CN1028409C - Produciton of chinese medicine "Xulu" liquid and its equipment - Google Patents

Abstract

The present invention discloses a preparation method for 'xiluye' which is a traditional Chinese medicine and processing equipment thereof. The method takes java brucea fruit, common scouring rush herb, lightyellow sophora root, heartleaf houttuynia herb, lithospermum, common herons bill herb, prairie milk vetch, armadillidium vulgare, giant knotweed rhizome and borneol as raw materials which are extracted by organic solvent, such as petroleum ether and ethanol to obtain effective components of the java brucea fruit, the common scouring rush herb, the lightyellow sophora root, the heartleaf houttuynia herb, the lithospermum, the common herons bill herb, the prairie milk vetch, the armadillidium vulgare, the giant knotweed rhizome and the borneol. Then, glycerol, peanut oil, ethanol, paraffin wax, vaseline, etc. are added, mixed and prepared to prepare the 'xiluye' which is a traditional Chinese medicine. The equipment is composed of a heating leaching kettle, a leacher, a condenser, a transfusion bucket (or a pump) and a cooling cabinet, and is used for extracting the effective components of the raw materials of the present invention.

Description

Produciton of chinese medicine "Xulu" liquid and its equipment

The present invention relates to a kind of production method and production equipment thereof of middle medicine hoping liquid.The novel technology for extracting that belongs to Chinese crude drug.

The treatment condyloma acuminatum generally adopts two class methods at present: the one, and physical method comprises excision, freezing and laser ablation; The 2nd, the medicine embolic chemotherapy comprises and uses trichloroacetic acid, ZUYECAO acid etc.But these two kinds of methods exist a lot of shortcomings: for the many condyloma acuminatum patients of big, the sharp body quantity of area, operation, laser, medicine chemotherapy all can not once be carried out (1), must repeatedly carry out, with the problems of avoiding wound area to bring greatly; (2) postoperative and medicine chemotherapy wound convalescent period are long; (3) clinical zest is strong, and pain is strong, and side effect is big; (4) accompanying infection, easily recurrence; (5) condyloma acuminatum of woman vagina infection is difficult to operation and medicine chemotherapy; (6) must be at hospital's internal therapy, the patient can not oneself treat.In order to address the above problem, the application provides a kind of middle medicine hoping liquid for the treatment of condyloma acuminatum.

The object of the present invention is to provide a kind of production method and production equipment thereof for the treatment of the middle medicine hoping liquid of condyloma acuminatum, to overcome the existing problem of treatment condyloma acuminatum in the prior art.

The present invention is achieved in that

One, material choice:

Fructus Bruceae, Herba Equiseti Hiemalis, Radix Sophorae Flavescentis, Herba Houttuyniae, Radix Arnebiae (Radix Lithospermi), Herba Erodii, Herba Violae, Armadillidium, Rhizoma Polygoni Cuspidati, Borneolum Syntheticum.

Two, extraction process flow process: (using equipment of the present invention)

1,, puts into medicinal cupping (filling medicinal cupping) with after the pulverizing medicinal materials

2, solution is injected heating kettle, the quantity of solution should be 3 times of leacher capacity.

3, heating kettle uses the liquor boiling temperature to be controlled in the specified scope by name.

4, solvent is heated to boiling point, and its steam enters leacher, rises to cooler bin and becomes liquid, flows back in the leacher.

5, when liquid rises to widely different stream pipe suitable for reading, widely different flowing back in the heating kettle.

6, the solution of acquisition, through concentrating under reduced pressure, it is standby that the steam of solvent becomes liquids recovery through cooling cabinet.

7, the medicine leaching liquid of Huo Deing is drawn through mozzle, and is standby.

Three, the concrete extraction process of raw material:

1, the extraction of Oleum Fructus Bruceae:

(1) Fructus Bruceae is pulverized in the powder charge batch can, placed in the leacher;

(2) be that 60 ℃-90 ℃ petroleum ether is injected in the heating kettle with boiling point;

(3) heating kettle is heated to 90 ℃, keeps constant temperature;

(4) after reflux for several times (general 8 times to 10 times), stop heating;

(5) open the transfusion valve, allow solution vapor enter cooling cabinet through tube for transfusion and be condensed into liquid the recovery, the Oleum Fructus Bruceae of acquisition is drawn through mozzle, and is standby.

