CN102884073A - 用于促进血管生成的肽及其用途 - Google Patents
用于促进血管生成的肽及其用途 Download PDFInfo
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- CN102884073A CN102884073A CN2011800216180A CN201180021618A CN102884073A CN 102884073 A CN102884073 A CN 102884073A CN 2011800216180 A CN2011800216180 A CN 2011800216180A CN 201180021618 A CN201180021618 A CN 201180021618A CN 102884073 A CN102884073 A CN 102884073A
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Abstract
Description
SEQ ID NO. | 肽名称 | 序列 |
1 | Pep_1 | AGES |
2 | Pep_2 | PKAGES |
3 | Pep_3 | KNAGDS |
4 | Pep_4 | KNAGHS |
5 | Pep_5 | RQAGDS |
6 | Pep_6 | RQAGHS |
7 | Pep_11 | AGESQK |
肽/对照组 | 细胞增殖(%) |
阴性对照(未处理的) | 100 |
阳性对照(VEGF) | 166.0 |
Pep_1 | 109.6 |
Pep_2 | 104.4 |
Pep_3 | 115.7 |
Pep_4 | 119.6 |
Pep_5 | 207.5 |
Pep_6 | 138.0 |
Pep_11 | 146.5 |
肽/对照组 | 细胞迁移(%) |
阴性对照(未处理的) | 100 |
阳性对照(VEGF) | 146.3 |
Pep_1 | 118.0 |
Pep_2 | 159.5 |
Pep_3 | 125.8 |
Pep_4 | 135.5 |
Pep_5 | 165.4 |
Pep_6 | 138.6 |
Pep_11 | 202.2 |
Claims (12)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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KR1020100027373A KR101297037B1 (ko) | 2010-03-26 | 2010-03-26 | 혈관신생촉진용 펩타이드 및 이의 용도 |
KR10-2010-0027373 | 2010-03-26 | ||
PCT/KR2011/002080 WO2011119008A2 (en) | 2010-03-26 | 2011-03-25 | Peptides for promoting angiogenesis and an use thereof |
Publications (2)
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CN102884073A true CN102884073A (zh) | 2013-01-16 |
CN102884073B CN102884073B (zh) | 2014-12-10 |
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CN201180021618.0A Active CN102884073B (zh) | 2010-03-26 | 2011-03-25 | 用于促进血管生成的肽及其用途 |
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US (1) | US9249185B2 (zh) |
EP (2) | EP2552940A4 (zh) |
JP (1) | JP5752782B2 (zh) |
KR (1) | KR101297037B1 (zh) |
CN (1) | CN102884073B (zh) |
WO (1) | WO2011119008A2 (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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JP5725489B2 (ja) | 2008-06-27 | 2015-05-27 | 公立大学法人大阪市立大学 | 医療用組成物および医療用キット |
US20110251128A1 (en) * | 2010-02-26 | 2011-10-13 | The Board Of Regents Of The University Of Texas System | THYMOSIN Beta4 PEPTIDES PROMOTE TISSUE REGENERATION |
KR101337767B1 (ko) * | 2011-07-26 | 2013-12-09 | 서울대학교산학협력단 | Vegf 발현을 증가시키는 신규한 펩타이드 및 이를 함유하는 약학적 조성물 |
Citations (3)
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WO1997027299A1 (en) * | 1996-01-24 | 1997-07-31 | Schering Corporation | Mammalian cx3c chemokine genes |
WO2000046359A2 (en) * | 1999-02-05 | 2000-08-10 | Neutec Pharma Plc | Medicament |
CN101600451A (zh) * | 2006-12-11 | 2009-12-09 | 犹他大学研究基金会 | 用于治疗病理性血管生成和血管通透性的组合物和方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4395404A (en) * | 1982-05-14 | 1983-07-26 | George Washington University | Synthetic thymosin β3 and β4 analogues |
US5352664A (en) * | 1986-10-31 | 1994-10-04 | Board Of Regents, The University Of Texas System | Thrombin derived polypeptides; compositions and methods for use |
US5073492A (en) | 1987-01-09 | 1991-12-17 | The Johns Hopkins University | Synergistic composition for endothelial cell growth |
