CN102836206B - Chinese and western medicine compound emulsifiable paste for diminishing melanins and brightening and preparation method thereof - Google Patents
Chinese and western medicine compound emulsifiable paste for diminishing melanins and brightening and preparation method thereof Download PDFInfo
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- CN102836206B CN102836206B CN 201210339585 CN201210339585A CN102836206B CN 102836206 B CN102836206 B CN 102836206B CN 201210339585 CN201210339585 CN 201210339585 CN 201210339585 A CN201210339585 A CN 201210339585A CN 102836206 B CN102836206 B CN 102836206B
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Abstract
The invention relates to a Chinese and western medicine compound emulsifiable paste for diminishing melanins and brightening and a preparation method of the Chinese and western medicine compound emulsifiable paste. The Chinese and western medicine compound emulsifiable paste is mainly composed of the following components in parts by weight: 25 to 35 parts of tranexamic acid, 10,000 to 15,000 parts of licoflavone, 30,000 to 50,000 parts of vitamin E, 25,000 to 35,000 parts of herba leonuri, 40,000 to 75,000 parts of castor oil, 40,000 to 70,000 parts of stearic acid, 20,000 to 40,000 parts of glycerol monostearate, 100,000 to 150,000 parts of liquid paraffin, 5,000 to 15,000 parts of 10% by mass fraction of ethylparaben alcohol solution, 100,000 to 150,000 parts of glycerol, 400,000 to 500,000 parts of pure water and the maintenance dose of essence. The preparation method comprises four steps, namely main material preparation, adjuvants preparation, emulsifiable paste preparation and quality inspection. The obtained cream is uniform and fine in components and easy to absorb, and the long-term clinical verifications show that the cream is safe and free from side effects and the effects on diminishing melanins and brightening are remarkable.
Description
Technical field
The present invention relates to medicine and pharmacology ointment field, particularly a kind of shiny black white Chinese medicine and western medicine compound cream and preparation method thereof that takes off.
Background technology
Along with social development, the mankind pursue the natural whitening of skin more, are reluctant that skin is coated with thick cosmetics, and this just synthesizes for check melanin, bright color, and then the various brightening agents that reach the skin-whitening effect provide vast potential for future development.In the market although to take off shiny black white product category various, mostly be chemical composition, as mequinol, vitamin C, lead, hydrargyrum etc.It,, when meeting the mankind and pursuing skin-whitening, has also produced some harmful effects to human body skin or whole body.As hydroquinone, be stronger skin whitener, can cause that the scytitis pigment increases, have and highly bring out mutation effect and cytotoxicity, therefore various countries, the world are used and still have dispute it at present.Separately have in some skin-whitening agents and contain hydrargyrum, hydrargyrum is a kind of generally acknowledged metallic poison, can cause the infringements such as kidney.Therefore, the whitening product that prolonged application is such, often can cause the generation of cosmetic dermatosis, as swashed dermatitis, allergy dermatitis, acne cosmetica etc.
In the traditional medicine of China, existing many square medicines that take off black whitening, but both controlling nocturnal emission with astringent drugs kidney tonifying of majority, but whitening and skin-protecting again, reached the dual purpose of health preserving and whitening.But these Chinese medicinal formulaes mostly are powder, onset is slow, and during use, the skin poor permeability, affect the treatment, and uses inconvenience.
Summary of the invention
For solving the problems of the technologies described above, the present invention proposes a kind of shiny black white Chinese medicine and western medicine compound cream and preparation method thereof that takes off.During it adopts, Western medicine associating prescription, each component interpenetrates, and learns from other's strong points to offset one's weaknesses, and gives full play to the effect of reason of resetting of the rapid-action and Chinese medicine of Western medicine, and adopts modern preparation technique to be prepared into oil/water type ointment.This ointment has the good effect of taking off shiny black pale skin, and compares Chinese medicinal formulae in the past, and its skin good penetrability is rapid-action, easy to use.
Technical scheme of the present invention is: take off shiny black white Chinese medicine and western medicine compound cream, mainly be comprised of following raw material: 25～35 parts of tranexamic acids, preferably 30 parts; 10000～15000 parts of licoflavones, preferably 12000 parts; 30000～50000 parts of vitamin Es, preferably 40000 parts; 25000～35000 parts of Herba Leonuris, preferably 30000 parts; 40000～75000 parts of Oleum Ricini, preferably 60000 parts; 40000～70000 parts of stearic acid, preferably 60000 parts; 20000～40000 parts of monoglycerides, preferably 30000 parts; 100000～150000 parts of liquid paraffin, preferably 125000 parts; 5000～15000 parts of the ethyl hydroxybenzoate alcoholic solutions that mass fraction is 10%, preferably 10000 parts; 100000～150000 parts of glycerol, preferably 125000 parts; 400000～500000 parts of pure water, preferably 450000 parts; The essence convention amount; Wherein, described umber is parts by weight.
