CN102836288B - Magnetic Chinese medicine dressing for treating scars and preparation method of same - Google Patents
Magnetic Chinese medicine dressing for treating scars and preparation method of same Download PDFInfo
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- CN102836288B CN102836288B CN201210340472.2A CN201210340472A CN102836288B CN 102836288 B CN102836288 B CN 102836288B CN 201210340472 A CN201210340472 A CN 201210340472A CN 102836288 B CN102836288 B CN 102836288B
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Abstract
The invention relates to a magnetic Chinese medicine dressing for treating scars, which consists of a medicine film protective layer, a medicine film layer, a magnetic layer and a lining layer which are sequentially arranged. The dressing is prepared by the following steps: 1, preparing a Chinese medicine extract and a substrate and mixing to prepare a medicine film paste; 2, preparing the magnetic layer; 3, preparing the lining layer; and 4, preparing the dressing, packaging and disinfecting. The magnetic Chinese medicine dressing is suitable for all scar patients and has the characteristics of precise and fast therapeutic effect, convenience, low price, no adverse reaction or toxic side effect and the like. Due to the built-in magnetic layer, the dressing can improve partial microcirculation, increase vascular permeability, accelerate the repair of benign fibroblast hyperplasia and alleviate scars through a magnetic field generated by the magnetic layer.
Description
Technical field
The present invention relates to external dressing medicine field, be specifically related to a kind of magnetic Chinese medicinal dressing for the treatment of cicatrix and preparation method thereof.
Background technology
Cicatrix is the mode of appearance of caused normal skin tissue and the general designation of tissue pathologies change after various wounds, and it is product inevitable in human body processes of wound repair.In a broad sense, do not have scar tissue just there is no the healing of wound yet.But cicatrix growth surpasses certain limit, and various complication will occur, such as the destruction of profile and functional activity obstacle etc., brings huge human body misery and psychic pain to patient, the cicatrix of especially burning, leaving over after scald, severe trauma.Both at home and abroad the world of medicine has carried out long-term a large amount of experimentation, from tissue, is deep into cell, molecule and gene level safe, the method safely and effectively to finding can shorten the damage phase, promote wound healing.The method of using at present mainly contains: oral drug therapy, injection of drug, laser therapy etc., oral drug therapy and injection of drug are dispelled cicatrix of skin can produce certain side effect and untoward reaction, as headache, stomachache, feel sick, vomiting etc., it is more expensive that cicatrix of skin expense is dispelled in laser therapy, therapeutic effect is undesirable, there is in various degree pigmentation or de-mistake in above-mentioned therapy simultaneously after treatment, and what have also can produce the situations such as recurrence, regeneration.
Summary of the invention
The object of the invention is the deficiency for solving the problems of the technologies described above, a kind of magnetic Chinese medicinal dressing for the treatment of cicatrix and preparation method thereof is provided, magnetic Chinese medicinal dressing is for the restorative treatment of various cicatrixs, esy to use, safe and reliable, have no side effect, effective ingredient is difficult for scattering and disappearing, coordinating magnetosphere therapeutic effect better, is a kind of comparatively desirable scar treatment medicine.
The present invention is the deficiency solving the problems of the technologies described above, the technical scheme adopting is: a kind of magnetic Chinese medicinal dressing for the treatment of cicatrix, the medicine film overcoat, medicine film layer, magnetosphere and the backing layer that successively arrange, consist of, medicine film layer, magnetosphere and backing layer are fixedly connected with; Described medicine film overcoat and the area of backing layer are equal, and the area of magnetospheric area and medicine film layer is equal, and the area of backing layer is greater than magnetospheric area; Described medicine film layer is comprised of non-woven fabrics and the medicine film cream spreading upon on non-woven fabrics, and the smearing thickness of medicine film cream is 0.5～5mm; Described medicine film overcoat is single silicon release paper, and single silicon release paper is covered with silicone oil with the one side that the medicine film cream of medicine film layer contacts; Described backing layer is non-woven fabrics, at backing layer, towards the periphery of magnetospheric one side, is provided with a circle adhesive sticker, and the width of adhesive sticker is 2～5 ㎝;
Described medicine film cream is comprised of Chinese medicine extract and substrate, and the percentage by weight of Chinese medicine extract and substrate is: Chinese medicine extract 30～50%, substrate 50～70%;
The crude drug of described Chinese medicine extract is by Radix Salviae Miltiorrhizae, Galla Chinensis, Herba speranskiae tuberculatae, itea orientalis Hemsl., Rheum forrestii Diels, Radix et Rhizoma Rhei Wittrockii, Semen Persicae, Radix Genkwa, Radix Desmodii Caudati, vinegar Pyritum (processed), eupolyphaga, Hirudo, Borneolum Syntheticum, Camphora, Olibanum and Myrrha form, the ratio of weight and number that each medical material adds is respectively: 50～70 parts of Radix Salviae Miltiorrhizaes, 50～70 parts of Galla Chinensiss, 20～40 parts of Herba speranskiae tuberculataes, 20～40 parts of itea orientalis Hemsl., 50～70 parts of Rheum forrestii Diels, 50～70 parts of Radix et Rhizoma Rhei Wittrockiis, 20～40 parts, Semen Persicae, 20～40 parts of Radix Genkwa, 50～70 parts of Radix Desmodii Caudatis, 20～40 parts of vinegar Pyritum (processed), 20～40 parts of eupolyphaga, 20～40 parts of Hirudos, 8～15 parts of Borneolum Syntheticums, 8～15 parts of Camphoras, 20～40 parts of 20～40 parts of Olibanums and Myrrhas,
Described substrate is comprised of polyvidone, glycerol, micropowder silica gel, purified water, chitosan, polyvinyl alcohol and tablet vinegar, and the ratio of weight and number that each raw material adds is respectively: 40～70 parts of 5～10 parts of polyvidones, 30～50 parts of glycerol, 15～40 parts of micropowder silica gels, 8～15 parts of chitosans, 1～5 part of polyoxyethylene alcohol, 5～10 parts of tablet vinegar and purified water;
The bafta that magnetized in magnetic field is dried and be placed in to described magnetosphere, for the suspension dipping through magnetic powder and chitosan,, and the bafta after magnetization has the magnetic field intensity of 50～200mT;
Described magnetic powder is to add dysprosium Dy element in Nd-Fe-B/ α-Fe matrix phase, magnetic powder consist of Nd
xfe
yb
zdy
w, wherein, x+y+z+w=100, and 1.0≤x≤18.0,2.0≤z≤12.0,1≤w≤5.0;
A preparation method for the magnetic Chinese medicinal dressing of cicatrix, preparation method is as follows:
One, prepare medicine film cream
(one), prepare Chinese medicine extract
(1), by weight, get 20～40 parts of 50～70 parts of Radix Salviae Miltiorrhizaes, 50～70 parts of Galla Chinensiss, 20～40 parts of Herba speranskiae tuberculataes, 20～40 parts of itea orientalis Hemsl., 50～70 parts of Rheum forrestii Diels, 50～70 parts of Radix et Rhizoma Rhei Wittrockiis, 20～40 parts, Semen Persicae, 20～40 parts of Radix Genkwa, 50～70 parts of Radix Desmodii Caudatis, 20～40 parts of vinegar Pyritum (processed), 20～40 parts of eupolyphaga, 20～40 parts of Hirudos, 8～15 parts of Borneolum Syntheticums, 8～15 parts of Camphoras, 20～40 parts of Olibanums and Myrrhas, standby;
(2), by the vinegar Pyritum (processed), Borneolum Syntheticum, Camphora, Olibanum and the Myrrha that take out in step (1), be crushed to respectively 200～400 orders, standby;
(3), by the Radix Salviae Miltiorrhizae, Galla Chinensis, Herba speranskiae tuberculatae, itea orientalis Hemsl. and the Rheum forrestii Diels mix homogeneously that take out in step (1), after pulverizing, cross 10 mesh sieves, then the medical material after sieving is inserted in percolator, adding concentration is that 10～100% ethanol soaks, the addition of ethanol, for soaking 1.2～1.5 times of medical material volume, is soaked after 12～48 hours, then adds and soak the ethanol that the concentration of 3～10 times of medical material original volumes is 10～100%, carry out percolation, collect percolate standby;
(4), will after the eupolyphaga taking out in step (1), Hirudo, Radix et Rhizoma Rhei Wittrockii, Semen Persicae, Radix Genkwa and Radix Desmodii Caudati mixing, be ground into coarse powder, then be placed in extraction pot, add purified water to decoct, the addition of purified water is 10～15 times of decocting herbs weight, extraction time is 2 hours, extracts altogether 3 times, after each extraction, filters, finally the extracting solution of 3 extractions is merged, standby;
(5), percolate that step (3) is collected sends in vacuum decompressioning and concentrating tank, being evaporated to density is 1.10～1.30g/cm
