CN105748149B - A kind of equipment for cancer operation fluorescence navigation and residual cancer tracer and removing - Google Patents
A kind of equipment for cancer operation fluorescence navigation and residual cancer tracer and removing Download PDFInfo
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- CN105748149B CN105748149B CN201610249900.9A CN201610249900A CN105748149B CN 105748149 B CN105748149 B CN 105748149B CN 201610249900 A CN201610249900 A CN 201610249900A CN 105748149 B CN105748149 B CN 105748149B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/06—Devices, other than using radiation, for detecting or locating foreign bodies ; determining position of probes within or on the body of the patient
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N5/0603—Apparatus for use inside the body for treatment of body cavities
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
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Abstract
The present invention proposes that a kind of equipment for the navigation of cancer operation fluorescence and residual cancer tracer and removing is by being composed with cyclelog, fluorescence-reflected light image processor, image display, image illumination with the host and the devices such as image illumination and collector, optical dynamic therapy illuminator for treating the components such as mains lighting supply.Surgical navigational can be carried out after the targeted nano photosensitizer of patient injection suitable dosage, residual cancer tracer in art implements precisely treatment for cancer patient and provides crucial information.Also the cancer remnants in the occult Primary Cancer and blood on periphery can be detected in art, and carries out selectively killing tumor cell, not damage or damage substantially lesser optical dynamic therapy to health tissues, eradicate remaining cancerous swelling.To reach cancer operation treatment after without big Radiotherapy chemotherapy is injured to human health come prevent canceration recur and transfer, quality of life of the survival rate and cancer patient that improve cancer patient of going a long way greatly during rehabilitation.
Description
Technical field:
The invention belongs to Medical Instruments technical field, be related to it is a kind of for the navigation of cancer operation fluorescence and residual cancer tracer with clearly
The equipment removed
Technical background:
Talk cancer discoloration describe this become the cancer of the first killer of the mankind it is so rampant to can not fear degree a bit
It draws it mild.The newest world statistics data that the World Health Organization collects show that the whole world increases 14,000,000 cases of cancer, report newly every year
Road claims, and 22% is Chinese in present whole world cancer patient, and it is 3,070,000 people that Cancer in China, which increases patient newly,.Prediction number after 20 years
According to more bad, global cancer patient will increase by 70%, imply that the epoch of " tumour is suddenly in tiger " arrive.
China has also spent nearly hundred billion expense for treatment of cancer every year, but still is that effect is little.Most patient's meetings
It is half dead under the torment of the serious illness, it is less than 30% according to medical statistics cancer patient existence in 5 years.
Be in the presence of this it is miserable be the wherein cancer because caused by lacking its effective treatment means in cancer treatment
Operative treatment is difficult to find remaining cancer, and more difficult removing enters sanguimotor cancer cell, so as to cause cancer return and
Transfer；Big to the injury of body using Radiotherapy chemotherapy treatment, immune system defence capability is greatly reduced or even thoroughly collapses, a bit
Small infection or complication are just enough to make cancer patient fatal, and caused by waiting factors, excessive injury in the treatment is more aobvious
Treatment method now is how to be pale and weak out.
The present invention propose it is a kind of for the equipment of the navigation of cancer operation fluorescence and residual cancer tracer and removing can during surgery into
It goes and navigates, residual cancer detection in art can also be to the cancer in the occult Primary Cancer and blood for performing the operation periphery while improving and performing the operation precision
Remnants carry out optical dynamic therapy, thus reach cancer operation treatment after without Radiotherapy chemotherapy come prevent canceration recur and transfer
Purpose, be likely to become that a kind for the treatment of of cancer is most safe and effective method, it is advantageous to improve quality of life in cancer patients and existence
Rate.
Summary of the invention:
It is a kind of for the navigation of cancer operation fluorescence and residual cancer tracer the purpose of the present invention is being to provide in cancer operation
It is navigated with the equipment of removing with solving current cancer operation scene shortage, residual cancer detection discovery in time and removing equipment and skill in art
The problem of art, this kind of equipment for be grown in the important device of human body it is dirty on cancer treatment and Postoperative recurrent rate it is high, poor prognosis it is swollen
Tumor perform the operation (such as brain glioma) especially need because this kind of equipment fluorescence navigation can indicate that naked eyes be difficult to differentiate between it is more smart
True lesion boundary range improves the correctness of Operative Range, in addition residual cancer detection and removing in art, can use up big reservation
Under the premise of the dirty function of patient's device, more accurate all to cut pathological tissues, change is not navigated in the past, and residual cancer tracer is set with removing
For that can not know cancerous issue, whether there are also the presence of residual cancer, and cause Postoperative determination poor, are easy the miserable office of relapse and metastasis
The appearance in face.
