CN102885613A - Biological safety detection method for LED (light-emitting diode) light - Google Patents
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Abstract
The invention discloses a biological safety detection method for LED (light-emitting diode) light, which belongs to the illuminating engineering field, and specifically relates to a safety detection method of a light source, in particular to the safety detection method of an LED light source. In order to better detect the biological safety of the LED light, the invention provides a novel biological safety detection method for the LED light; in the prior art, detecting the extent of the damage on retina is currently mainly used as a method for measuring the biological safety of the LED light. The inventor of the invention provides a new way, introduces a functional magnetic resonance imaging technology and analyzes the cerebral function by the functional magnetic resonance imaging to evaluate the biological safety of the LED light; the detection method is objective and belongs to a noninvasive test method; the change of a BOLD-fMRI (blood oxygenation level dependent-functional magnetic resonance imaging) signal caused by the change of the brain blood flow when the human eye is stimulated by different light sources is changes before the retina change obtained by various inspection methods. Therefore, using the fMRI to evaluate the biological safety of the LED light is feasible.
Description
Technical field
The invention belongs to the illuminating engineering field, be specifically related to the safety detecting method of light source, particularly the biological safety detection method of the safety detecting method of led light source, especially LED light.
Background technology
Along with the approaching and energy-conserving and environment-protective of energy crisis, the raising of low-carbon (LC) consciousness, the world market prospect of New LED (light emitting diodes, light emitting diode) lighting source is more bright.The LED illumination is subject to the great attention of country and local governments at all levels just gradually as the strategic new industry of energy-conserving and environment-protective.Along with the progress and development of technology, the LED Lighting Industry will become green energy conservation industry new growth point, and under market interest trend and laws and regulations stimulation, global LED industry size is the gesture of rapid growth.
Led light source have use that supply voltage is low, efficient energy-saving, applied widely, the characteristics such as stability is strong, response time is short, the life-span is long, pollution-free, will replace the artificial light sources such as electric filament lamp, fluorescent lamp future, become the main lighting source in city.Yet at LED industry rapid growth, the ever-increasing while of application scenario, led light source may bring harm and the impact that biological daily life may bring is become one for retina and more and more be subjected to people's problems of concern.In the light radiation wave band, ultraviolet radiation and blue ray radiation are particularly evident to the harm of human body.LED as a kind of emerging light source because developing rapidly in recent years, the power of chip and external quantum efficiency all improve greatly, the shortwave led chip of ultraviolet and blue wave band is widely used, and the integrated and secondary optical design technical development of multi-chip is so that the hazardness of LED is more remarkable.
The photo bio safety refers to the hazardness of light source light Radiation On Human body, can cause skin carcinoma, cataract etc. such as ultraviolet radiation, and high light can calcination skin, retina etc.In the past, because science and technology is undeveloped, what people were subject to mainly is solar radiation, and since the protective effect of atmosphere, the harm less that light radiation causes.And now scientific and technical develop rapidly, increasing artificial light source is manufactured out, although these artificial light source have improved people's life, they also are exposed to people in the larger light radiation harm.In addition, the in recent years develop rapidly of LED industry, high brightness, high-power LED continue to bring out, and the LED emergent light in past can not be gone for ever to the epoch that human body works the mischief, and people have to begin to pay close attention to the photo bio safety of LED product.Also have laser product also to strengthen the probability that people are subject to light radiation harm in the use of the every field such as optic communication, demonstration, indication.Therefore, make as early as possible people recognize that the importance of photo bio safety is extremely urgent.
Difference according to the measured light type, the test and evaluation of photo bio safety is divided into photo bio security test and the evaluation of coherent source and incoherent light source, to this, illumination committee of country has all published relevant standard with International Electrotechnical Commission, but remains in deficiency in some place.International Non-ionizing radiation protection committee (ICNIRP) provides according to the assessment to bio-physical data and recommends the exposure restriction, and guilding principle and the statement of publishing the photo bio secure context of incoherent light source and laser beam.International Commission on Illumination (CIE) has published CIE S 009/E:2002 standard, and regulation has been made in the photo bio safety of lamp and lamp system.The few publishing standard of CIE, CIE S 009/E:2002 are one of only several standards of CIE publication, and the importance of this standard has some idea of, and IEC all quoted in 2002.CIE S 009/E:2002 causes the spoke limit value that exposes to the sun of the harm such as near ultraviolet harm, the harm of retina blue light photochemistry, the harm of retina aphakia photochemistry, the harm of retina heat and skin heat harm of photochemistry harm, the eyes of skin and eyes to make regulation to light radiation, these spoke limit values that expose to the sun are that the response guilding principle according to ICNIPR obtains.Simultaneously, this standard also provides with reference to test condition, and the photo bio harm that produces from the light radiation of noncoherent broadband light source for assessment and control provides the classifying rules of a safe class.IEC provides the manufacturing industry standard, comprises the standard of processing the reflective optical security problem, and such as the light safety criterion IEC-60825 of laser product, again because IEC and industry relations are tightr, its standard is often promoted more than the standard of its hetero-organizations such as CIE.American-European wait developed country that the requirement of photo bio safety is taken its place in the front ranks of the world especially, nowadays all laser and LED products of selling to Europe all must pass through strict test evaluation according to EN-60825.And the laser product that enters the U.S. will be in strict conformity with the FDA subordinate's of FDA Food and Drug Administration equipment and instrument and the 21CFR1040.10 of radiation health center (CDRH) formulation and 1040.11 requirement.In addition, some state of the U.S. also has the regulations of oneself, such as the laws and regulations on the management (FAC) of Florida.
