CN102861258B - Drug composition for treating coma, preparation method and application thereof - Google Patents
Drug composition for treating coma, preparation method and application thereof Download PDFInfo
- Publication number
- CN102861258B CN102861258B CN201210394954.6A CN201210394954A CN102861258B CN 102861258 B CN102861258 B CN 102861258B CN 201210394954 A CN201210394954 A CN 201210394954A CN 102861258 B CN102861258 B CN 102861258B
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- pharmaceutical composition
- coma
- fever
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a drug composition for treating coma. The drug composition is prepared by following raw materials of, by weight, 35-65 parts of cornu bubali or 5-15 parts of rhinoceros horns, 5.6-10.4 parts of coptidis rhizome, 5.6-10.4 parts of aical skullcap roots, 14-26 parts of dried radix rehmanniae, 10-20 parts of figwort, 10-20 parts of dwarf lilyturf tuber, 10-20 parts of red-rooted salvia roots, 10-20 parts of Chinese herbaceous peony, 7-13 parts of tree peony root barks, 10-20 parts of gromwell roots, 10-20 parts of honeysuckle, 8-16 parts of weeping forsythia capsule, 8-16 parts of indigowoad roots, 8-16 parts of black bamboo, 10-20 parts of snakegourd roots and 8-16 parts of grassleaf sweetflag rhizome. The invention further provides a preparation method and an application of the drug composition. According to the drug composition, fever caused by unknown reasons or common cold can be effectively eliminated or greatly relieved, blood-heat can be eliminated, the coma caused by the fever can be treated, and a new choice is provided for clinical medication.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of coma and its production and use.
Background technology
Coma, refers to and causes heart and brain to be subject to heresy by various disease conditions, key network is obstructed, gods are covered, with the common internal medicine acute disease that syncope, coma are feature, having more the performance that the consciousness such as existing stupor, delirium, unconsciousness is abnormal, is one of common Severe acute disease of Epidemic Febrile Disease.The traditional Chinese medical science is thought, the common type of coma mainly contains heat-blockage pericardium, expectorant covers refreshing key, exhaustion of YIN YANG-depletion, functional activities of the body fluid be for de-, unconsciousness and collapse etc., the visible mind of its symptom is muddle-headed, or mutter delirium, or call out loudly, or floccitation and aimless action as if twisting thread appearing in the delirious patient, to dance for joy, even clonic convulsion is twitched, or unconsciousness, or merry laugh or angry curse; Or send out speckle, epistaxis, hemoptysis, haematemesis, hematuria, have blood in stool etc. (Li Yaohui etc., coma is distinguished and controlled pre-test, Jilin Chinese medicine, 29 volume 11 phases in 2009).
FUO or cold, fever, control if lose, wrong treatment, and cause the state of an illness sharply to worsen, body temperature goes up not down, and can cause coma, this situation, how with crimson tongue or dry deep red or purple deep red, full and large pulse or stringy and rapid pulse, the Chinese medicine tongue arteries and veins sign such as to count accurately.FUO and cold, fever are symptom comparatively common clinically or sufferer, and all age group all can occur.Wherein, FUO (fever of unknown origin, FUO), refer to that fever time was more than 3 weeks, body temperature, more than 38.5 DEG C, still can not be clarified a diagnosis through detailed medical history-taking, physical examination and Routine Test Lab inspection.It is symptom comparatively common clinically or sufferer, and all age group all can occur, and is common with afternoon or outbreak at dusk.The generation of flu is empty mainly due to body, resistance against diseases weakens, when climate change, human body is defended external work and can be adapted to, and pathogen is taken advantage of a weak point in opponent's defence by fur, mouth and nose and entering, and causes a series of lung to defend symptom, if vital QI cannot conquer pathogen, evil long-pending heat-transformation is then generated heat, the pyrogen namely described in doctor trained in Western medicine directly act on heat production that thermotaxic centre, heat center dysfunction or a variety of causes cause too much, heat radiation reduces, and causes body temperature to increase to over normal range.Cold, fever is harmful also favourable, and adstante febre immune function of human body obviously strengthens, and this is conducive to removing pathogen and promoting the recovery from illness of disease, if but body temperature more than 38.5 DEG C, just must treat, particularly Drug therapy.