It is of the invention a kind of for the navigation of cancer operation fluorescence and residual cancer tracer and removing to achieve the above object
Equipment is by host (1), image illumination and collector (2), and the big device of optical dynamic therapy illuminator (3) etc. three is formed.Image
Illumination is shelved on the bracket of host (1) with collector (2) by handle (15), optical dynamic therapy illuminator (3) installation up-regulation
It can be fixed on the lifting stick of host (1) after section bracket (16).Wherein: host (1) has cyclelog (4) fluorescence-reflected light
The components such as image processor (5), image display (6), image illumination and treatment mains lighting supply (7)；Image illumination and collector
(2) there is the colored CCD camera (8) with camera lens at front end center, periphery covers the LED Luminous Ring (9) illuminated for two kinds,
And the components such as illumination-acquisition control module (10)；Have in dynamic therapy luminaire (3) and is integrated by multiple feux rouges high-brightness LEDs
There is the integrating by certain regular array arrangement of two uniformities for being used to improve red light irradiation in piece (11), the integration slice front end that shines
There are the portions such as fan (13) and the light treatment control module (14) of air blast cooling in micro lens array (12), the integration slice rear end that shines
Part.
It between the big device of equipment three of the invention is worked with following connection type, the program control in host (1)
Device (4) processed issues control signal and reaches image illumination and the control module (10) in collector by signal wire A, and LED is made to shine
Ring (9) carries out double light and alternately illuminates, and is radiated on the tumor focus for the navigation that need to perform an operation, in image illumination and collector (2)
The colored CCD camera (8) with camera lens can collect the images of two kinds of different light sources illuminations, pass through transmission line B and be sent into master
Fluorescence-reflected light image processor (5) in machine (1), fluorescence-reflected light image processor (5) are sent in reception by signal wire C
Program actuator (4) synchronization signal after examination classification is carried out to the image of two kinds of different light sources illuminations, and respectively in fluorescence-
Reflected light image processor (5) is handled, and benign tumors can be distinguished by generating expression tumor focus form true color image and expression
Property with pernicious fluorescence pseudo color image, and set after two images show size and locations and be transmitted to by signal wire D
Image display (6) is shown.Image illumination on host and treatment mains lighting supply (7) respectively by bis- lines of F, G to
The light treatment control module (14) of the illumination-acquisition control module (10) and optical dynamic therapy illuminator of image illumination and collector
It is powered.Equipment of the invention is navigated by fluorescence and provides foundation for precisely operation, and residual cancer can also be further detected in art
Carry out tracer and removing.When carrying out residual cancer tracer and removing, use can generate photochemistry to tumor tissues during surgery first
The photosensitizer of reaction makes have more photosensitizer to enter in tumour cell by receptor targeted mediation, due to neoformation tissue pair
The intake of photosensitizer advantage, and the long period is detained in it, the ratio between tumour/normal tissue concentration of photosensitizer is 10-30 times reachable, this
Sample is just significantly enhanced the fluorescent emission ability for the tumour for taking in photosensitizer, is not easily susceptible to the interference of tissue autofluorescence, mentions
The high accuracy of cancer operation navigation and residual cancer tracer and elimination.This equipment enters tumour cell using photosensitizer before surgery
After interior, tumor focus is detected with image illumination and collector (2), is observed by image display (6) screen picture, into
Row surgical navigational and the latent infiltrating carcinoma for finding the remaining fragment of cancer and falling off on cancerous swelling in blood and peripheral lymphoid
After change, light needed for optical dynamic therapy then is set in the cyclelog (4) of host (1) according to the information that remaining cancer detects
According to power and light application time, the light treatment control module (14) of optical dynamic therapy illuminator is issued instructions to by signal wire E, is risen
Dynamic optical dynamic therapy is irradiated treatment to residual cancer position.