EP0506477B1 (en) | 1991-03-28 | 1999-06-23 | Merck & Co. Inc. | Vascular endothelial cell growth factor C subunit |
PT1100529E (pt) * | 1998-07-30 | 2005-10-31 | Us Gov Health & Human Serv | A timosina beta 4 promove a preparacao de feridas |
AU6090200A (en) | 1999-07-15 | 2001-02-05 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Peptides and their utility in modulation of behavior of cells expressing alpha3beta1 integrins |
AU2002231736A1 (en) * | 2000-12-22 | 2002-07-08 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Use of repulsive guidance molecule (rgm) and its modulators |
JP2005502672A (ja) * | 2001-08-29 | 2005-01-27 | リジェナークス・バイオファーマスーティカルズ・インコーポレイテッド | サイモシンβ4、類似体、アイソフォームおよびその他の誘導体を用いて心筋障害の発生前、発生中または発生後に発生する炎症、損傷およびその他の変化を治癒または予防する方法 |
US20040052810A1 (en) | 2002-09-04 | 2004-03-18 | Mark Nesbit | Abrogen polypeptides, nucleic acids encoding them and methods for using them to inhibit angiogenesis |
WO2004074460A2 (en) * | 2003-02-19 | 2004-09-02 | The Rockefeller University | Nucleotide and protein sequences of coc genes and methods based thereon |
WO2005094865A1 (ja) | 2004-03-31 | 2005-10-13 | Cardio Incorporated | 血管新生作用化合物 |
GB0717864D0 (en) * | 2007-09-13 | 2007-10-24 | Peptcell Ltd | Peptide sequences and compositions |
-
2010
- 2010-03-26 KR KR1020100027373A patent/KR101297037B1/ko not_active IP Right Cessation
-
2011
- 2011-03-25 EP EP11759757.5A patent/EP2552940A4/en not_active Withdrawn
- 2011-03-25 US US13/637,604 patent/US9249185B2/en not_active Expired - Fee Related
- 2011-03-25 CN CN201180021618.0A patent/CN102884073B/zh active Active
- 2011-03-25 WO PCT/KR2011/002080 patent/WO2011119008A2/en active Application Filing
- 2011-03-25 JP JP2013502458A patent/JP5752782B2/ja not_active Expired - Fee Related
- 2011-03-25 EP EP15172588.4A patent/EP2963053A1/en not_active Withdrawn
Patent Citations (4)
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WO1997027299A1 (en) * | 1996-01-24 | 1997-07-31 | Schering Corporation | Mammalian cx3c chemokine genes |
WO2000046359A2 (en) * | 1999-02-05 | 2000-08-10 | Neutec Pharma Plc | Medicament |
WO2000046359A3 (en) * | 1999-02-05 | 2000-12-07 | Neutec Pharma Plc | Medicament |
CN101600451A (zh) * | 2006-12-11 | 2009-12-09 | 犹他大学研究基金会 | 用于治疗病理性血管生成和血管通透性的组合物和方法 |
Non-Patent Citations (1)
Title |
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P.LAHDESMAKI ET AL: "Characterization of two synaptosomal peptides in calf brain", 《ACTA CHEMICA SCANDINAVICA》 * |
Also Published As
Publication number | Publication date |
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JP5752782B2 (ja) | 2015-07-22 |
US20130085108A1 (en) | 2013-04-04 |
CN102884073B (zh) | 2014-12-10 |
JP2013523719A (ja) | 2013-06-17 |
US9249185B2 (en) | 2016-02-02 |
WO2011119008A2 (en) | 2011-09-29 |
KR20110108079A (ko) | 2011-10-05 |
WO2011119008A3 (en) | 2012-04-26 |
EP2552940A2 (en) | 2013-02-06 |
KR101297037B1 (ko) | 2013-08-14 |
EP2963053A1 (en) | 2016-01-06 |
EP2552940A4 (en) | 2013-10-16 |
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