At present, for the FUO, coma etc. that cannot investigate and prosecute the concrete cause of disease, doctor trained in Western medicine cannot accurately administration; Or find and be cold, fever and lose to control wrong treatment and cause that sb.'s illness took a turn for the worse, the chemicals that some toxic and side effects are larger of having to again use, cause weak and the old and the weak patient thin body that originally declined more to be made the matter worse.The traditional Chinese medical science then can according to its state of an illness, the cause of disease, pathogenesis, the course of disease, sick position, with determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs system and the therapeutic rules of the traditional Chinese medical science such as differentiation of syndromes in seasonal febrile diseases according to four phases: WEI,QI,YING and XUE systems, imposes science, effective, the Fang Zhi that has no side effect.
Summary of the invention
The pharmaceutical composition of the treatment coma that the object of the present invention is to provide a kind of drug effect good.Present invention also offers preparation method and the purposes of this pharmaceutical composition.
The invention provides a kind of pharmaceutical composition for the treatment of coma, it is the preparation be prepared from by the crude drug of following weight proportion:
Cornu Bubali 35-65 part, Rhizoma Coptidis 5.6-10.4 part, Radix Scutellariae 5.6-10.4 part, Radix Rehmanniae 14-26 part, Radix Scrophulariae 10-20 part, Radix Ophiopogonis 10-20 part, Radix Salviae Miltiorrhizae 10-20 part, Radix Paeoniae 10-20 part, Cortex Moutan 7-13 part, Radix Arnebiae (Radix Lithospermi) 10-20 part, Flos Lonicerae 10-20 part, Fructus Forsythiae 8-16 part, Radix Isatidis 8-16 part, Folium Bambosae 8-16 part, Radix Trichosanthis 10-20 part, Rhizoma Acori Graminei 8-16 part.Further, it is the preparation be prepared from by the crude drug containing, for example lower weight proportion:
Cornu Bubali 45-55 part, Rhizoma Coptidis 6-10 part, Radix Scutellariae 6-10 part, Radix Rehmanniae 17-23 part, Radix Scrophulariae 12-17 part, Radix Ophiopogonis 12-17 part, Radix Salviae Miltiorrhizae 12-17 part, Radix Paeoniae 12-17 part, Cortex Moutan 8-12 part, Radix Arnebiae (Radix Lithospermi) 12-17 part, Flos Lonicerae 12-17 part, Fructus Forsythiae 10-14 part, Radix Isatidis 10-14 part, Folium Bambosae 10-14 part, Radix Trichosanthis 12-17 part, Rhizoma Acori Graminei 10-14 part.
Further preferably, it is the preparation be prepared from by the crude drug containing, for example lower weight proportion:
Cornu Bubali 50 parts, Rhizoma Coptidis 8 parts, Radix Scutellariae 8 parts, 20 parts, the Radix Rehmanniae, Radix Scrophulariae 15 parts, Radix Ophiopogonis 15 parts, Radix Salviae Miltiorrhizae 15 parts, Radix Paeoniae 15 parts, Cortex Moutan 10 parts, Radix Arnebiae (Radix Lithospermi) 15 parts, Flos Lonicerae 15 parts, Fructus Forsythiae 12 parts, Radix Isatidis 12 parts, Folium Bambosae 12 parts, Radix Trichosanthis 15 parts, Rhizoma Acori Graminei 12 parts.
Wherein, described Radix Paeoniae is the Radix Paeoniae Alba: Radix Paeoniae Rubra=(melange of 1-2) ﹕ (1-2).
Wherein, described preparation is oral formulations.
Further, described oral formulations is granule, powder, pill, drop pill, capsule, soft capsule, tablet or oral liquid.
Present invention also offers the preparation method of aforementioned pharmaceutical compositions, it comprises following operating procedure:
(1) by prescription weight proportion weighting raw materials;
(2) Cornu Bovis seu Bubali powder of fetching water is for subsequent use; After each medicines of other except Cornu Bubali decoct, collect decocting liquid, add Cornu Bubali powder and pharmaceutically can adjuvant or complementary composition be prepared into conventional formulation.