The emulsifiable paste character: major ingredient extracting solution and volatile oil are suspended in substrate and emulsifying agent, form uniform semisolid, and exquisiteness is coated nonfused stable emulsifiable paste on skin, must not detect the particle that is greater than 180 μ m; Must not detect pathogenic bacterium.
The above-mentioned preparation method that takes off shiny black white Chinese medicine and western medicine compound cream is: comprise step: the major ingredient preparation, and the adjuvant preparation, emulsifiable paste preparation and quality inspection:
(1) major ingredient preparation
1. take the dosage tranexamic acid, dissolve with the 20g purified water, standby;
2. take the dosage Herba Leonuri, be crushed to 80～100 orders, merceration 1h, by solid-to-liquid ratio, 1:25 decocts with water 4h; It is 1/14～1/15 of amount of water that decoction liquor is concentrated into residual volume, obtains Herba Leonuri decocting liquid, standby;
(2) adjuvant preparation
1. take respectively dosage Oleum Ricini, liquid paraffin, stearic acid and monoglyceride, mix, be heated to fusing, obtain substrate mixture, standby;
2. ethyl hydroxybenzoate alcoholic solution and glycerol that the mass fraction that takes respectively dosage is 10%, add the dosage pure water after mixing, be heated to molten after even emulsifying agent, standby;
(3) emulsifiable paste preparation
Substrate mixture is joined in emulsifying agent, mix, when temperature is down to 45 ± 5 ℃, add respectively tranexamic acid aqueous solution and Herba Leonuri decocting liquid, after stirring evenly, then add the dosage licoflavone, dosage vitamin E and dosage essence, continue to be stirred to evenly, stablize emulsifiable paste;
(4) quality inspection
Require to carry out quality inspection according to cosmetics, be after product is qualified and take off shiny black white Chinese medicine and western medicine compound cream.
In above-mentioned raw materials:
Tranexamic acid (Tranexamic Acid) has another name called tranamic acid, research is found, thereby the end product melanocyte that tranexamic acid can replace tyrosine to be combined with enzyme reduces the tyrosine metabolism is synthetic, thereby thering is the black effect of taking off, its treatment chloasma of existing a large amount of clinical research confirmations has definite curative effect.
Licoflavone (Glycyrrhiza Flavonoids) is the component of extracting from the certain species Radix Glycyrrhizae, and the activity of its energy restraint of tyrosinase has the oxygen of removing order by base and oxidation resistance simultaneously, is a kind of natural, efficient brilliant white skin component.
Herba Leonuri (Leonurux japonicu) begins to be stated from Shennong's Herbal " Fructus Leonuri " bar, classifies as top grade.For labiate, have another name called Herba Leonuri Chinese mugwort, Herba Leonuri, HERBA LEONURI, Herba Linderniae Crustaceae etc.This product bitter in the mouth suffering, cold nature, return liver, kidney, pericardium channel, has the merit of promoting blood flow to regulate menstruation, inducing diuresis to remove edema, heat-clearing and toxic substances removing, is described as " blood man panacea ", " multiparity good medicine " by ancient Chinese medicine doctor.How on the books its whitening, acne-removing be also, and clinical research shows that it has definite beauty functions.
Vitamin E (Vitamin E) can increase the skin blood circulation to free radical resisting, reduces melanic formation.There is speckle dispelling, whitening, lock water and promote the effect that skin care item absorb.
Above-mentioned all medicines Chinese and Western is share, and can bring into play it and take off shiny black white synergism.The present invention verifies through long-term clinical application, remarkable to the shiny black white effect of taking off of skin, do not find so far untoward reaction.
In the present invention, ointment preparation technology's main feature is according to each constitutive property, respectively by its extracts active ingredients out, then extract is joined in emulsifiable paste matrix successively.Wherein tranexamic acid and Herba Leonuri are extracted into and are divided into water-soluble substances, add at first, add subsequently fat-soluble licoflavone and vitamin E.The ointment of preparation according to the present invention, composition is even, fine and smooth, and viscosity is suitable, is easy to skin and absorbs.
