CN102973774B - Medicine composition for treating speckles and preparation method and application of composition - Google Patents
Medicine composition for treating speckles and preparation method and application of composition Download PDFInfo
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Abstract
The invention provides a medicine composition for treating speckles. The medicine composition is prepared from the following components in parts by weight: 35 to 65 parts of cornu bubali or 5 to 15 parts of rhinoceros horn, 20 to 40 parts of gypsum, 8 to 16 parts of rhizoma anemarrhenae, 10 to 20 parts of indigo naturalis, 14 to 26 parts of radix scrophulariae, 14 to 26 parts of radix rehmanniae recen, 10 to 20 parts of Chinese herbaceous peony, 7 to 13 parts of cortex moutan, 8 to 16 parts of jasmine, 8 to 16 parts of coptis chinensis, 17 to 31 parts of sweet wormwood, 4 to 8 parts of ginseng and 3 to 7 parts of honey-fried licorice root. The invention also provides a preparation method and application of the medicine composition. The medicine composition can effectively eliminate or greatly relieve speckling caused by heat in body, blood heat, blood forcing and blood on the skin as well as traditional Chinese symptoms of heat and distraction which are caused by heat in body, heat dispersion and great heat and can treat partial primary diseases to a certain extent; and a new selection is supplied to clinical medicine use.
Description
Technical field
The present invention relates to a kind for the treatment of and send out pharmaceutical composition of speckle and its production and use.
Background technology
Sending out speckle is one of common clinically symptom, especially multiple with teenager." speckle " is normal is collectively referred to as " macule " with " rash ", but " speckle " refers to the skin lesion not being in the way touching that the color of slabbing or bulk is red or purple.Speckle can be sent out in any body part of any sex of any age in any season." YANG toxin syndrome " be send out speckle commonly encountered diseases because of, YANG toxin syndrome is sent out speckle and is generally in showing tremendous enthusiasm biography, intense heat in the blood, the absurd row of forcing blood, due to excessive skin.Send out speckle and can damage skin, when sending out its redness of speckle and spread to surrounding as erysipelas, the redness of central authorities disappears, desquamation, and color transfers to pale brown.While sending out speckle, have shiver with cold, heating onset, and accompany general malaise, feel sick, the symptom such as vomiting, then local appearance and the normal skin clearly erythema of demarcating, or be edema, surface is nervous shinny, and expansion rapidly towards periphery, and that touches has a hotness, tenderness is obvious, sometimes also can there is vesicle not of uniform size in skin lesion surface, can cause subcutaneous lymphatic vessel obstruction, hypertrophy and form rubber lower limb, and can be with regional glandular enlargement.Modern study is found, sends out speckle reason a lot, virus, antibacterial, intimately, daylight, freezing, worm stings (thorn), damaged by rats and multiple physics, chemical factor all can cause.
Sending out in the treatment of speckle, doctor trained in Western medicine there is no special-purpose specific medicament at present.And motherland's medical science is on the books to sending out speckle as far back as Han dynasty, in the 3rd piece of the deficient > > of < < gold: " YANG toxin syndrome be disease, flushed complexion is full of stains or spots as bright and beautiful stricture of vagina "; Wang Shuhe is on Zhong Jing " YANG toxin syndrome " basis, with Cimicifugae Decoction treatment " YANG toxin syndrome "; Black cream treatment macule for Ge Hong, etc.Hence one can see that, and the traditional Chinese medical science is sent out in speckle disease in treatment, has had long-term treatment experience.Therefore, with Chinese medicine, send out speckle at present and there is certain advantage.
Summary of the invention
The object of the present invention is to provide the good treatment of a kind of drug effect to send out the pharmaceutical composition of speckle, and its production and use.