Present invention also offers the purposes of aforementioned pharmaceutical compositions in the medicine of the caused coma of preparation treatment heating.
Further, described heating is FUO or cold, fever.
Further, described medicine is treatment because edema caused by disorder of QI pathogenic heat import battalion point into, consumption liquid wound battalion, caused fever of the body excessive thirst, mind unconsciousness, delirium, sends out speckle, conjunctival congestion, erosion of the oral mucosa or/and pharynx is rotten; Or the pathogenic heat attacking blood system in febrile diseases, the absurd row of forcing blood, caused sends out speckle, epistaxis, hemoptysis, haematemesis, hematuria, has blood in stool or/and crimson tongue.
Present invention also offers the purposes of aforementioned pharmaceutical compositions in the medicine preparing treatment FUO or cold, fever.
Generally acknowledged that " organic conception ", " determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs ", " compound recipe use ", " compound compatibility medication is as used military forces " are the traditional Chinese medical science the most effective most scientific several large advantages at present, wherein " compound compatibility medication is as used military forces " is the original theory of Chinese medicine of very science.The tight compatibility that in traditional Chinese medical science prescription, each medicine is all linked with one another as arrayed troops for battle is that it is better than the effective means of Western medicine formula.Tcm prescription theory is thought, each prescription, not only need to select the appropriate compatibility of suitable medicine according to etiology and pathogenesis, also should meet the basic structure of prescription simultaneously, the i.e. prescription compatibility theory of " monarch, minister, help, make ", the prescription compatibility of so-called " monarch, minister, help, make " is exactly that it is based upon the scientific matching on the comprehensive judgement basis of disease pathogenesis.In medical side by too many levels, Mutiple Targets Integrate adjustment biological mechanism, the cause of disease complicated difficult like this for the treatment of the present invention is looked into, patient's condition sparrow hawk opens, the defensive-qi-nutrient-blood course of disease stage lapses to swift and violent and fantastic polytropy sufferer, doctor trained in Western medicine cannot be put in poison or the many toxic and side effects of medication, the very difficult illness for the treatment of or symptom regulate and control,, more thoroughly therapeutic effect better than Western medicine can be obtained, and this curative effect be based upon the above-mentioned traditional Chinese medical science tradition original theory accurate instruction on, prescription of the present invention just have followed this principle.
In traditional Chinese medical science traditional theory, FUO extensively relates to internal organs, tissue, the meridians such as lung, stomach (spleen), liver (gallbladder) kidney, bone arteries and veins, and table is defended, is defended the different sick bit depth such as gas, gas battalion, nutrient blood, blood system, age is different, sex is different, natural endowment body constitution is different, environment is different, all can be suffered from by different pathogeny and, suffered from the heating of different symptoms performance.And if these heating delays are not controlled, or malpractice, body temperature just may continue to rise, be further developed into heat and disturb pericardium, the heart does not keep god, occurs that the various diseases of coma are seen, as mind is muddle-headed, or mutter delirium, even call out loudly, or floccitation and aimless action as if twisting thread appearing in the delirious patient, to dance for joy, even twitch, or unconsciousness, or merry laugh or angry curse, how with flushing, thirsty, crimson tongue or dry deep red or purple deep red, full and large pulse or stringy and rapid pulse, the sign such as to count accurately; Or the pathogenic heat attacking blood system in febrile diseases, the absurd row of forcing blood, occurs sending out a speckle, epistaxis, hemoptysis, haematemesis, hematuria, levying of having blood in stool.Too, when its exopathogen is flourishing or positive exogenous pathogen contains, suffer mistake to control wrong treatment again, the state of an illness just can sharply worsen cold, fever, and body temperature goes up not down, and then occurs above-mentioned a series of coma or enters mass formed by blood stasis shape.
