JP2012523388A - プリン作動性ｐ２ｘ７受容体結合剤を用いた中枢神経系のイメージング - Google Patents

プリン作動性ｐ２ｘ７受容体結合剤を用いた中枢神経系のイメージング Download PDF

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Publication number
JP2012523388A
JP2012523388A JP2012503993A JP2012503993A JP2012523388A JP 2012523388 A JP2012523388 A JP 2012523388A JP 2012503993 A JP2012503993 A JP 2012503993A JP 2012503993 A JP2012503993 A JP 2012503993A JP 2012523388 A JP2012523388 A JP 2012523388A
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JP
Japan
Prior art keywords
vivo imaging
imaging agent
subject
agent according
precursor
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Withdrawn
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JP2012503993A
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English (en)
Japanese (ja)
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JP2012523388A5 (https=
Inventor
アレクザンドラー ジャクソン，
モリソン・アイベソン・ベロニック
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GE Healthcare Ltd
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GE Healthcare Ltd
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Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Publication of JP2012523388A publication Critical patent/JP2012523388A/ja
Publication of JP2012523388A5 publication Critical patent/JP2012523388A5/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2012503993A 2009-04-09 2010-04-06 プリン作動性ｐ２ｘ７受容体結合剤を用いた中枢神経系のイメージング Withdrawn JP2012523388A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16789309P 2009-04-09 2009-04-09
GBGB0906274.6A GB0906274D0 (en) 2009-04-09 2009-04-09 Imaging the central nervous system
GB0906274.6 2009-04-09
US61/167,893 2009-04-09
PCT/EP2010/054517 WO2010115881A1 (en) 2009-04-09 2010-04-06 Imaging the central nervous system with purinergic p2x7 receptor binding agents

Publications (2)

Publication Number Publication Date
JP2012523388A true JP2012523388A (ja) 2012-10-04
JP2012523388A5 JP2012523388A5 (https=) 2013-05-16

Family

ID=40750455

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012503993A Withdrawn JP2012523388A (ja) 2009-04-09 2010-04-06 プリン作動性ｐ２ｘ７受容体結合剤を用いた中枢神経系のイメージング

Country Status (6)

Country Link
US (1) US20120034165A1 (https=)
EP (1) EP2416808A1 (https=)
JP (1) JP2012523388A (https=)
CN (1) CN102834120A (https=)
GB (1) GB0906274D0 (https=)
WO (1) WO2010115881A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI618544B (zh) 2006-12-26 2018-03-21 藍瑟斯醫學影像公司 使心臟神經分布顯像之配位體
AU2011253052B2 (en) 2010-05-11 2015-05-14 Lantheus Medical Imaging, Inc. Compositions, methods and systems for the synthesis and use of imaging agents
US20150352185A1 (en) * 2010-11-16 2015-12-10 Denis G. Kay Method for increasing neprilysin expression and activity
EP2753605B1 (en) 2011-09-09 2019-03-27 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
WO2020227159A2 (en) 2019-05-03 2020-11-12 Flagship Pioneering Innovations V, Inc. Methods of modulating immune activity

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2627114A1 (en) * 2005-11-07 2007-05-18 Abbott Laboratories P2x7 receptor antagonists and methods of use
CA2645652A1 (en) 2006-03-16 2007-09-27 Renovis, Inc. Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
TWI464148B (zh) 2006-03-16 2014-12-11 Evotec Us Inc 作為ｐ２ｘ7調節劑之雙環雜芳基化合物與其用途
ATE489088T1 (de) * 2006-06-06 2010-12-15 Glaxo Group Ltd N- (phenylmethyl) -2- (1h-pyrazol-4-yl) acetamid- derivate als p2x7-antagonisten zur behandlung von schmerzen, entzündungen und neurodegeneration
WO2008064432A1 (en) 2006-12-01 2008-06-05 The University Of Sydney Polycyclic molecular compounds
GB0803729D0 (en) * 2008-02-29 2008-04-09 Ge Healthcare Ltd Imaging the central nervous system

Also Published As

Publication number Publication date
WO2010115881A1 (en) 2010-10-14
EP2416808A1 (en) 2012-02-15
GB0906274D0 (en) 2009-05-20
US20120034165A1 (en) 2012-02-09
CN102834120A (zh) 2012-12-19

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