The invention provides a kind for the treatment of and send out the pharmaceutical composition of speckle, it is the preparation that the crude drug by following weight proportion is prepared from:
Cornu Bubali 35-65 part or Cornu rhinocerotis 5-15 part, Gypsum Fibrosum 20-40 part, Rhizoma Anemarrhenae 8-16 part, Indigo Naturalis 10-20 part, Radix Scrophulariae 14-26 part, Radix Rehmanniae 14-26 part, Radix Paeoniae 10-20 part, Cortex Moutan 7-13 part, Fructus Gardeniae 8-16 part, Rhizoma Coptidis 8-16 part, Herba Artemisiae Annuae 17-31 part, Radix Ginseng 4-8 part, Radix Glycyrrhizae Preparata 3-7 part.
Further, it is the preparation being prepared from by the crude drug that contains following weight proportion:
Cornu Bubali 45-55 part or Cornu rhinocerotis 5-12 part, Gypsum Fibrosum 26-34 part, Rhizoma Anemarrhenae 10-14 part, Indigo Naturalis 13-17 part, Radix Scrophulariae 18-22 part, Radix Rehmanniae 18-22 part, Radix Paeoniae 13-17 part, Cortex Moutan 8-12 part, Fructus Gardeniae 10-14 part, Rhizoma Coptidis 10-14 part, Herba Artemisiae Annuae 22-26 part, Radix Ginseng 5-7 part, Radix Glycyrrhizae Preparata 4-6 part.
Further, it is the preparation being prepared from by the crude drug that contains following weight proportion:
50 parts of Cornu Bubalis or Cornu rhinocerotis 6-10 part, 30 parts, Gypsum Fibrosum, 12 parts of the Rhizoma Anemarrhenaes, 15 parts of Indigo Naturaliss, 20 parts of Radix Scrophulariaes, 20 parts of Radix Rehmanniae, 15 parts of Radix Paeoniaes, 10 parts of Cortex Moutans, 12 parts of Fructus Gardeniaes, 12 parts of Rhizoma Coptidis, 24 parts of Herba Artemisiae Annuaes, 6 parts of Radix Ginsengs, 5 parts of Radix Glycyrrhizae Preparatas.
Further, described Radix Paeoniae is the Radix Paeoniae Alba: the melange of ﹕ (1-2) w/w of Radix Paeoniae Rubra=(1-2).
Further preferably, the melange that described Radix Paeoniae is the Radix Paeoniae Alba: Radix Paeoniae Rubra=1:1w/w.
Wherein, described preparation is oral formulations.
Further, described oral formulations is granule, powder, pill, drop pill, capsule, soft capsule, tablet or oral liquid.
The present invention also provides the preparation method of aforementioned pharmaceutical compositions, and it comprises following operating procedure:
(1) by prescription weight proportion weighting raw materials;
(2) get Gypsum Fibrosum and be decocted first, then add each medicine except Herba Artemisiae Annuae, Cornu Bubali or Cornu rhinocerotis, decoct altogether, collect decocting liquid, then will again Cornu Bubali or Cornu rhinocerotis be beaten after powder or mill juice, add that pharmaceutically available adjuvant or complementary composition are prepared into conventional formulation.
The present invention also provides the purposes of aforementioned pharmaceutical compositions in the medicine of a preparation treatment speckle.
Further, described medicine is the medicine that treatment YANG toxin syndrome is sent out speckle.
Further, described YANG toxin syndrome is sent out that speckle is in pathogenic heat enters, is sent out speckle due to intense heat in the blood, the absurd row of forcing blood, excessive skin.
Generally acknowledged that at present " organic conception ", " determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs ", " compound recipe use ", " compound compatibility medication is as used military forces " are the most scientific the most several large advantages of the traditional Chinese medical science, wherein " compound compatibility medication is as used military forces " is the original theory of Chinese medicine of very science.Each medicine tight compatibility all linked with one another as arrayed troops for battle in traditional Chinese medical science prescription is its effective means that is better than Western medicine formula.Tcm prescription theory is thought, each prescription, not only need to select the appropriate compatibility of suitable medicine according to etiology and pathogenesis, also should meet the basic structure of prescription simultaneously, the i.e. prescription compatibility theory of " monarch, minister, help, make ", the prescription compatibility of so-called " monarch, minister, help, make " is exactly that it is based upon the scientific matching on the comprehensive judgement basis of disease pathogenesis.In medical square tube cross too many levels, many target spots and integrate the biological mechanism regulating, to sending out illness or the symptom of the such excessive noxious heat of speckle, regulate and control, can obtain better than Western medicine, more lastingly, therapeutic effect that more green natural has no side effect, and this curative effect is to be based upon on the accurate instruction of the original theory of above-mentioned traditional Chinese medical science tradition, prescription of the present invention is just being followed this principle.