3thick paste, density measurement is carried out in the time of 50 ℃, reclaims solvent simultaneously, the alcohol extraction thick paste making is standby;
(6), extracting solution that step (4) is collected sends in vacuum decompressioning and concentrating tank, being evaporated to density is 1.10～1.30g/cm
3thick paste, density measurement is carried out in the time of 50 ℃, reclaims solvent simultaneously, the water extraction thick paste making is standby;
(7), the medicated powder mix homogeneously prepared of alcohol extraction thick paste that step (5) is made, water extraction thick paste that step (6) makes and step (2), after oven dry, be ground into 200～400 object fine powders, make Chinese medicine extract;
(two), preparation substrate
(1), by weight, get 5～10 parts of 5～10 parts of polyvidones, 40～70 parts of purified water, 1～5 part of polyvinyl alcohol, 30～50 parts of glycerol, 15～40 parts of micropowder silica gels, 8～15 parts of chitosans and tablet vinegar, standby;
(2), 10～20 parts of the polyvidone taking out in step (1) and purified water are added in reactor, be warming up to 60～70 ℃, stir 30～60 minutes, make it abundant swelling, obtain polyvidone swelling solution, standby;
(3), the polyvinyl alcohol and the glycerol that take out in step (1) are added in reactor, be warmed up to 70 ℃, stir 30min, mix homogeneously, obtains alcohol oil solution, standby;
(4), by 30～50 parts of the micropowder silica gel of taking out in step (1), chitosan, tablet vinegar and purified water, add in reactor, stir 1～2 minute, the alcohol oil solution that adds again above-mentioned steps (3) to make, be warmed up to 40～70 ℃, stir 2～10 minutes, stop stirring and static 2～5 minutes; Again the mixed solution in reactor is warming up to 50 ℃ afterwards, the polyvidone swelling solution that adds above-mentioned steps (2) to make, stirs 2～10 minutes, makes substrate;
(three), prepare medicine film cream
Get by weight percentage substrate prepared by Chinese medicine extract prepared by 30～50% above-mentioned steps () and 50～70% above-mentioned steps (two); First substrate is added in reactor, make the substrate in reactor be warming up to 45～55 ℃, then Chinese medicine extract is added in reactor, stir 20～40 minutes, make medicine film cream;
Two, preparation is with the medicine film layer of medicine film overcoat
The medicine film cream that above-mentioned steps one is made, evenly spreads upon on non-woven fabrics, is then cut into the shape and size that need, and makes medicine film layer, and wherein, the smearing thickness of medicine film cream is 0.5～5mm; The film overcoat of getting it filled afterwards, makes the silicone oil of medicine film overcoat facing to medicine film cream, then covers on medicine film cream, and medicine film cream is between non-woven fabrics and medicine film overcoat, makes the medicine film layer with medicine film overcoat;
Three, prepare magnetosphere
(one), get Nd, Fe, B and Dy metal simple-substance raw material, in the ratio proportioning of atomic ratio Nd:Fe:B:Dy=x:y:z:w, wherein x+y+z+w=100, and 1.0≤x≤18.0,2.0≤z≤12.0,1.0≤w≤5.0, then mix homogeneously makes batching, standby;
(two), the batching in step () is put into vacuum arc furnace ignition, be evacuated to 3 * 10
-3below Pa, and be filled with high-purity argon gas and carry out prepurging, then under argon shield atmosphere, batching melting is made to mother alloy ingot, standby;
(three), the mother alloy ingot making in step (two) is carried out to remelting in quick quenching furnace, then on atwirl water cooled rolls, fast quenching strip or scale;
(four), rectangular or scale that step (three) is obtained is placed in Annealing Crystallization stove, carries out Annealing Crystallization and processes 3～15min, and then pulverize at 500 ℃～900 ℃ temperature, controlling particle diameter is 1～10 μ m, obtains magnetic powder;
(five), get by weight percentage the magnetic powder that the step (four) of 40～70% chitosan and 30～60% makes, add water to make suspension, the weight that adds water is magnetic powder and chitosan gross weight 1～30 times, then use bafta through repeatedly flooding, in dipping process, the magnetic powder in suspension can enter the inside of bafta, by the oven dry of bafta after abundant dipping, and be placed in magnetic field and magnetize, make bafta there is the magnetic field intensity of 50～200mT, make magnetosphere;
Four, prepare backing layer
Get non-woven fabrics, according to the shape and size of reserving in advance, cut out in flakes, in the surrounding of a face of non-woven fabrics of cutting out, the wide adhesive sticker of one circle 2～5 ㎝ is set, make backing layer;
Five, prepare magnetic dressing
(one), get that above-mentioned steps two makes with one of the medicine film layer of medicine film overcoat, on work platform for placing, wherein, medicine film overcoat under, medicine film layer is upper;
(two), get one of the magnetosphere that above-mentioned steps three prepares, magnetosphere is pasted on the nonwoven cloth cover of medicine film layer;
(three), get one of the backing layer that above-mentioned steps four prepares, backing layer surrounding is pasted on magnetosphere with the one side of adhesive sticker, the adhesive sticker of backing layer surrounding sticks on medicine film overcoat;
(four), pack dressing into composite film packaging bag, evacuation, sealed composite film package bag;
(five), the sealed composite film package bag that dressing is housed being sent into sterilization chamber carries out
60co radiosterilization, completes the sterilization of dressing according to medical required standard, make the magnetic dressing for scar treatment.
In the step of described step 3 (two), batching argon arc melting in argon atmospher is no less than three times.
In the step of described step 3 (three), water cooled rolls is water-cooled copper roller or water-cooled molybdenum roller.
The quick quenching furnace using in the step of described step 3 (three) is induction quick quenching furnace, and the linear velocity of water cooled rolls is 5m/s～50m/s.
The quick quenching furnace using in the step of described step 3 (three) is arc type quick quenching furnace, and the linear velocity of water cooled rolls is 5m/s～20m/s.
beneficial effect
1, magnetic Chinese medicinal dressing of the present invention is applicable to all cicatrix patients, adopts Chinese medicinal components and magnetosphere combined therapy, have curative effect certain, rapid, convenient, inexpensive, have no adverse reaction and the feature such as toxic and side effects.
2, in the Chinese medicine formula of magnetic Chinese medicinal dressing of the present invention, Radix et Rhizoma Rhei Wittrockii, Semen Persicae, Radix Salviae Miltiorrhizae, Galla Chinensis, Herba speranskiae tuberculatae, Olibanum, Myrrha have hemostasis convergence, promote the effect of wound healing; Itea orientalis Hemsl., Rheum forrestii Diels, Radix Genkwa, Radix Desmodii Caudati, eupolyphaga, Hirudo, vinegar Pyritum (processed), have and nourish blood and blood, the effect of promoting the circulation of blood dissipating blood stasis analgesic therapy, and can improve local microcirculation, and strengthen local blood fortune, improve wound nutrition; The hemostasis of can regulating the flow of vital energy of Borneolum Syntheticum, Camphora, vinegar, clots absorbing analgesic therapy, removing the necrotic tissue and promoting granulation, has the anabolic effect of improvement.All medicines share, and have the effect of blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, elimination cicatrix, for the treatment of cicatrix of skin, can make large scar diminish, hardness deliquescing, and little scar is eliminated, and local function is recovered.
3, in magnetic Chinese medicinal dressing of the present invention, be provided with magnetosphere, it has been generally acknowledged that hypertrophic cicatrix is that body tissue is subject to post-traumatic abnormal reparation result, although the blood capillary quantity in hypertrophic cicatrix is more, great majority in endotheli ocytosis, substrate thicken, obliteration or the inaccessible state of part.In hyperplastic nodule, be in fact in a kind of microcirculation disturbance, blood for not enough state.Histanoxia, low nutritional status may be to cause the paraplasm startup factor of common hypertrophic cicatrix.The magnetic field producing by magnetosphere can be by improving local microcirculation, increasing vascular permeability, promote local immunity phylactic power defensive power, and the anti-inflammation detumescence effect such as relieve the pain, accelerated wound healing, improve the reparation of fibroblast hyperplasia of prostate, alleviate cicatrization, and may effectively reduce free radical damage by free radical mechanism and microcirculation mechanism, be reduced to fibrocyte pathological proliferation, lower collagen deposition, reduce plump cicatrization, alleviate collateral circulation compensation, promote cicatrix ripe, promote myofibroblast to degenerate, alleviate cicatricial contracture.
Accompanying drawing explanation
Fig. 1 is the structural representation of magnetic Chinese medicinal dressing of the present invention.
