CN102908476B - Medicinal composition for treating rheumatoid arthritis - Google Patents
Medicinal composition for treating rheumatoid arthritis Download PDFInfo
- Publication number
- CN102908476B CN102908476B CN201110223378.4A CN201110223378A CN102908476B CN 102908476 B CN102908476 B CN 102908476B CN 201110223378 A CN201110223378 A CN 201110223378A CN 102908476 B CN102908476 B CN 102908476B
- Authority
- CN
- China
- Prior art keywords
- pharmaceutical composition
- rheumatoid arthritis
- radix aconiti
- medicinal composition
- weight portion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Abstract
The invention discloses a medicinal composition for treating rheumatoid arthritis. The medicinal composition is prepared from monkshood, orientvine, astragalus root, processed radix aconiti, scorpion, rhizome of large-headed atractylodes, white grub, yam rhizome, liquoric root, arisacma consanguineum and pinellia tuber. The conventional auxiliary materials are added into the raw material medicines to prepare the clinically acceptable various formulations, such as capsules, granules, tablets and oral liquid preparation, according to the conventional process. The invention also provides application of the medicinal composition preparation to preparation of medicaments for treating the rheumatoid arthritis and various pains and edema caused by rheumatism.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly a kind of various pain that rheumatoid arthritis, rheumatoid cause and pharmaceutical composition of edema for the treatment of.
Background technology
Rheumatoid, the traditional Chinese medical science is thought, belongs to impediment syndrome category, due to positive QI-insufficiency, caused by liver and kidney deficiency, positive QI-insufficiency is morbidity endogenous cause of ill, plays conclusive effect.In positive QI-insufficiency, the heresy that external wind and cold is damp and hot just can be attacked limbs joint muscle in an opponent's defence, makes passages through which vital energy circulates impatency obstructed, and sends out numbness disease." Ling Shu Miraculous Pivot or Divine Axis all kinds of diseases and ailments begin raw " are pointed out " wind and rain cold and heat must not be empty, and heresy can not solely be hurted sb.'s feelings, and soldier so meets violent storm and patient not, Gai Yuanxu.Old pathogen can not solely be hurted sb.'s feelings ".Chinese Zhang Zhongjing is said when what is said or talked about " severe and migratory arthralgia " pathogenesis in " gold doctor's outline apoplexy severe and migratory arthralgia abnormal pulse card is controlled " " SHAO YIN pulse being floating and weak, weak pulse indicating insufficiency of blood, floating be wind, blood conflicting with wind, i.e. tugging pain.Radix Aconiti Lateralis Preparata, Xin Ganre, poisonous, enters the heart, spleen, kidney channel, has recuperating depleted YANG to mend fire, effect essentials of Matea Medica of dispelling cold and removing dampness: " the kidney invigorating life fire, wet by wind and cold." Caulis Sinomenii, bitter, flat, there is wind-damp dispelling, diuresis, dispelling the wind and dampness pathogens arthralgia pain, the arthroncus of knee, edema, " middle traditional Chinese medicines are planted will ": " dehumidifying, dispels the wind, circulation of qi promoting, diuretic." Radix Astragali, bitter, cold, enter lung, gallbladder, large intestine channel, there is removing the relative excess fire, except damp and hot, effect of hemostasis. Radix Aconiti Preparata, hot, poisonous, enter spleen, gate of vitality's warp, cure mainly dispelling cold and dampness, the ailment said due to cold or exposure of faling apart, warming the meridian, pain relieving, can anemofrigid-damp arthralgia processed, severe and migratory arthralgia gout, spasm of the limbs.Radix Aconiti Kusnezoffii Preparata, hot, poisonous, enter liver, spleen, lung meridian, function is searched wind prevailing over dampness, and dispersing cold for relieving pain is opened expectorant, and detumescence, cures mainly anemofrigid-damp arthralgia." book on Chinese herbal medicine is stated ": " all anemofrigid-damp arthralgia, cold type of pain in bone, and damage is to the marrow, year is sore for a long time, or all carbuncle of yin nature toxic swellings, suitable Radix Aconiti Kusnezoffii ".Scorpio, salty pungent, flat, poisonous, enter meridian of Foot-JUE YIN, dispel the wind, relieving convulsion, Tongluo Jiedu, " beautiful Chinese catalpa medicine solution " " wears muscle deep, the effect by wind except wind." Rhizoma Atractylodis Macrocephalae, bitter, Gan Wen, enter spleen, stomach warp, spleen reinforcing stomach reinforcing, and dampness, and in, control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, " herbal classic ": " heat extraction helps digestion for main anemofrigid-damp arthralgia, dead flesh." Holotrichia diomphalia Bates, salty in the mouth, tepor, enter Liver Channel, removing blood stasis, and clots absorbing, eliminating stagnation, controls and loses stasis of blood pain, ventilates etc.Bi
, bitter, flat, enter liver, stomach, urinary bladder channel, dispel the wind, dampness removing, dispelling the wind and dampness pathogens insensitive impediment, lumbocrural pain.Radix Glycyrrhizae, sweet, flat, enter spleen, stomach, lung meridian, and middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription.Rhizoma Arisaematis (processed), toil, temperature, poisonous, enter lung, liver, spleen channel, drying dampness to eliminate phlegm, expelling wind for relieving convulsion, dispersing swelling and dissipating binds, " Kaibao Bencao ": " main apoplexy, expectorant, paralysis, the therapeutic method to keep the adverse QI flowing downwards, broken hard long-pending, subduing inflammation." Rhizoma Pinelliae, pungent, warm, poisonous, enter spleen, stomach warp, drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.
