CN102834120A - 用嘌呤能p2x7受体结合剂成像中枢神经系统 - Google Patents

用嘌呤能p2x7受体结合剂成像中枢神经系统 Download PDF

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Publication number
CN102834120A
CN102834120A CN2010800164529A CN201080016452A CN102834120A CN 102834120 A CN102834120 A CN 102834120A CN 2010800164529 A CN2010800164529 A CN 2010800164529A CN 201080016452 A CN201080016452 A CN 201080016452A CN 102834120 A CN102834120 A CN 102834120A
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CN
China
Prior art keywords
vivo imaging
imaging agent
group
qualification
limits
Prior art date
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Pending
Application number
CN2010800164529A
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English (en)
Chinese (zh)
Inventor
A·杰克逊
V·莫里森-艾夫森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
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GE Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Publication of CN102834120A publication Critical patent/CN102834120A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN2010800164529A 2009-04-09 2010-04-06 用嘌呤能p2x7受体结合剂成像中枢神经系统 Pending CN102834120A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16789309P 2009-04-09 2009-04-09
GBGB0906274.6A GB0906274D0 (en) 2009-04-09 2009-04-09 Imaging the central nervous system
GB0906274.6 2009-04-09
US61/167893 2009-04-09
PCT/EP2010/054517 WO2010115881A1 (en) 2009-04-09 2010-04-06 Imaging the central nervous system with purinergic p2x7 receptor binding agents

Publications (1)

Publication Number Publication Date
CN102834120A true CN102834120A (zh) 2012-12-19

Family

ID=40750455

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800164529A Pending CN102834120A (zh) 2009-04-09 2010-04-06 用嘌呤能p2x7受体结合剂成像中枢神经系统

Country Status (6)

Country Link
US (1) US20120034165A1 (https=)
EP (1) EP2416808A1 (https=)
JP (1) JP2012523388A (https=)
CN (1) CN102834120A (https=)
GB (1) GB0906274D0 (https=)
WO (1) WO2010115881A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI618544B (zh) 2006-12-26 2018-03-21 藍瑟斯醫學影像公司 使心臟神經分布顯像之配位體
AU2011253052B2 (en) 2010-05-11 2015-05-14 Lantheus Medical Imaging, Inc. Compositions, methods and systems for the synthesis and use of imaging agents
US20150352185A1 (en) * 2010-11-16 2015-12-10 Denis G. Kay Method for increasing neprilysin expression and activity
EP2753605B1 (en) 2011-09-09 2019-03-27 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
WO2020227159A2 (en) 2019-05-03 2020-11-12 Flagship Pioneering Innovations V, Inc. Methods of modulating immune activity

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007141267A1 (en) * 2006-06-06 2007-12-13 Glaxo Group Limited N- (phenylmethyl) -2- (1h-pyraz0l-4-yl) acetamide derivatives as p2x7 antagonists for the treatment of pain, inflammation and neurodegeneration

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2627114A1 (en) * 2005-11-07 2007-05-18 Abbott Laboratories P2x7 receptor antagonists and methods of use
CA2645652A1 (en) 2006-03-16 2007-09-27 Renovis, Inc. Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
TWI464148B (zh) 2006-03-16 2014-12-11 Evotec Us Inc 作為ｐ２ｘ7調節劑之雙環雜芳基化合物與其用途
WO2008064432A1 (en) 2006-12-01 2008-06-05 The University Of Sydney Polycyclic molecular compounds
GB0803729D0 (en) * 2008-02-29 2008-04-09 Ge Healthcare Ltd Imaging the central nervous system

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007141267A1 (en) * 2006-06-06 2007-12-13 Glaxo Group Limited N- (phenylmethyl) -2- (1h-pyraz0l-4-yl) acetamide derivatives as p2x7 antagonists for the treatment of pain, inflammation and neurodegeneration

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ALAN S. FLORJANCIC ET AL.: "Synthesis and in vitro activity of 1-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-1H-1,2,4-triazol-5-amine and 4-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-4H-1,2,4-triazol-3-amine P2X7 antagonists", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》, vol. 18, 31 December 2008 (2008-12-31) *

Also Published As

Publication number Publication date
WO2010115881A1 (en) 2010-10-14
EP2416808A1 (en) 2012-02-15
JP2012523388A (ja) 2012-10-04
GB0906274D0 (en) 2009-05-20
US20120034165A1 (en) 2012-02-09

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C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20121219