Fig. 2 is the hierarchy schematic diagram of magnetic Chinese medicinal dressing of the present invention.
Fig. 3 is the structural representation of magnetic Chinese medicinal dressing backing layer of the present invention.
Labelling in figure: 1, medicine film overcoat, 2, medicine film layer, 3, magnetosphere, 4, backing layer, 5, composite film packaging bag.
The specific embodiment
Below by a plurality of embodiment, the preparation method of first aid dressing of the present invention is described further, but the present embodiment does not mean that any limitation of the invention.
embodiment 1
A preparation method for the magnetic Chinese medicinal dressing of cicatrix, preparation method is as follows:
One, prepare medicine film cream
(one), prepare Chinese medicine extract
(1), by weight, get 20 parts of 50 parts of Radix Salviae Miltiorrhizaes, 55 parts of Galla Chinensiss, 25 parts of Herba speranskiae tuberculataes, 20 parts of itea orientalis Hemsl., 60 parts of Rheum forrestii Diels, 65 parts of Radix et Rhizoma Rhei Wittrockiis, 40 parts, Semen Persicae, 20 parts of Radix Genkwa, 70 parts of Radix Desmodii Caudatis, 20 parts of vinegar Pyritum (processed), 35 parts of eupolyphaga, 30 parts of Hirudos, 8 parts of Borneolum Syntheticums, 12 parts of Camphoras, 40 parts of Olibanums and Myrrhas, standby;
(2), by the vinegar Pyritum (processed), Borneolum Syntheticum, Camphora, Olibanum and the Myrrha that take out in step (1), be crushed to respectively 200 orders, standby;
(3), by the Radix Salviae Miltiorrhizae, Galla Chinensis, Herba speranskiae tuberculatae, itea orientalis Hemsl. and the Rheum forrestii Diels mix homogeneously that take out in step (1), after pulverizing, cross 10 mesh sieves, then the medical material after sieving is inserted in percolator, adding concentration is that 10% ethanol soaks, the addition of ethanol, for soaking 1.5 times of medical material volume, is soaked after 48 hours, then adds and soak the ethanol that the concentration of 3 times of medical material original volumes is 100%, carry out percolation, collect percolate standby;
(4), will after the eupolyphaga taking out in step (1), Hirudo, Radix et Rhizoma Rhei Wittrockii, Semen Persicae, Radix Genkwa and Radix Desmodii Caudati mixing, be ground into coarse powder, then be placed in extraction pot, add purified water to decoct, the addition of purified water is 10 times of decocting herbs weight, extraction time is 2 hours, extracts altogether 3 times, after each extraction, filters, finally the extracting solution of 3 extractions is merged, standby;
(5), percolate that step (3) is collected sends in vacuum decompressioning and concentrating tank, being evaporated to density is 1.10～1.30g/cm
3thick paste, density measurement is carried out in the time of 50 ℃, reclaims solvent simultaneously, the alcohol extraction thick paste making is standby;
(6), extracting solution that step (4) is collected sends in vacuum decompressioning and concentrating tank, being evaporated to density is 1.10～1.30g/cm
3thick paste, density measurement is carried out in the time of 50 ℃, reclaims solvent simultaneously, the water extraction thick paste making is standby;
(7), the medicated powder mix homogeneously prepared of alcohol extraction thick paste that step (5) is made, water extraction thick paste that step (6) makes and step (2), after oven dry, be ground into 400 object fine powders, make Chinese medicine extract;
Radix et Rhizoma Rhei Wittrockii in raw material has broken hard removing blood stasis, the effect of antibiotic convergence; Semen Persicae has activating blood circulation, the effect of the blood stasis dispelling that dispels the wind; Radix Salviae Miltiorrhizae can disappear and tie loose pain, stasis-dispelling and pain-killing; Herba speranskiae tuberculatae has expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral, the effect of eliminating toxic substances to remove stasis; Itea orientalis Hemsl. can damp eliminating blood stasis dispelling, reducing swelling and alleviating pain; Radix Desmodii Caudati can heat-clearing and toxic substances removing, detumescence eliminating stasis to stop pain; Eupolyphaga has relaxing muscles and tendons and activating QI and blood in the collateral, promoting blood circulation and stopping pain; Hirudo can removing blood stasis, the meridian dredging; Vinegar Pyritum (processed) has eliminating stasis to stop pain, coordinates Olibanum can reach the effect of promoting blood circulation to remove blood stasis; Borneolum Syntheticum has the effect of pain relieving erosion prevention and muscle growing; The tablet vinegar beneficial blood of can invigorating blood circulation, the removing toxic substances pain that disappears, blood stasis dispelling is dismissed.
(two), preparation substrate
(1), by weight, get 5 parts of polyvidones, 40 parts of purified water, 1 part of polyvinyl alcohol, 30 parts of glycerol, 15 parts of micropowder silica gels, 8 parts of chitosans, 5 parts of tablet vinegar, standby;
(2), 10 parts of the polyvidone taking out in step (1) and purified water are added in reactor, be warming up to 60 ℃, stir 60 minutes, make it abundant swelling, obtain polyvidone swelling solution, standby;
(3), the polyvinyl alcohol and the glycerol that take out in step (1) are added in reactor, be warmed up to 70 ℃, stir 30min, mix homogeneously, obtains alcohol oil solution, standby;
(4), by 30 parts of the micropowder silica gel of taking out in step (1), chitosan, tablet vinegar and purified water, add in reactor, stir 1～2 minute, the alcohol oil solution that adds again above-mentioned steps (3) to make, be warmed up to 40 ℃, stir 10 minutes, stop stirring and static 5 minutes; Again the mixed solution in reactor is warming up to 50 ℃ afterwards, the polyvidone swelling solution that adds above-mentioned steps (2) to make, stirs 10 minutes, makes substrate;
Chitosan is that the chitin extensively being existed by nature obtains through deacetylation, chemical name is Chitosan (1-4)-2-amino-B-D glucose, its chemical constitution is similar to cellulose, within the scope of lower PH, can dissolve the macromolecule cation gel solution that forms thickness, there is good film property, the technical program be take chitosan as major ingredient, be equipped with the adjuvants such as micropowder silica gel, polyvidone and Borneolum Syntheticum, the substrate resilient flexibility preparing is good, coordinate Chinese medicine rete, for clinical various skin, the burn of mucosa, trauma care, effect is very good.
(three), prepare medicine film cream
Get by weight percentage substrate prepared by the above-mentioned steps (two) of Chinese medicine extract prepared by 30% above-mentioned steps () and 70%; First substrate is added in reactor, make the substrate in reactor be warming up to 45 ℃, then Chinese medicine extract is added in reactor, stir 40 minutes, make medicine film cream;
Two, preparation is with the medicine film layer of medicine film overcoat
The medicine film cream that above-mentioned steps one is made, evenly spreads upon on non-woven fabrics, is then cut into the shape and size that need, and makes medicine film layer, and wherein, the smearing thickness of medicine film cream is 0.5mm; The film overcoat of getting it filled afterwards, makes the silicone oil of medicine film overcoat facing to medicine film cream, then covers on medicine film cream, and medicine film cream is between non-woven fabrics and medicine film overcoat, makes the medicine film layer with medicine film overcoat;
Three, prepare magnetosphere
(one), get Nd, Fe, B and Dy metal simple-substance raw material, in the ratio proportioning of atomic ratio Nd:Fe:B:Dy=2:71:12:5, then mix homogeneously makes batching, standby;
(two), the batching in step () is put into vacuum arc furnace ignition, be evacuated to 3 * 10
-3below Pa, and be filled with high-purity argon gas prepurging, then under argon shield atmosphere, batching melting made to mother alloy ingot, standby, batching argon arc melting in argon atmospher is no less than three times.
(three), the mother alloy ingot making in step (two) is carried out to remelting in induction quick quenching furnace, then on atwirl water-cooled copper roller, fast quenching strip or scale, the linear velocity of water cooled rolls is 5m/s～50m/s;
(four), rectangular or scale that step (three) is obtained is placed in Annealing Crystallization stove, carries out Annealing Crystallization and processes 10min, and then pulverize at 600 ℃ of temperature, controlling particle diameter is 1～10 μ m, obtains magnetic powder;
(five), get by weight percentage the magnetic powder that the step (four) of 40% chitosan and 60% makes, add water to make suspension, the weight that adds water is magnetic powder and chitosan gross weight 10 times, then uses bafta through repeatedly flooding, oven dry is placed in magnetic field magnetizes, and makes magnetosphere;
The mechanism of action in magnetic field:
1, in human body, have bioelectric current, bioelectric current produces biological magnetic field, applies externally-applied magnetic field the biological magnetic field in body is regulated under pathologic condition, makes biological magnetic field in body tend to normal.
