CN102861242A - Chinese medicine composition for preventing and treating dizziness and preparation method thereof - Google Patents
Chinese medicine composition for preventing and treating dizziness and preparation method thereof Download PDFInfo
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- CN102861242A CN102861242A CN2011101860957A CN201110186095A CN102861242A CN 102861242 A CN102861242 A CN 102861242A CN 2011101860957 A CN2011101860957 A CN 2011101860957A CN 201110186095 A CN201110186095 A CN 201110186095A CN 102861242 A CN102861242 A CN 102861242A
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Abstract
The invention discloses a novel Chinese medicine composition for treating vertigo, mainly comprising pinellia ternate, fried bighead atractylodes rhizome, gastrodia elata, rhizoma alismatis, acorus tatarinowii, radix bupleuri, radix scutellariae, uncaria, raw oyster shell, and radix cyathulae. The Chinese medicine composition disclosed herein is applied for treating vertigo which is caused by hypertensive, hypertension, cerebral arteriosclerosis, meniere's syndrome, transient ischemic attack, cerebral infarction, and cervical spondylosis, has the symptoms of dizziness, fullness in head or giddiness, is mainly paroxysmal, and can be accompanied by headache, nausea, vomit, tinnitus and deafness, eyes bulging, hot eyes, bitter taste, choking sensation in chest, soreness of waist, body tremor, even faint and the like, and the clinical curative effect is significant. According to the invention, by basically using a medicine having the homology of medicine and food prescribed in national formulary, the advantages of low cost, no obvious side effect, etc. are achieved.
Description
Technical field
The present invention relates to a kind ofly take Chinese herbal medicine as raw material and have the dizzy Chinese medicine composition for the treatment of, belong to technical field of Chinese medicines.
Background technology
Dizzy is one of clinical modal symptom of internal medicine, and dizzy is dim eyesight, and dizzy is dizzy, and the two normal while also sees, therefore be referred to as " dizzy ".The lighter closes order and namely ends; Severe one is such as ship by bus, and it is indefinite to rotate, can not stand, or with feel sick, vomiting, tinnitus, sweating, very then the symptom such as wish servant has a strong impact on Health and Living, the clinical onset rate has the trend of continuous rising in recent years.
Cause that dizzy kinds of Diseases are a lot, nearly hundreds of, particularly common with hypertension, hyperlipidemia, cerebral arteriosclerosis, Meniere disease, transient ischemic attack, cerebral infarction, cervical spondylosis etc.Although modern medicine in blood pressure lowering, blood fat reducing, improve targetedly medicine of the aspect such as cerebral ischemia, effect is not good enough improving aspect the clinical symptoms such as dizzy.How understanding that Traditional Chinese Medicine has " all wind trembling and dizziness all belong to liver ", " dizziness must be caused by phlegm ", " dizziness must be due to deficiency " etc. discussed from liver-wind, deficiency of kidney-essence, deficiency of qi and blood, endogenous fire, phlegm-damp etc. and controlled, and curative effect is in various degree arranged.Yet the dizzy pathogenesis of clinical findings is how comparatively complicated, and deficiency in origin, mark are real doublely to be seen, especially common to disturb on liver-wind stirring up internally, the folder expectorant stasis of blood, limited for the therapeutic effect of single pathogenesis.The present invention is based on the principle that the dizzy differential diagnosis of diseases of Chinese traditional treatment, Coryza Treated by Syndrome Differentiation combine, giving consideration to both the incidental and fundamental to take stopgap measures as main, is groped on the classics recipe basis, constantly simplifying sanction forms repeatedly, and clinical efficacy is remarkable, non-evident effect.
Summary of the invention
Technical problem to be solved by this invention is to overcome above-described shortcoming, provides a kind for the treatment of evident in efficacy, with low cost, few side effects dizzy Chinese medicine composition.
Technical problem to be solved by this invention is realized by following technical scheme.
On classics prescription basis, for " wind-phlegm " this crucial pathogenesis, by continuous practice, find out gradually the dizzy core prescription for the treatment of: the Rhizoma Pinelliae 5～30g, the Rhizoma Atractylodis Macrocephalae (stir-fry) 5～30g, Rhizoma Gastrodiae 5～60g, Rhizoma Alismatis 5～60g, Ramulus Uncariae Cum Uncis 5～60g, Concha Ostreae (life) 10～60g.Dizzy unclear, sleepy drowsiness person adds Rhizoma Acori Graminei 5～30g; Bitter taste is obvious, adds Radix Bupleuri 3～20g, Radix Scutellariae 3～20g; Facial flush, tongue are dark or the petechia ecchymosis is arranged, and add Radix Cyathulae 5～60g.Can use clinically this method and treat all kinds of dizzyly, have significant effect, have no apparent side effect.
Particularly, the present invention treats the core prescription of the Chinese medicine composition of vertiginous disorder, comprising: Rhizoma Pinelliae 5-30 part, the Rhizoma Atractylodis Macrocephalae (stir-fry) 5-30 part, Rhizoma Gastrodiae 5-60 part, Rhizoma Alismatis 5-60 divide, Ramulus Uncariae Cum Uncis 5-60 part, Concha Ostreae (life) 10-60 part.
Be preferably: Rhizoma Pinelliae 8-15 part, the Rhizoma Atractylodis Macrocephalae (stir-fry) 8-15 part, Rhizoma Gastrodiae 25-35 part, Rhizoma Alismatis 25-35 part, Ramulus Uncariae Cum Uncis 25-35 part, Concha Ostreae (life) 25-35 part.More preferably: 10 parts of the Rhizoma Pinelliaes, 12 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 30 parts in Rhizoma Gastrodiae, 30 parts of Rhizoma Alismatis, 30 parts of Ramulus Uncariae Cum Uncis, 30 parts of Concha Ostreaes (life).
Chinese medicine composition of the present invention, also can further comprise the crude drug weight proportion be in the Radix Cyathulae of the Radix Scutellariae of Radix Bupleuri, 3-20 part of Rhizoma Acori Graminei, 3-20 part of 5-30 part or 5-60 part any one or multiple.