In traditional Chinese medical science traditional theory, send out heresy that speckle mostly is pyretic toxicity offend cause, inward transmission of pathogenic heat, intense heat in the blood, the absurd row of forcing blood, excessive skin, can cause YANG toxin syndrome to send out speckle, meanwhile, in pathogenic heat enters, fills the air three warmers, also can there is levying of large hot severe restlessness in excessive heat in QI system.Therefore, according to the treatment principle of the traditional Chinese medical science, the present invention uses the method for eliminating fire and detoxication, cooling blood and dissolving purpura, and prescription is as pharmaceutical composition of the present invention.Indigo Naturalis be take as monarch drug in side, and the ministerial drug in the left halls such as Heshui Cornu Bovis seu Bubali, Radix Scrophulariae, Radix Rehmanniae is together brought into play the effect of removing pathogenic heat from blood and toxic substance from the body.Gypsum Fibrosum, the Rhizoma Anemarrhenae are the heat that the large clearing heat in QI system of ministerial drug in right hall divides.Left road adjuvant drug Radix Paeoniae and Cortex Moutan, not only removing heat from blood, and the speckle removing of invigorating blood circulation, can assist a ruler in governing a country Indigo Naturalis, Cornu Bubali, Radix Scrophulariae, Radix Rehmanniae and bring into play better effect.Right wing adjuvant drug Rhizoma Coptidis, Fructus Gardeniae, Herba Artemisiae Annuae, the former two's (Cape jasmine connect) eliminating fire and detoxication, and by the saturating soothing the liver effect of Herba Artemisiae Annuae liver heat removing, to let out liver-fire, is eliminating fire and detoxication, cooling blood for resolving macula effect with the compatibility such as Indigo Naturalis altogether.Radix Ginseng, Radix Glycyrrhizae Preparata two tastes make medicine inspire healthy energy, not only have the meaning of strengthening vital QI to eliminate pathogenic factors, go back all medicines of tunable for making.Below respectively organize flavour of a drug post clearly demarcated, complement each other, given full play to the sexology research methodology marrow of analyzing mentally as the exclusive compound compatibility medication Ru Pai army of Chinese medicine structures the formation, therefore can obtain good efficacy.
Inward transmission of pathogenic heat can effectively be eliminated or greatly alleviate to pharmaceutical composition of the present invention, intense heat in the blood, the absurd row of forcing blood, YANG toxin syndrome due to excessive skin is sent out speckle, and in pathogenic heat enters, fill the air three warmers, the TCM Syndrome Type such as large hot severe restlessness and symptom due to excessive heat in QI system, can cure to a certain extent its part primary disease, for clinical application provides a kind of new selection.
The specific embodiment
The preparation of embodiment 1 pharmaceutical composition of the present invention
Get 30 grams, Gypsum Fibrosum, 12 grams of the Rhizoma Anemarrhenaes, 15 grams of Indigo Naturaliss, 20 grams of Radix Scrophulariaes, 20 grams of Radix Rehmanniae, 50 grams of Cornu Bubalis, 15 grams of Radix Paeoniaes, 10 grams of Cortex Moutans, 12 grams of Fructus Gardeniaes, 12 grams of Rhizoma Coptidis, 24 grams of Herba Artemisiae Annuaes, 6 grams of Radix Ginsengs, 5 grams of Radix Glycyrrhizae Preparatas.Each flavour of a drug take according to quantity, mix with enough water purification, slow fire is decocted first Gypsum Fibrosum after 30 minutes to 60 minutes, add again each medicine except Herba Artemisiae Annuae, Cornu Bubali (to comprise the Indigo Naturalis powder that bundle, why with gauze, decocting a drug wrapped, is to avoid floating being stained with of powder to decoct ware surrounding, is fried boiling after 15～20 minutes, finally descend Herba Artemisiae Annuae (gauze parcel) to decoct again about 8 minutes, collect decocting liquid; Medicinal residues decoct with water 2 times again, merge each decocting liquid and call in Cornu Bubali or Cornu rhinocerotis smalls, obtain decoction.