The international present situation for the LED standard formulation of prospect, the standard that existing IEC and CIE formulate is that various countries work out the standard that own standard is main reference.They mainly are the tests for monomer LED, and project comprises luminous intensity, light distribution and radiant intensity etc., and calculates thus luminous flux.
In Japan, Japan's illumination meeting, Japan illumination committee, Japanese ligthing paraphernalia industry meeting, and the standard of a cover for the method for testing of illumination LED of having implemented be finished and be issued to industrial can jointly the formulation the end of the year in 2004 of Japanese electric ball, the white light LEDs numerical value that employing is crossed by the luminous standard Light source correction is as the standard foundation, measure illumination white light LEDs and module thereof, the light value of mensuration CIE average photometric, full gloss bundle, correlated color temperature, light distribution characteristic etc.And standard be used for some basic parameters in the illumination, as defined the structure of led chip and module, colour temperature, spectrum, the life-span of LED, input current, input voltage, consumption electric energy etc., and confirm that measurement should just can measure behind the light stable output.
North America Illuminating Engineering Society (IESNA) has also finished the method for testing standard of the many kinds of parameters of illumination LED product at present, comprising: optical parameter, electrical quantity and life-span etc.U.S. Energy Star has listed illuminating LED in its approval scope, and has put into effect Related product requirement and method of testing draft the end of the year 2006.
China has put into effect 20 multinomial standards and guidelines for illuminating industry at present, and the formulation of China's standard mainly is with reference to the IEC standard.What issue was implemented at present mainly is: illumination LED product device detection method standard; Three standards of the blank detail specification of power-type LED and led chip standard comprise noun and letter symbol, general specification, sub specification, blank detail specification, method of testing, rated value and characteristic, machinery and environmental suitability and specific product closed specification.But, the LED performance is very complicated, product type is rich and varied, new technique emerges in an endless stream, these standards and norms can not satisfy the needs of illumination LED production development far away, so domestic a lot of mechanism is still carrying out the examination criteria research of illuminating LED, but because strength is disperseed, the test of most of mechanism is lacked experience, so consideration is more unilateral when formulating the method for testing standard, and cause the waste work of many repeatability.
For the research of photo bio safety, developed country especially Europe is in absolute leading position, and China still is in the starting stage to the research of this respect, with the larger gap of international presence., China is world today's manufacturing industry machining center, and accession to WTO, initiatively just must dwindle this gap in order to obtain in international competition.
Summary of the invention
For the biological safety to LED light better detects, the invention provides a kind of novel LED photo bio safety detecting method.Mainly be used as weighing at present the method for LED photo bio safety in the prior art by the detection to the amphiblestroid extent of damage, the inventor of the invention wards off new footpath in addition, introduce Functional magnetic resonance imaging, the analysis of brain function has been used as estimating the method for LED photo bio safety by the function nuclear magnetic resonance, NMR.
Functional mri (functional magnetic resonance imaging, fMRI) is a kind of new imaging technique that develops rapidly on Conventional MRI imaging basis in the recent decade.Theoretically, the mr imaging technique take reflection organ functional status as the imaging purpose all should be referred to as functional mri.FMRI indicates that MR diagnosis studies the systematic study that form and function combines from single morphology.The Functional magnetic resonance imaging that comparatively generally uses at present has perfusion weighted magnetic resonance imaging (PWI), Diffusion weighted MR imaging (DWI), Magnetic Resonance Spectrum and spectroscopic imaging technology (MRS) and blood oxygen level to rely on mr imaging technique (BOLD-fMRI).The functional mri (BOLD-fMRI) that blood oxygen level relies on has been a kind of non-invasive live body Function detection technology with the fastest developing speed in the brain function research field since the nineties in 20th century, has become the important means of research human brain high-grade movable.Its time and spatial resolution all are better than PET, be at present the most effective, use the most general cerebral function imaging technology.The activation situation in correlation function brain district when using BOLD-fMRI imaging technique to observe tested irriate more intuitively.There is no at present and utilize the fMRI technology to carry out research to the safety of LED photo bio.