The invention aims at the patient hot deep toxic heavy, disturbed mind and the god delusion, thermal forcing blood folly so spot disease, therefore, the pharmaceutical composition of the invention is to reuse <b TranNum= in "95" > water buffalo </b> as monarch drug, Liang heart Xiegan, Qing Ying and blood heat, heat Qing God since the static, the fire down blood ning.<b TranNum="96">rhizoma Coptidis, Radix Scutellariae</b>principal drug assistance expels the heat-evil removing toxic substances;<b TranNum="97">the Radix Rehmanniae, Radix Scrophulariae, Radix Arnebiae (Radix Lithospermi)</b>principal drug assistance clearing away heat from YING and blood systems;<b TranNum="98">rhizoma Acori Graminei</b>causing resuscitation with aromatic drugs, assists monarch drug treatment unconsciousness and delirium primary symptom.Assist monarch drug from different perspectives, therefore be all ministerial drug for above three groups.In addition, though some patients maybe can occur that epistaxis sends out the blood system symptoms such as speckle in sufferer, the product of the sluggish hemostasis of Radix Rubiae, Herba Agrimoniae, Nodus Nelumbinis Rhizomatis and so on now early should not be used, and should by the work of clearing away heat from YING and blood systems in order to reach hemostasis object, therefore, prescription of the present invention is used<b TranNum="99">radix Paeoniae, Cortex Moutan, Radix Salviae Miltiorrhizae</b>removing pathogenic heat from blood and dissipating blood stasis promoting the circulation of blood, serves as " left " adjuvant drug, and monarch drug and the Radix Rehmanniae, Radix Scrophulariae, Radix Arnebiae (Radix Lithospermi) obtain this three medicine and assist a ruler in governing a country, and have both enhanced clearing away heat from YING and blood systems effect, can prevent from again occurring because monarch drug and the Radix Rehmanniae, Radix Scrophulariae, Radix Arnebiae (Radix Lithospermi) are too cold and cool the drawback that blood stasis is stagnated.In addition,<b TranNum="100">the Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis, Radix Trichosanthis, Radix Salviae Miltiorrhizae</b>again can YIN supplementing and fluids increasing, heat being gone and body fluid is supplemented, is " right wing " adjuvant drug in the present invention.<b TranNum="101">flos Lonicerae, Fructus Forsythiae, Radix Isatidis, Folium Bambosae, Radix Trichosanthis</b>being good at the heat that clearing heat in QI system divides, allocating in prescription of the present invention, as making medicine, not only collaboratively strengthening heat-clearing toxin-expelling functions, and the meaning of " inducing Ying heat into Qi phase still all right of joining the army " in exclusive Epidemic Febrile Disease theory, pathogenic heat dark for sick position is drawn outside the more shallow edema caused by disorder of QI in sick position, clearly outer.Pharmaceutical composition Chinese medicine number of the present invention more and orderly not disorderly, each group of flavour of a drug " location of determining a post ", post is clearly demarcated, brings out the best in each other, given full play to the exclusive compound compatibility medication of Chinese medicine as row army structure the formation as sexology research methodology of analyzing mentally, therefore can good efficacy be obtained.
Pharmaceutical composition of the present invention effectively can not only be eliminated or greatly alleviate FUO or cold, fever, can also eliminate heat in blood, treats the coma caused by heating, for clinical application provides a kind of selection newly.
Detailed description of the invention
the preparation of embodiment 1 pharmaceutical composition of the present invention
Water intaking 50 grams, Cornu Bovis seu Bubali, Rhizoma Coptidis 8 grams, Radix Scutellariae 8 grams, 20 grams, the Radix Rehmanniae, Radix Scrophulariae 15 grams, Radix Ophiopogonis 15 grams, Radix Salviae Miltiorrhizae 15 grams, Radix Paeoniae 15 grams, Cortex Moutan 10 grams, Radix Arnebiae (Radix Lithospermi) 15 grams, Flos Lonicerae 15 grams, Fructus Forsythiae 12 grams, Radix Isatidis 12 grams, Folium Bambosae 12 grams, Radix Trichosanthis 15 grams, Rhizoma Acori Graminei 12 grams.Each flavour of a drug take according to quantity, mix with enough water purification, after other each medicines that intense fire is fried boiling except Cornu Bubali, change slow fire and decoct 15 minutes to 25 minutes again.After collecting decocting liquid, then decoct with water 2 times, merge each decocting liquid, obtain decoction.Meanwhile, Cornu Bubali is rasped to smalls, takes after mixing it with water with decoction gradation, also graded calls in decoction with clothes.