In the present invention, principal agent raw material tranexamic acid, licoflavone, Herba Leonuri and vitamin E are nontoxic composition, are conventional using dosage; The ethyl hydroxybenzoate alcoholic solution that stearic acid, monoglyceride, liquid paraffin, mass fraction are 10%, glycerol, essence etc. are substrate commonly used or the additive of ointment, and their safety is extensively verified already.Therefore, the present invention has higher-security.
Beneficial effect of the present invention is: the present invention utilizes modern extraction process to take off shiny black white extracts active ingredients out by having in Chinese medicine, and combine with the western medicine component with same effect, make ointment, both retain the effective ingredient in the Chinese prescription, there are again the rapid-action characteristics of western medicine component.Chinese medicine and western medicine component wherein, all do not have the various infringements to human body skin, taking off the shiny black purpose that has reached skin protection in white, has the advantages that zest is little, untoward reaction is few, safe, easy to use.
The specific embodiment
Illustrate the present invention below in conjunction with embodiment.
Embodiment 1 minima
One, raw material and weight thereof: tranexamic acid, 25mg; Licoflavone, 10g; Vitamin E, 30g; Herba Leonuri, 25g; Oleum Ricini, 50g; Stearic acid, 50g; Monoglyceride, 20g; Liquid paraffin, 100g; The ethyl hydroxybenzoate alcoholic solution that mass fraction is 10%, 5g; Glycerol, 100g; Purified water, 400g; Essence, 2g.
Two, its preparation method is:
(1) major ingredient preparation
1. take the tranexamic acid of weight described in one, dissolve with the 20g purified water, standby;
2. take the Herba Leonuri of weight described in one, be crushed to 80～100 orders, merceration 1h, by solid-to-liquid ratio, 1:25 decocts with water 4h; It is 1/14～1/15 of amount of water that decoction liquor is concentrated into residual volume, obtains Herba Leonuri decocting liquid, standby;
(2) adjuvant preparation
1. take respectively Oleum Ricini, liquid paraffin, stearic acid and the monoglyceride of weight described in one, mix, be heated to fusing, obtain substrate mixture, standby;
2. ethyl hydroxybenzoate alcoholic solution and glycerol that the mass fraction that takes respectively weight described in one is 10%, add the pure water of weight described in one after mixing, be heated to molten after even emulsifying agent, standby;
(3) emulsifiable paste preparation
The substrate mixture that step (2) is made joins in emulsifying agent, mix, when temperature is down to 45 ± 5 ℃, the tranexamic acid aqueous solution that adds respectively step (1) to make and Herba Leonuri decocting liquid, after stirring evenly, the licoflavone that adds again weight described in one, vitamin E and essence, continue to be stirred to evenly, stablize emulsifiable paste;
(4) quality inspection
Require to carry out quality inspection according to cosmetics, be after product is qualified and take off shiny black white Chinese medicine and western medicine compound cream, packing gets final product.
The character that makes ointment is: major ingredient extracting solution and volatile oil are suspended in substrate and emulsifying agent, form uniform semisolid, exquisiteness, coat nonfused stable emulsifiable paste on skin, detect by the pharmacopeia microbial limit test, do not detect the particle that is greater than 180 μ m; Do not detect pathogenic bacterium.
Above-mentioned all medicines Chinese and Western is share, and can bring into play it and take off shiny black white synergism.
Its preparation technology is according to each constitutive property, respectively by its extracts active ingredients out, then extract is joined in emulsifiable paste matrix successively.Wherein tranexamic acid and Herba Leonuri are extracted into and are divided into water-soluble substances, add at first, add subsequently fat-soluble licoflavone and vitamin E.The ointment made, composition is even, fine and smooth, and viscosity is suitable, is easy to skin and absorbs.Through the long-term clinical application checking, remarkable to the shiny black white effect of taking off of skin, do not find so far untoward reaction.
Embodiment 2
One, raw material and weight thereof: tranexamic acid, 30mg; Licoflavone, 12g; Vitamin E, 40g; Herba Leonuri, 30g; Oleum Ricini, 60g; Stearic acid, 60g; Monoglyceride, 30g; Liquid paraffin, 125g; The ethyl hydroxybenzoate alcoholic solution that mass fraction is 10%, 10g; Glycerol, 125g; Purified water, 450g; Essence, 3g.
All the other are with embodiment 1.
Embodiment 3
One, raw material and weight thereof: tranexamic acid, 35mg; Licoflavone, 15g; Vitamin E, 50g; Herba Leonuri, 35g; Oleum Ricini, 70g; Stearic acid, 70g; Monoglyceride, 40g; Liquid paraffin, 150g; The ethyl hydroxybenzoate alcoholic solution that mass fraction is 10%, 15g; Glycerol, 150g; Purified water, 500g; Essence, 4g.
