kidney granule of chronic renal failure may further comprise the steps:
(1) gets 3 parts of Herba Hedyotidis Diffusaes, 3 parts of Radix Salviae Miltiorrhizaes, 2 parts of Herba Artemisiae Scopariaes, 2 parts of Herba Leonuris, 1.5 parts of Semen Coiciss, 1 part of Rhizoma Coptidis, 1 part of Semen Vignae Cylindricae KOUREN, 1 part of the Rhizoma Atractylodis Macrocephalae, 1 part in Seem Lablab Album, 1 part of Polyporus, 1 part in Poria, 1 part of Rhizoma Alismatis, 1 part of Herba Plantaginis, 0.8 part of Radix Et Rhizoma Rhei, decoct with water and extract three times, extract the water that adds in 10 times of amounts of drug weight for the first time, decoct 1.5h, the water that adds in 8 times of amounts of drug weight is extracted in second and third time, decoct 1h, merge extractive liquid;
(2) with the extracting liquid filtering that obtains in the step (1), staticly settle 48h, draw supernatant;
(3) supernatant that obtains in the step (2) is evaporated to relative proportion 1.10, obtains concentrated solution;
(4) concentrated solution that obtains in the step (3) is added dextrin and do bed material, in 80 ℃ of following spray dryinges of temperature, granulate, granulate (top sieve adopts 10 orders, and following sieve adopts 60 orders) obtains kidney finished granule clearly.
Embodiment 3
A kind of clear kidney granule for the treatment of chronic renal failure, the preparation of employing raw material of Chinese medicine, its active component is as follows by weight: 4 parts of Herba Hedyotidis Diffusaes, 4 parts of Radix Salviae Miltiorrhizaes, 3 parts of Herba Artemisiae Scopariaes, 2 parts of Herba Leonuris, 2 parts of Semen Coiciss, 0.8 part of Rhizoma Coptidis, 1 part of Semen Vignae Cylindricae KOUREN, 1.3 parts of the Rhizoma Atractylodis Macrocephalaes, 1.2 parts in Seem Lablab Album, 0.9 part of Polyporus, 0.7 part in Poria, 0.8 part of Rhizoma Alismatis, 1 part of Herba Plantaginis, 0.9 part of Radix Et Rhizoma Rhei.
A kind of preparation method for the treatment of the clear kidney granule of chronic renal failure may further comprise the steps:
(1) gets 4 parts of Herba Hedyotidis Diffusaes, 4 parts of Radix Salviae Miltiorrhizaes, 3 parts of Herba Artemisiae Scopariaes, 2 parts of Herba Leonuris, 2 parts of Semen Coiciss, 0.8 part of Rhizoma Coptidis, 1 part of Semen Vignae Cylindricae KOUREN, 1.3 parts of the Rhizoma Atractylodis Macrocephalaes, 1.2 parts in Seem Lablab Album, 0.9 part of Polyporus, 0.7 part in Poria, 0.8 part of Rhizoma Alismatis, 1 part of Herba Plantaginis, 0.9 part of Radix Et Rhizoma Rhei, decoct with water and extract three times, extract the water that adds in 10 times of amounts of drug weight for the first time, decoct 1.5h, the water that adds in 8 times of amounts of drug weight is extracted in second and third time, decoct 1h, merge extractive liquid;
(2) with the extracting liquid filtering that obtains in the step (1), staticly settle 48h, draw supernatant;
(3) supernatant that obtains in the step (2) is evaporated to relative proportion 1.10, obtains concentrated solution;
(4) concentrated solution that obtains in the step (3) is added dextrin and do bed material, in 80 ℃ of following spray dryinges of temperature, granulate, granulate (top sieve adopts 10 orders, and following sieve adopts 60 orders) obtains kidney finished granule clearly.
Below only be that of the present invention for example protection scope of the present invention is as the criterion with the content of claim, any based on modification of the present invention all within protection scope of the present invention.
Claims (8)
1. clear kidney granule for the treatment of chronic renal failure, the preparation of employing raw material of Chinese medicine, it is characterized in that: its active component is as follows by weight: 2～4 parts of Herba Hedyotidis Diffusaes, 2～4 parts of Radix Salviae Miltiorrhizaes, 1～3 part of Herba Artemisiae Scopariae, 1～3 part of Herba Leonuri, 1～2 part of Semen Coicis, 0.5～1.5 part of Rhizoma Coptidis, 0.5～1.5 part of Semen Vignae Cylindricae KOUREN, 0.5～1.5 part of the Rhizoma Atractylodis Macrocephalae, 0.5～1.5 part in Seem Lablab Album, 0.5～1.5 part of Polyporus, 0.5～1.5 part in Poria, 0.5～1.5 part of Rhizoma Alismatis, 0.5～1.5 part of Herba Plantaginis, 0.4～1.2 part of Radix Et Rhizoma Rhei.