Its leaching process is:

Fructus Bruceae is pulverized (petroleum ether)/(backflow) (decompression)/(concentrating) (cooling)/(water) Oleum Fructus Bruceae

2, the extraction of other drug:

(1) other drug is pulverized, in the spice jar in the leacher of packing into;

(2) 77 ℃ of-79 ℃ of ethanol of boiling point inject heating kettle;

(3) temperature with heating kettle is controlled at 79 ℃, keeps constant temperature;

(4) stop heating through the widely different stream of several (8-10 time).

(5) open the transfusion valve, allow solvent vapour enter the condensation cabinet, be cooled to liquid the recovery through tube for transfusion.The medicine leaching liquid that obtains is drawn through mozzle, and is standby.

Four, allotment:

The leaching liquid of above-mentioned each composition is obtained extractum through concentrating under reduced pressure

Oleum Fructus Bruceae 8-12%, Herba Equiseti Hiemalis's extractum 4-6%

Herba Houttuyniae extractum 4-6%, Radix Sophorae Flavescentis extractum 8-12%

Radix Arnebiae (Radix Lithospermi) extractum 4-6%, Herba Violae extractum 4-6%

Armadillidium extractum 4-6%, geranium extract 4-6%

Rhizoma Polygoni Cuspidati extractum 4-6%, Borneolum Syntheticum 2-6%

Other (Oleum Arachidis hypogaeae semen, glycerol, ethanol) 40-50%

According to different needs above-mentioned composition is deployed into liquor, ointment, distillate medicinal water, suppository or spray.

Oleum Arachidis hypogaeae semen in the above-mentioned prescription, glycerol and ethanol are also different because of the different uses of dosage form.

Above-mentioned composition is mixed with liquor, only use ethanol, account for 46%, and without Oleum Arachidis hypogaeae semen and glycerol, usefulness vaseline 26% and Oleum Arachidis hypogaeae semen 20% and, can be mixed with ointment without glycerol and ethanol; Only cooperate with active ingredient and can be formulated into distillate medicinal water with ethanol, water and glycerol; Mix to can be formulated into suppository with paraffin 36%, Oleum Arachidis hypogaeae semen 10% with active ingredient, mix can be formulated into spray by ethanol with active ingredient.

Five, description of equipment:

Be preparation product of the present invention, the present invention has also designed a kind of equipment that is used to prepare product of the present invention, and as shown in drawings, Arabic numerals representative structure title wherein is as follows:

1, coolant outlet 2, cooling water intake 3, cooler bin 4, widely different stream pipe 5, thermometer 6, liquid level meter 7, the dustproof valve 8 of automatic and adjustable decompression, coil 9, condenser 10, spice jar 11, leacher 12, check valve 13, connection tube 14, Pressure gauge 15, tube for transfusion 16, immersion still 17, zone of heating 18, heat-insulation layer 19, mozzle 20, coolant outlet 21, cooling cabinet 22, cooling water inlet 23, container 24, transfusion bucket (or pump)

Specifically details are as follows (and with reference to accompanying drawing) for each structure composition, function, operation sequence and annexation

A, heating leaching still

1, equipment: amount (immersion still) (16) volume is 30,000 milliliters (looking the volume of production decision) in (1)

(2) middle level is zone of heating (17), and the employing steam heats up (coil) or electricity heats up, oil heats up all can.

(3) outermost layer is heat-insulation layer (18)

(4) optional equipment of immersion still has:

(1) liquid level meter (6): the position and the volume of liquid in the indication still

(2) thermometer (5): the temperature of indication heating

(3) Pressure gauge (14): the pressure in the indication still.

(4) tube for transfusion (15) (double as solvent gasification fairlead) links with transfusion bucket (24).

(5) speed position pipe (13) is connected with the leacher of top.

(6) mozzle (19) is used for container is injected in the medicinal liquid drain.

2, effect: (1) is used for solvent is heated.Become steam.

(2) be used for the solution of leaching is distilled, reclaim solution.

3, operating console: (summary) is switch cubicle

4, operation sequence:

(1) after the switch (valve) of opening tube for transfusion and transfusion bucket injects in the immersion still by transfusion bucket (or pump) solution, closes above valve.

(2) volume of solvent is determined in the position of record liquid level meter.

(3) heat up after opening valve on the last connection tube with leacher.

(4) observe intensification situation and pressure at any time, among the inscription record.

Operation (controlling) under constant temperature when (5) reaching assigned temperature with thermoregulator.

(6) at any time the position of (regularly per half an hour) record liquid level meter.

(7) (number of times in accordance with regulations) stops to heat when widely different stream reaches more than eight times.