The overall structure of image illumination and collector (2) can design for multiple types such as bell, straight barrel types, and handle can give birth to
Side by, can also give birth at top.The colored CCD with camera lens is placed at image illumination and the front end center of collector (2) to image
Head (8), the camera lens equipped before colored CCD camera are selected according to work purposes, and normal usage uses automatic focus-adjusting lens
Or with manual focusing, tight shot, very-short-reach work fish eye lens or uses telecentric mirror at long range work telephoto lens
Head.
Image illumination and collector (2) have the LED illuminated for two kinds in the surrounding of the colored CCD camera with camera lens
Luminous Ring (9), LED Luminous Ring (9) are distributed on a ring of light or multiple rings of light by two kinds of different LED light tube, and two kinds are not
Same LED is alternate placement on each ring of light, symmetrically arranges, is a kind of LED of types of illumination, side
It must be the LED of another types of illumination, there is the LED light ring of like this arranged distribution to be just able to satisfy two kinds of different LED illuminations
Approximation and uniformity.
Illumination-acquisition control module (10) in image illumination and collector (2) is placed on image illumination and collector (2)
Rear end, receive from cyclelog (4) instruction, hand over LED Luminous Ring (9) to the tumor focus of tumor operation
For switching illumination；Illumination-acquisition control module (10) can also according to collect tumor image brightness height to LED Luminous Ring
(9) luminous intensity of two kinds of illumination LEDs in carries out real-time control, to make the defeated of the colored CCD camera (8) with camera lens
Image is in the moderate optimum state of brightness always out, and it is excessively and remote to be unlikely to the image exposure when closely detect
The occurrence of image illumination is insufficient when detection.
Fluorescence-reflected light image processor (5) be a kind of collection traditional optical imaging technique and unconventional fluorescence ratio at
The a variety of dedicated processors of image being integrated as technology.By having " image reading, image distribution, analog-to-digital conversion (A/D), AOI
The image intelligent acquisition module and sequence controller of acceleration ", dsp processor, region Chooser, nonlinear detector, pixel point
The processing modules such as analysis processor, edge and line recognition processor, image gateway are constituted.It can be image illumination and collector
(2) image of transmit two kinds different LED illuminations is screened and is handled, to using adumbration intensification data side in reflected light image
Method carrys out reconstructed picture, improves lesion morphological image expression effect, uses fluorescent image according to benign tumors, pernicious criterion
It carries out pseudo-colours weighting and carrys out reconstructed picture, lesion canceration magnitude range outstanding behaviours is come out, the advantageous knowledge for improving cancer diagnosis
Other ability.
The weighting of fluorescent image pseudo-colours is that the pixel of normal tissue image is used in fluorescence-reflected light image processor (5)
Certain color, such as green indicate, and the color of the pixel of cancerous issue image can carry out any setting, can use single kind of face
Color table shows canceration pixel, it is also possible to which multiple color goes to respectively indicate the pixel of different canceration degree in cancerous tissue.
Fluorescence-reflected light image processor (5) can make diversified marshalling setting to the display format of two images, it
It can be set to the display arranged in parallel of two images or two image longitudinal arrangements shown, it is small that an image can also be carried out
And another image is big is shown, the display position of two images can also be interchangeable.
Image display (6) is the reflected light reconstructed picture for transporting out fluorescence-reflected light image processor (5) and glimmering
Light pseudo-colours reconstructed picture is displayed on the screen by the format of its setting.
Image illumination and treatment mains lighting supply (7) are the pressure stabilizing of one kind of multiple purposes, constant-current supply.Image illumination and treatment
When mains lighting supply (7) is image illumination and collector (2) and optical dynamic therapy illuminator (3) power supply, in addition to LED illumination to be had
Outside the power supply of the constant current of different size high stable, also high stable is provided not for its respective control module and its peripheral equipment
The regulated power supply of same specification.
Optical dynamic therapy illuminator (3) can export the residual cancerous tissue of strong red light irradiation, make the photosensitizer of tissue resorption by
Excitation, and the photosensitizer of excitation state energy transmission to the oxygen of surrounding, generate highly active singlet oxygen, singlet oxygen and adjacent
Large biological molecule oxidation reaction occurs, generate cytotoxic effect, and then lead to cell damage or even death.Optical dynamic therapy
Feux rouges used in illuminator (3), wavelength are 630nm ± 30nm, irradiation power density≤100mW/CM2, it is by several numbers
The red LED of the high brightness of amount is attached on the aluminium sheet for being easy heat dissipation, weaves into LED integration slice (11)；The quantity and feux rouges of red LED
The irradiated area of output is related with power density.Integral micro-lens array (12) are placed to change in LED integration slice (11) output front
The luminous uniformity of the aluminium sheet of the LED of kind point of column arrangement；LED patch (11) is followed by the fan (13) and light treatment of air blast cooling
Control module (14), light treatment control module (14) are that receive the instruction of the cyclelog (4) on host dynamic to light
Power treatment illuminator (3) carries out treatment irradiation control.
