CN102824368B - Pearl vitamin C tablet and preparation method thereof - Google Patents
Pearl vitamin C tablet and preparation method thereof Download PDFInfo
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- CN102824368B CN102824368B CN201210324703.0A CN201210324703A CN102824368B CN 102824368 B CN102824368 B CN 102824368B CN 201210324703 A CN201210324703 A CN 201210324703A CN 102824368 B CN102824368 B CN 102824368B
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Abstract
The invention provides a pearl vitamin C tablet and a preparation method of the pearl vitamin C tablet. The pearl vitamin C tablet is prepared by the following components by weight: 100-600 parts of water-soluble pearl micro powder, 70-100 parts of vitamin C, 100-200 parts of oyster extract, 3-6 parts of vitamin B1, 1-3 parts of vitamin B2, 5-10 parts of vitamin B3, 1-3 parts of vitamin B5, 1-3 parts of vitamin B6, 9-20 parts of a bonding agent and 4-12 parts of a lubricating agent. The invention further provides the preparation method of the pearl vitamin C tablet, and the pearl vitamin C tablet prepared by using the method and a formula has double medicinal effects of pearl and vitamin C, simultaneously is excellent in other performances, and can have effects of preventing and treating diseases.
Description
Technical field
The present invention relates to technical field of Chinese patent medicine, refer to especially a kind of pearl vitamin C tablet, the invention still further relates to a kind of manufacture method of pearl vitamin C tablet.
Background technology
Margarita energy angiocardiopathy preventing, there is blood vessel dilating, increase coronary flow, improve heart vigor, stimulating central nervous system system, reduce blood pressure and cholesterol, vessel softening and diuresis and sedation, Margarita also has cardiotonic, also helpful to senile heart disease, in addition, Margarita can also appetite-stimulating indigestion-relieving, in a lot of digestant medicines, all adopted Margarita, Margarita also has the effect of blood circulation promoting and blood stasis dispelling, contribute to remove local congestion state, traumatic injury is had to auxiliary curative effect, Margarita has contraction to uterus, anemia of pregnant woman, there is the effect expediting the emergence of just before giving birth time, and can promote uterine involution in puerperal, the generation of free radical is blocked and reduced to the substances such as the flavonoid that Margarita is contained and vitamin C carotene, the immunity of enhancing body, have anti-aging, anticancer effect, in Margarita, also contain to relieving asthma and reduce phlegm, anti-bacteria, the composition for the treatment of diarrhoea stomachache, vitamin C has the characteristic of synthetic collagen protein, and collagen protein is the important substrate that forms skeleton, tooth, soft tissue, skin and blood vessel, and vitamin C claims again ascorbic acid, can prevent that angiorrhexis is hemorrhage.Vitamin C participates in the detoxification processes of liver, and participates in vivo oxidation reduction reaction, is one of main material of antioxidation in human body, free radical resisting, and it participates in the synthetic of immunoglobulin, is conducive to body and improves immunocompetence.Reduce the infection chance of various pathogenic microorganisms, vitamin C promotes collagen protein synthesis, and the effect of removing skin free radical, maintaining skin indirectly, the B same clan vitamin prescriptions such as vitamin B1, B2, nicotinic acid (B3), pantothenic acid (B5) have good health-care effect, have appetite-stimulating indigestion-relieving to improve heart vigor, blood circulation promoting improves the good action of the immunity of human body; At present, on market, Margarita and vitamin C, for selling separately or selling as the component of other drug, do not combine both, fully by both effect combinations.
Summary of the invention
The present invention proposes a kind of pearl vitamin C tablet and preparation method thereof, and pearl vitamin C tablet of the present invention can reach better medicinal effects, meets medical demand.
Technical scheme of the present invention is achieved in that a kind of pearl vitamin C tablet, by the component of following weight parts, is made:
100～600 parts of water-soluble pearl micropowders, 70～100 parts of vitamin Cs, 100～200 parts of Concha Ostreae extracts, 3～6 parts of vitamin B1s, 1～3 part of vitamin B2,5～10 parts of vitamin B3s, 1～3 part of vitamin B5,1～3 part of vitamin B6,9～20 parts of binding agents, 4～12 parts of lubricants.
Further, described binding agent is hydroxypropyl emthylcellulose and polyvidone, and wherein, the content of described hydroxypropyl emthylcellulose is 1～5 part, and the content of described polyvidone is 8～15 parts.
Further, described lubricant is silicon dioxide and magnesium stearate, and wherein, the content of described silicon dioxide is 2～6 parts, and the content of described magnesium stearate is 2～6 parts.
Further, the fineness of described water-soluble pearl micropowder is not less than 180 orders.