(8) open the tube for transfusion valve, allow solution vapor enter cooling cabinet and reclaim by transfusion.

B, leacher: (11)

1, equipment: (1) inner capacities is 10,000 milliliters (looking the volume of production decision)

(2) be built-in with the usefulness that aperture Sheng medical material is arranged on the bucket (jar) (10)

(3) optional equipment:

1, return duct (4): the end opening that is connected with leacher suitable for reading is connected with connecting piece (13).

2, globe valve (12) is in the leacher bottom

2, effect: the steam of (1) solvent enters the condenser at top by spice by leacher.Becoming liquid through condensation falls after rise in the leacher.

(2) through the immersion of steam and solvent, the stripping medicinal liquid when solution rises to return duct suitable for reading, utilizes pressure reduction to be back in the immersion still to spice in leacher.

(3) through steam cooling leaching repeatedly

→ liquefaction → backflow.Composition in the medical material is collected in the immersion still by leaching.

3, operation sequence:

(1) opens spherical check valve.

(2) open the convex head of leacher, spice is poured in the spice jar.End socket is put.

C, condenser: (9)

1, equipment (1) coil (8) end opening is connected with tee T with leacher.

(2) open top suitable for reading has the dustproof valve (7) of automatic and adjustable decompression

(3) outside has cooler bin (3) that water inlet (2) and outlet (1) are arranged

2, effect: the steam of (1) solvent becomes liquid return in leacher after entering coil under the effect of cooling water.

D, transfusion bucket (or pump) (24)

Equipment: connect the transfusion bucket on tube for transfusion, (or pump) (24) are poured solvent into and are utilized pressure to inject immersion still (16) automatically or add armored pump in the bucket to squeeze into still, close the check valve door after the injection.

E, cooling cabinet (21)

1, equipment: (1) cooling tube: middle unload to connect with several balls mouthful be connected with defeated liquid-in pipe, in the end opening feeding vessel port.

(2) cooling cabinet (21) is established in the outside, and water inlet (22) and outlet (20) are arranged.

(3), the steam of container (23) solvent is standby after cooling cabinet becomes liquid injecting container.

Product Xulu liquid of the present invention compared with prior art has outstanding advantage and good effect.By the clinical proof of several large hospitals, easy to use, to the non-stimulated non-corrosiveness of skin, therapeutic effect is good, but, many wart patient equal seance big to area, and it has antiinflammation, there is not the rotten to the corn problem that infects in the treatment, to original rotten to the corn effect (1-2 days) that rapid healing is arranged that infects; Little for illness position zest, the patient suffering is little, and treatment back preventing from scar does not recur.And the condyloma acuminatum patient can oneself use Xulu liquid to treat, and is safe and reliable, solved the requirement that the patient hides one's sickness for fear of treatment.Product of the present invention has solved easily recurrence of condyloma acuminatum, large tracts of land, multi-section position can not one-time treatment, the treatment difficulty is big and the woman vagina patient is difficult to operation.Can not use a series of problems such as original medicine chemotherapy, the effect that it has dampness, antiinflammatory, blood stasis dispelling, strips off voluntarily, the non-stimulated no burn into of normal skin is had no side effect, has the effect that increases different rapidly abnormal cell tissue of eliminating, to multiple viral pathogenic bacteria, pathogenic microorganism all has powerful killing action, therefore has exploitation and is worth.

Embodiment: Fructus Bruceae is pulverized in the powder charge batch can, place in the leacher, the injection boiling point is 60-90 ℃ a petroleum ether in heating kettle, heating kettle is heated to 90 ℃, keep constant temperature, reflux through 8-10 time, after stop to heat, open the transfusion valve, allow solvent vapour enter cooling cabinet and be condensed into liquid the recovery through tube for transfusion.Oleum Fructus Bruceae is drawn standby through mozzle.With Herba Equiseti Hiemalis, Radix Sophorae Flavescentis, Herba Swertiae davidi, Radix Arnebiae (Radix Lithospermi), Herba Erodii, Herba Violae, Armadillidium, Rhizoma Polygoni Cuspidati pulverize separately, in the spice jar in the leacher of packing into, the injection boiling point is 77 ℃-79 ℃ a ethanol in heating kettle again.The temperature of heating kettle is controlled at 79 ℃ of maintenance constant temperature,, stops heating, open the transfusion valve, allow solvent vapour enter the condensation cabinet, be cooled to liquid the recovery through tube for transfusion through 8-10 widely different stream.The Chinese medicine leaching liquid is flowed out by mozzle through concentrating under reduced pressure, and reconcentration becomes extractum, presses Oleum Fructus Bruceae 10% then, Herba Equiseti Hiemalis's extractum 5%, Herba Houttuyniae extractum 5%, Radix Sophorae Flavescentis extractum 10%, Radix Arnebiae (Radix Lithospermi) extractum 5%, Herba Violae extractum 5%, Armadillidium extractum 5%, geranium extract 5%, Rhizoma Polygoni Cuspidati extractum 5%, Borneolum Syntheticum 4% Oleum Arachidis hypogaeae semen, glycerol and ethanol totally 46% ratio are modulated, and make product.