Feux rouges used in optical dynamic therapy illuminator (3), can be used laser and is replaced.
It is to be fixed on host energy lift adjustment stick after optical dynamic therapy illuminator (3) installation and adjustment bracket (16), makes light
Dynamic therapy illuminator (3) can carry out freely adjusting for orientation angle around host lifting stick；Optical dynamic therapy illuminator (3) is also
The opposite adjustment of distance and position can be carried out, to meet to any site residues tumour of patient by the flexible of adjusting bracket
The needs for the treatment of.
Cyclelog (4) is the command centre that present device carries out various operations, and function is can to pass through parameter
Setting issues to image illumination and collector (2) and fluorescence-reflected light image processor (5) instruct simultaneously, carries out two kinds of differences
The LED type of type carries out alternately illumination, and alternately the switching frequency of illumination can need to carry out according to the display of image display (6)
Setting, cyclelog (4) can also be provided and remove in treatment to residual tumor according to the residual tumor situation that equipment detects
Using irradiation power, irradiation time etc., and instruction is issued to optical dynamic therapy illuminator (3), residual tumor progress light power is controlled
It treats.
The host (1) and image illumination of apparatus as discussed above and collector (2), optical dynamic therapy illuminator are between (3)
It being connected using signal wire or line and is mutually controlled, the equipment of this structure is one of preferred embodiment of the invention, in addition,
There are also other preferred embodiments, wherein having the host (1) and image illumination and collector (2) in equipment, optical dynamic therapy irradiation
The structure being wirelessly connected between the big device of device (3) etc. three.
The structure of cancer operation fluorescence navigation and residual cancer tracer and the equipment of removing being wirelessly connected:
1) it needs image illumination and collector (2) first, optical dynamic therapy illuminator (3) is powered using built-in power, is taken off
From using image illumination and treatment mains lighting supply (7) wired powering mode, the light-duty electricity of environment-friendly and high-performance is can be used in built-in power
Source；
2) operational order of cyclelog (4) can be by radio transmission apparatus, such as infrared remote control, bluetooth are various does not arrange
Respectively to image illumination and collector (2), optical dynamic therapy illuminator (3) is controlled bright Radio Transmission Technology；
3) the image wire transmission between image illumination and collector (2) and fluorescence-reflected light image processor (5), can
It is changed to image wireless transmission form, image illumination and collector (2) is completed and fluorescence-reflected light image processor is schemed between (5)
As Wireless transceiver and communication.
To realize equipment of the invention in host (1), image illumination and collector (2), optical dynamic therapy illuminator (3)
Deng flexibility wireless connected between three big devices, that increase equipment uses.It on the basis of this, can also be by optical dynamic therapy
Illuminator (3) is removed on the liftable stick of host (1), is mounted on moveable platform, makes equipment of the invention by using
Cancer operation navigation (including the detection of residual cancer and tracer) function and optical dynamic therapy irradiation function are divided into the big portion of relatively independent two
The device divided, more flexibly.
The medicine have the advantages that navigating during surgery, residual cancer detection can be implement to perform the operation precisely treatment and operation
Periphery carries out optical dynamic therapy, and the cancerous swelling removed in recessive cancerous swelling fragment and blood is remaining, to prevent postoperative recurrence and transfer from doing
Actual contribution is gone out, numerous cancer patients is made to eliminate postoperative chemotherapy, radiotherapy to grievous injury brought by body, to improve
The quality of life and cure rate of cancer patient all plays a positive role.
