CN102846765B - Hawthorn vitamin C tablets and production method thereof - Google Patents
Hawthorn vitamin C tablets and production method thereof Download PDFInfo
- Publication number
- CN102846765B CN102846765B CN201210324701.1A CN201210324701A CN102846765B CN 102846765 B CN102846765 B CN 102846765B CN 201210324701 A CN201210324701 A CN 201210324701A CN 102846765 B CN102846765 B CN 102846765B
- Authority
- CN
- China
- Prior art keywords
- vitamin
- parts
- fructus crataegi
- tablet
- micropowder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention provides hawthorn vitamin C tablets and a production method thereof. The hawthorn vitamin C tablets are produced from the following components, by weight, 100-400 parts of hawthorn micropowder, 70-100 parts of vitamin C, 1-8 parts of vitamin B1, 1-3 parts of vitamin B2, 5-10 parts of vitamin B3, 1-3 parts of vitamin B5, 4-20 parts of an adhesive, and 9-32 parts of a lubricating agent, wherein the adhesive is hydroxypropyl methyl cellulose and povidone, and the lubricating agent is silicon dioxide and magnesium stearate. The present invention further provides a production method for the hawthorn vitamin. With the formula and the corresponding production method, the resulting product has double medicinal effects of the hawthorn and the vitamin C. In addition, a plurality of difficulties in vitamin C product preparation are overcome through the production method of the present invention, and the resulting finished product has excellent quality.
Description
Technical field
The present invention relates to technical field of Chinese patent medicine, refer to especially a kind of Fructus Crataegi vitamin C tablet, the invention still further relates to a kind of manufacture method of Fructus Crataegi vitamin C tablet.
Background technology
Fructus Crataegi energy angiocardiopathy preventing, there is blood vessel dilating, increase coronary flow, improve heart vigor, stimulating central nervous system system, reduce blood pressure and cholesterol, vessel softening and diuresis and sedation, Crataegolic acid also has cardiotonic, also helpful to senile heart disease, in addition, Fructus Crataegi can also appetite-stimulating indigestion-relieving, in a lot of digestant medicines, all adopt Fructus Crataegi, Fructus Crataegi also has effect of blood circulation promoting and blood stasis dispelling, contribute to remove local congestion state, traumatic injury is had to auxiliary curative effect, Fructus Crataegi has contraction to uterus, there is the effect expediting the emergence of just before giving birth time anemia of pregnant woman, and can promote uterine involution in puerperal, the generation of free radical is blocked and reduced to the substances such as the flavonoid that Fructus Crataegi is contained and vitamin C carotene, the immunity of enhancing body, have anti-aging, anticancer effect, in Fructus Crataegi, also contain to relieving asthma and reduce phlegm, anti-bacteria, the composition for the treatment of diarrhoea stomachache, vitamin C has the characteristic of synthetic collagen protein, and collagen protein is the important substrate that forms skeleton, tooth, soft tissue, skin and blood vessel, and vitamin C claims again ascorbic acid, can prevent that angiorrhexis is hemorrhage.Vitamin C participates in the detoxification processes of liver, and participates in vivo oxidation reduction reaction, is one of main material of antioxidation in human body, free radical resisting, and it participates in the synthetic of immunoglobulin, is conducive to body and improves immunocompetence.Reduce the infection chance of various pathogenic microorganisms, vitamin C promotes collagen protein synthesis, and effect of removing skin free radical, indirectly maintaining skin, the B same clan vitamin prescriptions such as vitamin B1, B2, nicotinic acid (B3), pantothenic acid (B5) have good health-care effect, have appetite-stimulating indigestion-relieving to improve heart vigor, blood circulation promoting improves the good action of the immunity of human body; At present, on market, Fructus Crataegi and vitamin C, for selling separately or selling as the component of other drug, do not combine both, fully by both effect combinations.
Summary of the invention
The present invention proposes a kind of Fructus Crataegi vitamin C tablet and preparation method thereof, and Fructus Crataegi vitamin C tablet of the present invention can reach better medicinal effects, meets medical demand.
Technical scheme of the present invention is achieved in that a kind of Fructus Crataegi vitamin C tablet, is made up of the component of following weight parts;
100～400 parts of Fructus Crataegi micropowder, 70～100 parts of vitamin Cs, VB11～8 part, 1～3 part of vitamin B2,5～10 parts of vitamin B3s, 1～3 part of vitamin B5,4～20 parts of binding agents, 9～32 parts of lubricants.