A manufacture method for pearl vitamin C tablet, comprises the following steps:
A, described polyvidone is made to 5%～11% glue, under stirring, slowly added described water-soluble pearl micropowder that it is dissolved, continue to be stirred to described water soluble Margarita ultrafine powder and all dissolve, obtain the first mixing slurry, standby;
B, described hydroxypropyl emthylcellulose is made to 2.5% slurry, added the first mixing slurry, mix homogeneously obtains the second mixing slurry, standby;
C, described vitamin B1, described vitamin B2, described vitamin B3, described vitamin B5, described vitamin B6 and described Concha Ostreae extract are joined in one-step-granulating method, set inlet temperature at 70～100 ℃, 45 ℃ of leaving air temps, discharge rate 100～500ml/ minute;
D, by described second, mix slurry and spray into corning in the material of boiling, after spraying, continue again dry 5 minutes;
E, discharging 12～24 orders on oscillating granulator are granulated, and control moisture and are being less than 4%;
F, in three-dimensional mixer, add described vitamin C, mix and add described mix lubricant 15～30 minutes after 1～3 hour;
G, assay, determination of water, calculating tablet weight, tablet agent, transparent membrane coating, packing.
Beneficial effect of the present invention is: by water soluble Margarita ultrafine powder and vitamin C are combined and make tablet, can fully both beneficial functionals be combined, as the good medicine of preventing and curing diseases, and, vitamin C has and keeps in dark place, To Be Protected from Heat, the special natures such as the moisture absorption, conventional method step is loaded down with trivial details, end product quality is unstable, apt to deteriorate, and by formula provided by the invention and preparation method thereof, vitamin C, film-coated granular material, take described water-soluble pearl micropowder to mix slurry granulating process as diluent, select described magnesium stearate and described silicon dioxide as lubricant, and when mixing, room temperature adds described vitamin C, thereby the described pearl vitamin C tablet content obtaining is high, long shelf-life, do not add other any additives, and the hardness of tablet is greater than 5KG, disintegration is less than 10 minutes, technique is simple, easy to make.
The specific embodiment
For understanding better the present invention; below by an embodiment, the present invention is done to further concrete elaboration; but unintelligible is limitation of the invention; some nonessential improvement and adjustment of for those skilled in the art, according to foregoing invention content, doing, be also considered as dropping in protection scope of the present invention.
A pearl vitamin C tablet, by the component of following weight parts, made:
100～600 parts of water-soluble pearl micropowders, 70～100 parts of vitamin Cs, 100～200 parts of Concha Ostreae extracts, 3～6 parts of vitamin B1s, 1～3 part of vitamin B2,5～10 parts of vitamin B3s, 1～3 part of vitamin B5,1～3 part of vitamin B6,9～20 parts of binding agents, 4～12 parts of lubricants.
Further, binding agent is hydroxypropyl emthylcellulose and polyvidone, and wherein, the content of hydroxypropyl emthylcellulose is 1～5 part, and the content of polyvidone is 8～15 parts.
Further, lubricant is silicon dioxide and magnesium stearate, and wherein, the content of silicon dioxide is 2～6 parts, and the content of magnesium stearate is 2～6 parts.
Further, the fineness of water-soluble pearl micropowder is 180 order to 500 orders or thinner.
Then, we adopt the manufacture method of a kind of pearl vitamin C tablet that the present invention proposes, and carry out following operating process:
A, 12g polyvidone is made to 9% glue, under stirring, slowly added 500g water-soluble pearl micropowder that it is dissolved, continue to be stirred to described water soluble Margarita ultrafine powder and all dissolve, obtain the first mixing slurry, standby;
B, 3g hydroxypropyl emthylcellulose is made to 2.5% slurry, added the first mixing slurry, mix all and obtain second and mix slurry, standby;
C, 4.16g vitamin B1,1.67g vitamin B2,8.3g vitamin B3,1.67g vitamin B5,1.68g vitamin B6 and 150g Concha Ostreae extract are joined in one-step-granulating method, set inlet temperature at 85 ℃, 45 ℃ of leaving air temps, discharge rate 400ml/ minute;
D, the second mixing slurry is sprayed into corning in the material of boiling, after spraying, continue again dry 5 minutes;
E, discharging 24 orders on oscillating granulator are granulated, and control moisture and are being less than 4%;
F, in three-dimensional mixer, add 83.3g vitamin C, mix and add described mix lubricant 25 minutes after 1.5 hours;
G, assay, determination of water, calculating tablet weight, tablet agent, transparent membrane coating, packing.