Claims (4)

1, a kind of external preparation method of Chinese medicine, it is characterized in that with Fructus Bruceae, Herba Equiseti Hiemalis, Herba Houttuyniae, Radix Sophorae Flavescentis, Radix Arnebiae (Radix Lithospermi), Herba Violae, Armadillidium, Herba Erodii, Rhizoma Polygoni Cuspidati, Borneolum Syntheticum be raw material, by using organic solvent Petroleum ether extraction Oleum Fructus Bruceae, effective ingredient with ethanol extraction Herba Equiseti Hiemalis, Herba Houttuyniae, Radix Sophorae Flavescentis, Radix Arnebiae (Radix Lithospermi), Herba Violae, Armadillidium, Herba Erodii, Rhizoma Polygoni Cuspidati gets extracting solution, behind concentrating under reduced pressure, get extractum, add Borneolum Syntheticum, mixed preparing forms after adding Oleum Arachidis hypogaeae semen or glycerol or ethanol or paraffin or vaseline again, and the proportioning of each effective ingredient is during mixing:

Oleum Fructus Bruceae B-12% Herba Equiseti Hiemalis extractum 4-6%

Herba Houttuyniae extractum 4-6% Radix Sophorae Flavescentis extractum 8-12%

Radix Arnebiae (Radix Lithospermi) extractum 4-6% Herba Violae extractum 4-6%

Armadillidium extractum 4-6% geranium extract 4-6%

Rhizoma Polygoni Cuspidati extractum 4-6% Borneolum Syntheticum 2-6%

Oleum Arachidis hypogaeae semen, glycerol, ethanol is 40-50% altogether

2, according to the method for claim 1, the proportioning of each effective ingredient is when it is characterized in that mixing:

Oleum Fructus Bruceae 10% Herba Equiseti Hiemalis's extractum 5%

Herba Houttuyniae extractum 5% Radix Sophorae Flavescentis extractum 10%

Radix Arnebiae (Radix Lithospermi) extractum 5% Herba Violae extractum 5%

Armadillidium extractum 5% geranium extract 5%

Rhizoma Polygoni Cuspidati extractum 5% Borneolum Syntheticum 4%

Oleum Arachidis hypogaeae semen, glycerol, ethanol totally 46%

3,, it is characterized in that said Oleum Arachidis hypogaeae semen, glycerol, ethanol can replace with paraffin or vaseline according to the method for claim 1 or 2.

4, a kind of Chinese medicine extraction equipment, it is characterized in that it is by heating leaching still (16), leacher (11), condenser (9), transfusion bucket (or pump) (24) and condensation cabinet (21) are formed, heating leaching still is by immersion still (16), zone of heating (17) and heat-insulation layer (18) are formed, and have a liquid level meter (6), thermometer (5), piezometer (14), be connected by connection tube (13) and leacher above, have conduit (19) below, and link to each other with cooling cabinet by tube for transfusion (15), transfusion bucket (or pump) (24) are housed on the tube for transfusion, the built-in bucket of leacher (jar) (10), aperture is arranged above, link to each other with heating leaching still below by connecting piece (13), and globe valve (12) is housed in leacher bottom, return duct (4) is suitable for reading to link to each other with leacher, end opening links to each other with heating leaching still, condenser (9) is made up of coil (8) and cooler bin (3), the bipass of the end opening of coil and leacher (11) usefulness links, upper opening, and the dustproof valve (7) of automatic and adjustable decompression is arranged at the top, there is cooler bin (3) outside, link to each other with outlet (1) with the import (2) of cooling water, cooling cabinet (21) leaches still by tube for transfusion (15) and heating and links to each other, in several spheroidal cooling tubes are arranged, suitable for readingly be connected with tube for transfusion, end opening feeds in the container (23), and cooling cabinet is established in the outside, links to each other with outlet (20) with cooling water inlet (22).

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