2, the action of a magnetic field can change the size of human-body biological electric current when human body, direction, and can produce faint vortex flow, affect distribution, concentration and the movement velocity of the interior electron motion direction of body and the inside and outside ion of cell, change cell membrane potential, the irritability affecting the nerves.
3, magnetic field can change blood flow, promotes the clear of algogenic substance, activates endocrine hormone, the utilization of trace element, and magnetic field can affect the activity of enzyme and the biologically in body.
4, magnetic field changes the permeability of cell membrane, and mass exchange and Biochemical processes that cell is inside and outside affect the orientation of membrane receptor and membrane protein molecule.
Magnetospheric therapeutical effect:
1, anti-inflammation detumescence: blood circulation promoting, accelerate absorption and the dissipation of inflammatory exudate, and can reduce the colloid osmotic pressure between tissue, eliminate swelling.
2, analgesic effect: magnetic field energy reduces sensory nerve ending irritant reaction to external world, reduce sensorineural transmission and pain relieving, under the effect in magnetic field, blood circulation improves, make algogenic substance with inflammatory resolution alleviating pain, under the effect of another exterior magnetic field, morphine-like substance increases and plays analgesic effect.
3, promote wound healing: under the effect in magnetic field, blood circulation improves the healing that is conducive to accelerate wound.
4, softening cicatrix: magnetic field has the effect that significantly prevents cicatrization and softening cicatrix, its mechanism is that under the action of a magnetic field, blood circulation improves, effluent absorbs and dissipates and accelerates, and for reducing cicatrization, has created condition.Under the action of a magnetic field, in fibrocyte, moisture and salts substances increase, secretory functional disturbance, and in fibrocyte, lysosome increases, and promotes cytophagy, stops the formation of cicatrix.
Four, prepare backing layer
Get non-woven fabrics, according to the shape and size of reserving in advance, cut out in flakes, in the surrounding of a face of non-woven fabrics of cutting out, the wide adhesive sticker of one circle 2～5 ㎝ is set, make backing layer;
Five, prepare magnetic dressing
(one), get that above-mentioned steps two makes with one of the medicine film layer of medicine film overcoat, on work platform for placing, wherein, medicine film overcoat under, medicine film layer is upper;
(two), get one of the magnetosphere that above-mentioned steps three prepares, magnetosphere is pasted on the nonwoven cloth cover of medicine film layer;
(three), get one of the backing layer that above-mentioned steps four prepares, backing layer surrounding is pasted on magnetosphere with the one side of adhesive sticker, the adhesive sticker of backing layer surrounding sticks on medicine film overcoat;
(four), pack dressing into composite film packaging bag, evacuation, sealed composite film package bag;
Composite film packaging bag adopts composite packaging bag with high barrier property, include the co-extrusion MPE layer of the 3-10 layer of pet layer, pure aluminum foil layer and bottom, wherein, be also provided with successively a PE layer, co-extrusion PVC layer and the 2nd PE layer between pure aluminum foil layer and co-extrusion MPE layer, barrier property is very good.
(five), the sealed composite film package bag that dressing is housed being sent into sterilization chamber carries out
60co radiosterilization, completes the sterilization of dressing according to medical required standard, make the magnetic dressing for scar treatment.
60co radiation sterilization, as a kind of new method for disinfection and sterilization, has been incorporated into American Pharmacopeia.
60the mechanism of Co radiation sterilization is mainly to utilize
60co-energy of γ ray transmittance process, destroys the DNA in bacterial cell, makes it lose synthetic protein and Genetic Function, and bacterial cell propagation is stopped and death.Also someone thinks, due to the hydrone of ray indirect action in bacterial cell, to have produced activated free radical, thereby destroyed cyton, reaches the object of sterilizing.
During sterilizing, sealed and packed first aid dressing is put in special-purpose sterile chamber, first aid dressing in 60cm left and right, is selected irradiation dose apart from radiation source, and solid preparation is generally 8-10kGy, and exposure time is generally 4-5h.
60co radiation sterilization has following outstanding feature:
1, penetration power is strong, generally can reach 40-60cm;
2, under normal temperature and pressure, can carry out, also can not cause that temperature significantly rises;
3, sterilization process simple, be applicable to large-scale industrialization application, and can not there is radioactive pollution or residual, free from environmental pollution, generally also can not cause the significant change of pharmacology and toxicity, safe and effective.
A preparation method for the magnetic Chinese medicinal dressing of cicatrix, preparation method is as follows:
One, prepare medicine film cream
(one), prepare Chinese medicine extract
(1), by weight, get 40 parts of 55 parts of Radix Salviae Miltiorrhizaes, 60 parts of Galla Chinensiss, 20 parts of Herba speranskiae tuberculataes, 25 parts of itea orientalis Hemsl., 65 parts of Rheum forrestii Diels, 60 parts of Radix et Rhizoma Rhei Wittrockiis, 35 parts, Semen Persicae, 25 parts of Radix Genkwa, 65 parts of Radix Desmodii Caudatis, 40 parts of vinegar Pyritum (processed), 40 parts of eupolyphaga, 35 parts of Hirudos, 10 parts of Borneolum Syntheticums, 15 parts of Camphoras, 35 parts of Olibanums and Myrrhas, standby;
(2), by the vinegar Pyritum (processed), Borneolum Syntheticum, Camphora, Olibanum and the Myrrha that take out in step (1), be crushed to respectively 400 orders, standby;
(3), by the Radix Salviae Miltiorrhizae, Galla Chinensis, Herba speranskiae tuberculatae, itea orientalis Hemsl. and the Rheum forrestii Diels mix homogeneously that take out in step (1), after pulverizing, cross 10 mesh sieves, then the medical material after sieving is inserted in percolator, adding concentration is that 100% ethanol soaks, the addition of ethanol, for soaking 1.2 times of medical material volume, is soaked after 12 hours, then adds and soak the ethanol that the concentration of 3 times of medical material original volumes is 100%, carry out percolation, collect percolate standby;
(4), will after the eupolyphaga taking out in step (1), Hirudo, Radix et Rhizoma Rhei Wittrockii, Semen Persicae, Radix Genkwa and Radix Desmodii Caudati mixing, be ground into coarse powder, then be placed in extraction pot, add purified water to decoct, the addition of purified water is 15 times of decocting herbs weight, extraction time is 2 hours, extracts altogether 3 times, after each extraction, filters, finally the extracting solution of 3 extractions is merged, standby;
(5), percolate that step (3) is collected sends in vacuum decompressioning and concentrating tank, being evaporated to density is 1.10～1.30g/cm
3thick paste, density measurement is carried out in the time of 50 ℃, reclaims solvent simultaneously, the alcohol extraction thick paste making is standby;
(6), extracting solution that step (4) is collected sends in vacuum decompressioning and concentrating tank, being evaporated to density is 1.10～1.30g/cm
3thick paste, density measurement is carried out in the time of 50 ℃, reclaims solvent simultaneously, the water extraction thick paste making is standby;
(7), the medicated powder mix homogeneously prepared of alcohol extraction thick paste that step (5) is made, water extraction thick paste that step (6) makes and step (2), after oven dry, be ground into 200 object fine powders, make Chinese medicine extract;
(two), preparation substrate
(1), by weight, get 8 parts of polyvidones, 70 parts of purified water, 2 parts of polyvinyl alcohol, 35 parts of glycerol, 25 parts of micropowder silica gels, 12 parts of chitosans, 7 parts of tablet vinegar, standby;
(2), 20 parts of the polyvidone taking out in step (1) and purified water are added in reactor, be warming up to 70 ℃, stir 30 minutes, make it abundant swelling, obtain polyvidone swelling solution, standby;
(3), the polyvinyl alcohol and the glycerol that take out in step (1) are added in reactor, be warmed up to 70 ℃, stir 30min, mix homogeneously, obtains alcohol oil solution, standby;
(4), by 50 parts of the micropowder silica gel of taking out in step (1), chitosan, tablet vinegar and purified water, add in reactor, stir 2 minutes, the alcohol oil solution that adds again above-mentioned steps (3) to make, be warmed up to 40 ℃, stir 10 minutes, stop stirring and static 2 minutes; Again the mixed solution in reactor is warming up to 50 ℃ afterwards, the polyvidone swelling solution that adds above-mentioned steps (2) to make, stirs 10 minutes, makes substrate;
(three), prepare medicine film cream
Get by weight percentage substrate prepared by the above-mentioned steps (two) of Chinese medicine extract prepared by 50% above-mentioned steps () and 50%; First substrate is added in reactor, make the substrate in reactor be warming up to 45 ℃, then Chinese medicine extract is added in reactor, stir 40 minutes, make medicine film cream;
Two, preparation is with the medicine film layer of medicine film overcoat
The medicine film cream that above-mentioned steps one is made, evenly spreads upon on non-woven fabrics, is then cut into the shape and size that need, and makes medicine film layer, and wherein, the smearing thickness of medicine film cream is 2mm; The film overcoat of getting it filled afterwards, makes the silicone oil of medicine film overcoat facing to medicine film cream, then covers on medicine film cream, and medicine film cream is between non-woven fabrics and medicine film overcoat, makes the medicine film layer with medicine film overcoat;
Three, prepare magnetosphere
(one), get Nd, Fe, B and Dy metal simple-substance raw material, in the ratio proportioning of atomic ratio Nd:Fe:B:Dy=18:79:2:1, then mix homogeneously makes batching, standby;
(two), the batching in step () is put into vacuum arc furnace ignition, be evacuated to 3 * 10
-3below Pa, and be filled with high-purity argon gas prepurging, then under argon shield atmosphere, batching melting made to mother alloy ingot, standby, batching argon arc melting in argon atmospher is no less than three times.
(three), the mother alloy ingot making in step (two) is carried out to remelting in induction quick quenching furnace, then on atwirl water-cooled copper roller, fast quenching strip or scale, the linear velocity of water cooled rolls is 5m/s～50m/s;
(four), rectangular or scale that step (three) is obtained is placed in Annealing Crystallization stove, carries out Annealing Crystallization and processes 10min, and then pulverize at 600 ℃ of temperature, controlling particle diameter is 1～10 μ m, obtains magnetic powder;
(five), get by weight percentage the magnetic powder that the step (four) of 70% chitosan and 30% makes, add water to make suspension, the weight that adds water is magnetic powder and chitosan gross weight 10 times, then uses bafta through repeatedly flooding, oven dry is placed in magnetic field magnetizes, and makes magnetosphere;
Four, prepare backing layer
Get non-woven fabrics, according to the shape and size of reserving in advance, cut out in flakes, in the surrounding of a face of non-woven fabrics of cutting out, the wide adhesive sticker of one circle 2～5 ㎝ is set, make backing layer;
Five, prepare magnetic dressing
(one), get that above-mentioned steps two makes with one of the medicine film layer of medicine film overcoat, on work platform for placing, wherein, medicine film overcoat under, medicine film layer is upper;
(two), get one of the magnetosphere that above-mentioned steps three prepares, magnetosphere is pasted on the nonwoven cloth cover of medicine film layer;
(three), get one of the backing layer that above-mentioned steps four prepares, backing layer surrounding is pasted on magnetosphere with the one side of adhesive sticker, the adhesive sticker of backing layer surrounding sticks on medicine film overcoat;
(four), pack dressing into composite film packaging bag, evacuation, sealed composite film package bag;
(five), the sealed composite film package bag that dressing is housed being sent into sterilization chamber carries out
60co radiosterilization, completes the sterilization of dressing according to medical required standard, make the magnetic dressing for scar treatment.
A preparation method for the magnetic Chinese medicinal dressing of cicatrix, preparation method is as follows:
One, prepare medicine film cream
(one), prepare Chinese medicine extract
(1), by weight, get 30 parts of 65 parts of Radix Salviae Miltiorrhizaes, 70 parts of Galla Chinensiss, 30 parts of Herba speranskiae tuberculataes, 40 parts of itea orientalis Hemsl., 50 parts of Rheum forrestii Diels, 70 parts of Radix et Rhizoma Rhei Wittrockiis, 30 parts, Semen Persicae, 35 parts of Radix Genkwa, 55 parts of Radix Desmodii Caudatis, 35 parts of vinegar Pyritum (processed), 20 parts of eupolyphaga, 40 parts of Hirudos, 12 parts of Borneolum Syntheticums, 10 parts of Camphoras, 30 parts of Olibanums and Myrrhas, standby;
(2), by the vinegar Pyritum (processed), Borneolum Syntheticum, Camphora, Olibanum and the Myrrha that take out in step (1), be crushed to respectively 400 orders, standby;
(3), by the Radix Salviae Miltiorrhizae, Galla Chinensis, Herba speranskiae tuberculatae, itea orientalis Hemsl. and the Rheum forrestii Diels mix homogeneously that take out in step (1), after pulverizing, cross 10 mesh sieves, then the medical material after sieving is inserted in percolator, adding concentration is that 50% ethanol soaks, the addition of ethanol, for soaking 1.2 times of medical material volume, is soaked after 36 hours, then adds and soak the ethanol that the concentration of 3 times of medical material original volumes is 100%, carry out percolation, collect percolate standby;
(4), will after the eupolyphaga taking out in step (1), Hirudo, Radix et Rhizoma Rhei Wittrockii, Semen Persicae, Radix Genkwa and Radix Desmodii Caudati mixing, be ground into coarse powder, then be placed in extraction pot, add purified water to decoct, the addition of purified water is 12 times of decocting herbs weight, extraction time is 2 hours, extracts altogether 3 times, after each extraction, filters, finally the extracting solution of 3 extractions is merged, standby;
(5), percolate that step (3) is collected sends in vacuum decompressioning and concentrating tank, being evaporated to density is 1.10～1.30g/cm
3thick paste, density measurement is carried out in the time of 50 ℃, reclaims solvent simultaneously, the alcohol extraction thick paste making is standby;
(6), extracting solution that step (4) is collected sends in vacuum decompressioning and concentrating tank, being evaporated to density is 1.10～1.30g/cm
3thick paste, density measurement is carried out in the time of 50 ℃, reclaims solvent simultaneously, the water extraction thick paste making is standby;
(7), the medicated powder mix homogeneously prepared of alcohol extraction thick paste that step (5) is made, water extraction thick paste that step (6) makes and step (2), after oven dry, be ground into 400 object fine powders, make Chinese medicine extract;
(two), preparation substrate
(1), by weight, get 7 parts of polyvidones, 50 parts of purified water, 3 parts of polyvinyl alcohol, 40 parts of glycerol, 32 parts of micropowder silica gels, 10 parts of chitosans, 8 parts of tablet vinegar, standby;
(2), 20 parts of the polyvidone taking out in step (1) and purified water are added in reactor, be warming up to 65 ℃, stir 60 minutes, make it abundant swelling, obtain polyvidone swelling solution, standby;
(3), the polyvinyl alcohol and the glycerol that take out in step (1) are added in reactor, be warmed up to 70 ℃, stir 30min, mix homogeneously, obtains alcohol oil solution, standby;
(4), by 30 parts of the micropowder silica gel of taking out in step (1), chitosan, tablet vinegar and purified water, add in reactor, stir 1～2 minute, the alcohol oil solution that adds again above-mentioned steps (3) to make, be warmed up to 40 ℃, stir 10 minutes, stop stirring and static 5 minutes; Again the mixed solution in reactor is warming up to 50 ℃ afterwards, the polyvidone swelling solution that adds above-mentioned steps (2) to make, stirs 10 minutes, makes substrate;
(three), prepare medicine film cream
Get by weight percentage substrate prepared by the above-mentioned steps (two) of Chinese medicine extract prepared by 40% above-mentioned steps () and 60%; First substrate is added in reactor, make the substrate in reactor be warming up to 45 ℃, then Chinese medicine extract is added in reactor, stir 40 minutes, make medicine film cream;
Two, preparation is with the medicine film layer of medicine film overcoat
The medicine film cream that above-mentioned steps one is made, evenly spreads upon on non-woven fabrics, is then cut into the shape and size that need, and makes medicine film layer, and wherein, the smearing thickness of medicine film cream is 5mm; The film overcoat of getting it filled afterwards, makes the silicone oil of medicine film overcoat facing to medicine film cream, then covers on medicine film cream, and medicine film cream is between non-woven fabrics and medicine film overcoat, makes the medicine film layer with medicine film overcoat;
Three, prepare magnetosphere
(one), get Nd, Fe, B and Dy metal simple-substance raw material, in the ratio proportioning of atomic ratio Nd:Fe:B:Dy=12:78:6:4, then mix homogeneously makes batching, standby;
(two), the batching in step () is put into vacuum arc furnace ignition, be evacuated to 3 * 10
-3below Pa, and be filled with high-purity argon gas prepurging, then under argon shield atmosphere, batching melting made to mother alloy ingot, standby, batching argon arc melting in argon atmospher is no less than three times.