Described Radix Paeoniae is that the Radix Paeoniae Alba and Radix Paeoniae Rubra are by the melange of 1 ﹕ 1 weight ratio.In the present invention, though Radix Paeoniae selects melange, but the alone Radix Paeoniae Alba or Radix Paeoniae Rubra also can, in < < Treatise on Febrile Diseases > >, < < Medical Treasures of the Golden Chamber > > without minute (Wang Qingqi of Radix Paeoniae Rubra, the Radix Paeoniae Alba, Zhang Zhongjing uses the rule analysis of Radix Paeoniae, Liaoning Journal of Traditional Chinese Medicine, 6 phases in 1984).
In we, Cornu Bubali also available Cornu rhinocerotis is replaced, and Cornu rhinocerotis drug effect is strong compared with Cornu Bubali, and Cornu rhinocerotis is protection of resources kind, and therefore, Cornu rhinocerotis is used as medicine with 1/5 to 1/8 dosage of Cornu Bubali.
The preparation of embodiment 2 pharmaceutical compositions of the present invention
Water intaking Cornu Bovis seu Bubali 35g, Gypsum Fibrosum 40g, Rhizoma Anemarrhenae 16g, Indigo Naturalis 20g, Radix Scrophulariae 26g, Radix Rehmanniae 26g, Radix Paeoniae 20g, Cortex Moutan 13g, Fructus Gardeniae 16g, Rhizoma Coptidis 16g, Herba Artemisiae Annuae 31g, Radix Ginseng 8g, Radix Glycyrrhizae Preparata 7g.Each flavour of a drug take according to quantity, mix with enough water purification, slow fire is decocted first Gypsum Fibrosum after 30 minutes to 60 minutes, add again each medicine except Herba Artemisiae Annuae, Cornu Bubali (to comprise the Indigo Naturalis powder that bundle, why with gauze, decocting a drug wrapped, is to avoid floating being stained with of powder to decoct ware surrounding), be fried boiling after 15～20 minutes, finally descend Herba Artemisiae Annuae (gauze parcel) to decoct again about 8 minutes, collect decocting liquid; Medicinal residues decoct with water 2 times again, after concentrating, then add Cornu Bubali powder and appropriate dextrin, granulate, and obtain granule.
The preparation of embodiment 3 pharmaceutical compositions of the present invention
Water intaking Cornu Bovis seu Bubali 65g, Gypsum Fibrosum 20g, Rhizoma Anemarrhenae 8g, Indigo Naturalis 10g, Radix Scrophulariae 14g, Radix Rehmanniae 14g, Radix Paeoniae 10g, Cortex Moutan 7g, Fructus Gardeniae 8g, Rhizoma Coptidis 8g, Herba Artemisiae Annuae 17g, Radix Ginseng 4g, Radix Glycyrrhizae Preparata 3g.Each flavour of a drug take according to quantity, mix with enough water purification, slow fire is decocted first Gypsum Fibrosum after 30 minutes to 60 minutes, add again each medicine except Herba Artemisiae Annuae, Cornu Bubali (to comprise the Indigo Naturalis powder that bundle, why with gauze, decocting a drug wrapped, is to avoid floating being stained with of powder to decoct ware surrounding), be fried boiling after 15～20 minutes, finally descend Herba Artemisiae Annuae (gauze parcel) to decoct again about 8 minutes, collect decocting liquid; Medicinal residues decoct with water 2 times again, after concentrating, then add Cornu Bubali powder and appropriate dextrin, granulate, encapsulated, obtain capsule.