Different patients with vertigo tends to show different external symptom, such as, some patients show as dizzy unclear, sleepy drowsiness; It is obvious that some patients then show as bitter taste; The patient who also has shows as Facial flush, tongue is dark or the petechia ecchymosis is arranged, and the patient for these outward manifestations differ can on the basis of above-mentioned core prescription, carry out the plus-minus of flavour of a drug.
Among the present invention, the Chinese medicine composition of described treatment vertiginous disorder also can be on the basis of core prescription, the Rhizoma Acori Graminei that further comprises the 5-30 weight portion, be preferably the Rhizoma Acori Graminei of 8-15 weight portion, the Rhizoma Acori Graminei of 12 weight portions more preferably is to be used for dizzy unclear, sleepy drowsiness patient.
Among the present invention, the Chinese medicine composition of described treatment dizziness, also can be on the basis of core prescription, further comprise the Radix Bupleuri of 3-20 weight portion, the Radix Scutellariae of 3-20 weight portion, be preferably the Radix Bupleuri of 8-15 weight portion, the Radix Scutellariae of 8-15 weight portion, the Radix Scutellariae of the Radix Bupleuri of 9 weight portions, 9 weight portions more preferably is to be used for the treatment of the obvious patients with vertigo of bitter taste.
The Chinese medicine composition of the dizziness for the treatment of described in the present invention, also can be on the basis of core prescription, the Radix Cyathulae that further comprises the 5-60 weight portion, be preferably the Radix Cyathulae of 10-20 weight portion, the Radix Cyathulae of 15 weight portions more preferably is to be used for the treatment of Facial flush, tongue is dark or the patients with vertigo of petechia ecchymosis is arranged.
For having dizzy unclear, the sleepy drowsiness and obvious patient of bitter taste concurrently, can be on the basis of the dizzy Chinese medicine composition for the treatment of of the present invention, further comprise Rhizoma Acori Graminei, Radix Bupleuri and Rhizoma Coptidis, described Rhizoma Acori Graminei is the 5-30 weight portion, and described Radix Bupleuri is that 3-20 weight portion, described Radix Scutellariae are the 3-20 weight portion.
For having dizzy unclear, sleepy drowsiness and Facial flush concurrently, tongue is dark or the patient of petechia ecchymosis being arranged, can be on the basis of the dizzy Chinese medicine composition for the treatment of of the present invention, further comprise Rhizoma Acori Graminei and Radix Cyathulae, described Rhizoma Acori Graminei is the 5-30 weight portion, and described Radix Cyathulae is the 5-60 weight portion.
For having bitter taste concurrently obviously and Facial flush, tongue is dark or the patient of petechia ecchymosis is arranged, can be on the basis of the dizzy Chinese medicine composition for the treatment of of the present invention, further comprise Radix Bupleuri, Radix Scutellariae and Radix Cyathulae, described Radix Bupleuri is the 3-20 weight portion, described Radix Scutellariae is the 3-20 weight portion, and described Radix Cyathulae is the 5-60 weight portion.
For having dizzy unclear, sleepy drowsiness, bitter taste concurrently obviously and Facial flush, tongue is dark or the patient of petechia ecchymosis is arranged, and can on the basis of former core prescription, further comprise Rhizoma Acori Graminei, Radix Bupleuri, Radix Scutellariae and Radix Cyathulae.
Further, the Chinese medicine composition that treatment of the present invention is dizzy mainly comprises the crude drug of following weight ratio example:
5～30 parts of the Rhizoma Pinelliaes, 5～30 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 5～60 parts in Rhizoma Gastrodiae, 5～60 parts of Rhizoma Alismatis, 5～30 parts of Rhizoma Acori Graminei, 3～20 parts of Radix Bupleuri, 3～20 parts of Radix Scutellariaes, 5～60 parts of Ramulus Uncariae Cum Uncis, 10～60 parts of Concha Ostreaes (life), 5～60 parts of Radix Cyathulaes.
Be preferably: Rhizoma Pinelliae 8-15 part, the Rhizoma Atractylodis Macrocephalae (stir-fry) 8-15 part, Rhizoma Gastrodiae 25-35 part, Rhizoma Alismatis 25-35 part, Rhizoma Acori Graminei 8-15 part, Radix Bupleuri 8-15 part, Radix Scutellariae 8-15 part, Ramulus Uncariae Cum Uncis 25-35 part, Concha Ostreae (life) 25-35 part, Radix Cyathulae 10-20 part.
More preferably: 10 parts of the Rhizoma Pinelliaes, 12 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 30 parts in Rhizoma Gastrodiae, 30 parts of Rhizoma Alismatis, 12 parts of Rhizoma Acori Graminei, 9 parts of Radix Bupleuri, 9 parts of Radix Scutellariaes, 30 parts of Ramulus Uncariae Cum Uncis, 30 parts of Concha Ostreaes (life), 15 parts of Radix Cyathulaes.
A further object of the present invention is to provide a kind of method for preparing prevention of the present invention and treatment vertiginous disorder Chinese medicine composition primary raw material medicine active component, and described method can comprise:
By the prescription weight proportion, weighting raw materials, polar solvent extracts 1-5 time, filters, and gets extracting solution, and extracting solution concentrating under reduced pressure, drying get final product to get described crude drug active component.
Particularly, the extracting method of crude drug active component of the present invention can be: by prescription proportioning weighting raw materials, be ground into coarse powder, merge, extract 3 times with water or aquiferous ethanol, filter, and merging filtrate, filtrate decompression is concentrated, and drying namely gets active component.
Among the present invention, the polar solvent that extracting method is used can be in water, methanol, ethanol, the acetone any one, or wherein arbitrarily several mixing, during mixing, is preferably the mixed solvent of water and ethanol, methanol or acetone.
Described extracting method can be to soak extraction method, water boiling and extraction method, solvent permeating extraction, reflux extraction or super critical extraction.
Among the present invention, described drying includes but not limited to vacuum drying or spray drying.
The preparation of active component of the present invention can also be directly described crude drug to be ground into fine powder, then directly takes the fine powder of pulverizing as the therapeutic activity composition.
A further object of the present invention is to provide a kind of preparation that contains crude drug active component of the present invention, and described preparation is oral formulations, as being oral liquid, capsule, granule, tablet etc.