(three), the mother alloy ingot making in step (two) is carried out to remelting in induction quick quenching furnace, then on atwirl water-cooled copper roller, fast quenching strip or scale, the linear velocity of water cooled rolls is 5m/s～50m/s;
(four), rectangular or scale that step (three) is obtained is placed in Annealing Crystallization stove, carries out Annealing Crystallization and processes 10min, and then pulverize at 600 ℃ of temperature, controlling particle diameter is 1～10 μ m, obtains magnetic powder;
(five), get by weight percentage the magnetic powder that the step (four) of 50% chitosan and 50% makes, add water to make suspension, the weight that adds water is magnetic powder and chitosan gross weight 10 times, then uses bafta through repeatedly flooding, oven dry is placed in magnetic field magnetizes, and makes magnetosphere;
Four, prepare backing layer
Get non-woven fabrics, according to the shape and size of reserving in advance, cut out in flakes, in the surrounding of a face of non-woven fabrics of cutting out, the wide adhesive sticker of one circle 2～5 ㎝ is set, make backing layer;
Five, prepare magnetic dressing
(one), get that above-mentioned steps two makes with one of the medicine film layer of medicine film overcoat, on work platform for placing, wherein, medicine film overcoat under, medicine film layer is upper;
(two), get one of the magnetosphere that above-mentioned steps three prepares, magnetosphere is pasted on the nonwoven cloth cover of medicine film layer;
(three), get one of the backing layer that above-mentioned steps four prepares, backing layer surrounding is pasted on magnetosphere with the one side of adhesive sticker, the adhesive sticker of backing layer surrounding sticks on medicine film overcoat;
(four), pack dressing into composite film packaging bag, evacuation, sealed composite film package bag;
(five), the sealed composite film package bag that dressing is housed being sent into sterilization chamber carries out
60co radiosterilization, completes the sterilization of dressing according to medical required standard, make the magnetic dressing for scar treatment.
embodiment 4
A preparation method for the magnetic Chinese medicinal dressing of cicatrix, preparation method is as follows:
One, prepare medicine film cream
(one), prepare Chinese medicine extract
(1), by weight, get 35 parts of 70 parts of Radix Salviae Miltiorrhizaes, 65 parts of Galla Chinensiss, 40 parts of Herba speranskiae tuberculataes, 30 parts of itea orientalis Hemsl., 70 parts of Rheum forrestii Diels, 50 parts of Radix et Rhizoma Rhei Wittrockiis, 20 parts, Semen Persicae, 40 parts of Radix Genkwa, 50 parts of Radix Desmodii Caudatis, 30 parts of vinegar Pyritum (processed), 30 parts of eupolyphaga, 20 parts of Hirudos, 15 parts of Borneolum Syntheticums, 8 parts of Camphoras, 20 parts of Olibanums and Myrrhas, standby;
(2), by the vinegar Pyritum (processed), Borneolum Syntheticum, Camphora, Olibanum and the Myrrha that take out in step (1), be crushed to respectively 400 orders, standby;
(3), by the Radix Salviae Miltiorrhizae, Galla Chinensis, Herba speranskiae tuberculatae, itea orientalis Hemsl. and the Rheum forrestii Diels mix homogeneously that take out in step (1), after pulverizing, cross 10 mesh sieves, then the medical material after sieving is inserted in percolator, adding concentration is that 80% ethanol soaks, the addition of ethanol, for soaking 1.4 times of medical material volume, is soaked after 24 hours, then adds and soak the ethanol that the concentration of 3 times of medical material original volumes is 100%, carry out percolation, collect percolate standby;
(4), will after the eupolyphaga taking out in step (1), Hirudo, Radix et Rhizoma Rhei Wittrockii, Semen Persicae, Radix Genkwa and Radix Desmodii Caudati mixing, be ground into coarse powder, then be placed in extraction pot, add purified water to decoct, the addition of purified water is 10 times of decocting herbs weight, extraction time is 2 hours, extracts altogether 3 times, after each extraction, filters, finally the extracting solution of 3 extractions is merged, standby;
(5), percolate that step (3) is collected sends in vacuum decompressioning and concentrating tank, being evaporated to density is 1.10～1.30g/cm
3thick paste, density measurement is carried out in the time of 50 ℃, reclaims solvent simultaneously, the alcohol extraction thick paste making is standby;
(6), extracting solution that step (4) is collected sends in vacuum decompressioning and concentrating tank, being evaporated to density is 1.10～1.30g/cm
3thick paste, density measurement is carried out in the time of 50 ℃, reclaims solvent simultaneously, the water extraction thick paste making is standby;
(7), the medicated powder mix homogeneously prepared of alcohol extraction thick paste that step (5) is made, water extraction thick paste that step (6) makes and step (2), after oven dry, be ground into 400 object fine powders, make Chinese medicine extract;
(two), preparation substrate
(1), by weight, get 10 parts of polyvidones, 60 parts of purified water, 5 parts of polyvinyl alcohol, 50 parts of glycerol, 40 parts of micropowder silica gels, 15 parts of chitosans, 10 parts of tablet vinegar, standby;
(2), 15 parts of the polyvidone taking out in step (1) and purified water are added in reactor, be warming up to 60 ℃, stir 60 minutes, make it abundant swelling, obtain polyvidone swelling solution, standby;
(3), the polyvinyl alcohol and the glycerol that take out in step (1) are added in reactor, be warmed up to 70 ℃, stir 30min, mix homogeneously, obtains alcohol oil solution, standby;
(4), by 45 parts of the micropowder silica gel of taking out in step (1), chitosan, tablet vinegar and purified water, add in reactor, stir 1～2 minute, the alcohol oil solution that adds again above-mentioned steps (3) to make, be warmed up to 40 ℃, stir 10 minutes, stop stirring and static 5 minutes; Again the mixed solution in reactor is warming up to 50 ℃ afterwards, the polyvidone swelling solution that adds above-mentioned steps (2) to make, stirs 10 minutes, makes substrate;
(three), prepare medicine film cream
Get by weight percentage substrate prepared by the above-mentioned steps (two) of Chinese medicine extract prepared by 45% above-mentioned steps () and 55%; First substrate is added in reactor, make the substrate in reactor be warming up to 45 ℃, then Chinese medicine extract is added in reactor, stir 40 minutes, make medicine film cream;
Two, preparation is with the medicine film layer of medicine film overcoat
The medicine film cream that above-mentioned steps one is made, evenly spreads upon on non-woven fabrics, is then cut into the shape and size that need, and makes medicine film layer, and wherein, the smearing thickness of medicine film cream is 3mm; The film overcoat of getting it filled afterwards, makes the silicone oil of medicine film overcoat facing to medicine film cream, then covers on medicine film cream, and medicine film cream is between non-woven fabrics and medicine film overcoat, makes the medicine film layer with medicine film overcoat;
Three, prepare magnetosphere
(one), get Nd, Fe, B and Dy metal simple-substance raw material, in the ratio proportioning of atomic ratio Nd:Fe:B:Dy=16:71:2:4, then mix homogeneously makes batching, standby;
(two), the batching in step () is put into vacuum arc furnace ignition, be evacuated to 3 * 10
-3below Pa, and be filled with high-purity argon gas prepurging, then under argon shield atmosphere, batching melting made to mother alloy ingot, standby, batching argon arc melting in argon atmospher is no less than three times.
(three), the mother alloy ingot making in step (two) is carried out to remelting in induction quick quenching furnace, then on atwirl water-cooled copper roller, fast quenching strip or scale, the linear velocity of water cooled rolls is 5m/s～50m/s;
(four), rectangular or scale that step (three) is obtained is placed in Annealing Crystallization stove, carries out Annealing Crystallization and processes 10min, and then pulverize at 600 ℃ of temperature, controlling particle diameter is 1～10 μ m, obtains magnetic powder;
(five), get by weight percentage the magnetic powder that the step (four) of 55% chitosan and 45% makes, add water to make suspension, the weight that adds water is magnetic powder and chitosan gross weight 10 times, then uses bafta through repeatedly flooding, oven dry is placed in magnetic field magnetizes, and makes magnetosphere;
Four, prepare backing layer
Get non-woven fabrics, according to the shape and size of reserving in advance, cut out in flakes, in the surrounding of a face of non-woven fabrics of cutting out, the wide adhesive sticker of one circle 2～5 ㎝ is set, make backing layer;
Five, prepare magnetic dressing
(one), get that above-mentioned steps two makes with one of the medicine film layer of medicine film overcoat, on work platform for placing, wherein, medicine film overcoat under, medicine film layer is upper;
(two), get one of the magnetosphere that above-mentioned steps three prepares, magnetosphere is pasted on the nonwoven cloth cover of medicine film layer;
(three), get one of the backing layer that above-mentioned steps four prepares, backing layer surrounding is pasted on magnetosphere with the one side of adhesive sticker, the adhesive sticker of backing layer surrounding sticks on medicine film overcoat;
(four), pack dressing into composite film packaging bag, evacuation, sealed composite film package bag;
(five), the sealed composite film package bag that dressing is housed being sent into sterilization chamber carries out
60co radiosterilization, completes the sterilization of dressing according to medical required standard, make the magnetic dressing for scar treatment.
zoopery
By following experimental technique, further illustrate the therapeutic effect of magnetic Chinese medicinal dressing of the present invention to cicatrix, concrete test method is: get 3 of commercially available piglets, and every heavy 10～15kg, random number is A, B, C.Respectively at spinal column both sides, back, cervical region and buttocks health symmetry totally 6 position depilations of every piglet, and under anesthesia, at the depilation position of every piglet, be about the otch of 5cm, deeply reach flesh layer, after hemostasis, use 3-0 silk suture wound.