Detailed description of the invention:
The fluorescence of cancer operation Fig. 1 of the invention navigates and the scantling plan of residual cancer tracer and removing equipment
Fig. 2, connection figure between the fluorescence navigation of cancer operation of the present invention and residual cancer tracer and removing equipment components
The autofluorescence comparison diagram of Fig. 3 photosensitizer HPD and tissue
The clinical effectiveness display diagram of Fig. 4 Patients Undergoing Operation fluorescence navigation of the present invention, residual cancer tracer and removing
Fig. 5, image illumination and collector structural schematic diagram
Fig. 6, fluorescence-reflected light image processor workflow schematic diagram
Fig. 7, optical dynamic therapy illuminator structural schematic diagram
The absolute construction schematic diagram that Fig. 8, optical dynamic therapy illuminator and host are wirelessly connected
Figure label: 1 host, 2 image illumination and 3 optical dynamic therapy illuminator of collector, 4 cyclelog
5 fluorescence-reflected light image processor, 6 image display, 7 image illumination and treatment mains lighting supply
8 have 10 illuminations of colored CCD camera 9LED Luminous Ring-acquisition control module 11LED integration slice of camera lens
14 light treatment control module of fan, 15 handle, 16 adjusting bracket of 12 integral micro-lens array, 13 air blast cooling
17 18 white light LEDs of royal purple wave band LED, 19 tumor focus
Specific embodiment:
The structure of equipment of the invention as shown in Figure 1 is shone by host (1), image illumination and collector (2), optical dynamic therapy
The big device of emitter (3) etc. three is formed.There are cyclelog (4), fluorescence-reflected light image processor (5), figure on host (1)
As display (6), image illumination and treat components such as mains lighting supply (7)；Have one at image illumination and collector (2) front end center
A colored CCD camera (8) with camera lens, periphery cover the LED Luminous Ring (9) and illumination-acquisition illuminated for two kinds
The components such as control module (10)；It is integrated in dynamic therapy luminaire (3) by the LED being made of multiple feux rouges high brightness LED chips
Piece (11), the integration slice front end that shines have for the micro- by integrating for certain regular array arrangement of the uniformity that improves red light irradiation
There are the components such as fan (13) and the light treatment control module (14) of air blast cooling in lens array (12), the integration slice rear end that shines.This
It between a little components is worked with connection type shown in Fig. 2, the cyclelog (4) in host (1) issues control letter
Number the control module (10) in image illumination and collector is reached by signal wire A, so that LED Luminous Ring (9) is shone and carry out double light
Alternately illuminate, be radiated on the tumor focus for the navigation that need to perform an operation, double optical illumination images on tumor focus by image illumination and
It is anti-to be sent into the fluorescence-in host (1) by transmission line B for colored CCD camera (8) acquisition with camera lens in collector (2)
It penetrates light image processor (5), the program actuator (4) that fluorescence-reflected light image processor (5) is sent in reception by signal wire C
Synchronization signal after examination classification is carried out to the image of two kinds of different light sources illuminations, and respectively in fluorescence-reflected light image processing
Device (5) is handled, and the benign and pernicious fluorescence of tumour can be distinguished by generating expression tumor focus form true color image and expression
Pseudo color image, and the setting of two image Display on the same screen formats is carried out, image display (6) are transmitted to by signal wire D and are carried out
Display provides foundation for precisely operation.If after detecting remaining cancerous swelling in art, can be purged with equipment of the invention, then
The light treatment of optical dynamic therapy illuminator is issued instructions to by signal wire E by cyclelog (4) in the host (1) in equipment
Control module (14), start optical dynamic therapy device (3) in LED integration slice (11) shine treatment is irradiated to residual cancer position.
Image illumination and treatment mains lighting supply (7) on host pass through illumination-of bis- lines of F, G to image illumination and collector respectively
Acquisition control module (10) and the light treatment control module (14) of optical dynamic therapy illuminator are powered, and are the normal fortune of equipment
Turn to provide safeguard.This equipment is when the fluorescence navigation of cancer operation and residual cancer tracer are with removing, using can generate to tumor tissues
Photochemically reactive photosensitizer HPD, mediates by receptor targeted, makes have more photosensitizer to enter in tumour cell, due to new
Photosensitizer advantage is absorbed by biological tissue, and the long period is detained in it, and the ratio between tumour/normal tissue concentration of photosensitizer is reachable
10-30 times, as shown in Figure 3.The tumour for taking in photosensitizer has very strong fluorescent emission energy, is not easily susceptible to tissue autofluorescence
Interference, improve cancer operation navigation and residual cancer tracer and elimination accuracy, Fig. 4 is the fluorescence of the cancer operation of this equipment
The effect of navigation and residual cancer tracer and removing.