Described Radix Paeoniae is the Radix Paeoniae Alba and the Radix Paeoniae Rubra melange by 1 ﹕ 1 weight ratio.In the present invention, though Radix Paeoniae selects melange, the alone Radix Paeoniae Alba or Radix Paeoniae Rubra also can, in treatise on Febrile Diseases, " Medical Treasures of the Golden Chamber " namely without Radix Paeoniae Rubra, the Radix Paeoniae Alba point (Wang Qingqi, Zhang Zhongjing uses the rule of Radix Paeoniae to analyse, Liaoning Journal of Traditional Chinese Medicine, 6 phases in 1984).
In we, the consumption of Cornu Bubali should be larger.
Folium Bambosae of the present invention, also known as bamboo pin, the bamboo heart, is grass family phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle
phyllostachys nigra(Ledd.ex Lindl.) Munro var.
henonis(Mitf.) Stapf ex Rendle or cizu
neosinocalamns affinis(Rendle) spire do not put of the volume face of Keng f..
the preparation of embodiment 2 pharmaceutical composition of the present invention
Prepare decoction by embodiment 1 prescription and method, wherein, described Radix Paeoniae is the Radix Paeoniae Alba and the Radix Paeoniae Rubra melange by 2 ﹕ 1 ratios.Get decoction, after concentrated, after adding Cornu Bubali smalls, granulate after adding proper starch, dextrin mixing.
the preparation of embodiment 3 pharmaceutical composition of the present invention
Prepare decoction by embodiment 1 prescription and method, wherein, described Radix Paeoniae is the Radix Paeoniae Alba and the Radix Paeoniae Rubra melange by 1 ﹕ 2 ratio.Get decoction, after concentrated, add Cornu Bubali smalls, after appropriate dextrin, soluble starch are granulated, tabletting, obtains tablet.
Beneficial effect of the present invention is illustrated below by way of test example.
clinical (outpatient service) of test example pharmaceutical composition of the present invention treats situation
(1) patient profiles is accepted for medical treatment
Gender and the range of age: contain men and women, old and young, in the majority with juvenile, possess following symptom feature, accept 53 examples altogether for medical treatment.
Symptom feature: persistent fever, body temperature more than 38.5 DEG C, even the heating course of disease reach 3 weeks longer, but not clarify a diagnosis the cause of disease through the inspection that doctor trained in Western medicine one week is detailed; Or cold, fever body temperature is more than 38.5 DEG C.
Above two kinds of situations and initial symptoms further develop, and body temperature rises to more than 40 DEG C, patient's fever of the body excessive thirst, flushing conjunctival congestion, god knows muddle-headed, or mutter delirium, even call out loudly, or floccitation and aimless action as if twisting thread appearing in the delirious patient, to dance for joy, even clonic convulsion, tic, or unconsciousness, or merry laugh or angry curse; Or pathogenic heat enters blood system, the absurd row of forcing blood, occurs sending out a speckle epistaxis, hemoptysis is spitted blood, hematuria has blood in stool, how with crimson tongue or the dry deep red or sign such as purple deep red, full and large pulse or disease number.After diagnosing, the coma disease described in the traditional Chinese medical science is belonged to.
(2) standard is treated
Recovery from illness: above-mentioned symptom disappears completely, temperature recovery is normally also checked and is had no index of correlation extremely.
Evident in efficacy: above-mentioned symptom disappears substantially, body temperature has certain degree to decline simultaneously.
Curative effect is obvious: the number of times that above-mentioned symptom occurs obviously reduces or degree obviously alleviates, and body temperature declines to some extent.
Have certain effect: patients symptomatic makes moderate progress, or body temperature slightly declines.
Invalid: symptom still, do not improve by body temperature index.