All the other are with embodiment 1.
Embodiment 4
One, raw material and weight thereof: tranexamic acid, 27mg; Licoflavone, 12g; Vitamin E, 35g; Herba Leonuri, 27g; Oleum Ricini, 40g; Stearic acid, 40g; Monoglyceride, 25g; Liquid paraffin, 110g; The ethyl hydroxybenzoate alcoholic solution that mass fraction is 10%, 7g; Glycerol, 110g; Purified water, 430g; Essence, 3g.
All the other are with embodiment 1.
Embodiment 5
One, raw material and weight thereof: tranexamic acid, 33mg; Licoflavone, 14g; Vitamin E, 45g; Herba Leonuri, 33g; Oleum Ricini, 75g; Stearic acid, 65g; Monoglyceride, 35g; Liquid paraffin, 140g; The ethyl hydroxybenzoate alcoholic solution that mass fraction is 10%, 13g; Glycerol, 140g; Purified water, 470g; Essence, 5g.
All the other are with embodiment 1.
Embodiment 6
One, raw material and weight thereof: tranexamic acid, 25mg; Licoflavone, 10g; Vitamin E, 50g; Herba Leonuri, 35g; Oleum Ricini, 40g; Stearic acid, 70g; Monoglyceride, 20g; Liquid paraffin, 150g; The ethyl hydroxybenzoate alcoholic solution that mass fraction is 10%, 5g; Glycerol, 100g; Purified water, 500g; Essence, 7g.
All the other are with embodiment 1.
Embodiment 7
One, raw material and weight thereof: tranexamic acid, 25mg; Licoflavone, 15g; Vitamin E, 30g; Herba Leonuri, 25g; Oleum Ricini, 75g; Stearic acid, 40g; Monoglyceride, 40g; Liquid paraffin, 100g; The ethyl hydroxybenzoate alcoholic solution that mass fraction is 10%, 15g; Glycerol, 150g; Purified water, 400g; Essence, 2g.
All the other are with embodiment 1.
Embodiment 8
One, raw material and weight thereof: tranexamic acid, 30mg; Licoflavone, 10g; Vitamin E, 50g; Herba Leonuri, 25g; Oleum Ricini, 50g; Stearic acid, 60g; Monoglyceride, 40g; Liquid paraffin, 120g; The ethyl hydroxybenzoate alcoholic solution that mass fraction is 10%, 7g; Glycerol, 130g; Purified water, 450g; Essence, 1g.
All the other are with embodiment 1.
Embodiment 9
One, raw material and weight thereof: tranexamic acid, 30mg; Licoflavone, 15g; Vitamin E, 25g; Herba Leonuri, 35g; Oleum Ricini, 60g; Stearic acid, 50g; Monoglyceride, 30g; Liquid paraffin, 150g; The ethyl hydroxybenzoate alcoholic solution that mass fraction is 10%, 15g; Glycerol, 100g; Purified water, 500g; Essence, 5g.
All the other are with embodiment 1.
Embodiment 10
One, raw material and weight thereof: tranexamic acid, 28mg; Licoflavone, 13g; Vitamin E, 32g; Herba Leonuri, 34g; Oleum Ricini, 65g; Stearic acid, 55g; Monoglyceride, 35g; Liquid paraffin, 130g; The ethyl hydroxybenzoate alcoholic solution that mass fraction is 10%, 8g; Glycerol, 130g; Purified water, 480g; Essence, 4g.
All the other are with embodiment 1.
Embodiment 11
One, raw material and weight thereof: tranexamic acid, 32mg; Licoflavone, 15g; Vitamin E, 45g; Herba Leonuri, 29g; Oleum Ricini, 45g; Stearic acid, 60g; Monoglyceride, 25g; Liquid paraffin, 140g; The ethyl hydroxybenzoate alcoholic solution that mass fraction is 10%, 13g; Glycerol, 120g; Purified water, 420g; Essence, 3g.
All the other are with embodiment 1.
Embodiment 12
One, raw material and weight thereof: tranexamic acid, 25mg; Licoflavone, 15g; Vitamin E, 45g; Herba Leonuri, 30g; Oleum Ricini, 45g; Stearic acid, 60g; Monoglyceride, 25g; Liquid paraffin, 120g; The ethyl hydroxybenzoate alcoholic solution that mass fraction is 10%, 10g; Glycerol, 120g; Purified water, 450g; Essence, 3g.
All the other are with embodiment 1.
