CN102895464A - Medicament for treating children diarrhea - Google Patents

Abstract

The invention discloses a medicament for treating children diarrhea. The medicament is prepared by the following steps of: mixing medicaments including scorched large-head atractylodes rhizome, officinal magnolia bark, dried orange peel, indian buead, oriental waterplantain rhizome, scorched medicated leaven, scorched fructus crataegi, chicken gizzard membrane, dark plum fruit, Chinese yam, umbellate pore fungus, red halloysite and roasted liquoric root uniformly in parts by weight; adding water for decocting for 2-4 times, every time for 1-2 hours; combining decoctions; filtering; concentrating a filtrate into clear paste of which the relative density is 1.15-1.18 at the temperature of 70 DEG C; refrigerating and standing; filtering a supernatant; adding conventional auxiliary materials into the filtrate; mixing uniformly; adding purified water till the medicament content is 1g/mL; and filling and sterilizing to obtain an oral liquid preparation. The medicament disclosed by the invention has the effects of depressing qi, relieving flatulence, strengthening the spleen, replenishing qi, promoting the circulation of qi, dissipating blood stasis, dissolving turbidity, lowering lipid, regulating qi-flowing for strengthening spleen and promoting digestion, and has a remarkable curative effect on children diarrhea.

Description

A kind of medicine for the treatment of children's diarrhae

Technical field

The present invention relates to a kind of medicine for the treatment of children's diarrhae, particularly relate to a kind of medicine of the treatment children's diarrhae for preparing take Chinese medicine as crude drug.

Background technology

Children's diarrhae is divided into infectious and non-infectious two classes according to the cause of disease, be by many cause of diseases, multifactor cause take the one group clinical syndrome of diarrhoea as leading.Age of onset is many below 2 years old, and every year is died from the child of diarrhoea up to 5,000,000～18,000,000 in the whole world.In China, children's diarrhae is the 2nd commonly encountered diseases, the frequently-occurring disease that is only second to respiratory tract infection, if can not treat timely and effectively, mortality rate is also very high.Causing dead major reason, is health dehydration and cylinder electrolyte disorder that diarrhoea causes.

The peak of children's diarrhae mainly occurs in 6 annual-November.Summer diarrhea mostly is mucus just due to normally being infected by antibacterial, has stench flavor; Rotavirus enteritis is many to be caused by rotavirus, just common with rare water sample or magma, but without stench flavor.

Treatment primary disease Western medicine is a lot of at present, and mainly by antibiotic antidiarrheal, but the child uses antibiotic side effect very large, is unfavorable for growing up healthy and sound of child.

Summary of the invention

The purpose of this invention is to provide a kind of medicine for the treatment of children's diarrhae, this medicine is comprised of Chinese medicine, has the effect of replenishing QI to invigorate the spleen and middle antidiarrheal, promoting diuresis to eliminate damp pathogen, can play instant effect, the little purpose of side effect to the treatment of children's diarrhae.

Medicine of the present invention is that the Chinese medicine by following parts by weight is that crude drug prepares:

Rhizoma Atractylodis Macrocephalae preparata 8-15 Cortex Magnoliae Officinalis 5-15 Pericarpium Citri Reticulatae 4-14

Poria 5-15 Rhizoma Alismatis 5-15 Massa Medicata Fermentata (parched to brown) 5-15

Fructus Crataegi (parched to brown) 5-15 Endothelium Corneum Gigeriae Galli 4-14 Fructus Mume 4-15

Rhizoma Dioscoreae 8-15 Polyporus 4-14 Halloysitum Rubrum 5-15

Radix Glycyrrhizae Preparata 1-10.

Said medicine can be made any dosage form on the pharmaceutics, such as tablet, pill, powder, capsule etc., the preferred dosage form of the present invention is oral liquid.

The concrete preparation method of above-mentioned each component being made medicine of the present invention is:

The medicament mixed of above-mentioned weight portion is even, decoct with water 2-4 time, each 1-2 hour, collecting decoction, filter, filtrate is condensed into the clear paste of 70 ℃ of relative density 1.15-1.18, and cold preservation is left standstill, and gets supernatant liquid filtering, add conventional adjuvant in the filtrate, mixing, adding purified water is 1g/mL to containing the crude drug amount, oral liquid formulations is made in fill, sterilization.

Using method: oral, each 1, every 10mL, every day 3 times.