(3) Therapeutic Method
1, the made pharmaceutical composition of embodiment 1, each serving with 200 to 400ml, or daily 1 bowl, rice bowl used of having a meal (child to be cut down according to the circumstance dosing by preceding method, but need drink to add day take number of times), littlely took once up to 6 hours every 4, takes according to quantity on time.
2, science conditioning daily life, pay special attention to:
1. maintain the circulation of air.If there is air-conditioning in family, room temperature is adjusted between 25 DEG C ~ 27 DEG C.2. clothing appropriate.If extremity and trick burn and panhidrosis, then need heat radiation, can take off too much medicated clothing, appropriateness is worn the clothes thing less.3. warm water wipes bath.Upper and lower with about 37 DEG C warm water towels rubbing whole bodies, one can distend the blood vessels advantageous heat dissipation, and second aqueous vapor is when body surface evaporates, also can absorb and take away body heat.4. drink water more, to help diaphoresis, and anti-dehydration.Water has the effect of regulate body temperature, can make temperature decline and dehydration in added body.5. fever person adds and uses alcohol wipe.
In addition, do not drink, smoke, not eating and drinking too much at one meal, do not eat or eat less the food of " heat-dissipating of getting angry " " the scorching impairment of YIN " such as pungent frying, delicious food savoury, eat more fresh, light, have clearing away heat and promoting production of body fluid effect and more nutritious food; Keep one's hair on, get angry, self-closing cloudy gas or depressed of irritating, keep pleasant with happy; Afforest, beautified habitat environment, and make its sanitary; Have a rest and activity appropriateness, and more regular.Etc..
(4) therapeutic outcome
With embodiment 1 medicine composite for curing primary disease men and women, old and young patient (juvenile is in the majority) 53 example between many decades, wherein coma person 29 example caused by FUO, caused by cold, fever, coma person 24 example, all obtains good curative effect.
Treatment time, the difference to some extent according to the difference of the concrete conditions such as each conditions of patients weight, age size, physical strength, generally just had obvious effect, within 2 weeks ~ about 8 weeks, can terminate treatment, use above-mentioned conditioning instead and namely receive merit in 2 days to 1 week.
By above-mentioned treatment standard, in the patient of coma caused by 29 routine FUOs, have 17 example recoveries from illness, cure rate reaches 58.6%; 5 routine Be very effective, reach 17.2%; 2 routine successfuls, account for 6.9%; 1 example has certain effect, accounts for 3.4%; 4 routine DeGrains (invalid), account for 13.9%.Total effective rate reaches 86.1%.
In the patient of coma caused by 24 routine cold, fevers, have 15 example recoveries from illness, cure rate reaches 62.5%; 4 routine Be very effective, reach 16.7%; 2 routine successfuls, account for 8.3%; 1 example has certain effect, accounts for 4.2%; 2 routine DeGrains (invalid), account for 8.3%.Total effective rate reaches 91.7%.
model case 1
Patient, female, 13 years old, patient's heating did not find the cause of disease 23, and heating is many after nightfall, and body temperature maintains more than 38.5 DEG C substantially, and daytime gradually falls, and early stage does not obtain effect through integrative therapy, its prescriptions of Chinese medicine, morely belonged to pungent and coolly to deliver or the agent of clearing up internal heat by using drugs of bitter in taste and cold in nature.See its flushed face with red ears, brothers wave, and mouth goes out delirium, talk nonsense and laugh, excessive thirst taking fluids profusely, two swift pulse number, dry and crimson tongue, haves a medical check-up 40.5 DEG C, yellowish or reddish urine, defecates slightly dry and hard, menses menophania had more than year, but passed through and often do not come at the appointed time, and the nearly moon, the red dense thick amount of color was slightly many in advance extremely.After examining, give pharmaceutical composition of the present invention and give clothes (embodiment 1), took once every 4 hours, and by the conditioning of above-mentioned " Therapeutic Method " it " 2 " science.Take medicine one to two, namely body temperature fall about 39.5 DEG C, and brothers are slightly quiet, and delirium reduces.Continue to take, conditioning is as front.Spend again 2, body temperature is down to less than 39 DEG C, is substantially maintained at about 38.5 DEG C.Following the service 2 days again, unconsciousness and delirium, brothers wave symptom and entirely disappear, and only body temperature is not yet multiple normal, fluctuates between 38 DEG C to 38.5 DEG C.Continue conditioning three weeks, temperature recovery is normal, and the symptoms such as coma are not shown effect again.