Current Chinese medicine in treating rheumatoid arthritis there will be administration time long conventionally, analgesia and antiinflammatory slow curative effect, and poor repeatability, is difficult for the shortcomings such as radical cure.
Summary of the invention
The object of the invention is to provide a kind of pharmaceutical composition, and another object of the present invention is to provide the purposes of this pharmaceutical composition.
The present invention seeks to be achieved through the following technical solutions
The crude drug of pharmaceutical composition of the present invention consists of:
Above-mentioned raw materials medicine preferred weight proportioning is as follows:
The Radix Aconiti Lateralis Preparata 1 weight portion Caulis Sinomenii 4 weight portion Radix Astragali 10 weight portion Radix Aconiti Preparata 1 weight portions
The Rhizoma Atractylodis Macrocephalae 2 weight portion Radix Aconiti Kusnezoffii Preparata 1 weight portion Scorpio 0.5 weight portion Holotrichia diomphalia Bates 1 weight portions
Bi
the 1 weight portion Radix Glycyrrhizae 2 weight portion Rhizoma Pinelliae 1 weight portion Rhizoma Arisaematis (processed) 0.5 weight portions
Above-mentioned raw materials medicine preferred weight proportioning is as follows:
The Radix Aconiti Lateralis Preparata 0.6 weight portion Caulis Sinomenii 7 weight portion Radix Astragali 6 weight portion Radix Aconiti Preparata 1.5 weight portions
The Rhizoma Atractylodis Macrocephalae 1.5 weight portion Radix Aconiti Kusnezoffii Preparata 1.8 weight portion Scorpio 0.3 weight portion Holotrichia diomphalia Bates 1.9 weight portions
Bi
the 0.7 weight portion Radix Glycyrrhizae 3 weight portion Rhizoma Pinelliae 0.8 weight portion Rhizoma Arisaematis (processed) 0.8 weight portions
Above-mentioned raw materials medicine preferred weight proportioning is as follows:
The Radix Aconiti Lateralis Preparata 1.8 weight portion Caulis Sinomenii 3 weight portion Radix Astragali 13 weight portion Radix Aconiti Preparata 0.6 weight portions
The Rhizoma Atractylodis Macrocephalae 3 weight portion Radix Aconiti Kusnezoffii Preparata 0.8 weight portion Scorpio 0.8 weight portion Holotrichia diomphalia Bates 0.6 weight portions
Bi
the 1.6 weight portion Radix Glycyrrhizae 1.5 weight portion Rhizoma Pinelliae 1.5 weight portion Rhizoma Arisaematis (processed) 0.4 weight portions
Get pharmaceutical composition above-mentioned raw materials medicine of the present invention, add conventional adjuvant, be prepared into clinical acceptable various dosage forms according to common process, as: capsule, granule, tablet, oral liquid, aqueous injection or lyophilized injectable powder.
Pharmaceutical composition of the present invention has invigorating the kidney and strengthening the bones, blood circulation promoting and blood stasis dispelling, and dispelling wind and removing obstruction in the collateral, effect of benefiting qi and nourishing blood, various pain and edema that rheumatoid arthritis, rheumatoid are caused have good therapeutical effect.Preparation prepared by pharmaceutical composition of the present invention, has overcome the large drawback of Chinese patent medicine dose, have active ingredient high, take safe, with strong points, suitable crowd feature widely.
Following experimental example and embodiment are used for further illustrating but are not limited to the present invention.