This test is divided into three groups: (1), negative control group, and (2), nonmagnetic traditional Chinese medicine dressing group, (3), magnetic Chinese medicinal dressing group, wherein, nonmagnetic traditional Chinese medicine dressing group is not for there is no magnetospheric dressing group.
(1), negative control group: the cervical region of the cervical region of piglet A, piglet B, the cervical region of piglet C; After negative control group makes to disinfect in alcohol, direct sew up wound.
(2), nonmagnetic traditional Chinese medicine dressing group: the back of the back of piglet A, piglet B, the back of piglet C; First disinfecting wound in alcohol, then at wound note, apply nonmagnetic dressing, within every three days, change a dressing, is a course for the treatment of, adopts iodine disinfection wound, to off-test while changing dressings at every turn.
(3), magnetic Chinese medicinal dressing group: the buttocks of the buttocks of piglet A, piglet B, the buttocks of piglet C.First disinfecting wound in alcohol, then at wound note, apply magnetic dressing, within every three days, change a dressing, is a course for the treatment of, adopts iodine disinfection wound, to off-test while changing dressings at every turn.
two, result of the test
1, observed result
Postoperative three porkling healths are good, without diarrhoea, the untoward reaction such as refusing to eat are movable normal.
A, postoperative 3 days
Negative control group: the incrustation of part wound, part wound fluid is more, and wound circumference is red and swollen.
Nonmagnetic traditional Chinese medicine dressing group: wound incrustation, inflammatory reaction is lighter, and wound circumference is without obvious redness;
Magnetic Chinese medicinal dressing group: wound is more clean, and sepage is less, part wound has a little incrustation, and inflammatory reaction is light, and wound circumference is without obvious redness;
B, postoperative 6 days
Negative control group: the most of incrustation of wound, wound circumference is slightly red and swollen, and suture reaction is heavier;
Nonmagnetic traditional Chinese medicine dressing group: epidermal area is healing substantially, without red and swollen, part wound has
Suture reaction;
Magnetic Chinese medicinal dressing group: epidermal area heals, without red and swollen, part wound has lighter
Suture reaction;
C, postoperative 9,12,15,18,21,24,27,30 days
Negative control group: wound healing is good, visible significantly healing line;
Nonmagnetic traditional Chinese medicine dressing group: wound healing is good;
Magnetic Chinese medicinal dressing group: wound healing is good, without the line that significantly heals;
2, histology changes
A, postoperative 3 days
Negative control group: epidermal area and skin corium do not heal, in skin corium, visible part is organized internal hemorrhage, and fibroblast quantity is few, and inflammatory cell is more;
Nonmagnetic traditional Chinese medicine dressing group: epidermal area and skin corium do not heal, visible more fibroblast and inflammatory cell in skin corium;
Magnetic Chinese medicinal dressing group: epidermal area is healing substantially, visible newborn blood capillary and more fibroblast in skin corium, inflammatory cell infiltration is less, inorganization internal hemorrhage in skin corium;
B, postoperative 6 days
Negative control group: epidermal area heals substantially, fibroblast in wound skin corium, is spindle shape, and quantity is few, sparse, and nucleus is little, has more inflammatory cell;
Nonmagnetic traditional Chinese medicine dressing group: epidermal area is healing substantially, in skin corium, visible more fibroblast, is spindle shape, and nucleus is larger;
Magnetic Chinese medicinal dressing group: epidermal area heals, part skin corium also heals, and in skin corium, visible a large amount of fibroblast, is spindle shape, nucleus hypertrophy and a small amount of inflammatory cell;
C, postoperative 9 days
Each organizes healing substantially of wound
Negative control group: in skin corium, value-added fibroblast is few compared with respectively organizing quantity above, newborn collagen is also few;
Nonmagnetic traditional Chinese medicine dressing group: the visible more fibroblast of skin corium and new crude rubber original fiber;
Magnetic Chinese medicinal dressing group: the visible a large amount of fibroblast of skin corium and a large amount of new crude rubber original fibers;
D, postoperative 12,30 days
Negative control group: the cicatrix of wound healing is larger; Nonmagnetic traditional Chinese medicine dressing group: wound scar is less compared with matched group; Magnetic Chinese medicinal dressing group: in healing of wound, cicatrix is little.
Claims (6)
1. a magnetic Chinese medicinal dressing for the treatment of cicatrix, is characterized in that: the medicine film overcoat (1) successively arranging, medicine film layer (2), magnetosphere (3) and backing layer (4), consist of, medicine film layer (2), magnetosphere (3) and backing layer (4) are fixedly connected with; Described medicine film overcoat (1) and the area of backing layer (4) are equal, and the area of the area of magnetosphere (3) and medicine film layer (2) is equal, and the area of backing layer (4) is greater than the area of magnetosphere (3); Described medicine film layer (2) is comprised of non-woven fabrics and the medicine film cream spreading upon on non-woven fabrics, and the smearing thickness of medicine film cream is 0.5～5mm; Described medicine film overcoat (1) is single silicon release paper, and single silicon release paper is covered with silicone oil with the one side that the medicine film cream of medicine film layer (2) contacts; Described backing layer (4) is non-woven fabrics, at backing layer (4), towards the periphery of the one side of magnetosphere (3), is provided with a circle adhesive sticker, and the width of adhesive sticker is 2～5 ㎝;
Described medicine film cream is comprised of Chinese medicine extract and substrate, and the percentage by weight of Chinese medicine extract and substrate is: Chinese medicine extract 30～50%, substrate 50～70%;
The crude drug of described Chinese medicine extract is by Radix Salviae Miltiorrhizae, Galla Chinensis, Herba speranskiae tuberculatae, itea orientalis Hemsl., Rheum forrestii Diels, Radix et Rhizoma Rhei Wittrockii, Semen Persicae, Radix Genkwa, Radix Desmodii Caudati, vinegar Pyritum (processed), eupolyphaga, Hirudo, Borneolum Syntheticum, Camphora, Olibanum and Myrrha form, the ratio of weight and number that each medical material adds is respectively: 50～70 parts of Radix Salviae Miltiorrhizaes, 50～70 parts of Galla Chinensiss, 20～40 parts of Herba speranskiae tuberculataes, 20～40 parts of itea orientalis Hemsl., 50～70 parts of Rheum forrestii Diels, 50～70 parts of Radix et Rhizoma Rhei Wittrockiis, 20～40 parts, Semen Persicae, 20～40 parts of Radix Genkwa, 50～70 parts of Radix Desmodii Caudatis, 20～40 parts of vinegar Pyritum (processed), 20～40 parts of eupolyphaga, 20～40 parts of Hirudos, 8～15 parts of Borneolum Syntheticums, 8～15 parts of Camphoras, 20～40 parts of 20～40 parts of Olibanums and Myrrhas,
Described substrate is comprised of polyvidone, glycerol, micropowder silica gel, chitosan, polyvinyl alcohol, tablet vinegar and purified water, and the ratio of weight and number that each raw material adds is respectively: 40～70 parts of 5～10 parts of polyvidones, 30～50 parts of glycerol, 15～40 parts of micropowder silica gels, 8～15 parts of chitosans, 1～5 part of polyoxyethylene alcohol, 5～10 parts of tablet vinegar and purified water;
The bafta that magnetized in magnetic field is dried and be placed in to described magnetosphere, for the suspension dipping through magnetic powder and chitosan,, and the bafta after magnetization has the magnetic field intensity of 50～200mT;
Described magnetic powder is to add dysprosium Dy element in Nd-Fe-B/ α-Fe matrix phase, magnetic powder consist of Nd
xfe
yb
zdy
w, wherein, x+y+z+w=100, and 1.0≤x≤18.0,2.0≤z≤12.0,1.0≤w≤5.0.