Rhizoma Atractylodis Macrocephalae preparata in the prescription of the present invention, invigorating the spleen to arrest diarrhea; Cortex Magnoliae Officinalis, the dampness expectorant, the therapeutic method to keep the adverse QI flowing downwards is except full; Pericarpium Citri Reticulatae, regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Poria, detoxifcation, dehumidifying, easing joint movement; Rhizoma Alismatis, promoting diuresis to eliminate damp pathogen expels the heat-evil, and changes turbid blood fat reducing; Massa Medicata Fermentata (parched to brown) has dyspepsia and intestinal stasis relieving, and the stomach function regulating preventing or arresting vomiting is separated the swollen dysentery of controlling, and increases appetite, promotes metabolism; Fructus Crataegi (parched to brown), promoting digestion and removing stagnation, antidiarrheal; Endothelium Corneum Gigeriae Galli, invigorating the stomach and promoting digestion, arresting seminal emission; Fructus Mume is astringed the lung, and astringing intestine to stop diarrhea promotes the production of body fluid, relieving colic caused by ascaris; Rhizoma Dioscoreae, spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission; Polyporus, promoting diuresis to eliminate damp pathogen; Halloysitum Rubrum, astringing intestine to stop diarrhea, hemostasis, promoting tissue regeneration and ulcer healing; Radix Glycyrrhizae Preparata, spleen reinforcing stomach function regulating, Yiqi and vein recovery, coordinating the actions of various ingredients in a prescription.All medicines share, and can play the therapeutic method to keep the adverse QI flowing downwards except full, invigorating the spleen and benefiting QI, and the circulation of qi promoting dissipating blood stasis is changed turbid blood fat reducing, regulating qi-flowing for strengthening spleen, the effect of dyspepsia and intestinal stasis relieving, evident in efficacy to the treatment children's diarrhae.

For further investigating clinical efficacy and the safety of medicine of the present invention, select 86 routine children's diarrhae patients that the curative effect of medicine of the present invention has been carried out clinical observation.All cases is the People's Hospital's outpatient service in January, 2011 to May and inpatient.

All cases all according to the diagnostic criteria of " disease of tcm Standardization of diagnosis and curative effect ", is diagnosed as children's diarrhae.

Diagnostic criteria:

1 times of defecation increases, and nearly more than 10 times, is faint yellow every day 3～5 times, and such as egg soup sample, or color is brown and smelly, and a small amount of mucus can be arranged.Or with feeling sick, vomiting, stomachache, heating thirstyly waits disease.

2 have excess in feeding, unhygienic diet or experience the medical history of seasonal pathogen.

3 severe one diarrhoea and vomiting be than severe patient, visible oliguria, fervescence, excessive thirst god withers, skin is shrivelled, sunken fontanel, the order pearl is sunk, crying without tears, the lip cherry is red, breathe profound, the diseases such as abdominal distention.

4 stool microscopies can have Oil globule, a small amount of red white corpuscle.

5 stool pathogenic examinations can have the growths such as Escherichia coli, or separate rotavirus etc.

6 severe diarrheas have dehydration, acid base imbalance and electrolyte disturbance.

Syndrome Differentiation of Traditional Chinese Medicine: minute sudden attack of spouting diarrhea and chronic diarrhea.Sudden attack of spouting diarrhea: diarrhea due to damp-heat; Cold-damp is had loose bowels; Indigestion diarrhea.Chronic diarrhea: diarrhea due to hypofunction of the spleen; Suffer from a deficiency of the kidney and have loose bowels; The diseases caused by retention of fluid laxation; Resistance intestinal network becomes silted up.

Observe several 86 examples of total example, be divided into the catabasis and suddenly send out the phase.Each phase is divided equally observation group and matched group, and the catabasis is totally 16 examples, wherein observation group's 10 routine matched group 6 examples; Anxious phases 70 example, wherein observation group's 50 routine matched group 20 examples sent out.

Observational technique:

Selected patient is with being observation group and matched group.It 1 ~ 7 day was a course for the treatment of from medication.The oral Chinese medicine preparation of the present invention of catabasis observation group, every day three times, each 10mL; Catabasis matched group umbilicus pastes " DINGHUIER QITIE " (inferior precious Pharmaceutical preparation) and exchanged cards with personal and family details when becoming sworn brothers once in per 12 hours.

Therapeutic outcome:

By observing the cardinal symptom curative effect relatively, show that observation group obviously is better than matched group.