Described preparation such as oral liquid, can refer to the preparation general designation of the liquid oral made, and decoction, the fill after directly decocting such as medical material becomes the low dose of oral liquid in the medicament reservoir, perhaps the mixture of the larger form of dosage etc.Capsule can be hard capsule preparation, also can be soft capsule.Tablet can be plain sheet, also can be coated tablet, such as sugar coating, gastric solubleness clothing, enteric coating etc.
When preparing preparation unit of the present invention, the present invention is extracted the effective ingredient of gained, add acceptable excipient in the pharmacy, adopt the preparation technique of this area routine, can prepare routine clinical required polarity.
Among the present invention, wherein excipient is for making the needed excipient of various dosage forms, as being filler, such as lactose, dextrin, microcrystalline cellulose, starch etc.; Disintegrating agent such as polyvinylpolypyrrolidone, cross-linking sodium carboxymethyl cellulose, carboxymethyl starch sodium etc., binding agent such as starch slurry, starch slurry sodium, hypromellose, polyvidone etc., surfactant such as dodecyl sodium sulfate, lubricant such as magnesium stearate, Pulvis Talci, Polyethylene Glycol etc., suspending agent, cosolvent, correctives, antiseptic etc. can also be arranged, specifically select any excipient collocation, decide according to the required preparation of making, when making common preparation, selecting which kind of excipient is that those skilled in the art just can know according to prior art.
The present invention is directed to the crucial pathogenesis of dizzy " wind, fire, expectorant, void ", in treatment dizzy four large classics recipes---on banxia baizhu tianma decoction, Rhizoma Alismatis soup, TIANMA GOUTENG YIN, the Herba Sidae Rhombifoliae soup basis, in conjunction with clinical experience repeatedly practise grope, innovation side that simplifying sanction forms.Rhizoma Gastrodiae suppressing the hyperactive liver and subsiding YANG, the endogenous wind stopping that reduces phlegm in the side, Rhizoma Pinelliae drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, Ramulus Uncariae Cum Uncis suppressing the hyperactive liver and subsiding YANG endogenous wind stopping is monarch drug altogether; Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae (stir-fry) invigorating spleen to remove dampness, with Du's the source of producing phlegm, Concha Ostreae (life) nourishing YIN for suppressing the hyperactive YANG, tranquillization with heavy prescription are ministerial drug altogether; The Rhizoma Acori Graminei refreshment of eliminating phlegm for resuscitation, to strengthen the merit of dampness removing, Radix Bupleuri Shugan Qingre, Radix Scutellariae heat clearing and damp drying removing heat from blood, the kind clear mutually fire of sun that lacks, and can prevent that fire caused by hyperactivity of liver-YANG and phlegm-damp accumulate the heat of giving birth to of a specified duration, Radix Bupleuri and Rhizoma Alismatis compatibility also have the merit of ascending the clear and descending the turbid, Radix Cyathulae invigorating the liver and kidney, blood circulation promoting and blood stasis dispelling, taking into account the trouble of deficiency in origin and the folder stasis of blood, is adjuvant drug altogether; The justice that it is descending that Radix Cyathulae still can be drawn heat in blood, and have " control wind and control first blood, blood wind is from going out " is held concurrently as making medicine.All medicines share, and play altogether the merit of the dampness removing that reduces phlegm, suppressing the hyperactive liver to relieve the wind syndrome, the heat clearing away of invigorating blood circulation, ascending the clear and descending the turbid.
The used herbal raw material medicine of the present invention all can be buied from the shop of Chinese medicines, and its specification meets national medical standard.
Primary treatment hypertension of the present invention, hyperlipidemia, cerebral arteriosclerosis, Meniere disease, transient ischemic attack, cerebral infarction, it is dizzy that cervical spondylosis outbreak etc. causes, show as giddy, feeling of fullness in the head or very dizzy sense, be ictal more, can be with headache, feel sick, vomiting, Hiccough and deaf, ophthalmic bloated, conjunctival congestion, bitter taste, gastral cavity painful abdominal mass uncomfortable in chest, the soreness of waist, limb tremor, very then lose consciousness the symptoms such as servant, various crude drug cooperatively interact, the common dampness removing that reduces phlegm of bringing into play, suppressing the hyperactive liver to relieve the wind syndrome, the heat clearing away of invigorating blood circulation, the effect of ascending the clear and descending the turbid, improve the evident in efficacy of dizzy symptom, and cheap, non-evident effect.
Therefore, a further object of the present invention is to provide crude drug compositions of the present invention to have utilization in the dizzy medicine that prevention and treatment hypertension, hyperlipidemia, cerebral arteriosclerosis, Meniere disease, transient ischemic attack, cerebral infarction, cervical spondylosis outbreak etc. cause in preparation.
In one embodiment of the present of invention, provide core prescription of the present invention and carried out the flavour of a drug plus-minus to the clinical treatment effect of the patients with vertigo of different symptoms at the core prescription, the core prescription reaches the flavour of a drug plus-minus that carries out at the core prescription all has good therapeutical effect to patients with vertigo, and total effective rate can be more than 90%.
In the enforcement of the present invention, provided the clinical treatment of the vertiginous disorder that Chinese medicine composition oral liquid of the present invention causes a variety of causes, in the 280 routine cases of investigating, cure rate can reach 50%, total effective rate can reach more than 93%, patients with vertigo is had preferably therapeutical effect, and its therapeutic effect is better than oral flunarizine.
Among the again embodiment of the present invention, provided the dizzy treatment that different reasons are caused, can reach more than 85% various dizzy total effective rates.
Among the also embodiment of the present invention, provide several model case patients' of the court's treatment follow-up observation, followed up a case by regular visits to the patient of healing, after the healing, the state of an illness all do not occurred repeatedly.
The specific embodiment
The present invention further illustrates by following embodiment, but any embodiment or its combination not should be understood to the restriction to scope of the present invention or embodiment.Scope of the present invention is limited by appended claims, and in conjunction with the general general knowledge of this description and this area, those of ordinary skills can clearly understand claims limited range.Under prerequisite without departing from the spirit and scope of the present invention, those skilled in the art can carry out any modification or change to technical scheme of the present invention, and this modification and change are also contained in the scope of the present invention.
Embodiment 1 Chinese prescription effective site of the present invention is extracted
30 parts of the Rhizoma Pinelliaes, 30 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 60 parts in Rhizoma Gastrodiae, Rhizoma Alismatis 60 minutes, 60 parts of Ramulus Uncariae Cum Uncis, 60 parts of Concha Ostreaes (life), every part is the 1kg meter by weight.
Take by weighing by weight medical material, be ground into coarse powder, with 10 times of amount alcohol reflux of 70% 3 times, filter, merging filtrate, filtrate decompression is concentrated, vacuum drying is pulverized, both active site.
Embodiment 2 ethanol percolate extraction methods are extracted effective site of the present invention
15 parts of the Rhizoma Pinelliaes, 15 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 35 parts in Rhizoma Gastrodiae, Rhizoma Alismatis 35 minutes, 35 parts of Ramulus Uncariae Cum Uncis, 35 parts of Concha Ostreaes (life), every part is the 1kg meter by weight.
Take by weighing by weight medical material, be ground into coarse powder, thin out to the percolate color with 10 times 60% ethanol percolate extraction, merge percolate, filtrate decompression is concentrated, and vacuum drying is pulverized, and has both got active site.
Embodiment 3 decocts extraction method and prepares effective site of the present invention
10 parts of the Rhizoma Pinelliaes, 12 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 30 parts in Rhizoma Gastrodiae, 30 parts of Rhizoma Alismatis, 30 parts of Ramulus Uncariae Cum Uncis, 30 parts of Concha Ostreaes (life), every part is the 1kg meter by weight.
Take by weighing by weight medical material, be ground into coarse powder, with 10 times of water boiling and extraction 3 times, filter, merging filtrate, filtrate decompression is concentrated, vacuum drying is pulverized, both active site.
Embodiment 4 soaks extraction method and prepares effective site of the present invention
8 parts of the Rhizoma Pinelliaes, 8 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 25 parts in Rhizoma Gastrodiae, 25 parts of Rhizoma Alismatis, 25 parts of Ramulus Uncariae Cum Uncis, 25 parts of Concha Ostreaes (life), every part is the 1kg meter by weight.
Take by weighing by weight medical material, be ground into coarse powder, with 12 times of water gagings immersions 12 hours, soak filtered, and so extracts three times, merges soaked extracting solution, and filtrate decompression is concentrated, and vacuum drying is pulverized, and has both got active site.
Embodiment 5 direct comminuting methods prepare active site of the present invention
5 parts of the Rhizoma Pinelliaes, 5 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 5 parts in Rhizoma Gastrodiae, 5 parts of Rhizoma Alismatis, 5 parts of Ramulus Uncariae Cum Uncis, 10 parts of Concha Ostreaes (life), every part is the 1g meter by weight.
Take by weighing medical material, mix, be ground into fine powder, fine powder is crossed 80 mesh sieves, both.
Embodiment 6
5 parts of the Rhizoma Pinelliaes, 5 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 5 parts in Rhizoma Gastrodiae, 5 parts of Rhizoma Alismatis, 5 parts of Ramulus Uncariae Cum Uncis, 10 parts of Concha Ostreaes (life), 5 parts of Rhizoma Acori Graminei, every part is the 1kg meter by weight.
30 parts of the Rhizoma Pinelliaes, 30 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 60 parts in Rhizoma Gastrodiae, Rhizoma Alismatis 60 minutes, 60 parts of Ramulus Uncariae Cum Uncis, 60 parts of Concha Ostreaes (life), 30 parts of Rhizoma Acori Graminei, every part is the 1kg meter by weight.
10 parts of the Rhizoma Pinelliaes, 12 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 30 parts in Rhizoma Gastrodiae, 30 parts of Rhizoma Alismatis, 30 parts of Ramulus Uncariae Cum Uncis, 30 parts of Concha Ostreaes (life), 12 parts of Rhizoma Acori Graminei, every part by 1kg.
Above each prescription, the method for pressing embodiment 1 is extracted preparation effective site.
Embodiment 7
5 parts of the Rhizoma Pinelliaes, 5 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 5 parts in Rhizoma Gastrodiae, 5 parts of Rhizoma Alismatis, 5 parts of Ramulus Uncariae Cum Uncis, 10 parts of Concha Ostreaes (life), 3 parts of Radix Bupleuri, 3 parts of Radix Scutellariaes, every part is the 1kg meter by weight.
30 parts of the Rhizoma Pinelliaes, 30 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 60 parts in Rhizoma Gastrodiae, Rhizoma Alismatis 60 minutes, 60 parts of Ramulus Uncariae Cum Uncis, 60 parts of Concha Ostreaes (life), 20 parts of Radix Bupleuri, 20 parts of Radix Scutellariaes, every part is the 1kg meter by weight.
10 parts of the Rhizoma Pinelliaes, 12 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 30 parts in Rhizoma Gastrodiae, 30 parts of Rhizoma Alismatis, 30 parts of Ramulus Uncariae Cum Uncis, 30 parts of Concha Ostreaes (life), 9 parts of Radix Bupleuri, 9 parts of Radix Scutellariaes, every part by 1kg.
Above each prescription extracts preparation effective site with the decocting cooking method.
Embodiment 8
5 parts of the Rhizoma Pinelliaes, 5 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 5 parts in Rhizoma Gastrodiae, 5 parts of Rhizoma Alismatis, 5 parts of Ramulus Uncariae Cum Uncis, 10 parts of Concha Ostreaes (life), 5 parts of Radix Cyathulaes, every part is the 1kg meter by weight.
30 parts of the Rhizoma Pinelliaes, 30 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 60 parts in Rhizoma Gastrodiae, Rhizoma Alismatis 60 minutes, 60 parts of Ramulus Uncariae Cum Uncis, 60 parts of Concha Ostreaes (life), 60 parts of Radix Cyathulaes, every part is the 1kg meter by weight.
10 parts of the Rhizoma Pinelliaes, 12 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 30 parts in Rhizoma Gastrodiae, 30 parts of Rhizoma Alismatis, 30 parts of Ramulus Uncariae Cum Uncis, 30 parts of Concha Ostreaes (life), 15 parts of Radix Cyathulaes, every part by 1kg.
Above each prescription extracts the preparation effective ingredient with percolation.
Embodiment 9
10 parts of the Rhizoma Pinelliaes, 12 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 30 parts in Rhizoma Gastrodiae, 30 parts of Rhizoma Alismatis, 30 parts of Ramulus Uncariae Cum Uncis, 30 parts of Concha Ostreaes (life), 12 parts of Rhizoma Acori Graminei, 9 parts of Radix Bupleuri, 9 parts of Radix Scutellariaes, every part by 1kg.
10 parts of the Rhizoma Pinelliaes, 12 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 30 parts in Rhizoma Gastrodiae, 30 parts of Rhizoma Alismatis, 30 parts of Ramulus Uncariae Cum Uncis, 30 parts of Concha Ostreaes (life), 9 parts of Radix Bupleuri, 9 parts of Radix Scutellariaes, 15 parts of Radix Cyathulaes, every part by 1kg.
10 parts of the Rhizoma Pinelliaes, 12 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 30 parts in Rhizoma Gastrodiae, 30 parts of Rhizoma Alismatis, 30 parts of Ramulus Uncariae Cum Uncis, 30 parts of Concha Ostreaes (life), 12 parts of Rhizoma Acori Graminei, 15 parts of Radix Cyathulaes, every part by 1kg.
Above each prescription extracts preparation effective site with water-extraction method.
The preparation of embodiment 10 granules of the present invention
Take by weighing: 5 parts of the Rhizoma Pinelliaes, 5 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 60 parts in Rhizoma Gastrodiae, Rhizoma Alismatis 50 minutes, 10 parts of Rhizoma Acori Graminei, 3 parts of Radix Bupleuri, 3 parts of Radix Scutellariaes, 60 parts of Ramulus Uncariae Cum Uncis, 60 parts of Concha Ostreaes (life), 50 parts of Radix Cyathulaes, every part is the 1kg meter by weight;
Perhaps, take by weighing: 30 parts of the Rhizoma Pinelliaes, 30 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 60 parts in Rhizoma Gastrodiae, Rhizoma Alismatis 50 minutes, 30 parts of Rhizoma Acori Graminei, 20 parts of Radix Bupleuri, 20 parts of Radix Scutellariaes, 60 parts of Ramulus Uncariae Cum Uncis, 60 parts of Concha Ostreaes (life), 60 parts of Radix Cyathulaes, every part is the 1kg meter by weight.
Each pulverizing medicinal materials becomes coarse powder, and mix homogeneously adds 10 times of water gagings and decocts and extract 3 times, and each 1.5h filters, merging filtrate, and 60 ℃ of filtrates are evaporated to density and are about 1.15 thick paste, get activity extract.
Above-mentioned activity extract adds acceptable excipient in the pharmacy, such as starch, microcrystalline Cellulose, and soft material processed, granulation, drying, granulate, packing namely get granule of the present invention.
The preparation of embodiment 11 tablets of the present invention
Take by weighing: 15 parts of the Rhizoma Pinelliaes, 15 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 35 parts in Rhizoma Gastrodiae, Rhizoma Alismatis 35 minutes, 15 parts of Rhizoma Acori Graminei, 15 parts of Radix Bupleuri, 15 parts of Radix Scutellariaes, 35 parts of Ramulus Uncariae Cum Uncis, 35 parts of Concha Ostreaes (life), 20 parts of Radix Cyathulaes, every part is the 1kg meter by weight.
Each pulverizing medicinal materials becomes coarse powder, and mix homogeneously adds 8 times and measures 60% ethanol, reflux, extract, 3 times, and each 2h filters, merging filtrate, 60 ℃ of concentrating under reduced pressure of filtrate, drying get activity extract.
Above-mentioned activity extract adds acceptable excipient in the pharmacy, such as lactose, microcrystalline Cellulose, sucrose, magnesium stearate, and soft material processed, granulation, drying, granulate, and then add magnesium stearate, tabletting namely gets tablet of the present invention.
The preparation of embodiment 12 capsules of the present invention
Take by weighing: 8 parts of the Rhizoma Pinelliaes, 8 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 25 parts in Rhizoma Gastrodiae, Rhizoma Alismatis 25 minutes, 8 parts of Rhizoma Acori Graminei, 8 parts of Radix Bupleuri, 8 parts of Radix Scutellariaes, 25 parts of Ramulus Uncariae Cum Uncis, 25 parts of Concha Ostreaes (life), 10 parts of Radix Cyathulaes, every part is the 1kg meter by weight.
Each pulverizing medicinal materials becomes coarse powder, and mix homogeneously adds 70% ethanol percolate extraction, and is thin out to the percolate color, merges the extracting solution of filtering, and 60 ℃ of concentrating under reduced pressure of filtrate, drying get activity extract.
Above-mentioned activity extract adds acceptable excipient starch in the pharmacy, and mix homogeneously in the hard capsule of packing into, namely gets capsule of the present invention.
The preparation of embodiment 13 oral liquids of the present invention
Take by weighing: 30 parts of the Rhizoma Pinelliaes, 30 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 10 parts in Rhizoma Gastrodiae, Rhizoma Alismatis 10 minutes, 5 parts of Rhizoma Acori Graminei, 20 parts of Radix Bupleuri, 20 parts of Radix Scutellariaes, 10 parts of Ramulus Uncariae Cum Uncis, 10 parts of Concha Ostreaes (life), 10 parts of Radix Cyathulaes, every part is the 1kg meter by weight.
Each pulverizing medicinal materials becomes coarse powder, and mix homogeneously adds 10 times of water gagings and soaks extraction 3 times, each 12h filters merging filtrate, 60 ℃ of filtrates are evaporated to density and are about 1.00 clear paste, leave standstill, and filter, get supernatant, add flavoring agent such as aspartame, antiseptic such as potassium sorbate, antioxidant such as sodium sulfite, mixing, canned, namely get oral liquid.
The preparation that embodiment 14 the present invention decoct decoction
10 parts of the Rhizoma Pinelliaes, 12 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 30 parts in Rhizoma Gastrodiae, 30 parts of Rhizoma Alismatis, 12 parts of Rhizoma Acori Graminei, 9 parts of Radix Bupleuri, 9 parts of Radix Scutellariaes, 30 parts of Ramulus Uncariae Cum Uncis, 30 parts of Concha Ostreaes (life), 15 parts of Radix Cyathulaes are pressed 1g for every part and calculate.
Above-mentioned medical material is merged, and 5 times of water gagings decoct twice, and each 0.5h filters, merging filtrate, and filtrate shakes up, and namely gets decoction.
The preparation of embodiment 15 powders of the present invention
5 parts of the Rhizoma Pinelliaes, 5 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 10 parts in Rhizoma Gastrodiae, 10 parts of Rhizoma Alismatis, 5 parts of Rhizoma Acori Graminei, 3 parts of Radix Bupleuri, 3 parts of Radix Scutellariaes, 10 parts of Ramulus Uncariae Cum Uncis, 10 parts of Concha Ostreaes (life), 10 parts of Radix Cyathulaes, every part by 1g.
Above-mentioned medical material mixes, and is ground into fine powder, crosses 80 mesh sieves, and gained fine powder packing namely gets powder of the present invention.
The different proportioning core prescriptions of embodiment 16 the present invention are to the therapeutical effect of dizzy model mice
Get firmly to set up and escape mice (the modeling list of references: Fu Jihua of clicking reflection, Yu Shuqin, Liu Jun, Deng. the foundation of Animal Model of Experimental Vertigo [J]. the journal .2002:508-520 of China Medicine University), at first measure postrotational escape before the administration and click reflex latency (rotating speed 390/min, each rotation 1min), measure altogether three times, interval 30min is measured twice in front and back, with administration 3 times the meansigma methods of measurement result as administration before the result, then use gastric infusion (ig) mode, be administered once every day, and the administration cycle is continuous 2 weeks, the incubation period of measuring the rear Reflex of escaping lightening stroke of rotation on the 120th minute after the last administration, the result is to identify mice group and dosage incubation period, latency the results are shown in Table 1, table 2.Each organizes weight fraction, and all by every part 1 gram, compositions is extracted preparation effective site according to boiling water extraction method, is concentrated into equal volume (concentrated volume is 35ml at last).
The different proportionings grouping of writing out a prescription of table 1 core
The different proportioning core prescriptions of table 2 the present invention are to the therapeutical effect of dizzy model mice
Compare * P＜0.05, * * P＜0.01 with the normal saline group.
From table 2 result, can find out, core prescription of the present invention, different proportionings all can shorten the incubation period of mice electric shock reflection, wherein remarkable with C group and D group effect, 120 minutes still can obviously shorten the incubation period that mice escapes electric shock after the last administration, compare with the normal saline group, difference has significance (P＜0.05), and relatively poor with the effect of A group, but compare than the normal saline group, also will shorten the incubation period that mice escapes electric shock.
Behind embodiment 17 the present invention sides of plus-minus, to the therapeutical effect of dizzy model mice
The fixing proportioning of core prescription, take weight ratio as: 10 parts of the Rhizoma Pinelliaes, 30 parts of 12 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 30 parts in Rhizoma Gastrodiae, 30 parts of Rhizoma Alismatis, 30 parts of Ramulus Uncariae Cum Uncis, Concha Ostreae (life) be basic prescription, add and subtract flavour of a drug on this prescription basis, grouping and to the therapeutical effect of dizzy mice see Table respectively 3, table 4.Each organizes parts by weight, and all by every part 1 gram, extracting method finally is concentrated into equal volume (35mL) with water boiling and extraction, and its dosage regimen, cycle, 120min measured the incubation period of rotating rear Reflex of escaping lightening stroke after the same last administration with embodiment 16.
The grouping of table 3 plus-minus flavour of a drug
Behind table 4 the present invention side of plus-minus, to the therapeutical effect of dizzy model mice
The normal saline group is compared, *＜0.05.
As seen from Table 4, after in the core prescription, adding and subtracting different flavour of a drug, 120min all can shorten the incubation period that the mice electric shock reflects after each organized the last administration, compare with the normal saline group, difference has significance (P＜0.05), and difference does not have significance but respectively add and subtract between the flavour of a drug each other, this may be with on the plus-minus of core prescription, to show thick other symptom of coming and add and subtract for dizzy, and to the unified mice of this dizzy modelling, no significant difference each other.
The clinical observation on the therapeutic effect test of embodiment 18 traditional Chinese medicine composition for treating patients with vertigo of the present invention
Below estimate Chinese medicine composition of the present invention to the therapeutic effect of vertiginous disorder from clinical medicine effect for treating, selected concrete compositions proportioning, should not be understood as restriction drug weight proportion of composing of the present invention, in conjunction with the general general knowledge in claims, description and this area, in the situation that do not depart from spirit and scope of the invention, those skilled in the art also can make any modification or change according to the following example, and this change is also contained in the scope of the invention.
From 2002, on classics prescription basis, for " wind-phlegm " this crucial pathogenesis, by continuous practice, find out gradually the dizzy core prescription for the treatment of: in every dose, Rhizoma Pinelliae 5-30g, the Rhizoma Atractylodis Macrocephalae (stir-fry) 5-30g, Rhizoma Gastrodiae 5-60g, Rhizoma Alismatis 5-60g, Ramulus Uncariae Cum Uncis 5-60g, Concha Ostreae (life) 10-60g is with core prescribed treatment dizziness due to wind-phlegm patient 115 examples, dosage is in above-mentioned scope, concrete body constitution according to different patients, Age and sex is suitably adjusted, and takes with the decoction that decocts, and takes at twice after the decoction in every dose minute, sooner or later service once, treatment cycle is 7-14 days, result, clinical cure 46 examples, produce effects 35 examples, effective 22 examples, invalid 13 examples, total effective rate is 89%.
Unclear, sleepy drowsiness dizzy with giddy for 67 examples, on the basis of above-mentioned core prescription, add Rhizoma Acori Graminei 5-30g and treat, dosage is in above-mentioned scope, concrete body constitution, Age and sex according to different patients are suitably adjusted, take with the decoction that decocts, take at twice after the decoction in every dose minute, sooner or later service once, treatment cycle is 7-14 days, as a result, effective 63 examples, totall effective rate in clinical treatment is 94%.