The overall structure of image illumination and collector (2) designed for bell as shown in figure 5,
1) handle is raw by the side of bell shape, can also give birth at the top of bell shape.
2) the colored CCD camera (8) for having camera lens, colored CCD valid pixel >=30 are placed at the front end center of cover clock
Ten thousand pixels, camera lens are using conventional automatic focus-adjusting lens, effective working distance >=50mm.
3) there is the LED Luminous Ring (9) illuminated for two kinds in the surrounding of the colored CCD camera (8) of automatic focus-adjusting lens,
LED Luminous Ring (9) point two rings distribution, there is that white light LEDs are several, and royal purple wave band LED is several, and it is equal that misaligned interval formula is carried out in two rings
Equal distribution is as shown in Figure 2.White light LED color temperature 6000-65000, power 1W-3W, voltage 3V；Royal purple wave band LED power 1W-3W,
Voltage 3V.
4) illumination-acquisition control module (10) is placed on the rear end of cover mitriform, receives the instruction from cyclelog (4)
The LED Luminous Ring (9) illuminated to two kinds alternately shine, and carries out alternately illumination to the tumor focus of tumor operation, alternating is cut
Change illumination frequencies≤25HZ.
5) illumination-acquisition control module (10) can generate control information to two kinds of differences according to the brightness size of acquisition image
The electric current output negative-feedback of the constant-current supply of the LED of the illumination of type is controlled, and the colored CCD camera (8) for having camera lens is made
It collects image to be in always under optimal illumination state, the appearance for the collection effect for avoiding image flickering, Current Negative Three-Point Capacitance
Controlling depth≤80%.
By having, " image reading, image distribution, analog-to-digital conversion (A/D), AOI add fluorescence-reflected light image processor (5)
The image intelligent acquisition module and sequence controller, dsp processor, region Chooser, nonlinear detector, pixel analysis of speed "
The processing modules such as processor, edge and line recognition processor, image gateway are constituted.In a preferred approach, using with as Fig. 6
It will be anti-by image examination after such area's city selection, non-linear detection, picture signal DSP processing, under the modulation of image gateway
It penetrates light image and fluorescent image to separate, respectively enters and handle in next step, reflected light image is using adumbration intensification data method come weight
Group image, improves lesion morphological image expression effect, and fluorescent image is then pseudo- using being carried out according to benign tumors, pernicious criterion
Colour weighting come reconstructed picture workflow (FRI-RLIP) multifunctional processor, come undertake traditional optical image with it is non-
The processing of traditional fluorescence ratio image.
In FRI-RLIP multifunctional processor, the weighting of fluorescence pseudo-colours is to indicate normal using solid color (such as green)
Tissue；In addition cancerous issue is indicated with solid color (as red) to generate fluorescence pseudo color image.It is multi-functional in FRI-RLIP
Picture presentation format is the array format shown in parallel using two images, the same size of two images, Zuo Wei in processor
The lesion morphological image of reflected light, the right side are the setting of the fluorescence pseudo color image of lesion.
LED integration slice (11), integral micro-lens array (12), the pressure wind of optical dynamic therapy illuminator (3) as shown in Figure 7
Cold fan (13) and light treatment control module (14) are constituted.Wherein:
1) LED integration slice (11) is that the chip of the LED to be glowed by several high brightness is attached on aluminium flake, red-light LED hair
Optical wavelength 630nm ± 30nm, power 3W ± 0.5W, voltage 2.4V.
2) integral micro-lens array (12) is made of two fly's-eye lenses, is placed in parallel, between two fly's-eye lenses
Gap is equal to two times of fly's-eye lens focal length, and integral micro-lens array (12) is then placed on LED integration slice (11) light output
It can play the role of improving the utilization efficiency and uniform illumination of light on front position.
3) fan (13) of air blast cooling using axial cooling fan be placed on the aluminium flake of LED integration slice (11) followed by
Forced heat radiation.
4) light treatment control module (14) is placed on behind the fan (13) of air blast cooling.Receive cyclelog (4)
It instructs to shine to the LED integration slice (11) of optical dynamic therapy illuminator (3) and carries out treatment irradiation control.
Optical dynamic therapy illuminator (3) another preferred embodiment is replaced with one or more semiconductor laser.