model case 2
Patient, man, 8 years old, patient generated heat 3, be " cold, fever " through hospital diagnosis, did not move back to taking coldrex, and after several days, body temperature continues rising gradually, time the highest nearly 41 DEG C.Its entire body is rubescent, dry lip conjunctival congestion, brothers Chi Zong, mutter, unconsciousness, and dry tongue is deep red, swift pulse number, body temperature 40.7 DEG C.Suddenly give pharmaceutical composition prescription of the present invention (embodiment 1), again and again take, and adopt above-mentioned " Therapeutic Method " it " 2 " science to nurse one's health.Check body temperature next day slightly to decline, coma symptom is alleviated to some extent, takes number of times and reduces.Continue to take medicine, nurse one's health, clothes change into every 4 hours once.Every day like this observes, and symptom takes a turn for the better gradually, and body temperature fluctuates between 39.5 DEG C to 40 DEG C.By the 4th day, the symptoms such as delirium Chi is dynamic disappeared completely, and body temperature returns less than 39 DEG C.Spend again more than one week, body temperature is down to 37.5 DEG C, finally returns to about 37 DEG C, and coma symptom has no recurrence.
Above two examples, by hospital's check, have no Indexes Abnormality, follow up a case by regular visits to good and sound.
In sum, pharmaceutical composition of the present invention effectively can not only be eliminated or greatly alleviate FUO or cold, fever, can also eliminate heat in blood, treats the coma caused by heating, for clinical application provides a kind of selection newly.
Claims (1)
1. treat a pharmaceutical composition for coma, it is characterized in that: it is the preparation be prepared from by the crude drug of following weight proportion:
Cornu Bubali 50 parts, Rhizoma Coptidis 8 parts, Radix Scutellariae 8 parts, 20 parts, the Radix Rehmanniae, Radix Scrophulariae 15 parts, Radix Ophiopogonis 15 parts, Radix Salviae Miltiorrhizae 15 parts, Radix Paeoniae 15 parts, Cortex Moutan 10 parts, Radix Arnebiae (Radix Lithospermi) 15 parts, Flos Lonicerae 15 parts, Fructus Forsythiae 12 parts, Radix Isatidis 12 parts, Folium Bambosae 12 parts, Radix Trichosanthis 15 parts, Rhizoma Acori Graminei 12 parts.
2, pharmaceutical composition according to claim 1, is characterized in that: described Radix Paeoniae is the Radix Paeoniae Alba: Radix Paeoniae Rubra=(melange of 1-2) ﹕ (1-2) w/w.
3, pharmaceutical composition according to claim 1, is characterized in that: described preparation is oral formulations.
4, the preparation method of pharmaceutical composition described in claims 1 to 3 any one, is characterized in that: it comprises following operating procedure:
(1) by prescription weight proportion weighting raw materials;
(2) powder of water intaking Cornu Bovis seu Bubali is for subsequent use; After each medicines of other except Cornu Bubali decoct, collect decocting liquid, add Cornu Bubali powder and pharmaceutically can adjuvant or complementary composition be prepared into conventional formulation.
5, the purposes of pharmaceutical composition described in claims 1 to 3 any one in the medicine of the caused coma of preparation treatment heating.
6, purposes according to claim 5, is characterized in that: described heating is FUO or cold, fever.
7, purposes according to claim 6, is characterized in that: described medicine is treatment because edema caused by disorder of QI pathogenic heat import battalion point into, consumption liquid wound battalion, caused fever of the body excessive thirst, mind unconsciousness, delirium, sends out speckle, conjunctival congestion, erosion of the oral mucosa or/and pharynx is rotten; Or the pathogenic heat attacking blood system in febrile diseases, the absurd row of forcing blood, caused sends out speckle, epistaxis, hemoptysis, haematemesis, hematuria, has blood in stool or/and crimson tongue.