Embodiment 2
We adopt processing technology proposed by the invention and the proportioning of component, obtain pearl vitamin C tablet 2, wherein, the ratio of each component is Margarita micropowder 120g, vitamin B1 3g, vitamin B2 1.2g, vitamin B6 1.2g, vitamin B3 5.6g, vitamin B5 1.1g, vitamin C 72g, Concha Ostreae extract 108g, hydroxypropyl emthylcellulose 1.3g, polyvidone 8.6g, silicon dioxide 2.4g, magnesium stearate 2g.
Embodiment 3
We adopt processing technology proposed by the invention and the proportioning of component, obtain pearl vitamin C tablet 3, wherein, the ratio of each component is Margarita micropowder 600g, vitamin B1 5.9g, vitamin B2 3g, vitamin B6 3g, vitamin B3 9.9g, vitamin B5 2.8g, vitamin C 98g, Concha Ostreae extract 198g, hydroxypropyl emthylcellulose 4.6g, polyvidone 14g, silicon dioxide 4.8g, magnesium stearate 5.3g.
Pearl vitamin C tablet 1, pearl vitamin C tablet 2 and pearl vitamin C tablet 3 that by above three embodiment, we obtain, all there is Margarita and ascorbic double effects, can better play a role, simultaneously, we record its long shelf-life, surpass 2 years, and hardness is greater than 5KG, disintegration is less than 10 minutes etc., and properties is excellent.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (3)
1. a pearl vitamin C tablet, is characterized in that, described pearl vitamin C tablet is made by the component of following weight parts:
100～600 parts of water-soluble pearl micropowders, 70～100 parts of vitamin Cs, 100～200 parts of Concha Ostreae extracts, vitamin B
13～6 parts, vitamin B
21～3 part, vitamin B
35～10 parts, vitamin B
51～3 part, vitamin B
61～3 part, 9～20 parts of binding agents, 4～12 parts of lubricants, described binding agent is hydroxypropyl emthylcellulose and polyvidone, and wherein, the content of described hydroxypropyl emthylcellulose is 1～5 part, and the content of described polyvidone is 8～15 parts; Described lubricant is silicon dioxide and magnesium stearate, and wherein, the content of described silicon dioxide is 2～6 parts, and the content of described magnesium stearate is 2～6 parts.
2. pearl vitamin C tablet as described in claim 1, is characterized in that: the fineness of described water-soluble pearl micropowder is not less than 180 orders.
3. as the manufacture method of pearl vitamin C tablet as described in arbitrary in claim 1-2, it is characterized in that, comprise the following steps:
A, described polyvidone is made to 5%～11% glue, under stirring, slowly added described water-soluble pearl micropowder that it is dissolved, continue to be stirred to described water soluble Margarita ultrafine powder and all dissolve, obtain the first mixing slurry, standby;
B, described hydroxypropyl emthylcellulose is made to 2.5% slurry, added the first mixing slurry, mix homogeneously obtains the second mixing slurry, standby;
C, by described vitamin B
1, described vitamin B
2, described vitamin B
3, described vitamin B
5, described vitamin B
6join in one-step-granulating method with described Concha Ostreae extract, set inlet temperature at 70～100 ℃, 45 ℃ of leaving air temps, discharge rate 100～500ml/ minute;
D, by described second, mix slurry and spray into corning in the material of boiling, after spraying, continue again dry 5 minutes;
E, discharging 12～24 orders on oscillating granulator are granulated, and control moisture and are being less than 4%;
F, in three-dimensional mixer, add described vitamin C, mix and add described mix lubricant 15～30 minutes after 1～3 hour;
G, assay, determination of water, calculating tablet weight, tablet agent, transparent membrane coating, packing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210324703.0A CN102824368B (en) | 2012-09-03 | 2012-09-03 | Pearl vitamin C tablet and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210324703.0A CN102824368B (en) | 2012-09-03 | 2012-09-03 | Pearl vitamin C tablet and preparation method thereof |
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| Publication Number | Publication Date |
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| CN102824368A CN102824368A (en) | 2012-12-19 |
| CN102824368B true CN102824368B (en) | 2014-11-05 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201210324703.0A Expired - Fee Related CN102824368B (en) | 2012-09-03 | 2012-09-03 | Pearl vitamin C tablet and preparation method thereof |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1853654A (en) * | 2005-04-29 | 2006-11-01 | 浙江山下湖珍珠集团股份有限公司 | Oral preparation containing pearl and vitamine |
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2012
- 2012-09-03 CN CN201210324703.0A patent/CN102824368B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1853654A (en) * | 2005-04-29 | 2006-11-01 | 浙江山下湖珍珠集团股份有限公司 | Oral preparation containing pearl and vitamine |
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| Publication number | Publication date |
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| CN102824368A (en) | 2012-12-19 |
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