Cyclelog (4) is formed by functional production of integrated circuits, using the square wave electric pulse signal of period 40ms
Illumination-acquisition control module (10) in image illumination and collector (2) is controlled, LED Luminous Ring (9) is made to carry out alternately illumination；
It is set interval using clock circuit and controls the light treatment control module (14) for the treatment of illuminator, send out LED integration slice (11)
Light realizes photodynamic treatment irradiation.
Image illumination is made of with treatment mains lighting supply (7) the pressure stabilizing of plurality of specifications, constant-current supply.12V regulated power supply to
Colored CCD camera (8) in image illumination and collector (2) with camera lens is powered；Simultaneously also to optical dynamic therapy illuminator
(3) fan (13) of air blast cooling in is powered；Illumination-acquisition control of the 18V1A constant-current supply into image illumination and collector (2)
Molding block (10) power supply；Light treatment control module (14) of the 24V 7.5A constant-current supply in optical dynamic therapy illuminator (3) supplies
Electricity.
Image display (6) is shown using display or monitor to be sent by reflected light-fluorescence image processing device (5)
Image.
Another preferred embodiment, the structure of cancer operation fluorescence navigation and residual cancer tracer and the equipment of removing being wirelessly connected
Pattern:
1) image illumination and collector (2) and host wireless connection are utilized in image illumination and collector (2) and use
High performance lithium battery or capacitor energy-storing power supply etc. carry out built-in power supply；In image illumination and collector (2) and cyclelog
(4) operational order between can be remotely controlled by the wireless signal of marshalling switch type；The dress in image illumination and collector (2)
Upper high definition wireless image transmission transmitting module carries out the transmitting of tumour acquisition image, by fluorescence-reflected light image processor (5)
Image input load onto high definition wireless image transmission receiving module and received, solve image illumination and collector (2) and fluorescence-
Image transmission and communication between reflected light image processor (5).It thereby realizes image illumination and collector (2) is wirelessly connected
Structure shape pattern.
2) optical dynamic therapy illuminator (3) is removed on the liftable stick of host (1), has been mounted on independent current source and energy
Be arranged on the moveable platform of photodynamic treatment parameter, as shown in Figure 8, can make optical dynamic therapy illuminator (3) with
Host (1) carries out being divided into the most device of relatively independent two, uses it with more flexibility.
The above is only a kind of preferred embodiment of the invention, and those skilled in the art are come
It says, without departing from the principles of the present invention, several transformation and improvement can also be made, these transformation and improvement also should be regarded as
Protection scope of the present invention.
Claims (10)
1. a kind of equipment for cancer operation fluorescence navigation and residual cancer tracer and removing, it is characterised in that its equipment is by host
(1), the three big devices such as image illumination and collector (2), optical dynamic therapy illuminator (3) are formed；
There are cyclelog (4), fluorescence-reflected light image processor (5), image display (6), image illumination on host (1)
With treatment mains lighting supply (7)；
There are the colored CCD camera (8) for having camera lens, a periphery to cover and be used for two kinds of photographs on image illumination and collector (2)
Bright LED Luminous Ring (9) and illumination-acquisition control module (10)；
Have on optical dynamic therapy luminaire (3) LED integration slice (11), integral micro-lens array (12), air blast cooling fan
(13) and light treatment control module (14)；
It is to be worked between the component of equipment with following connection type, the cyclelog (4) in host (1) issues control
Signal reaches the control module (10) in image illumination and collector by signal wire A, starts image illumination and collector (2)
LED Luminous Ring (9) carries out double light to the tumor focus for the navigation that need to perform an operation and alternately illuminates, and the lesion image after irradiation is by having mirror
Colored CCD camera (8) acquisition of head, is sent into fluorescence-reflected light image processor (5) in host (1) by transmission line B,
Fluorescence-reflected light image processor (5) is after the synchronization signal for receiving the program actuator (4) sent by signal wire C to two kinds
The image of different light source illuminations carries out examination classification, and is respectively processed, and generates expression tumor focus form true color image
The benign and pernicious fluorescence pseudo color image of tumour can be distinguished with expression, and display format settings are carried out to two images, then
Image display (6) is transmitted to by signal wire D to be shown, carries out residual cancer tracer in fluorescence navigation and art for operation, it is postoperative
The case where can detecting also according to residual cancer, optical dynamic therapy illuminator is issued instructions to by signal wire E by cyclelog (4)
Light treatment control module (14) starts optical dynamic therapy device (3) work, the irradiation treatment eliminated to residual cancer position.