2. the preparation method of the magnetic Chinese medicinal dressing for scar treatment as claimed in claim 1, is characterized in that: preparation method is as follows:
One, prepare medicine film cream
(one), prepare Chinese medicine extract
(1), by weight, get 20～40 parts of 50～70 parts of Radix Salviae Miltiorrhizaes, 50～70 parts of Galla Chinensiss, 20～40 parts of Herba speranskiae tuberculataes, 20～40 parts of itea orientalis Hemsl., 50～70 parts of Rheum forrestii Diels, 50～70 parts of Radix et Rhizoma Rhei Wittrockiis, 20～40 parts, Semen Persicae, 20～40 parts of Radix Genkwa, 50～70 parts of Radix Desmodii Caudatis, 20～40 parts of vinegar Pyritum (processed), 20～40 parts of eupolyphaga, 20～40 parts of Hirudos, 8～15 parts of Borneolum Syntheticums, 8～15 parts of Camphoras, 20～40 parts of Olibanums and Myrrhas, standby;
(2), by the vinegar Pyritum (processed), Borneolum Syntheticum, Camphora, Olibanum and the Myrrha that take out in step (1), be crushed to respectively 200～400 orders, standby;
(3), by the Radix Salviae Miltiorrhizae, Galla Chinensis, Herba speranskiae tuberculatae, itea orientalis Hemsl. and the Rheum forrestii Diels mix homogeneously that take out in step (1), after pulverizing, cross 10 mesh sieves, then the medical material after sieving is inserted in percolator, adding concentration is that 10～100% ethanol soaks, the addition of ethanol, for soaking 1.2～1.5 times of medical material volume, is soaked after 12～48 hours, then adds and soak the ethanol that the concentration of 3～10 times of medical material original volumes is 10～100%, carry out percolation, collect percolate standby;
(4), will after the eupolyphaga taking out in step (1), Hirudo, Radix et Rhizoma Rhei Wittrockii, Semen Persicae, Radix Genkwa and Radix Desmodii Caudati mixing, be ground into coarse powder, then be placed in extraction pot, add purified water to decoct, the addition of purified water is 10～15 times of decocting herbs weight, extraction time is 2 hours, extracts altogether 3 times, after each extraction, filters, finally the extracting solution of 3 extractions is merged, standby;
(5), percolate that step (3) is collected sends in vacuum decompressioning and concentrating tank, being evaporated to density is 1.10～1.30g/cm
3thick paste, density measurement is carried out in the time of 50 ℃, reclaims solvent simultaneously, the alcohol extraction thick paste making is standby;
(6), extracting solution that step (4) is collected sends in vacuum decompressioning and concentrating tank, being evaporated to density is 1.10～1.30g/cm
3thick paste, density measurement is carried out in the time of 50 ℃, reclaims solvent simultaneously, the water extraction thick paste making is standby;
(7), the medicated powder mix homogeneously prepared of alcohol extraction thick paste that step (5) is made, water extraction thick paste that step (6) makes and step (2), after oven dry, be ground into 200～400 object fine powders, make Chinese medicine extract;
(two), preparation substrate
(1), by weight, get 5～10 parts of 5～10 parts of polyvidones, 40～70 parts of purified water, 1～5 part of polyvinyl alcohol, 30～50 parts of glycerol, 15～40 parts of micropowder silica gels, 8～15 parts of chitosans and tablet vinegar, standby;
(2), 10～20 parts of the polyvidone taking out in step (1) and purified water are added in reactor, be warming up to 60～70 ℃, stir 30～60 minutes, make it abundant swelling, obtain polyvidone swelling solution, standby;
(3), the polyvinyl alcohol and the glycerol that take out in step (1) are added in reactor, be warmed up to 70 ℃, stir 30min, mix homogeneously, obtains alcohol oil solution, standby;
(4), by 30～50 parts of the micropowder silica gel of taking out in step (1), chitosan, tablet vinegar and purified water, add in reactor, stir 1～2 minute, the alcohol oil solution that adds again above-mentioned steps (3) to make, be warmed up to 40～70 ℃, stir 2～10 minutes, stop stirring and static 2～5 minutes; Again the mixed solution in reactor is warming up to 50 ℃ afterwards, the polyvidone swelling solution that adds above-mentioned steps (2) to make, stirs 2～10 minutes, makes substrate;
(three), prepare medicine film cream
Get by weight percentage substrate prepared by the above-mentioned steps (two) of Chinese medicine extract prepared by 30～50% above-mentioned steps () and 50～70%; First substrate is added in reactor, make the substrate in reactor be warming up to 45～55 ℃, then Chinese medicine extract is added in reactor, stir 20～40 minutes, make medicine film cream;
Two, preparation is with the medicine film layer of medicine film overcoat
The medicine film cream that above-mentioned steps one is made, evenly spreads upon on non-woven fabrics, is then cut into the shape and size that need, and makes medicine film layer, and wherein, the smearing thickness of medicine film cream is 0.5～5mm; The film overcoat of getting it filled afterwards, makes the silicone oil of medicine film overcoat facing to medicine film cream, then covers on medicine film cream, and medicine film cream is between non-woven fabrics and medicine film overcoat, makes the medicine film layer with medicine film overcoat;
Three, prepare magnetosphere
(one), get Nd, Fe, B and Dy metal simple-substance raw material, in the ratio proportioning of atomic ratio Nd:Fe:B:Dy=x:y:z:w, wherein x+y+z+w=100, and 1.0≤x≤18.0,2.0≤z≤12.0,1.0≤w≤5.0, then mix homogeneously makes batching, standby;
(two), the batching in step () is put into vacuum arc furnace ignition, be evacuated to 3 * 10
-3below Pa, and be filled with high-purity argon gas prepurging, then under argon shield atmosphere, batching melting made to mother alloy ingot, standby;
(three), the mother alloy ingot making in step (two) is carried out to remelting in quick quenching furnace, then on atwirl water cooled rolls, fast quenching strip or scale;
(four), rectangular or scale that step (three) is obtained is placed in Annealing Crystallization stove, carries out Annealing Crystallization and processes 3～15min, and then pulverize at 500 ℃～900 ℃ temperature, controlling particle diameter is 1～10 μ m, obtains magnetic powder;
(five), get by weight percentage the magnetic powder that the step (four) of 40～70% chitosan and 30～60% makes, add water to make suspension, the weight that adds water is magnetic powder and chitosan gross weight 1～30 times, then use bafta through repeatedly flooding, in dipping process, the magnetic powder in suspension can enter the inside of bafta, by the oven dry of bafta after abundant dipping, and be placed in magnetic field and magnetize, make bafta there is the magnetic field intensity of 50～200mT, make magnetosphere;
Four, prepare backing layer
Get non-woven fabrics, according to the shape and size of reserving in advance, cut out in flakes, in the surrounding of a face of non-woven fabrics of cutting out, the wide adhesive sticker of one circle 2～5 ㎝ is set, make backing layer;
Five, prepare magnetic dressing
(one), get that above-mentioned steps two makes with one of the medicine film layer of medicine film overcoat, on work platform for placing, wherein, medicine film overcoat under, medicine film layer is upper;
(two), get one of the magnetosphere that above-mentioned steps three prepares, magnetosphere is pasted on the nonwoven cloth cover of medicine film layer;
(three), get one of the backing layer that above-mentioned steps four prepares, backing layer surrounding is pasted on magnetosphere with the one side of adhesive sticker, the adhesive sticker of backing layer surrounding sticks on medicine film overcoat;
(four), pack dressing into composite film packaging bag, evacuation, sealed composite film package bag;
(five), the sealed composite film package bag that dressing is housed being sent into sterilization chamber carries out
60co radiosterilization, completes the sterilization of dressing according to medical required standard, make the magnetic dressing for scar treatment.
3. the preparation method of the magnetic dressing for scar treatment as claimed in claim 2, is characterized in that: in the step of described step 3 (two), batching argon arc melting in argon atmospher is no less than three times.
4. the preparation method of the magnetic dressing for scar treatment as claimed in claim 2, is characterized in that: in the step of described step 3 (three), water cooled rolls is water-cooled copper roller or water-cooled molybdenum roller.
5. the preparation method of the magnetic dressing for scar treatment as claimed in claim 2, is characterized in that: the quick quenching furnace using in the step of described step 3 (three) is induction quick quenching furnace, and the linear velocity of water cooled rolls is 5m/s～50m/s.
6. the preparation method of the magnetic dressing for scar treatment as claimed in claim 2, is characterized in that: the quick quenching furnace using in the step of described step 3 (three) is arc type quick quenching furnace, and the linear velocity of water cooled rolls is 5m/s～20m/s.
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| Title |
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| 方凤，沈茜，管瑾.磁性中药贴外敷对易感儿细胞免疫功能的影响.《中国针灸》.1997,(第1期),15－16. * |
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