Functional mri (fMRI) is the unique non-invasive inspection method in the metabolic alterations of body research body.Owing to do not know that still LED is only no harmful at present, in order retina not to be caused organic injury, human eye should not expose under the LED luminous environment for a long time.When human eye is accepted the Different Light stimulation, the variation that the BOLD-MR signal intensity that the variation of brain blood flow causes obtains under other various detection methods prior to retina.Has safely feasibility so utilize fMRI to estimate the LED photo bio.
FMRI estimates the LED photo bio and has safely very large technical difficulty.The inventor inquires into through constantly groping, and has finally determined a kind of method of estimating LED photo bio safety by fMRI.
The first step by setting up luminous environment, is introduced the MR inspection chamber with Different Light, guarantees that all light sources and connecting line all have the magnetic field compatibility, do not affect the MR signals collecting.
When setting up luminous environment, because the particularity of LED spectrum, should consider that LED is as the aspect of light source, consider whether to meet again the aspect of laser safety, to consider the bio-safety effect in addition, only have the three is all taken into account, concerning user, be only safest, being the purpose that we formulate safety criterion, also is the important evidence that we set up luminous environment.Standard about the LED safety has CIE S 009/E:2002 and IEC 60825 in the world.
White light LEDs now mainly obtains by three kinds of modes: the one, and utilize the blue-light LED chip excitated fluorescent powder to penetrate white light; The 2nd, utilize ultraviolet ray excited fluorescent material to penetrate white light; The 3rd, utilize the trichroism chip hybrid of RGB to emit white light.Wherein more commonly utilize the white light LEDs product of blue chip excitated fluorescent powder.The present invention will adopt the luminous method of the trichroism chip hybrid of RGB to set up Lighting Luminous Environment.
The luminous method of the trichroism chip hybrid of RGB is as follows: this method is sent three kinds of primary lights of red, green, blue by electric current by them with three kinds of chip portfolios of red, green, blue of LED together, then is mixed into the visible light of full color.The white light that this method obtains has good color developing, wider reference color temperature, and used material and led chip also can conveniently obtain.This method adds control electric current I C (integrated circuit) chip in three led chips of being everlasting.Can control on the one hand the constant current of each chip of supplying with LED, prevent from because the LED operating current changes the dominant wavelength skew variable color that causes light the colour temperature of white light also being changed.On the other hand, can control the size of current by three RGB led chips, thereby make corresponding the changing of luminous intensity of three chips, realize that three primary colours light mixed proportion changes, and so just can produce the color of multiple conversion thereupon.
Because the contained magnet of nuclear magnetic resonance analyser that we adopt is permanent magnet, so the material that adopts is nonmagnetic substance entirely, must allow light fixture not affect the use of nuclear magnetic resonance analyser.Simultaneously, can not allow high-intensity magnetic field have influence on the switching of light source.For this reason, we solve by following technical solution through research: on the one hand, utilize the visual stimulus equipment of virtue medical treatment company limited, this equipment is by the exploitation of virtue medical treatment company limited, be exclusively used in the irritant test of Magnetic Resonance (MR) Room/ MRI Room, complete equipment is not subjected to the influence of magnetic field of magnetic resonance device.Equipment concentrates on the light of LED in the support bracket fastened illuminator of tested above-head, reflexes to tested eyes again; Then use special wireless remote control device at the switch of Magnetic Resonance (MR) Room/ MRI Room external control lamp brightness.This light fixture includes various light sources, can freely switch as required, thereby the light of ejaculation is changed to some extent, and the outgoing position of light does not have any change.On the other hand, we will adopt Siemens Company is that the special incandescent lamp bulb of Magnetic Resonance (MR) Room/ MRI Room is organized light source in contrast, takes simultaneously DC power supply, reduces light source to the interference of magnetic resonance running.
Second step, the design of LED light stimulus system device.
Described stimulating system is comprised of following four parts: first, visual system: LED light is sent in the magnetic resonance scanner, makes the person under inspection receive visual stimulus.Second portion, synchro system: drive stimulation by the magnetic resonance imaging radiofrequency signal and present.Third part, stimulation task/post processing of image work station: control stimulates output and the time thereof of picture or sound; Process the image that magnetic resonance gathers when brain region activates, to produce brain active region image and to merge with anatomic image.The 4th part, software section: (1) system controlling software: can be implemented in hardware system in the direct remote control screened room of operating room by remote control software.(2) stimulate control software (E-prime): the output of control thorn laser rays and the task design of time thereof.(3) brain function image the poster processing soft (SPM8): the view data that the processing capacity magnetic resonance experiments gathers, with produce brain activation map and with dissect visual fusion.
The 3rd step, select the tester, select suitable sources, and utilize the BOLD sequence scanning to obtain the MRI figure of brain.
The light source of selecting is as follows: (1) blank: dark surrounds; (2) standard light source: tungsten lamp, illumination 400 lumens; (3) experimental light sources (new type light source): various spectrum segment LED lamps, comprise the white led lamps of LED excitated fluorescent powder, illumination is consistent with traditional tengsten lamp to be 400 lumens.
Utilize the BOLD sequence scanning to obtain the MRI figure of brain under the following condition: when 1. dark surrounds and tungsten lamp luminous environment switch repeatedly; When 2. dark surrounds and LED light environment switch repeatedly; When 3. tungsten lamp luminous environment and LED light environment switch repeatedly.
The 4th step, data collection: adopt magnetic resonance device Siemens 3.0-Tesla to finish fMRI scanning, to carrying out the T2WI scan row except intracranial lesion behind each experimenter elder generation Scan orientation picture, the 3D-T1WI that goes again scans internal anatomy, and the EPI-BOLD signals collecting is used for obtaining the BOLD-fMRI signal.
In the 5th step, date processing: following 4 steps are used for carrying out the fMRI date processing: 1) experimenter's dynamic(al) correction; 2) time adjustment; 3) fusion of Brain mapping picture and structural images; 4) the structure data that merge and the normal distribution analysis of MINI standard brain; More than 4 steps adopt SPM software to finish.
In the 6th step, data analysis and mathematical modeling: fMRI analyzes brain is divided into 18 layers, and every layer thickness is 7.6 millimeters.Every layer of matrix by 64 * 64 sub-boxes consists of, and therefore defining full brain has 64 * 64 * 18=73728 sub-box to consist of.Set up mathematical model, the Brain MRI image segmentation is become 73728 voxels and obtain the signal value of each voxel, digitized then calculates the mean of each voxel signal value of brain.
For main cerebral lobe, nerve nucleus selective analysis that brain controls the emotion and remembers, the signal intensity of paying close attention to limbic system (comprising corpus amygdaloideum, hypothalamus, Hippocampus, parahippocampal gyrus etc.), Brain Stem Nuclei (rubrum, black substance) and frontal lobe carries out independent analysis.The voxel signaling point of this key area is 824.
According to the data that the detection of the 3rd step obtains, the front and back rate of change was calculated in each voxel signal value variation before and after the calculating light source switched.The present invention is defined as follows rate of change: (1) is if the voxel signal value before the voxel signal value before stimulating greater than post-stimulatory voxel signal value, stimulates/post-stimulatory voxel signal value=rate of change; (2) if stimulate front voxel signal value less than post-stimulatory voxel signal value, the voxel signal=rate of change before post-stimulatory voxel signal value/stimulation.
Analyzing the rate of change of each brain district under 400 lumen tengsten lamp conditions is reference value, and the change rate signal under other luminous environments and the reference value of tengsten lamp compare.
The present invention is set as following grade with rate of change:
I level:＜25%
II level: 25%～50%
III level: 50%～75%
IV level: 75%～100%
The V level:〉100%.
Full brain signal (73728 voxel summations) averages with the changing ratio of key area signal (824 voxel summations), the present invention's definition: full brain signal ratio+key area signal ratio/2=LED photo bio secure threshold ratio.Calculate the LED photo bio secure threshold ratio that obtains according to above-mentioned formula, corresponding following judge:
The I level:＜25%, think safety
The II level: 25%～50%, think comparatively safe
The III level: 50%～75%, thinking has security risk
The IV level: 75%～100%, thinking has larger security risk
The V level:〉100%, think and will carry out the system safety hazards assessment.
Because the safety of LED light is unpredictable, so the rate of change between the brain signal should be controlled within the specific limits under the brain signal under the LED luminous environment and the conventional tungsten mercerising source lighting environment.If the new type light source change rate signal surpasses traditional tungsten filament 50% rank of throwing light on, no matter useful unhelpful, all may there be potential safety hazard to the mankind.If the BOLD-fMRI signal of brain certain or several nuclear group produces constant variation at the special spectrum spectral coverage, if larger greater than 75% meaning, should be as the objective basis of LED bio-safety.
Different Light front and back change rate signal is accepted in calculating, is weighted according to 73728 tissue points; Because the rate of change of each tissue points is necessarily more than or equal to 1, therefore, if the experimenter is not subjected to any stimulation, the weighting rate of change should be more than or equal to 73728.
Noinvasive electroencephalogram (128 passage) obtains experimenter's brain wave frequency scattergram under the different luminous environments, frequency and amplitude digitized with the brain electricity that respectively leads, and calculating rate of change, the result does correlation analysis with magnetic resonance examination, concrete grammar is: gather the standard EEG signal of 128 road electroencephalograms under the irradiation of 400 lumen tengsten lamps, frequency acquisition is (0-2000Hz); Signal is carried out Fourier transform, calculate the amplitude of the distribution of main frequency.The rate of change of analyzing according to fMRI carries out correlation analysis greater than 100% brain district, extracts digital information, in conjunction with the experimental result of BOLD-fMRI, provides auxiliary bio-safety data.
It is significant that the present invention says that creatively the MRS technology is introduced LED photo bio safety detection.The present invention compared with prior art has following outstanding advantage:
The activation situation in correlation function brain district when (1) using BOLD-fMRI imaging technique to observe tested irriate more intuitively there is no at present and utilizes the fMRI technology to carry out research to the safety of LED photo bio, and the present invention has started this beginning;
(2) functional mri (fMRI) is the unique non-invasive inspection method in the metabolic alterations of body research body.Owing to do not know that still LED is only no harmful at present, in order retina not to be caused organic injury, human eye should not expose under the LED luminous environment for a long time.When human eye is accepted the Different Light stimulation, the variation that the BOLD-MR signal intensity that the variation of brain blood flow causes obtains under other various detection methods prior to retina.Has safely feasibility so utilize fMRI to estimate the LED photo bio;
(3) the present invention designs by the collaboration software of LED photostimulation and fMRI, and the light field that contacts in people's daily life is rendered to experimenter's retina, can guarantee again light source and nuclear magnetic resonance equipment non-interference, has obtained unforeseeable technique effect;
(4) functional mri (fMRI) technology is incorporated in the LED photo bio safety detection, by analyzing the dependency between subjects's correlation function brain district's biochemical metabolism and the stimulation, can inquire into physiological Foundations between tested and the institute's irriate from metaboilic level, this Research Thinking is showed ingenuity.
The specific embodiment
Below further describe the present invention by specific embodiment, but the present invention is not limited only to following examples.Those skilled in the art can use for reference this paper content, suitably improve or adjust step method of the present invention and can realize.Special needs to be pointed out is that all are similarly replaced and change, to those skilled in the art, is apparent, and they all are deemed to be included in the scope of the invention.
1 one kinds of LED photo bio of embodiment safety detecting method
One, early-stage preparations: prepare light source, support, computer and related software.
Light source
In a hemispheric lampshade assembly, the lampshade radius is 18 centimetres with three red, green, blue chips and an IC chip package for we.The operating current size of three chips of IC chip controls, three kinds of primary colours light intensity size of current change, and make the thereupon conversion of mixed light color of sending.The chip of light source can be replaced, thereby changes the parameter of LED lamp.The lampshade material is the aluminum of namagnetic substance, the transformator of LED is connected with lamp with electric wire, and the electric wire between transformator and the lamp surpasses 5 meters, thereby makes transformator can be positioned over outside the Magnetic Resonance (MR) Room/ MRI Room, prevent that transformator from being attracted by magnetic resonance magnetic field, avoid simultaneously transformator to affect the internal magnetic field of Magnetic Resonance (MR) Room/ MRI Room.
Electric filament lamp as the blank group links to each other with the unidirectional current current transformer, and electric filament lamp and LED lampshade are connected on the lamp bracket jointly.Electric wire between unidirectional current current transformer and the electric filament lamp surpasses 15 meters, thereby current transformer is placed outside the Magnetic Resonance (MR) Room/ MRI Room.
Lamp bracket
The lamp bracket material is plastics, forms (pillar that tetragon pedestal and long sticking plaster are made, and light fixture adheres to case, support part) by four parts.Material is plastics (support part that has is timber) entirely, and lamp box is surrounded by five plastic plate, has two holes not of uniform size on the anterior plastic plate, and the rear portion is without plate.Long sticking plaster passes from the lamp box middle part, and an end links to each other with pedestal, has aperture on the long sticking plaster.Support part is cross, and two support parts insert the sticking plaster aperture of lamp box upper and lower surface plastic plate below, support and adhere to case.
In order to simulate daily lighting condition, and then set up imitating luminous environment, the RGB component proportion can be changed the chip change of being correlated with as required in the light source of our design, thereby obtains according to demand optimum light distribution scheme.We adopt blue light (450-470nm), green glow (495-540nm), gold-tinted (570-585), HONGGUANG (620-680nm) combination through overtesting, can obtain higher color rendering index like this.
Software section
(1) system controlling software: can be implemented in hardware system in the direct remote control screened room of operating room by remote control software; (2) stimulate control software (E-prime): the output of control thorn laser rays and the task design of time thereof; (3) brain function image the poster processing soft (SPM8): the view data that the processing capacity magnetic resonance experiments gathers, with produce brain activation map and with dissect visual fusion.
Two, light source is combined with magnetic resonance
Bring light source into Magnetic Resonance (MR) Room/ MRI Room, be installed on the support, regulate height, make light source center parallel with magnetic resonance hatch center.
The coupling of luminous environment and nuclear magnetic resonance, NMR
Because the contained magnet of nuclear magnetic resonance analyser that we adopt is permanent magnet, so the material that adopts is nonmagnetic substance entirely, must allow light fixture not affect the use of nuclear magnetic resonance analyser.Simultaneously, can not allow high-intensity magnetic field have influence on the switching of light source.How the light field that contacts in people's daily life can be rendered to experimenter's retina, can guarantee again light source and nuclear magnetic resonance equipment non-interference, be a problem that challenge is arranged very much.
Our technical scheme is: utilize on the one hand the visual stimulus equipment of our stand-alone development, this equipment can be exclusively used in the irritant test of Magnetic Resonance (MR) Room/ MRI Room, and complete equipment is not subjected to the influence of magnetic field of magnetic resonance device.Equipment concentrates on the light of LED in the support bracket fastened illuminator of tested above-head, reflexes to tested eyes again; Then use special wireless remote control device at the switch of Magnetic Resonance (MR) Room/ MRI Room external control lamp brightness.This light fixture includes various light sources, can freely switch as required, thereby the light of ejaculation is changed to some extent, and the outgoing position of light does not have any change.On the other hand, we will adopt Siemens Company is that the special incandescent lamp bulb with DC powered of Magnetic Resonance (MR) Room/ MRI Room is organized light source in contrast, takes simultaneously DC power supply, reduces light source to the interference of magnetic resonance running.
Three, use system controlling software, light source switch is connected with wireless device.
Four,
Detect subjects's cerebral activity situation and brain wave situation.
Allow the subjects lie in the magnetic resonance device, utilizing stimulates control software, blas sequence according to design, light source is automaticallyed switch according to the order of the aobvious LED white light (15 minutes) of electric filament lamp (15 minutes)-height-low aobvious LED white light (15 minutes), allow simultaneously magnetic resonance device test subjects's cerebral activity situation, utilize simultaneously the subsidiary brain electric tester test subjects's of magnetic resonance device brain wave situation.
Stimulating system is comprised of following four parts: first, visual system: LED light is sent in the magnetic resonance scanner, makes the person under inspection receive visual stimulus.Second portion, synchro system: drive stimulation by the magnetic resonance imaging radiofrequency signal and present.Third part, stimulation task/post processing of image work station: control stimulates output and the time thereof of picture or sound; Process the image that magnetic resonance gathers when brain region activates, to produce brain active region image and to merge with anatomic image.The 4th part, software section: (1) system controlling software: can be implemented in hardware system in the direct remote control screened room of operating room by remote control software; (2) stimulate control software (E-prime): the output of control thorn laser rays and the task design of time thereof.(3) brain function image the poster processing soft (SPM8): the view data that the processing capacity magnetic resonance experiments gathers, with produce brain activation map and with dissect visual fusion.
Dissecting the location scans as scanner uni function picture
FMRI scanning is finished by Siemens 3.0-Tesla magnetic resonance device, and to carrying out the T2WI scan row except intracranial lesion behind each experimenter elder generation Scan orientation picture, the 3D-T1WI that goes again scans internal anatomy, and the EPI-BOLD signals collecting is used for obtaining the BOLD-fMRI signal.
Adopt echo-planar imaging (Echo Planar Imaging, EPI) technology, EPI can keep obtaining covering under the high-resolution prerequisite image of full brain during as a kind of multilayer imaging technology.T2WI parameter: repetition time (TR)=3000ms; Response time (1E)=50 ms, angle of revolution (FA)=90; The NEX=I visual field (FOV)=24cm * 24cm that effectively photographs; Matrix 64cm * 64cm; The number of plies=22; Bed thickness=5ram; Interlamellar spacing=lmm.All be 390s sweep time, obtains altogether original image 130 width of cloth, and wherein front 12s data abandon, and purpose is to make magnetic field reach even.
The coupling of electroencephalogram and nuclear magnetic resonance, NMR
" EasyCap " electrode cap that tested head-mount can use in high field intensity MRI chamber (the 10-20 system adds that FCl, FC2, CPl, CP2, FC5, FC6, CP5, CP6, TP9, IPl0 lead), reference electrode is arranged between Fz and the Cz, ring electrode is made by the Ag/AgCl material, the impedance of each electrode is 5 kft, the scalp impedance is lower than 10kll, in addition at the vertical eye electricity of left side eye socket lower edge electrodes record, at the parasternal electrodes record electrocardio of left chest; (sample rate is that 5000Hz, time constant are 10s to the amplifier of collection EEG signals, resolution is 16, dynamic range 16.38 mV) be placed on the head end of MRI examinating couch, by fiber optic cables, synchronously the data that collect be delivered to the notebook computer outside the MRI scanning room.Use Brain-Vision Analyser 1.05 editions that the EEG data are carried out off-line analysis, the method of using average artefact to subtract each other, remove because equal electromagnetism artefacts of producing of even gradient magnetic, use removal eye electricity and the steps such as electrocardio artefact, digital filtering and baseline correction that the EEG data are processed and analyzed, record the time that epilepsy wave produces, and it is converted into the time point of fMRI scanning.
Five, show based on the diversity after the extensive matrix calculus statistics examination LED photostimulation
The functional image the poster processing soft of requiring mental skill is processed image, and the applied mathematics formula is combined different LED lamps with the cerebral activity situation.And be the quality of benchmark evaluation different LED lamp according to the data of electric filament lamp.
Nuclear magnetic resonance data is processed
View data transforms form by SPM8 software, then carry out setting up model and doing estimation after the space pretreatment such as image alignment, a moving rectification, standardization and Gaussian smoothing, then adopt t check to do statistical analysis, activate range threshold and be set as 10 pixels (P＜O.01).And check the anatomical position that activates the brain district by REST software.And with activation level and the threshold value of SPM8 software analysis related brain areas.In addition, the time point of the generation photostimulation that provides according to the EEG time graph that input namely stimulates as signal, carry out the ideal response curve that convolutional calculation obtains stimulating with the hemodynamics equation, last computing function is as the response relation of data volume and this time graph.
The statistical analysis of data
Do statistical analysis with SPSS software, activation level intensity and the threshold value in correlation function brain district compared analysis.And further adopt repeated measure variance statistical analysis: the activation level in brain district, LED light intensity, electroencephalogram.Make different photostimulation to the mathematical model of the activation level of related brain areas, for the foundation of touchstone provides scientific basis.
By in this platform visual stimulus equipment, use this platform except can detecting the photo bio safety of LED, level of comfort, the safety that can also show for detection of 3D, the safety criterion that shows for 3D is formulated objective cerebral irritation data is provided.
Claims (3)
1. a LED photo bio safety detecting method is characterized in that, it is used as estimating the safety of LED photo bio by functional mri to the analysis of brain function.
2. a kind of LED photo bio safety detecting method as claimed in claim 1 is characterized in that it comprises following steps:
The first step by setting up luminous environment, is introduced the MR inspection chamber with Different Light, guarantees that all light sources and connecting line all have the magnetic field compatibility, do not affect the MR signals collecting;
Second step, the design of LED light stimulus system device
Stimulating system is comprised of following four parts:
(1) visual system: LED light is sent in the magnetic resonance scanner, makes the person under inspection receive visual stimulus; (2) synchro system: drive stimulation by the magnetic resonance imaging radiofrequency signal and present; (3) stimulation task/post processing of image work station: control stimulates output and the time thereof of picture or sound, processes the image that magnetic resonance gathers when brain region activates, to produce brain active region image and to merge with anatomic image;
(4) software section: 1. system controlling software: can be implemented in hardware system in the direct remote control screened room of operating room by remote control software;
2. stimulate control software: the output of control thorn laser rays and the task design of time thereof; 3. brain function image the poster processing soft: the view data that the processing capacity magnetic resonance experiments gathers, with produce brain activation map and with dissect visual fusion;
The 3rd step, select the tester, select suitable sources, and utilize the BOLD sequence scanning to obtain the MRI figure of brain,
The light source of selecting is as follows:
Blank: dark surrounds;
Standard light source: tungsten lamp, illumination 400 lumens;
Experimental light sources (new type light source): various spectrum segment LED lamps, comprise the white led lamps of LED excitated fluorescent powder, illumination is consistent with traditional tengsten lamp to be 400 lumens;
Utilize the BOLD sequence scanning to obtain the MRI figure of brain under the following condition:
When 1. dark surrounds and tungsten lamp luminous environment switch repeatedly;
When 2. dark surrounds and LED light environment switch repeatedly;
When 3. tungsten lamp luminous environment and LED light environment switch repeatedly;
The 4th step, data collection:
FMRI scanning is finished by Siemens 3.0-Tesla magnetic resonance device, and to carrying out the T2WI scan row except intracranial lesion behind each experimenter elder generation Scan orientation picture, the 3D-T1WI that goes again scans internal anatomy, and the EPI-BOLD signals collecting is used for obtaining the BOLD-fMRI signal;
In the 5th step, date processing: following 4 steps are used for carrying out the fMRI date processing:
(1) experimenter's dynamic(al) correction,
(2) time adjustment,
(3) fusion of Brain mapping picture and structural images,
(4) the structure data that merge and the normal distribution analysis of MINI standard brain,
More than 4 steps adopt SPM software to finish;
The 6th step, data analysis and mathematical modeling:
FMRI analyzes brain is divided into 18 layers, every layer thickness is 7.6 millimeters, every layer of matrix by 64 * 64 sub-boxes consists of, therefore defining full brain has 64 * 64 * 18=73728 sub-box to consist of, set up mathematical model, the Brain MRI image segmentation become 73728 voxels and obtain the signal value of each voxel, digitized then calculates the mean of each voxel signal value of brain;
Detect the data of acquisition according to the 3rd step, calculate light source and switch each voxel signal value variation of front and back, rate of change before and after calculating, the present invention is defined as follows rate of change: (1) is if the voxel signal value before the voxel signal value before stimulating greater than post-stimulatory voxel signal value, stimulates/post-stimulatory voxel signal value=rate of change; (2) if stimulate front voxel signal value less than post-stimulatory voxel signal value, the voxel signal=rate of change before post-stimulatory voxel signal value/stimulation;
Analyzing the rate of change of each brain district under 400 lumen tengsten lamp conditions is reference value, and the change rate signal under other luminous environments and the reference value of tengsten lamp compare;
The changing ratio of full brain signal and key area signal averages, the present invention's definition: full brain signal ratio+key area signal ratio/2=LED photo bio secure threshold ratio, and the present invention is set as following grade with rate of change:
The I level:＜25%, think safety
The II level: 25%～50%, think comparatively safe
The III level: 50%～75%, thinking has security risk
The IV level: 75%～100%, thinking has larger security risk
The V level:〉100%, think and will carry out the system safety hazards assessment.
3. a kind of LED photo bio safety detecting method as claimed in claim 2, it is characterized in that, the luminous environment of the described first step adopts the luminous method of the trichroism chip hybrid of RGB to set up, the luminous method of the trichroism chip hybrid of RGB is as follows: this method adds control electric current I C (integrated circuit) chip with three kinds of chip portfolios of red, green, blue of LED together, send three kinds of primary lights of red, green, blue by electric current by them, then be mixed into the visible light of full color.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103307559A (en) * | 2013-05-24 | 2013-09-18 | 中国人民解放军空军航空医学研究所 | Design method for light source subsystem of light environment simulation device |
| CN106959133A (en) * | 2017-03-23 | 2017-07-18 | 贵州省机械电子产品质量监督检验院 | A kind of LED illumination product photo-biological safety detection system |
| CN107340708A (en) * | 2016-04-28 | 2017-11-10 | Lg电子株式会社 | Watch style terminal and its control method |
| CN113670455A (en) * | 2020-05-13 | 2021-11-19 | 周卓煇 | Simple measuring device and method for permissible exposure time of retina |
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- 2011-07-19 CN CN 201110202324 patent/CN102885613A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103307559A (en) * | 2013-05-24 | 2013-09-18 | 中国人民解放军空军航空医学研究所 | Design method for light source subsystem of light environment simulation device |
| CN103307559B (en) * | 2013-05-24 | 2015-04-29 | 中国人民解放军空军航空医学研究所 | Design method for light source subsystem of light environment simulation device |
| CN107340708A (en) * | 2016-04-28 | 2017-11-10 | Lg电子株式会社 | Watch style terminal and its control method |
| US10732574B2 (en) | 2016-04-28 | 2020-08-04 | Lg Electronics Inc. | Watch type terminal and method for controlling the same |
| CN106959133A (en) * | 2017-03-23 | 2017-07-18 | 贵州省机械电子产品质量监督检验院 | A kind of LED illumination product photo-biological safety detection system |
| CN106959133B (en) * | 2017-03-23 | 2020-05-12 | 贵州省机械电子产品质量监督检验院 | Light biological safety detection system for LED lighting product |
| CN113670455A (en) * | 2020-05-13 | 2021-11-19 | 周卓煇 | Simple measuring device and method for permissible exposure time of retina |
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