2. a kind of clear kidney granule for the treatment of chronic renal failure according to claim 1, it is characterized in that: described active component is counted by weight: 3 parts of Herba Hedyotidis Diffusaes, 3 parts of Radix Salviae Miltiorrhizaes, 2 parts of Herba Artemisiae Scopariaes, 2 parts of Herba Leonuris, 1.5 parts of Semen Coiciss, 1 part of Rhizoma Coptidis, 1 part of Semen Vignae Cylindricae KOUREN, 1 part of the Rhizoma Atractylodis Macrocephalae, 1 part in Seem Lablab Album, 1 part of Polyporus, 1 part in Poria, 1 part of Rhizoma Alismatis, 1 part of Herba Plantaginis, 0.8 part of Radix Et Rhizoma Rhei.
3. the preparation method of the clear kidney granule of a treatment chronic renal failure as claimed in claim 1 is characterized in that: may further comprise the steps:
(1) gets 2～4 parts of Herba Hedyotidis Diffusaes, 2～4 parts of Radix Salviae Miltiorrhizaes, 1～3 part of Herba Artemisiae Scopariae, 1～3 part of Herba Leonuri, 1～2 part of Semen Coicis, 0.5～1.5 part of Rhizoma Coptidis, 0.5～1.5 part of Semen Vignae Cylindricae KOUREN, 0.5～1.5 part of the Rhizoma Atractylodis Macrocephalae, 0.5～1.5 part in Seem Lablab Album, 0.5～1.5 part of Polyporus, 0.5～1.5 part in Poria, 0.5～1.5 part of Rhizoma Alismatis, 0.5～1.5 part of Herba Plantaginis, 0.4～1.2 part of Radix Et Rhizoma Rhei, decoct with water and extract merge extractive liquid, three times;
(2) with the extracting liquid filtering that obtains in the step (1), staticly settle, draw supernatant;
(3) with the supernatant concentrating under reduced pressure that obtains in the step (2), obtain concentrated solution;
(4) concentrated solution that obtains in the step (3) is added dextrin and do bed material, spray drying is granulated, and granulate obtains kidney finished granule clearly.
4. a kind of preparation method for the treatment of the clear kidney granule of chronic renal failure according to claim 3, it is characterized in that: in the described step (1), 3 parts of Herba Hedyotidis Diffusaes, 3 parts of Radix Salviae Miltiorrhizaes, 2 parts of Herba Artemisiae Scopariaes, 2 parts of Herba Leonuris, 1.5 parts of Semen Coiciss, 1 part of Rhizoma Coptidis, 1 part of Semen Vignae Cylindricae KOUREN, 1 part of the Rhizoma Atractylodis Macrocephalae, 1 part in Seem Lablab Album, 1 part of Polyporus, 1 part in Poria, 1 part of Rhizoma Alismatis, 1 part of Herba Plantaginis, 0.8 part of Radix Et Rhizoma Rhei.
5. a kind of preparation method for the treatment of the clear kidney granule of chronic renal failure according to claim 3, it is characterized in that: in the described step (2), the time that staticly settles is 48h.
6. a kind of preparation method for the treatment of the clear kidney granule of chronic renal failure according to claim 3, it is characterized in that: in the described step (3), being evaporated to proportion is 1.10.
7. a kind of preparation method for the treatment of the clear kidney granule of chronic renal failure according to claim 3 is characterized in that: in the described step (4), and spray-dired temperature≤80 ℃.
8. a kind of preparation method for the treatment of the clear kidney granule of chronic renal failure according to claim 3, it is characterized in that: in the described step (4), in the granulate process, top sieve adopts 10 orders, and following sieve adopts 60 orders.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103800875A (en) * | 2014-01-16 | 2014-05-21 | 青岛市城阳区人民医院 | Traditional Chinese medicine for treating chronic renal failure and preparation method thereof |
| CN108743886A (en) * | 2018-08-31 | 2018-11-06 | 安徽中医药大学第附属医院 | A kind of prevention cholelithiasis herbal mixture electuary and preparation method thereof |
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| CN101024053A (en) * | 2007-02-08 | 2007-08-29 | 毕哲全 | Chinese medicine for treating chronic kidney disease |
| CN101167997A (en) * | 2007-11-05 | 2008-04-30 | 张旭明 | Chinese medicinal herb oral liquid cold tea preparation for preventing and treating acute and chronic damp-heat virus type nephritic edema |
| CN101406681A (en) * | 2007-10-12 | 2009-04-15 | 王学岭 | Chinese medicinal toxin-expelling decoction for uraemia |
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| CN101024053A (en) * | 2007-02-08 | 2007-08-29 | 毕哲全 | Chinese medicine for treating chronic kidney disease |
| CN101406681A (en) * | 2007-10-12 | 2009-04-15 | 王学岭 | Chinese medicinal toxin-expelling decoction for uraemia |
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| CN103800875A (en) * | 2014-01-16 | 2014-05-21 | 青岛市城阳区人民医院 | Traditional Chinese medicine for treating chronic renal failure and preparation method thereof |
| CN108743886A (en) * | 2018-08-31 | 2018-11-06 | 安徽中医药大学第附属医院 | A kind of prevention cholelithiasis herbal mixture electuary and preparation method thereof |
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Application publication date: 20130821 |