The experiment of experimental example 1 medicine composite for curing rheumatoid arthritis of the present invention clinical comparison
Treatment group: three courses for the treatment of of oral medicament composition capsule preparation of the present invention (being made by embodiment 1) (9 days courses for the treatment of), every day 3 times, each 2; Matched group: three courses for the treatment of of oral common treatment medicine for treating rheumatoid arthritis (etidocine tablet, specification: 25 milligrams of sheets), each 1, every day 3 times, one after each meal.By clinical comparison, the results are shown in Table 1.
" in cure the desease Standardization of diagnosis and curative effect " that criterion of therapeutical effect is implemented with reference to State Administration of Traditional Chinese Medicine 1994 drafted as follows:
Clinical recovery: tcm clinical practice symptom, sign disappear or substantially disappear;
Effective: tcm clinical practice symptom, sign obviously change;
Effective: tcm clinical practice symptom, sign all take a favorable turn;
Invalid: tcm clinical practice symptom, sign are all not improved;
Table 1 is treated Rheumatoid Arthritis contrast
| Group | Treatment number | Recovery from illness | Effective | Effectively | Invalid | Total effective rate |
| Treatment group | 80 | 32 | 17 | 20 | 6 | 92.5％ |
| Matched group | 80 | 20 | 23 | 22 | 15 | 81％ |
Observe by the clinical verification to 160 routine patient with rheumatoid arthritis, result shows: the total effective rate 92.5% of medicament composition capsule of the present invention to rheumatoid arthritis.In matched group, treat the total effective rate 81% of rheumatoid arthritis.Illustrate that treatment group is aspect rheumatoid arthritis, have certain treatment advantage.Preparation prepared by pharmaceutical composition of the present invention, has overcome the large drawback of Chinese patent medicine dose, have active ingredient high, take safe, with strong points, suitable crowd feature widely.
Experimental example 2 pharmaceutical composition of the present invention is alleviated the experiment of elbow joint enlargement and pain
Grandson, 30 years old, female, suffered from rheumatic arthritis 3 years.Symptom: patient's duplex arthroncus, without distortion, there is stiff and stiff feeling in the joint of getting up morning, joint joint stuffiness.
Treat a course for the treatment of by taking medicament composition capsule preparation of the present invention (being made up of embodiment 1), duplex arthroncus disappears, and arthralgia takes an evident turn for the better.Continual cure recovers normal four courses for the treatment of on inspection substantially.
Experimental example 3 pharmaceutical composition of the present invention is alleviated the experiment of arthralgia
Zhang, female, 55 years old.Symptom: the left lower limb ankle joint of patient, pain and swelling, walking disorder, because of work aggravation, is diagnosed as rheumatism after diagnosing.
Treat a course for the treatment of by taking medicament composition capsule preparation of the present invention (being made by embodiment 1), arthralgia is clearly better, left ankle joint function is obviously improved, and patient can normally walk, and continual cure recovers normal six courses for the treatment of on inspection substantially.
Following embodiment all can realize the effect described in above-mentioned experimental example.
The preparation of embodiment 1 capsule
Radix Aconiti Lateralis Preparata 1kg Caulis Sinomenii 4kg Radix Astragali 10kg Radix Aconiti Preparata 1kg Radix Aconiti Kusnezoffii Preparata 1kg Scorpio 0.5kg
Rhizoma Atractylodis Macrocephalae 2kg Holotrichia diomphalia Bates 1kg Bi
1kg Radix Glycyrrhizae 2kg Rhizoma Arisaematis (processed) 0.5kg Rhizoma Pinelliae 1kg
Get above-mentioned raw materials medicine, add conventional adjuvant, make powder and enter capsule, every 0.6g, every day 3 times, each 2 according to common process decocting in water, precipitate with ethanol, oven dry pulverizing.
The preparation of embodiment 2 capsules
Radix Aconiti Lateralis Preparata 0.6kg Caulis Sinomenii 7kg Radix Astragali 6kg Radix Aconiti Preparata 1.5kg
Rhizoma Atractylodis Macrocephalae 1.5kg Radix Aconiti Kusnezoffii Preparata 1.8kg Scorpio 0.3kg Holotrichia diomphalia Bates 1.9kg
Bi
0.7kg Radix Glycyrrhizae 3kg Rhizoma Pinelliae 0.8kg Rhizoma Arisaematis (processed) 0.8kg
Get above-mentioned raw materials medicine, add conventional adjuvant, make powder and enter capsule according to common process decocting in water, precipitate with ethanol, oven dry pulverizing.