To 52 examples with the obvious patients with vertigo of bitter taste, basis at above-mentioned core prescription adds Radix Bupleuri 3-20g, Radix Scutellariae 3-20g treats, dosage is suitably adjusted according to different patients' concrete body constitution, Age and sex in above-mentioned scope, takes with the decoction that decocts, took at twice after decocting in every dose minute, sooner or later service once, treatment cycle is 7-14 days, the result, treat effective 48 examples, totall effective rate in clinical treatment is 92%.
Dark or petechia ecchymosis patients with vertigo arranged with Facial flush, tongue to 72 examples, adding Radix Cyathulae 5-60g on the basis of above-mentioned core prescription treats, dosage is suitably adjusted according to different patients' concrete body constitution, Age and sex in above-mentioned scope, takes with the decoction that decocts, took at twice after decocting in every dose minute, sooner or later service once, treatment cycle is 7-14 days, the result, treatment effectively is 69 examples, and totall effective rate in clinical treatment is 96%.
Treat in all kinds of patients with vertigo more than 300 examples in this method of above-mentioned clinical practice, obtain significant effect, have no apparent side effect, especially for hypertension, hyperlipidemia, cerebral arteriosclerosis, Meniere disease, transient ischemic attack, cerebral infarction, cervical spondylosis outbreak etc. to disturb dizzy into main pathogenesis on the wind-phlegm, effective percentage can reach more than 90%, 1 dose of short person namely has positive effect, and the elder approximately needed for 4 weeks, and average effective time is many at 7～14 doses.Then should not use we for dizzy due to anemia, hypotension and the weakness due to chronic disease.
Embodiment 19
Between 2003～2009 years, utilize medicine of the present invention to treat altogether patients with vertigo 280 examples, male 122 examples wherein, women 158 examples; 32～70 years old age; The course of disease is the longest 15 years, and is the shortest 14 days.Hypertension 60 examples, hyperlipemia 24 examples, cerebral arteriosclerosis 48 examples, Meniere disease 20 examples, transient ischemic attack 36 examples, 50 Cases of Cerebral Infarction, cervical spondylosis 42 examples.
" the disease of tcm Standardization of diagnosis and curative effect " that Department of Medical Administration of Diagnosis of Vertigo standard reference State Administration of Traditional Chinese Medicine promulgates: 1. have a dizzy spell, depending on the thing rotation, the lighter closes order and namely ends, and severe one very then falls forward such as ship by bus; 2. can accompany nausea and vomiting, nystagmus, Hiccough and deaf, sweating, pale complexion etc.; 3. chronic onset increases the weight of gradually, or Acute onset, or repeatedly outbreak; 4. measuring blood pressure, the pigment of having a blood test, red blood cell count(RBC) and electrocardiogram, electric audiometry, brainstem evoked potential, electronystagmogram and cervical X-ray are taken the photograph sheet,
Transcranial doppler, cranium brain CT, magnetic resonance examination etc. help clarifies a diagnosis; 5. tumor, intracranial infection, vestibular neuronitis and serious hematopathy etc. except.
Grouping and administration: 280 routine patients are divided into each 140 example for the treatment of group and matched group at random, under the basic treatments such as original blood pressure lowering, blood fat reducing, antiplatelet remain unchanged situation, and 1, treatment group: 140 examples, press Rhizoma Pinelliae 10g for every dose, the Rhizoma Atractylodis Macrocephalae (stir-fry) 12g, Rhizoma Gastrodiae 30g, Rhizoma Alismatis 30g, Rhizoma Acori Graminei 12g, Radix Bupleuri 9g, Radix Scutellariae 9g, Ramulus Uncariae Cum Uncis 30g, Concha Ostreae (life) 30g, Radix Cyathulae 15g decocts with water 2 times and makes decoction, takes at twice, sooner or later service once, take 2 weeks as 1 course for the treatment of, took altogether for 2 courses for the treatment of; 2, matched group: 140 examples, oral flunarizine 10mg, 1 time every night, take 2 weeks as 1 course for the treatment of, took altogether for 2 courses for the treatment of.
Therapeutic evaluation: with reference to " new Chinese medicine guideline of clinical investigations " and " disease of tcm Standardization of diagnosis and curative effect ".Clinical cure: dizzy and simultaneous phenomenon disappears substantially; Produce effects: dizzy and simultaneous phenomenon obviously alleviates, but orthobiosis and work; Effectively: dizzy and simultaneous phenomenon alleviates, but life and work are still to a certain degree affected.Invalid: symptom, sign are unchanged before and after the treatment.
Result: treatment group clinical cure 70 examples, produce effects 37 examples, effective 24 examples, no effect 9, total effective rate 93.6%; Matched group clinical cure 42 examples, produce effects 34 examples, effective 35 examples, invalid 29 examples, 79.3%, two group of total effective rate relatively has significant difference (P＜0.001), and treatment group is improved dizzy successful and is better than matched group, sees Table 5.
Dizzy curative effect comparative result due to different sick the kind is seen Table 6.
Table 5 liang group to dizzy general curative effect relatively
Annotate: compare P＜0.001 with matched group
Dizzy curative effect relatively due to table 6 liang group was planted different diseases
Model case:
1, patient Liu, woman, 45 years old, peasant.
The patient had the Meniere disease medical history 8 years, and each outbreak is felt dizzy, very dizzy, dare not be opened eyes, companion's hyperemesis, normal 1 week～10 day of continuing, very institute is bitter, and outbreak is frequent gradually in recent years, approximately showed effect once in 2～3 months, the persistent period extends to about 2 weeks gradually.This time because fatigue shows effect again, completed stroke is 2 days when medical, and is obviously dizzy, dare not open eyes, and Hiccough and deaf, nausea and vomiting, poor appetite, two just still transfer, and night, dormancys felt unwell, and light red tongue is fat indentation, and white and thin fur is little is bored with rolling pulse.