2. equipment according to claim 1, it is characterised in that place and have at image illumination and collector (2) front end center
The colored CCD camera (8) of camera lens, the camera lens before colored CCD camera can be selected according to work purposes, conventional use
Using automatic focus-adjusting lens or with manual focusing, tight shot when way, fish eye lens when very-short-reach works works over long distances
When telephoto lens or use telecentric lens.
3. equipment according to claim 1, it is characterised in that image illumination and collector (2) are in the colour for having camera lens
The surrounding of CCD camera has the LED illuminated for two kinds to shine the ring of light (9), and LED shines what the ring of light (9) was shone by two kinds of differences
LED is distributed on a ring of light or multiple rings of light, and the luminous LED of two kinds of differences is alternate placement on each ring of light,
It symmetrically arranges, the LED illumination for keeping two kinds of differences luminous has approximation and uniformity.
4. equipment according to claim 1, it is characterised in that fluorescence-reflected light image processor (5) is a kind of collection tradition
The a variety of dedicated processors of image that optical image technology and unconventional fluorescence ratio imaging technique are integrated, by having " figure
The image intelligent acquisition module and sequence controller of picture reading, image distribution, analog-to-digital conversion (A/D), AOI acceleration ", DSP processing
Device, region Chooser, nonlinear detector, pixel analysis processor, edge and line recognition processor, image gateway processes module
It being constituted, it can screen the image for two kinds of different LED illuminations that image illumination and collector (2) transmit and handled,
Lesion morphological image expression effect is improved come reconstructed picture using adumbration intensification data method in reflected image；In fluorescent image
The middle criterion progress pseudo-colours weighting according to benign tumors, pernicious is come reconstructed picture, by the prominent table of lesion canceration magnitude range
Reveal and.
5. equipment according to claim 1, it is characterised in that fluorescent image is pseudo- in fluorescence-reflected light image processor (5)
Colour weighting be the pixel of normal tissue image is indicated with green, and the color of cancerous issue image pixel with another and
Above color is indicated, and respectively represents different canceration degree in cancerous tissue.
6. equipment according to claim 1, it is characterised in that fluorescence-reflected light image processor (5) can be to two images
Display format make diversified marshalling setting, it is arranged in parallel that it is two images that it, which can carry out two graphical arrangement modes,
Or the setting of longitudinal arrangement, can also carry out the setting of each image size and its display position.
7. equipment according to claim 1, it is characterised in that optical dynamic therapy illuminator (3) can export strong red light irradiation
Residual cancerous tissue, red light wavelength are 630nm ± 30nm, irradiation power density≤100mW/CM2, red with a number of high brightness
Color LED is attached on the aluminium sheet for being easy heat dissipation, weaves into LED integration slice (11).
8. equipment according to claim 1, it is characterised in that arranged in optical dynamic therapy illuminator (3) using integral micro-lens
Battle array (12) improves point the uniformity that the aluminium sheet of the LED of column arrangement shines.
9. equipment according to claim 1, it is characterised in that the irradiation of optical dynamic therapy illuminator (3) can use laser
Instead of.
10. equipment according to claim 1, it is characterised in that the host (1) and image illumination and collector of the equipment
(2), equipment can be made by using function to be divided into relatively using the structure that is wirelessly connected between optical dynamic therapy illuminator (3)
Independent device.
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| CN106236265B (en) * | 2016-08-31 | 2018-08-21 | 北京数字精准医疗科技有限公司 | A kind of hand-held molecular image navigation apparatus and system |
| CN106621022A (en) * | 2016-12-30 | 2017-05-10 | 深圳市和普利科技有限公司 | Biological herb inductive therapeutic instrument |
| WO2019049154A1 (en) * | 2017-09-06 | 2019-03-14 | Technion Research And Development Foundation Limited | Robotic system for minimally invasive surgery |
| CN111568549A (en) * | 2020-05-28 | 2020-08-25 | 维景医疗科技(浙江)有限公司 | Visualization system with real-time imaging function |
| CN117338427B (en) * | 2023-12-05 | 2024-02-27 | 四川大学华西医院 | Photodynamic intervention type catheter end positioning system and method |
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