The preparation of embodiment 4 pharmaceutical compositions of the present invention
Water intaking Cornu Bovis seu Bubali 55g, Gypsum Fibrosum 26g, Rhizoma Anemarrhenae 10g, Indigo Naturalis 13g, Radix Scrophulariae 18g, Radix Rehmanniae 18g, Radix Paeoniae 13g, Cortex Moutan 8g, Fructus Gardeniae 10g, Rhizoma Coptidis 10g, Herba Artemisiae Annuae 22g, Radix Ginseng 5g, Radix Glycyrrhizae Preparata 4g.Each flavour of a drug take according to quantity, mix with enough water purification, and slow fire is decocted first Gypsum Fibrosum after 30 minutes to 60 minutes, add again each medicine except Herba Artemisiae Annuae, Cornu Bubali, Indigo Naturalis, be fried boiling after 15～20 minutes, finally descend Herba Artemisiae Annuae (gauze parcel) to decoct again about 8 minutes, collect decocting liquid; Medicinal residues decoct with water 2 times again, after concentrating, then add Cornu Bubali powder, Indigo Naturalis and appropriate microcrystalline Cellulose, encapsulated, obtain capsule.
The preparation of embodiment 5 pharmaceutical compositions of the present invention
Water intaking Cornu Bovis seu Bubali 45g, Gypsum Fibrosum 26g, Rhizoma Anemarrhenae 14g, Indigo Naturalis 17g, Radix Scrophulariae 22g, Radix Rehmanniae 22g, Radix Paeoniae 17g, Cortex Moutan 12g, Fructus Gardeniae 14g, Rhizoma Coptidis 14g, Herba Artemisiae Annuae 26g, Radix Ginseng 7g, Radix Glycyrrhizae Preparata 6g.Each medicine, beats after powder, mixes, and prepares powder.
By test example, illustrate beneficial effect of the present invention below.
Clinical (outpatient service) treatment situation of test example 1 pharmaceutical composition of the present invention
(1) accept patient's situation for medical treatment
Gender and the range of age: contain men and women, old and young, but in the majority with teenager, possess following symptom feature, accept altogether 96 examples for medical treatment.
Symptom feature: obvious other omens of nothing or only conscious discomfort are sent erythema at some position of health then, how with large hot severe restlessness, red tongue, dry, rough and yellow fur, the symptoms such as the how loud sliding number of arteries and veins.Or occurring heating, shiver with cold, do not accommodating and feel sick after symptom, about a few hours to 1 day, send erythema, and the expansion of carrying out property, boundary clear.Some patients affected part Pi Wengao, anxiety, and there is scleroma and nonpitting edema, sending out speckle position has tenderness, causalgia, and lymphadenitis is accompanied or is not accompanied in the visible enlargement of lymph node nearby.Form is unicity sometimes, also has pleomorphism person, and can occur the hemorrhagic necrosis of pustule, vesicle or small size.Generally be apt to occur in shank, facial area, also send out in other places, general symmetry or limitation are asymmetric all visible, some dense distribution, and what have is dispersed in distribution, has the strip of being or band shape, also has along neural distribution person.But total feature is be not in the way (different from " rash ") of touching.
Above-mentioned symptom is a kind of pattern of syndrome conventionally, the heresy of pyretic toxicity offend cause, inward transmission of pathogenic heat, intense heat in the blood, the absurd row of forcing blood, excessive skin, can cause YANG toxin syndrome to send out speckle, meanwhile, in pathogenic heat enters, fills the air three warmers, can there is levying of large hot severe restlessness in excessive heat in QI system.
(2) treatment standard
Recovery from illness: above-mentioned symptom feature disappears completely, it is abnormal that check has no index of correlation.
Evident in efficacy: above-mentioned symptom obviously alleviates, test rating has certain degree to improve simultaneously.
There is certain effect: patient's symptom alleviates to some extent, or index is slightly improved.
Invalid: symptom still, do not improve by index.