Embodiment 13
One, raw material and weight thereof: tranexamic acid, 30mg; Licoflavone, 15g; Vitamin E, 45g; Herba Leonuri, 30g; Oleum Ricini, 45g; Stearic acid, 60g; Monoglyceride, 30g; Liquid paraffin, 120g; The ethyl hydroxybenzoate alcoholic solution that mass fraction is 10%, 10g; Glycerol, 150g; Purified water, 450g; Essence, 6g.
All the other are with embodiment 1.
Embodiment 14
One, raw material and weight thereof: tranexamic acid, 30mg; Licoflavone, 10g; Vitamin E, 50g; Herba Leonuri, 35g; Oleum Ricini, 50g; Stearic acid, 60g; Monoglyceride, 30g; Liquid paraffin, 120g; The ethyl hydroxybenzoate alcoholic solution that mass fraction is 10%, 10g; Glycerol, 100g; Purified water, 500g; Essence, 4g.
All the other are with embodiment 1.
Embodiment 15
One, raw material and weight thereof: tranexamic acid, 35mg; Licoflavone, 13g; Vitamin E, 40g; Herba Leonuri, 25g; Oleum Ricini, 60g; Stearic acid, 40g; Monoglyceride, 30g; Liquid paraffin, 100g; The ethyl hydroxybenzoate alcoholic solution that mass fraction is 10%, 10g; Glycerol, 120g; Purified water, 450g; Essence, 4g.
All the other are with embodiment 1.
Claims (1)
1. a preparation method that takes off shiny black white Chinese medicine and western medicine compound cream, is characterized in that,
Comprise step: the major ingredient preparation, the adjuvant preparation, emulsifiable paste preparation and quality inspection:
(1) major ingredient preparation
Get the raw materials ready: tranexamic acid, 25mg; Licoflavone, 10g; Vitamin E, 30g; Herba Leonuri, 25g; Oleum Ricini, 50g; Stearic acid, 50g; Monoglyceride, 20g; Liquid paraffin, 100g; The ethyl hydroxybenzoate alcoholic solution that mass fraction is 10%, 5g; Glycerol, 100g; Purified water, 400g; Essence, 2g;
1. take the dosage tranexamic acid, dissolve with the 20g purified water, standby;
2. take the dosage Herba Leonuri, be crushed to 80～100 orders, merceration 1h, by solid-to-liquid ratio, 1:25 decocts with water 4h; It is 1/14～1/15 of amount of water that decoction liquor is concentrated into residual volume, obtains Herba Leonuri decocting liquid, standby;
(2) adjuvant preparation
1. take respectively dosage Oleum Ricini, liquid paraffin, stearic acid and monoglyceride, mix, be heated to fusing, obtain substrate mixture, standby;
2. ethyl hydroxybenzoate alcoholic solution and glycerol that the mass fraction that takes respectively dosage is 10%, add the dosage pure water after mixing, be heated to molten after even emulsifying agent, standby;
(3) emulsifiable paste preparation
Substrate mixture is joined in emulsifying agent, mix, when temperature is down to 45 ± 5 ℃, add respectively tranexamic acid aqueous solution and Herba Leonuri decocting liquid, after stirring evenly, then add the dosage licoflavone, dosage vitamin E and dosage essence, continue to be stirred to evenly, stablize emulsifiable paste;
(4) quality inspection
Require to carry out quality inspection according to cosmetics, be after product is qualified and take off shiny black white Chinese medicine and western medicine compound cream.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210339585 CN102836206B (en) | 2012-09-13 | 2012-09-13 | Chinese and western medicine compound emulsifiable paste for diminishing melanins and brightening and preparation method thereof |
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| CN 201210339585 CN102836206B (en) | 2012-09-13 | 2012-09-13 | Chinese and western medicine compound emulsifiable paste for diminishing melanins and brightening and preparation method thereof |
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| CN102836206A CN102836206A (en) | 2012-12-26 |
| CN102836206B true CN102836206B (en) | 2013-12-18 |
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| CN105125794A (en) * | 2015-09-06 | 2015-12-09 | 青岛大学 | Pure traditional Chinese medicinal cream for treating closed injury caused by acute physical exercise and preparation method of pure traditional Chinese medicinal cream |
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| CN1215587A (en) * | 1997-08-21 | 1999-05-05 | 株式会社资生堂 | Cosmetic composition |
| CN102228415B (en) * | 2011-05-12 | 2012-09-26 | 康美药业股份有限公司 | Composition containing tranexamic acid, and preparation method and uses thereof |
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