Further, described binding agent is hydroxypropyl emthylcellulose and polyvidone, and wherein, the content of described hydroxypropyl emthylcellulose is 1～5 part, and the content of described polyvidone is 3～15 parts.
Further, described lubricant is silicon dioxide and magnesium stearate, and wherein, the content of described silicon dioxide is 6～20 parts, and the content of described magnesium stearate is 3～12 parts.
Further, the fineness of described Fructus Crataegi micropowder is 180 order to 500 orders.
A manufacture method for Fructus Crataegi vitamin C tablet, comprises the following steps;
A, Fructus Crataegi roguing is cleaned up and drains moisture in water, in drying baker, dry to moisture below 2～4% for 60～100 DEG C, first coarse powder again micropowder, to 180-500 order, obtains described Fructus Crataegi micropowder, for subsequent use;
B, described vitamin B1, described vitamin B2, described vitamin B3, described vitamin B5, with described silicon dioxide grinding in ball grinder 1 hour, obtain mixed powder;
C, described hydroxypropyl emthylcellulose is made to 2%～2.5% hydroxypropyl emthylcellulose slurry, described polyvidone is made respectively 5%～11% polyvidone slurry, and then mix homogeneously obtains binding agent and mixes slurry, for subsequent use;
D, described Fructus Crataegi micropowder is added in Fastmixinggranulator, then add described mixed powder to mix 5 minutes;
E, add described binding agent to mix slurry wet mixing 2～5 minutes;
F, 12～24 orders granulations on oscillating granulator, then 70 DEG C ± 5 DEG C airpillow-dry, control moisture and are being less than 4%;
G, in three-dimensional mixer, add described vitamin C, mix and add described mix lubricant 15～30 minutes after 1～3 hour;
H, assay, determination of water, calculating tablet weight tablet, transparent membrane coating, packaging.
Beneficial effect of the present invention is: by Fructus Crataegi and vitamin C are combined and make tablet, can fully both beneficial functionals be combined, as the good medicine of preventing and curing diseases, and, vitamin C has and keeps in dark place, To Be Protected from Heat, the special natures such as the moisture absorption, conventional method step is loaded down with trivial details, end product quality is unstable, apt to deteriorate, and by formula provided by the invention and preparation method thereof, vitamin C, film-coated granular material, take described Radix Isatidis micropowder to mix slurry granulating process as diluent, select described silicon dioxide and described magnesium stearate as lubricant, and in room temperature, add vitamin C, thereby the described Fructus Crataegi VITAMIN C TABLET agent content obtaining is high, long shelf-life, do not add other any additives, technique is simple, easy to make.
Detailed description of the invention
For understanding better the present invention; below by an embodiment, the present invention is done to further concrete elaboration; but unintelligible is limitation of the invention; the foregoing invention content of some nonessential improvement and adjustment do according to to(for) those skilled in the art, be also considered as dropping in protection scope of the present invention.
A kind of Fructus Crataegi vitamin C tablet, made by the component of following weight parts:
100～400 parts of Fructus Crataegi micropowder, 70～100 parts of vitamin Cs, VB11～8 part, 1～3 part of vitamin B2,5～10 parts of vitamin B3s, 1～3 part of vitamin B5,4～20 parts of binding agents, 9～32 parts of lubricants.
Further, binding agent is hydroxypropyl emthylcellulose and polyvidone, and wherein, the content of hydroxypropyl emthylcellulose is 1～5 part, and the content of polyvidone is 3～15 parts.
Further, lubricant is silicon dioxide and magnesium stearate, and wherein, the content of silicon dioxide is 6～20 parts, and the content of magnesium stearate is 3～12 parts.
Further, the fineness of Fructus Crataegi micropowder is 180 order to 500 orders.
Then, we adopt the manufacture method of a kind of Fructus Crataegi vitamin C tablet provided by the present invention, carry out following manufacturing process:
A, Fructus Crataegi roguing is cleaned up and drains moisture in water, in drying baker, dry to moisture below 2% for 60 DEG C, first coarse powder again micropowder, to 180-500 order, obtains 292g Fructus Crataegi micropowder, for subsequent use;
B, by 4.2g vitamin B1,1.7g vitamin B2,8.3g vitamin B3,1.67g vitamin B5, with 6g silicon dioxide grinding in ball grinder 1 hour, obtain mixed powder;
C, 3g hydroxypropyl emthylcellulose is made to 2.2% hydroxypropyl emthylcellulose slurry, 12g polyvidone is made respectively 7% polyvidone slurry, and then mix homogeneously obtains binding agent and mixes slurry, for subsequent use;
D, Fructus Crataegi micropowder is added in Fastmixinggranulator, then add mixed powder to mix 5 minutes;
E, add binding agent to mix slurry wet mixing 3 minutes;
F, 24 orders granulations on oscillating granulator, then 70 DEG C ± 5 DEG C airpillow-dry, control moisture and are being less than 4%;
G, in three-dimensional mixer, add 83.3g vitamin C, mix and add described mix lubricant 20 minutes after 2 hours;
H, assay, determination of water, calculating tablet weight tablet, transparent membrane coating, packaging.