(3) Therapeutic Method
1, the made decoction of embodiment 1, each serving with 200 to 400ml, or daily 1 bowl, the rice bowl used of having a meal (child dose by age cuts down according to the circumstance, take medicine by the preceding method dosing of cutting down according to the circumstance, but need to drink to add and day take number of times), every 4 hours to 6 hours, take once, take according to quantity on time.
2, note also science conditioning daily life, observe some necessary points for attention and (as: live a regular life; Like the clean anti-wound of paying attention to hygiene; Prevent contagious infection, and control as far as possible vector and potential host thereof; Strengthen care and the health care of skin, the strong probability of getting involved of the skin natural fibre line of meat reduces; Do not drink, smoke, do not eat or eat less the food of " heat-dissipating of getting angry " " the supporing yang risings " such as pungent frying, delicious food savoury and cattle and sheep Carnis Canitis, eat fresh, light and more nutritious food and vegetables and fruits group food more; Take a good rest, must guard against fatigue; Keep appropriate physical training, health invigorating; Keep one's hair on, get angry, the self-closing cloudy gas or depressed of irritating, keep pleasant with happy; Greening, beautified habitat environment, and made its health clean and tidy, door and window ventilates, and maintenance room air is fresh but can not room temperature too high or too low; Consolidate in time the state of an illness, prevent recurrence: after whole body and local transference cure, still must continue a few days of taking medicine, unsuitable drug withdrawal too early, and note protection original site, avoid unexpected and wound, worm stings, mosquito bite or firmly scratch).
(4) therapeutic outcome
Between many decades, in embodiment 1 medicine composite for curing primary disease men and women, old and young patient 96 examples (in the majority with teenager), obtained good curative effect.Treatment time, institute's difference according to the difference of the concrete conditions such as each conditions of patients weight, age size, physical strength and slightly, generally about 2 days～5 days, sending out speckle gets final product cancellation or obviously alleviates, 3 days to the 15 days various symptoms in left and right can entirely disappear and (after disappearing, still continue to take medicine 1 week, according to each patient's concrete condition, be kept to and take 1 time or 2 times every day), by above-mentioned science conditioning daily life, sincerely abide by points for attention, seldom recurrence.
By above-mentioned treatment standard, in 96 routine patients, there are 83 example recoveries from illness, cure rate reaches 86.5%; 9 routine effects are remarkable, reach 9.3%; 3 examples have certain effect, account for 3.1%; 1 routine DeGrain (invalid), accounts for 1.1%.Total effective rate reaches 98.9%.
Model case
Patient, man, 13 years old, student, patient feels uneasy, and occurs that fever with aversion to cold body oxysome levies, and is unable to bear scratching, and in the moment, extremity all send erythema, and the abdomen back of the body is also sent out.See its flushed face with red ears, declaration is not only hot but also tired, and both hands do not stop to scratch to scratch, upper and lower extremities all has comparatively dense erythema, and shirtfront, abdominal part, person's back are also dispersed in speckle, and boundary is distinct, that comforts is neither in the way, Pi Wenshang can, have no lymphadenectasis, dry tongue is red, yellow fur is alternate in vain, have a little small red dot, full and rapid pulse, examines as " YANG toxin syndrome is sent out speckle ".Give pharmaceutical composition of the present invention (embodiment 1 preparation), every 4 hours, take once, and sternly abide by science conditioning and the points for attention of above-mentioned " Therapeutic Method " they " 2 ".Patient takes medicine only 1 day, and speckle obviously alleviates, and excessive thirst is also extenuated to some extent, and still, pulse condition is loud for red tongue.Continue to take conditioning as front.Spend again 3, erythema is lost to the greatest extent, and excessive thirst is also eliminated substantially, the existing polishing of tongue, and red point has moved back, white and thin fur, faint and rapid pulse, so advise it to continue to take medicine 1 week, takes 1 time every day, thinks consolidation.By health check-up, have no Indexes Abnormality, follow up a case by regular visits to also not recurrence.