The preparation of embodiment 3 capsules
Radix Aconiti Lateralis Preparata 1.8kg Caulis Sinomenii 3kg Radix Astragali 13kg Radix Aconiti Preparata 0.6kg
Rhizoma Atractylodis Macrocephalae 3kg Radix Aconiti Kusnezoffii Preparata 0.8kg Scorpio 0.8kg Holotrichia diomphalia Bates 0.6kg
Bi
1.6kg Radix Glycyrrhizae 1.5kg Rhizoma Pinelliae 1.5kg Rhizoma Arisaematis (processed) 0.4kg
Get above-mentioned raw materials medicine, add conventional adjuvant, make powder and enter capsule according to common process decocting in water, precipitate with ethanol, oven dry pulverizing.
The preparation of embodiment 4 granules
Radix Aconiti Lateralis Preparata 1kg Caulis Sinomenii 4kg Radix Astragali 10kg Radix Aconiti Preparata 1kg Radix Aconiti Kusnezoffii Preparata 1kg Scorpio 0.5kg
Rhizoma Atractylodis Macrocephalae 2kg Holotrichia diomphalia Bates 1kg Bi
1kg Radix Glycyrrhizae 2kg Rhizoma Arisaematis (processed) 0.5kg Rhizoma Pinelliae 1kg
Get above-mentioned raw materials medicine, add conventional adjuvant, according to the agent of common process granulation.
The preparation of embodiment 5 tablets
Radix Aconiti Lateralis Preparata 0.6kg Caulis Sinomenii 7kg Radix Astragali 6kg Radix Aconiti Preparata 1.5kg
Rhizoma Atractylodis Macrocephalae 1.5kg Radix Aconiti Kusnezoffii Preparata 1.8kg Scorpio 0.3kg Holotrichia diomphalia Bates 1.9kg
Bi
0.7kg Radix Glycyrrhizae 3kg Rhizoma Pinelliae 0.8kg Rhizoma Arisaematis (processed) 0.8kg
Get above-mentioned raw materials medicine, add conventional adjuvant, make tablet according to common process.
The preparation of embodiment 6 oral liquids
Radix Aconiti Lateralis Preparata 1.8kg Caulis Sinomenii 3kg Radix Astragali 13kg Radix Aconiti Preparata 0.6kg
Rhizoma Atractylodis Macrocephalae 3kg Radix Aconiti Kusnezoffii Preparata 0.8kg Scorpio 0.8kg Holotrichia diomphalia Bates 0.6kg
Bi
1.6kg Radix Glycyrrhizae 1.5kg Rhizoma Pinelliae 1.5kg Rhizoma Arisaematis (processed) 0.4kg
Get above-mentioned raw materials medicine, add conventional adjuvant, make oral liquid according to common process.
The preparation of embodiment 7 aqueous injection
Radix Aconiti Lateralis Preparata 0.5kg Caulis Sinomenii 8kg Radix Astragali 5kg
Radix Aconiti Preparata 2kg Rhizoma Atractylodis Macrocephalae 4kg Radix Aconiti Kusnezoffii Preparata 0.5kg
Scorpio 1kg Holotrichia diomphalia Bates 0.5kg Bi
2kg
Radix Glycyrrhizae 1kg Rhizoma Pinelliae 0.5kg Rhizoma Arisaematis (processed) 1kg
Get above-mentioned raw materials medicine, add conventional adjuvant, be prepared into aqueous injection according to common process.
Claims (6)
1. treat a pharmaceutical composition for rheumatoid arthritis, it is characterized in that the crude drug of this pharmaceutical composition consists of:
2. pharmaceutical composition as claimed in claim 1, is characterized in that the crude drug of this pharmaceutical composition consists of:
3. pharmaceutical composition as claimed in claim 1, is characterized in that the crude drug of this pharmaceutical composition consists of:
4. pharmaceutical composition as claimed in claim 1, is characterized in that the crude drug of this pharmaceutical composition consists of:
5. the pharmaceutical composition as described in claim 1,2,3 or 4, the compositions crude drug that it is characterized in that getting it filled, adds conventional adjuvant, according to common process, makes capsule, granule, tablet, oral liquid, aqueous injection or lyophilized injectable powder.