Embodiment 2
Weight portion composition and fabrication processing that we adopt the present invention to propose, obtained Fructus Crataegi vitamin C tablet 2, wherein, the ratio of each component is Fructus Crataegi micropowder 115g, vitamin C 72g, vitamin B12 .3g, vitamin B2 1.08g, vitamin B3 5.46g, vitamin B5 1.3g, hydroxypropyl emthylcellulose 1.2g, polyvidone 4.3g, silicon dioxide 6.9g, magnesium stearate 6.2g.
Embodiment 3
Weight portion composition and fabrication processing that we adopt the present invention to propose, obtained Fructus Crataegi vitamin C tablet 3, wherein, the ratio of each component is Fructus Crataegi micropowder 380g, vitamin C 99g, laetrile .9g, vitamin B2 2.98g, vitamin B3 9.6g, vitamin B5 3g, hydroxypropyl emthylcellulose 4.6g, polyvidone 14.3g, silica 1 8g, magnesium stearate 11g.
Fructus Crataegi vitamin C tablet 1, Fructus Crataegi vitamin C tablet 2 and Fructus Crataegi L-sorbose tablet 3 that we obtain by above three embodiment, have Fructus Crataegi and ascorbic double effects, and not containing additive, long shelf-life, processing technology is simple.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (5)
1. a Fructus Crataegi vitamin C tablet, is characterized in that, described Fructus Crataegi vitamin C tablet is made up of the component of following weight parts:
100～400 parts of Fructus Crataegi micropowder, 70～100 parts of vitamin Cs, 1～8 part of vitamin B1,1～3 part of vitamin B2,5～10 parts of vitamin B3s, 1～3 part of vitamin B5,4～20 parts of binding agents, 9～32 parts of lubricants.
2. Fructus Crataegi vitamin C tablet as described in claim 1, is characterized in that: described binding agent is hydroxypropyl emthylcellulose and polyvidone, wherein, the content of described hydroxypropyl emthylcellulose is 1～5 part, and the content of described polyvidone is 3～15 parts.
3. Fructus Crataegi vitamin C tablet as described in claim 1, is characterized in that: described lubricant is silicon dioxide and magnesium stearate, wherein, the content of described silicon dioxide is 6～20 parts, and the content of described magnesium stearate is 3～12 parts.
4. Fructus Crataegi vitamin C tablet as described in claim 1, is characterized in that: the fineness of described Fructus Crataegi micropowder is 180 order to 500 orders.
5. as the manufacture method of Fructus Crataegi vitamin C tablet as described in arbitrary in claim 1-4, it is characterized in that, comprise the following steps:
A, Fructus Crataegi roguing is cleaned up and drains moisture in water, in drying baker, dry to moisture below 2～4% for 60～100 DEG C, first coarse powder is micropowder to 180～500 order again, obtains described Fructus Crataegi micropowder, for subsequent use;
B, described vitamin B1, described vitamin B2, described vitamin B3, described vitamin B5, with described silicon dioxide grinding in ball grinder 1 hour, obtain mixed powder;
C, described hydroxypropyl emthylcellulose is made to 2%～2.5% hydroxypropyl emthylcellulose slurry, described polyvidone is made respectively 5%～11% polyvidone slurry, and then mix homogeneously obtains binding agent and mixes slurry, for subsequent use;
D, described Fructus Crataegi micropowder is added in Fastmixinggranulator, then add described mixed powder to mix 1～5 minute;
E, add described binding agent to mix slurry wet mixing 2～5 minutes;
F, 12～24 orders granulations on oscillating granulator, then 70 DEG C ± 5 DEG C airpillow-dry, control moisture and are being less than 4%;
G, in three-dimensional mixer, add described vitamin C, mix and add described mix lubricant 15～30 minutes after 1～3 hour;
H, assay, determination of water, calculating tablet weight tablet, transparent membrane coating, packaging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210324701.1A CN102846765B (en) | 2012-09-03 | 2012-09-03 | Hawthorn vitamin C tablets and production method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210324701.1A CN102846765B (en) | 2012-09-03 | 2012-09-03 | Hawthorn vitamin C tablets and production method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102846765A CN102846765A (en) | 2013-01-02 |
| CN102846765B true CN102846765B (en) | 2014-06-04 |
Family
ID=47394010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210324701.1A Expired - Fee Related CN102846765B (en) | 2012-09-03 | 2012-09-03 | Hawthorn vitamin C tablets and production method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102846765B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103315361B (en) * | 2013-07-15 | 2014-10-08 | 于法周 | Processing method for haw electuary |