8, the purposes of pharmaceutical composition described in claims 1 to 3 any one in the medicine preparing treatment FUO or cold, fever.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210394954.6A CN102861258B (en) | 2012-10-17 | 2012-10-17 | Drug composition for treating coma, preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210394954.6A CN102861258B (en) | 2012-10-17 | 2012-10-17 | Drug composition for treating coma, preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102861258A CN102861258A (en) | 2013-01-09 |
| CN102861258B true CN102861258B (en) | 2014-12-31 |
Family
ID=47440573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210394954.6A Expired - Fee Related CN102861258B (en) | 2012-10-17 | 2012-10-17 | Drug composition for treating coma, preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102861258B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142989B (en) * | 2013-04-09 | 2014-07-30 | 杜京辉 | Traditional Chinese medicine composition for treating infantile cough and preparation method thereof |
| CN104027719B (en) * | 2014-04-03 | 2017-06-16 | 马艳春 | Traditional Chinese medicine compound composition of hypersplenia liver-depression and spleen-insufficiency type disease caused with treatment infectious endocarditis and preparation method thereof |
-
2012
- 2012-10-17 CN CN201210394954.6A patent/CN102861258B/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| 河北医学院.清热剂.《中医学(上册)》.人民卫生出版社,1981,第290-293页. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102861258A (en) | 2013-01-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101274087B (en) | Chinese medicine decoction for invigorating gallbladder and removing gall-stone | |
| CN101972338B (en) | Chinese medicinal preparation for treating infantile upper respiratory tract infection and preparation method thereof | |
| CN102836333B (en) | Medicine composition for treating fever of unknown origin as well as preparation method and application thereof | |
| CN103191321B (en) | Pharmaceutical composition for treating tonsillitis and preparation method and application thereof | |
| CN103191290B (en) | Pharmaceutical composition for treating nasosinusitis as well as preparation method and application thereof | |
| CN102423423B (en) | Traditional Chinese medicine for treating urinary tract infection | |
| CN103735943A (en) | Medicament composition for treating diarrhea and preparation method and application thereof | |
| CN103948782B (en) | Pharmaceutical composition for treating hyperplasia of mammary glands due to stagnation of liver qi as well as preparation method and application of pharmaceutical composition | |
| CN103169849B (en) | Pharmaceutical composition for treating sore carbuncle swollen poison, and preparation method and use thereof | |
| CN102861258B (en) | Drug composition for treating coma, preparation method and application thereof | |
| CN103041030B (en) | Pharmaceutical composition for treating fever with swollen head, as well as preparation method and application thereof | |
| CN102793876B (en) | Pharmaceutical composition for treating fever caused by unknown reason as well as preparation method and application of pharmaceutical composition | |
| CN102139051A (en) | Application of soft capsule capable of clearing heat and eliminating toxin in preparation of medicament for treating viral pneumonia | |
| CN103100072B (en) | Traditional Chinese medicine composition for treating proctitis and appendicitis, and restraining rectum cancer | |
| CN101095881B (en) | Decoction medicine for treating indigestion type biliary ascariasis and preparation method thereof | |
| CN103705842A (en) | Traditional Chinese medicine composition for treating diabetes | |
| CN105031487A (en) | Traditional Chinese medicine composition for treating children's jaundice caused by retention of dampness in the spleen and stomach | |
| CN102824482A (en) | Traditional Chinese medicine composition for treating icteric hepatitis | |
| CN103263580A (en) | Traditional Chinese medicine composition for treating diabetes | |
| CN102631618A (en) | Traditional Chinese medicine for treating diabetes | |
| CN103263595A (en) | Traditional Chinese medicine composition for treating diabetes | |
| CN102973774B (en) | Medicine composition for treating speckles and preparation method and application of composition | |
| CN104623282A (en) | Traditional Chinese medicine healthy preparation for conditioning hypertension | |
| CN104587017A (en) | Pharmaceutical composition for clearing heat and relaxing bowels, promoting qi and activating blood circulation as well as preparation method and application of pharmaceutical composition | |
| CN103599278A (en) | Traditional Chinese medicine for treating diabetes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20141231 Termination date: 20171017 |