Take 2 doses of dizzy symptoms of we and namely obviously alleviate, vomiting ends, and Hiccough and deaf alleviates, and receives the food amelioration, and continuing took traditional Chinese medicine to 1 week, and all diseases disappear, just like ordinary person.Follow up a case by regular visits to after half a year, do not reaccess dizzy.
2, the patient shuts out certain, man, 66 years old, retired cadre.
The patient previously has hypertension, hyperlipemia, cerebral infarction medical history.Nearly one all paroxysms are dizzy, walk unstable, and oriented one rolls the gesture of falling, and can recover normal in lasting several minutes, completed stroke 3 times, and the persistent period prolongs gradually.Do cranium brain CT old cerebral infarction, without obvious new focus.The diagnosis transient ischemic attack.Obesity, gastral cavity uncomfortable in chest is swollen, soreness of waist tinnitus, the time cough up white expectorant, receive food still can, defecate partially dried, urine is normal, sleep normally night.
Take our 1 week, symptom namely obviously alleviates, and only shows effect in 1 week 1 time, and dizzy degree is front light, and the persistent period is also shorter.Take medicine after 4 weeks, the dizziness of not reaccessing, gastral cavity uncomfortable in chest is swollen and tinnitus is all taken a turn for the better, and white expectorant also obviously reduces.
3, patient poplar, man, 55 years old, cadre.
The patient had hypertension history more than 10 years, was up to 160/100mmHg, took at ordinary times captopril, controlling of blood pressure between 130～140/85～95mmHg, the time feel dizzy feeling of fullness in the head, a nearly week because of anger after dizziness increase the weight of, blood pressure has fluctuation, be up to 150/95mmHg, the headache of companion's feeling of fullness in the head, conjunctival congestion ophthalmic bloated, bitter taste, vexed, irascible temperament usually, receiving sleeps two just can.Body of the tongue is partially red, and yellow fur is little greasy, and stringy and rolling pulse is number slightly.
Take we's 1 all dizzy feeling of fullness in the heads and obviously alleviate, remaining disease is also taken a turn for the better to some extent, and blood pressure is many took for 4 weeks between 120～135/75～85mmHg, and all diseases disappear substantially, and blood pressure is normal.
4, patient Liu, woman, 68 years old, retired worker.
Recurrent dizziness more than 10 years previously had hypertension history 15 years, and controlling of blood pressure still can.Nearly dizziness in January increases the weight of, murky sense, and insobriety, obesity, sleepy drowsiness, poor appetite, two just transfer, and the fat of having a blood test is normal, and transcranial doppler cerebral blood flow diagram bilateral vertebral artery flow velocity is fast, the diagnosis cerebral arteriosclerosis.Take the expansion of cerebral vascular effect of drugs such as flunarizine, Betahistine not good enough.
Take our 2 weeks, dizzy and murky sense obviously alleviates, before spiritedness, receive the food amelioration, continuing took for 2 weeks, all diseases disappear substantially.
Claims (9)
1. treat dizzy Chinese medicine composition for one kind, it is characterized in that containing the crude drug of following weight proportion: Rhizoma Pinelliae 5-30 part, the Rhizoma Atractylodis Macrocephalae (stir-fry) 5-30 part, Rhizoma Gastrodiae 5-60 part, Rhizoma Alismatis 5-60 divide, Ramulus Uncariae Cum Uncis 5-60 part, Concha Ostreae (life) 10-60 part.
2. the dizzy Chinese medicine composition for the treatment of according to claim 1, it is characterized in that, described Chinese medicine composition also comprise the crude drug weight proportion be in the Radix Cyathulae of the Radix Scutellariae of Radix Bupleuri, 3-20 part of Rhizoma Acori Graminei, 3-20 part of 5-30 part or 5-60 part any one or multiple.
3. the dizzy Chinese medicine composition for the treatment of according to claim 2, the weight proportion of wherein said crude drug is: Rhizoma Pinelliae 8-15 part, the Rhizoma Atractylodis Macrocephalae (stir-fry) 8-15 part, Rhizoma Gastrodiae 25-35 part, Rhizoma Alismatis 25-35 part, Ramulus Uncariae Cum Uncis 25-35 part, Concha Ostreae (life) 25-35 part, Rhizoma Acori Graminei 8-15 part, Radix Bupleuri 8-15 part, Radix Scutellariae 8-15 part, Radix Cyathulae 10-20 part.
4. the dizzy Chinese medicine composition for the treatment of according to claim 3, the weight proportion of described crude drug is: 10 parts of the Rhizoma Pinelliaes, 12 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 30 parts in Rhizoma Gastrodiae, 30 parts of Rhizoma Alismatis, 30 parts of Ramulus Uncariae Cum Uncis, 30 parts of Concha Ostreaes (life), 12 parts of Rhizoma Acori Graminei, 9 parts of Radix Bupleuri, 9 parts of Radix Scutellariaes, 15 parts of Radix Cyathulaes.
5. a method for preparing the described Chinese medicine composition active component of any claim in the claim 1 to 4 comprises: by prescription weight proportion, weighting raw materials, polar solvent extracts 1-5 time, filters, and gets extracting solution, extracting solution concentrating under reduced pressure, drying get final product to get described crude drug active component.
6. method according to claim 5, wherein said polar organic solvent is the mixing of water or ethanol or ethanol water.
7. method according to claim 5, wherein said being extracted as soaked in extraction, water boiling and extraction, percolation extraction, reflux, extract, or the supercritical extraction any one.
8. contain the oral drug preparation of the described Chinese medicine composition of any claim among the claim 1-4, the dosage form of wherein said preparation includes but not limited to oral liquid, granule, capsule or tablet.
9. the described Chinese medicine composition of any claim has application in the medicine of prevention and the vertiginous disorder that caused by vascular hypertension, hyperlipidemia, arteriosclerosis, Menieres disease, transient ischemic attack disease, cerebral infarction disease or cervical vertebra disease for the treatment of in preparation among the claim 1-4.
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| CN105663200A (en) * | 2016-01-22 | 2016-06-15 | 王丹旎 | Traditional Chinese medicine combination for treating dizziness and preparation method and application thereof |
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| CN112741890B (en) * | 2021-02-03 | 2022-05-31 | 郴州市中医医院 | Traditional Chinese medicine composition for treating vertigo and preparation method thereof |
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