Two groups of total effective rates and obvious effective rate all have very notable difference.10 examples in catabasises 16 example are drunk Chinese medicine preparation of the present invention, and 5 routine second days are havied loose bowels and obviously alleviated, and remain 5 examples the 3rd day and take a turn for the better, whole four days equal intact leaving hospital; 6 examples in the matched group have an example be because of skin infection with Chinese medicine preparation treatment, from being in hospital the improvement time all about a week, obviously Chinese medicine preparation of the present invention is evident in efficacy.Anxious observation group's 50 examples of sending out in phases 70 example are drunk Chinese medicine preparation of the present invention, and invalid all the other 49 examples of an example are wherein arranged, and sb.'s illness took a favorable turn in equal two to three days, and effective percentage accounts for 98%, recovers normal; Use DINGHUIER QITIE to have 2 routine skin umbilicuss to infect other method of migrating in 20 examples of matched group and treat or a routine invalid accounting example 15%, effective percentage accounts for 85%.All infant patients all do not find significant change, so Chinese medicine preparation of the present invention has no adverse effects to blood, urinary system, gastrointestinal and hepatic and renal function through blood, urine, just conventional regulating liver-QI, kidney function test after observation group and the treatment of control group.

The specific embodiment

Embodiment 1

Get Rhizoma Atractylodis Macrocephalae preparata 12kg, Cortex Magnoliae Officinalis 10kg, Pericarpium Citri Reticulatae 8kg, Poria 10kg, Rhizoma Alismatis 10kg, Massa Medicata Fermentata (parched to brown) 10kg, Fructus Crataegi (parched to brown) 10kg, Endothelium Corneum Gigeriae Galli 8kg, Fructus Mume 9kg, Rhizoma Dioscoreae 12kg, Polyporus 8kg, Halloysitum Rubrum 15g, Radix Glycyrrhizae Preparata 4kg, the medicament mixed of above-mentioned weight portion is even, decoct with water 2-4 time, each 1-2 hour, collecting decoction filters, and filtrate is condensed into the clear paste of 70 ℃ of relative density 1.15-1.18, cold preservation is left standstill, get supernatant liquid filtering, add conventional adjuvant, mixing in the filtrate, adding purified water is 1g/mL to containing the crude drug amount, and oral liquid formulations is made in fill, sterilization.

Embodiment 2

Get Rhizoma Atractylodis Macrocephalae preparata 15kg, Cortex Magnoliae Officinalis 15kg, Pericarpium Citri Reticulatae 14kg, Poria 15kg, Rhizoma Alismatis 13kg, Massa Medicata Fermentata (parched to brown) 14kg, Fructus Crataegi (parched to brown) 14kg, Endothelium Corneum Gigeriae Galli 14kg, Fructus Mume 13kg, Rhizoma Dioscoreae 13kg, Polyporus 14kg, Halloysitum Rubrum 14g, Radix Glycyrrhizae Preparata 10kg, the medicament mixed of above-mentioned weight portion is even, decoct with water 2-4 time, each 1-2 hour, collecting decoction filters, and filtrate is condensed into the clear paste of 70 ℃ of relative density 1.15-1.18, cold preservation is left standstill, get supernatant liquid filtering, add conventional adjuvant, mixing in the filtrate, adding purified water is 1g/mL to containing the crude drug amount, and oral liquid formulations is made in fill, sterilization.

Model case:

Dong Xiaohu just reaches an one full year of life, causes haveing loose bowels because often having milk powder.Symptom: times of defecation is many, is rare water sample yellow green just, and taste is smelly and unpleasant, cries and screams, and lethargy is depressed, is diagnosed as the not optimum diarrhoea of children's, hospitalization.Oral Chinese medicine preparation of the present invention, times of defecation minimizing behind the second day of taking medicine, stool color change, infant begin to suck the breast, and spirit takes a turn for the better, and continuing takes medicine to return to one's perfect health two days later leaves hospital.

Claims (1)

1. medicine for the treatment of children's diarrhae is that crude drug prepares by the Chinese medicine of following portions by weight:

Rhizoma Atractylodis Macrocephalae preparata 8-15 Cortex Magnoliae Officinalis 5-15 Pericarpium Citri Reticulatae 4-14

Poria 5-15 Rhizoma Alismatis 5-15 Massa Medicata Fermentata (parched to brown) 5-15

Fructus Crataegi (parched to brown) 5-15 Endothelium Corneum Gigeriae Galli 4-14 Fructus Mume 4-15

Rhizoma Dioscoreae 8-15 Polyporus 4-14 Halloysitum Rubrum 5-15

Radix Glycyrrhizae Preparata 1-10.