| CN113663009A (en) * | 2020-05-13 | 2021-11-19 | 鹤壁市人民医院 | Pharmaceutical composition for regulating nerves as well as preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1104093A (en) * | 1994-07-25 | 1995-06-28 | 广州兴华制药厂 | Method for preparation of ferrous sulfate compound release-controlling preparation |
| CN102512520A (en) * | 2011-11-28 | 2012-06-27 | 河南省康星药业有限公司 | Normal-temperature preparation method for ultrafine powder hawthorn and special bilateral airflow sieving machine thereof |
-
2012
- 2012-09-03 CN CN201210324701.1A patent/CN102846765B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1104093A (en) * | 1994-07-25 | 1995-06-28 | 广州兴华制药厂 | Method for preparation of ferrous sulfate compound release-controlling preparation |
| CN102512520A (en) * | 2011-11-28 | 2012-06-27 | 河南省康星药业有限公司 | Normal-temperature preparation method for ultrafine powder hawthorn and special bilateral airflow sieving machine thereof |
Non-Patent Citations (1)
| Title |
|---|
| 王猛，等.超微粉碎山楂粉营养面包制作工艺研究.《粮食科技与经济》.2012,第37卷(第2期),第44-46页. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102846765A (en) | 2013-01-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103005445A (en) | Compound healthcare product capable of improving immunity | |
| CN102846765B (en) | Hawthorn vitamin C tablets and production method thereof | |
| CN104705642A (en) | Cordyceps militaris oral tablet and preparation method thereof | |
| CN104605334A (en) | Cordyceps sinensis oral tablet and preparation method thereof | |
| CN103585314A (en) | Hawthorn vitamin C tablet and production method thereof | |
| CN101920003B (en) | Traditional Chinese medicine composite for reducing fat and losing weight and preparation method thereof | |
| CN102961654B (en) | Traditional Chinese medicine composition for treating kidney stone as well as preparation method and application of composition | |
| CN102824368B (en) | Pearl vitamin C tablet and preparation method thereof | |
| CN102274346B (en) | Medicament or health food composition for preventing hypertension and preparation method and purpose thereof | |
| CN102150841A (en) | Instant herbal health-care medicament with function of enhancing immunity and preparation method thereof | |
| CN103719403A (en) | Gentian hepatolithiasis health-care tea | |
| CN104489200A (en) | Health and beauty-maintaining tea for middle aged and elderly people and preparation method of health and beauty-maintaining tea | |
| CN1203887C (en) | Traditional Chinese medicine for treating arthralgia and preparation process thereof | |
| CN101342285B (en) | Chinese medicinal composition for treating exterior trauma and preparation method thereof | |
| CN103157077A (en) | Ginger jujube pill | |
| CN106860687A (en) | One kind treats alcoholism and liver-protecting medicine composition | |
| CN103494894A (en) | Traditional Chinese medicine composition with effect of reducing blood sugar, as well as preparation method and application thereof | |
| CN102772596A (en) | Weight-losing and vein-dredging capsules and preparation technology thereof | |
| CN100396296C (en) | Deer bone calcium | |
| CN102526184A (en) | Xinkangtai orally disintegrating tablet and preparation method thereof | |
| CN100459982C (en) | Dispersible tablet of doxifluridine | |
| CN103877529A (en) | Formula and production process for medicinal liquor used for treating rheumatism | |
| CN105687707A (en) | Pharmaceutical composition for treating 'collapse syndrome' type stroke | |
| CN105596249A (en) | Anti-couperose skin traditional Chinese medicine extract and application thereof in skin care products | |
| CN1205963C (en) | Medicine for treating female ovarian cyst and preparation process thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| DD01 | Delivery of document by public notice |
Addressee: Sun Peixiong Document name: payment instructions |
|
| DD01 | Delivery of document by public notice | ||
| DD01 | Delivery of document by public notice |
Addressee: Sun Peixiong Document name: Notice of termination of patent right |
|
| DD01 | Delivery of document by public notice | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140604 Termination date: 20200903 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |