CN102885950B - Pharmaceutical composition for treating cervix uteri postoperative bleeding - Google Patents
Pharmaceutical composition for treating cervix uteri postoperative bleeding Download PDFInfo
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- CN102885950B CN102885950B CN2012103984520A CN201210398452A CN102885950B CN 102885950 B CN102885950 B CN 102885950B CN 2012103984520 A CN2012103984520 A CN 2012103984520A CN 201210398452 A CN201210398452 A CN 201210398452A CN 102885950 B CN102885950 B CN 102885950B
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Abstract
The invention discloses a pharmaceutical composition for treating cervix uteri postoperative bleeding in order to solve the treatment problem of cervix uteri postoperative bleeding. The pharmaceutical composition is characterized by being processed from a plurality of Chinese medicinal herbs; and the raw material formula and the weight proportion are as follows: 6-10 parts of oxtongue, 8-15 parts of desert date bark, 8-15 parts of broomjutre sida herb, 6-10 parts of sowthistle-leaf ixeris seedling, 6-10 parts of radix paeoniae alba, 8-15 parts of immature bitter orange, 6-10 parts of rose, 8-15 parts of dried tangerine or orange peel and 3-6 parts of rhizoma cyperi. According to clinical trials, the pharmaceutical composition disclosed by the invention has the following characteristics of excellent treatment effect and higher security in the treatment of cervix uteri postoperative bleeding, so that the pharmaceutical composition is worthy of being applied and popularized.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to treat the pharmaceutical composition of cervix uteri postoperative hemorrhage.
Background technology
All uterine myomas only are confined to uterus neck and do not reach palace body person, all can carry out operation on cervix by vaginal approach, as the cervix uteri electricity of cervical polyp enucleation, cervical biopsy, chronic cervicitis is pressed and micro-wave therapeutic etc.
The postoperative hemorrhage of cervix of operation on cervix is hemorrhage different from other position of health, can not wrap up hemostasis, and hemostasis by compression easily damages mucosal tissue, and excessive pressure also can affect local blood fortune and delayed healing.
The multiplex pharmaceutical gauze filling of current treatment, such as silver nitrate, styptic powder etc., but the cervix uteri electricity to be pressed or the postoperative intractable bleeding that takes off the silly phase of microwave, said method is unsatisfactory, and indivedual case Chang Yin bleed profusely and hospitalization.And silver nitrate, styptic powder etc. can not improve the zest neoplasm and increase this symptom.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, and the pharmaceutical composition of the sure treatment cervix uteri postoperative hemorrhage of a kind of curative effect is provided.
The technical scheme that the present invention solves its technical problem is: a kind of pharmaceutical composition for the treatment of the cervix uteri postoperative hemorrhage, it is characterized in that being processed by plurality of Chinese, its composition of raw materials and weight proportion are: 6 ~ 10 parts of Folium Fumicis Dentatis, 8 ~ 15 parts of Cortex Elaeagni Angustifoliaes, 8 ~ 15 parts of Herba Sidae Rhombifoliaes, 6 ~ 10 parts of Herba Ixeritis Sonchifoliaes, 6 ~ 10 parts of the Radix Paeoniae Albas, 8 ~ 15 parts of Fructus Aurantii Immaturuss, 6 ~ 10 parts of Flos Rosae Rugosaes, 8 ~ 15 parts of Pericarpium Citri Reticulataes, 3 ~ 6 parts of Rhizoma Cyperis.
Its optimum weight proportioning is: 8 parts of Folium Fumicis Dentatis, 10 parts of Cortex Elaeagni Angustifoliaes, 10 parts of Herba Sidae Rhombifoliaes, 8 parts of Herba Ixeritis Sonchifoliaes, 8 parts of the Radix Paeoniae Albas, 10 parts of Fructus Aurantii Immaturuss, 8 parts of Flos Rosae Rugosaes, 10 parts of Pericarpium Citri Reticulataes, 5 parts of Rhizoma Cyperis.
Wherein said: Folium Fumicis Dentati is the leaf of polygonaceae plant rumex dentatus Rumex dentatus L..Nature and flavor are bitter, hot, flat.Return Liver Channel.Merit can be analgesic, analgesia, antiinflammatory.Modern pharmacological research shows, Folium Fumicis Dentati decocting liquid is to vascular strip being shown to obvious contraction, and thrombin is had to activation, can make clotting time shorten 5 ~ 6 minutes than normal value; Can increase erythrocyte aggregation, there is elevating blood viscosity and make the effect of slowing down of microcirculation velocity of blood flow.
Cortex Elaeagni Angustifoliae is the bark of Elaeangnaceae oleaster Fructus Elaeagni Angustifoliae Elaeagnus angustifolia L.Nature and flavor acid, micro-hardship, cool.But the merit clearing away heat and cooling blood, the convergence pain relieving.
Herba Sidae Rhombifoliae, for the Malvaceae plant carries on the back the herb of Radix sidae acutae Sida rhombifolia L. in vain.Nature and flavor are sweet; Hot; Cool.GUIXIN; Liver; Lung; Large intestine; Small intestine meridian.But merit clearing away heat-damp and promoting diuresis; Removing toxic substances and promoting subsidence of swelling.
Herba Ixeritis Sonchifoliae, for wild gutweed platymiscium Herba Ixeritis Sonchifoliae Ixeris sonchifolia (Bunge) Hance of Compositae, with all herbal medicine.Nature and flavor are bitter, hot, flat.But the merit heat-clearing and toxic substances removing, evacuation of pus, pain relieving.Modern pharmacological research shows: the analgesia of Herba Ixeritis Sonchifoliae tool, spasmolytic effect, the content of its analgesic effect and total flavones is also not parallel, and certain antiinflammatory action is arranged.
The Radix Paeoniae Alba is the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall..Nature and flavor are bitter, sour, are slightly cold.Return liver, spleen channel.But the pain relieving of merit suppressing the hyperactive liver, nourishing blood for regulating menstruation, astringing YIN to stop sweating.
Fructus Aurantii Immaturus is the dry young fruit of rutaceae Citrus aurantium Linn. Citrus aurantium L. and variety or Fructus Citri sinensis Citrus sinensis Osbeck.But merit dispelling the stagnated QI intestinal stasis relieving.Nature and flavor are bitter, hot, sour, temperature.Return spleen, stomach warp.But merit dispelling the stagnated QI removing food stagnancy, the loose painful abdominal mass of reducing phlegm.
Flos Rosae Rugosae is the dry flower of rosaceous plant Flos Rosae Rugosae Rosa rugosa Thunb..Sweet, the micro-hardship of nature and flavor, temperature.Return liver, spleen channel.But merit promoting QI circulation for relieving depression, and blood, pain relieving.
Pericarpium Citri Reticulatae is the dry mature skin of rutaceae orange Citrus reticulata Blanco and variety thereof.Nature and flavor are bitter, hot, temperature.Return lung, spleen channel.But the merit regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.
Rhizoma Cyperi, be the dry rhizome of sedge dried tuber Cyperus rotundus L., sing the hair must, put in boiling water slightly boil or steam after dry, or burn and directly dry afterwards.Nature and flavor suffering, micro-hardship, micro-sweet, flat.Return liver, spleen, tri-jiao channel.But the merit promoting QI circulation for relieving depression, menstruction regulating and pain relieving.
Compared with the prior art, the present invention has following characteristics:
1, prescription uniqueness, property is gentle, has avoided cooling blood for hemostasis or other cold haemostatic medicaments in the conventional Chinese medicine prescription, has reduced the stimulation to mucosa;
2, medicine used enters the liver spleen channel mostly, is equipped with soothing the liver circulation of qi promoting medicine simultaneously, contributes to the self-recovery of Liver Channel reproductive system, and the whole tonify without causing stagnation of prescription is capable and loose;
3, medicine material consumption of the present invention is groped in a large number to sum up through the inventor and is drawn, each raw material consumption is for all to have curative effect preferably in the following weight parts scope.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, the crude drug weight proportion: Folium Fumicis Dentati 6g, Cortex Elaeagni Angustifoliae 8g, Herba Sidae Rhombifoliae 8g, Herba Ixeritis Sonchifoliae 6g, Radix Paeoniae Alba 6g, Fructus Aurantii Immaturus 8g, Flos Rosae Rugosae 6g, Pericarpium Citri Reticulatae 8g, Rhizoma Cyperi 3g.
Embodiment 2, the crude drug weight proportion: Folium Fumicis Dentati 10g, Cortex Elaeagni Angustifoliae 15g, Herba Sidae Rhombifoliae 15g, Herba Ixeritis Sonchifoliae 10g, Radix Paeoniae Alba 10g, Fructus Aurantii Immaturus 15g, Flos Rosae Rugosae 10g, Pericarpium Citri Reticulatae 15g, Rhizoma Cyperi 6g.
Embodiment 3, the crude drug weight proportion: Folium Fumicis Dentati 8g, Cortex Elaeagni Angustifoliae 10g, Herba Sidae Rhombifoliae 10g, Herba Ixeritis Sonchifoliae 8g, Radix Paeoniae Alba 8g, Fructus Aurantii Immaturus 10g, Flos Rosae Rugosae 8g, Pericarpium Citri Reticulatae 10g, Rhizoma Cyperi 5g.
During use, Chinese medicine Folium Fumicis Dentati of the present invention, Cortex Elaeagni Angustifoliae, Herba Sidae Rhombifoliae, Herba Ixeritis Sonchifoliae, the Radix Paeoniae Alba, Fructus Aurantii Immaturus, Flos Rosae Rugosae, Rhizoma Cyperi and Pericarpium Citri Reticulatae are decocted with water to twice, merging filtrate.
This filtrate can infiltrate gauze and carry out part filling, because of the property of medicine is gentle also can be for oral.
Effective combination of aforementioned pharmaceutical compositions, coordinate mutually, can effectively reach the purpose for the treatment of cervix uteri postoperative hemorrhage, and side effect is less.
The above results is the clinical data sufficient proof, and interrelated data is as follows, and wherein the use of drugs compositions is the crude drug weight proportion in embodiment 3.
1 object and method.
1.1 object: choose in March, 2010～2011 year December temporary dwelling palace neck patient with operation 120 examples.Excision of cervical polyp 56 examples wherein, excision of myoma of cervix 3 examples, cervical biopsy 10 examples, the cervix uteri electricity is pressed electric cautery 36 examples, cervix uteri micro-wave therapeutic 15 examples.The vaginal secretions inspection of all going before all patient treatments is got rid of acute vaginitis, row colposcopy and TCT and is got rid of invasive carcinoma of cervix, and except internal medicine complication such as blood system disorders diseases, treatment time is the clean 3～7d of menstruation side by side.
1.2 method.
1.2.1 grouping: 120 routine patient ages are 25 ~ 53 years old.Be divided at random treatment group and matched group.Two groups of state of an illness, age differences, without significance, have comparability (P<0.05).
1.2.2 Therapeutic Method: matched group is the local use of silver nitrate.Treatment group is that pharmaceutical composition sliver of the present invention is filled.The making of infusion medicine yarn bar: Folium Fumicis Dentati, Cortex Elaeagni Angustifoliae, Herba Sidae Rhombifoliae, Herba Ixeritis Sonchifoliae, the Radix Paeoniae Alba, Fructus Aurantii Immaturus, Flos Rosae Rugosae, Rhizoma Cyperi and Pericarpium Citri Reticulatae are decocted with water to twice, and merging filtrate is standby; Launch in the sterilization kidney basin with the antiseptic gauze of sterility forceps clamping 25cmx25cm, cut a breach that 2cm is wide, 7cm is long by sterile scissors from the gauze side, note not cutting off, put into above-mentioned filtrate and fully infiltrate 3 ~ 5min; Include in until the hemorrhage of cervix face takes out after 24h, note observing cervix uteri local hemorrhage situation, if any obviously soaking blood then repetitive therapy.
1.2.3 observation index: record neoplasm amount, vaginal hemorrhage amount, bleeding time and wound healing situation.
1.2.4 curative effect determinate standard: efficacy assessment standard divides healing, produce effects, effective, invalid.Cure: after 1 medication, the cervix uteri local hemorrhage stops, and observes 24h and has no hemorrhage.Produce effects: need stop by the cervix uteri local hemorrhage after 2 medications.Effectively: need after 2 medications, have a little to soak blood in the cervix uteri part, but need not add medicine to again, observe 24h without hemorrhage.Invalid: after 2 medications, the cervix uteri wound surface is hemorrhage active, uses other method hemostasis instead.
1.2.5 statistical analysis: carry out statistical analysis with SPSS13.0, P<0.05 means to have significant.
2 results.
2.1 the curative effect of two groups of cases relatively: see the following form, cure rate and total effective rate treatment group obviously are better than matched group (P<0.05).
2.2 neoplasm situation: treatment group neoplasm amount is significantly less than matched group (P<0.05).
3. conclusion.
The demonstration of this result of study, the present invention treats cervix uteri postoperative hemorrhage determined curative effect, is worthy of promotion and application.
Claims (2)
1. a pharmaceutical composition for the treatment of the cervix uteri postoperative hemorrhage, it is characterized in that being processed by plurality of Chinese, its composition of raw materials and weight proportion are: 6 ~ 10 parts of Folium Fumicis Dentatis, 8 ~ 15 parts of Cortex Elaeagni Angustifoliaes, 8 ~ 15 parts of Herba Sidae Rhombifoliaes, 6 ~ 10 parts of Herba Ixeritis Sonchifoliaes, 6 ~ 10 parts of the Radix Paeoniae Albas, 8 ~ 15 parts of Fructus Aurantii Immaturuss, 6 ~ 10 parts of Flos Rosae Rugosaes, 8 ~ 15 parts of Pericarpium Citri Reticulataes, 3 ~ 6 parts of Rhizoma Cyperis.
2. a kind of pharmaceutical composition for the treatment of the cervix uteri postoperative hemorrhage according to claim 1, is characterized in that its weight proportion is: 8 parts of Folium Fumicis Dentatis, 10 parts of Cortex Elaeagni Angustifoliaes, 10 parts of Herba Sidae Rhombifoliaes, 8 parts of Herba Ixeritis Sonchifoliaes, 8 parts of the Radix Paeoniae Albas, 10 parts of Fructus Aurantii Immaturuss, 8 parts of Flos Rosae Rugosaes, 10 parts of Pericarpium Citri Reticulataes, 5 parts of Rhizoma Cyperis.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012103984520A CN102885950B (en) | 2012-10-19 | 2012-10-19 | Pharmaceutical composition for treating cervix uteri postoperative bleeding |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012103984520A CN102885950B (en) | 2012-10-19 | 2012-10-19 | Pharmaceutical composition for treating cervix uteri postoperative bleeding |
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| CN102885950A CN102885950A (en) | 2013-01-23 |
| CN102885950B true CN102885950B (en) | 2013-12-04 |
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| CN2012103984520A Expired - Fee Related CN102885950B (en) | 2012-10-19 | 2012-10-19 | Pharmaceutical composition for treating cervix uteri postoperative bleeding |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101254267A (en) * | 2007-11-13 | 2008-09-03 | 蒋坤元 | Medicament for curing organic lesion of cervix inflammation, metrauxe and the like |
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- 2012-10-19 CN CN2012103984520A patent/CN102885950B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101254267A (en) * | 2007-11-13 | 2008-09-03 | 蒋坤元 | Medicament for curing organic lesion of cervix inflammation, metrauxe and the like |
Non-Patent Citations (2)
| Title |
|---|
| 内外结合治疗宫颈糜烂物理疗法后出血经验介绍;郭红艳等;《黑龙江中医药》;19980815(第4期);第33页 * |
| 郭红艳等.内外结合治疗宫颈糜烂物理疗法后出血经验介绍.《黑龙江中医药》.1998,(第4期), |
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