6. the application of pharmaceutical composition in preparation treatment medicine for treating rheumatoid arthritis as described in claim 1,2,3 or 4.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110223378.4A CN102908476B (en) | 2011-08-05 | 2011-08-05 | Medicinal composition for treating rheumatoid arthritis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110223378.4A CN102908476B (en) | 2011-08-05 | 2011-08-05 | Medicinal composition for treating rheumatoid arthritis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102908476A CN102908476A (en) | 2013-02-06 |
| CN102908476B true CN102908476B (en) | 2014-05-28 |
Family
ID=47607209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110223378.4A Expired - Fee Related CN102908476B (en) | 2011-08-05 | 2011-08-05 | Medicinal composition for treating rheumatoid arthritis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102908476B (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1184654A (en) * | 1996-12-12 | 1998-06-17 | 张志兴 | Plaster for treating arthralgia-syndrome |
| CN1778383A (en) * | 2004-11-24 | 2006-05-31 | 香港赛马会中药研究院有限公司 | Herbal medical preparation for the treatment of arthritis |
| CN101254284A (en) * | 2007-02-26 | 2008-09-03 | 北京亚东生物制药有限公司 | Rheumatism treating medicine combination, preparation and quality control method |
| CN102000313A (en) * | 2010-11-23 | 2011-04-06 | 张秀兰 | Medicament for treating rheumatic arthritis and preparation method thereof |
-
2011
- 2011-08-05 CN CN201110223378.4A patent/CN102908476B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1184654A (en) * | 1996-12-12 | 1998-06-17 | 张志兴 | Plaster for treating arthralgia-syndrome |
| CN1778383A (en) * | 2004-11-24 | 2006-05-31 | 香港赛马会中药研究院有限公司 | Herbal medical preparation for the treatment of arthritis |
| CN101254284A (en) * | 2007-02-26 | 2008-09-03 | 北京亚东生物制药有限公司 | Rheumatism treating medicine combination, preparation and quality control method |
| CN102000313A (en) * | 2010-11-23 | 2011-04-06 | 张秀兰 | Medicament for treating rheumatic arthritis and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| 中医药治疗类风湿性关节炎研究进展;高海涛等;《现代中医药》;20051231(第02期);63-66 * |
| 张皖东等.类风湿性关节炎的中医药研究进展.《中国中医基础医学杂志》.2006,第12卷(第09期),714-719. |
| 类风湿性关节炎的中医药研究进展;张皖东等;《中国中医基础医学杂志》;20061231;第12卷(第09期);714-719 * |
| 高海涛等.中医药治疗类风湿性关节炎研究进展.《现代中医药》.2005,(第02期),63-66. |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102908476A (en) | 2013-02-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101732588B (en) | Formula of Chinese medicament for treating bodily pain syndrome | |
| CN103585614A (en) | Externally used traditional Chinese medicine wine for treating rheumatoid arthritis | |
| CN103768315B (en) | A kind of bone knitting plaster of setting bone and promoting blood flow | |
| CN103393862B (en) | Chinese medicinal composition for treating lumbocrural pain | |
| CN103142938A (en) | Plaster for treating traumatic injury and fracture | |
| CN103239579B (en) | Chinese medicine composition for treating acute facioplegia and preparation method thereof | |
| CN103251865A (en) | Traditional Chinese medicine composite for treating diarrhea | |
| CN102671046B (en) | Chinese medicament for treating chronic appendicitis | |
| CN102935163B (en) | The Chinese medicine preparation for the treatment of hyperosteogeny | |
| CN102100817A (en) | Chinese medicinal preparation for treating infection of upper respiratory tracts | |
| CN101926903A (en) | Chinese medicine preparation for curing facial paralysis | |
| CN101708292B (en) | Chinese medicament for treating rheumatic and rheumatoid diseases | |
| CN103784932A (en) | Traditional Chinese medicine decoction for treating hyperplasia of mammary glands | |
| CN102908476B (en) | Medicinal composition for treating rheumatoid arthritis | |
| CN105796891A (en) | Traditional Chinese medicinal composition for treating epigastric pain | |
| CN104800443A (en) | Bone setting agent with functions of tonifying kidney and regenerating bone marrow | |
| CN104383175A (en) | Medicine for treating chronic osteomyelitis and preparation method of medicine | |
| CN1322884C (en) | Purple perilla capsule and process for preparing the same | |
| CN103948763A (en) | Traditional Chinese medicinal composition for treating hepatosis | |
| CN101647897A (en) | Traditional Chinese medicine pill for treating hyperosteogeny | |
| CN104771528A (en) | Traditional Chinese medicine composition for treating urinary calculi | |
| CN104436036A (en) | Traditional Chinese medicine prepration for treating arthrosis like crane knees | |
| CN104887792A (en) | Traditional Chinese medicine composition for treating rheumatic arthritis | |
| CN104547947A (en) | Traditional Chinese medicine composition for treating scapulohumeral periarthritis | |
| CN104758693A (en) | Traditional Chinese medicine composition for treating acute tonsillitis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140528 Termination date: 20160805 |