In sum, inward transmission of pathogenic heat can effectively be eliminated or greatly alleviate to pharmaceutical composition of the present invention, intense heat in the blood, the absurd row of forcing blood, the YANG toxin syndrome due to excessive skin is sent out speckle, and in pathogenic heat enters, fill the air three warmers, the TCM Syndrome Type such as the large hot severe restlessness due to excessive heat in QI system and symptom, can cure its part primary disease to a certain extent, for clinical application provides a kind of new selection.
Claims (10)
1. a pharmaceutical composition for speckle is sent out in treatment, it is characterized in that: it is the preparation that the crude drug by following weight proportion is prepared from:
Cornu Bubali 35-65 part, Gypsum Fibrosum 20-40 part, Rhizoma Anemarrhenae 8-16 part, Indigo Naturalis 10-20 part, Radix Scrophulariae 14-26 part, Radix Rehmanniae 14-26 part, Radix Paeoniae 10-20 part, Cortex Moutan 7-13 part, Fructus Gardeniae 8-16 part, Rhizoma Coptidis 8-16 part, Herba Artemisiae Annuae 17-31 part, Radix Ginseng 4-8 part, Radix Glycyrrhizae Preparata 3-7 part.
2. pharmaceutical composition according to claim 1, is characterized in that: it is the preparation that the crude drug by following weight proportion is prepared from:
Cornu Bubali 45-55 part, Gypsum Fibrosum 26-34 part, Rhizoma Anemarrhenae 10-14 part, Indigo Naturalis 13-17 part, Radix Scrophulariae 18-22 part, Radix Rehmanniae 18-22 part, Radix Paeoniae 13-17 part, Cortex Moutan 8-12 part, Fructus Gardeniae 10-14 part, Rhizoma Coptidis 10-14 part, Herba Artemisiae Annuae 22-26 part, Radix Ginseng 5-7 part, Radix Glycyrrhizae Preparata 4-6 part.
3. pharmaceutical composition according to claim 2, is characterized in that: it is the preparation that the crude drug by following weight proportion is prepared from:
50 parts of Cornu Bubalis, 30 parts, Gypsum Fibrosum, 12 parts of the Rhizoma Anemarrhenaes, 15 parts of Indigo Naturaliss, 20 parts of Radix Scrophulariaes, 20 parts of Radix Rehmanniae, 15 parts of Radix Paeoniaes, 10 parts of Cortex Moutans, 12 parts of Fructus Gardeniaes, 12 parts of Rhizoma Coptidis, 24 parts of Herba Artemisiae Annuaes, 6 parts of Radix Ginsengs, 5 parts of Radix Glycyrrhizae Preparatas.
4. according to the pharmaceutical composition described in claim 1～3 any one, it is characterized in that: described Radix Paeoniae is the Radix Paeoniae Alba: the melange of ﹕ (1-2) w/w of Radix Paeoniae Rubra=(1-2).
5. pharmaceutical composition according to claim 4, is characterized in that: described Radix Paeoniae is the melange of the Radix Paeoniae Alba: Radix Paeoniae Rubra=1:1w/w.
6. according to the pharmaceutical composition described in claim 1-5 any one, it is characterized in that: described preparation is oral formulations.
7. the preparation method of the pharmaceutical composition described in claim 1～3 any one, is characterized in that: it comprises following operating procedure:
(1) by prescription weight proportion weighting raw materials;
(2) get Gypsum Fibrosum and be decocted first, then add each medicine except Herba Artemisiae Annuae, Cornu Bubali, decoct altogether, rear lower Herba Artemisiae Annuae, collects decocting liquid, then Cornu Bubali is beaten after powder or mill juice, adds that pharmaceutically available adjuvant or complementary composition are prepared into conventional formulation.
8. the pharmaceutical composition described in claim 1～6 any one is treated the purposes in the medicine of sending out speckle in preparation.
9. purposes according to claim 8, is characterized in that: described medicine is the medicine that treatment YANG toxin syndrome is sent out speckle.
10. purposes according to claim 9, is characterized in that: described YANG toxin syndrome sends out that speckle is in pathogenic heat enters, send out speckle due to intense heat in the blood, the absurd row of forcing blood, excessive skin.
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