CN102824640A - Capsule shell and preparation method thereof - Google Patents
Capsule shell and preparation method thereof Download PDFInfo
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- CN102824640A CN102824640A CN 201210277699 CN201210277699A CN102824640A CN 102824640 A CN102824640 A CN 102824640A CN 201210277699 CN201210277699 CN 201210277699 CN 201210277699 A CN201210277699 A CN 201210277699A CN 102824640 A CN102824640 A CN 102824640A
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Abstract
The invention relates to a capsule shell and a preparation method thereof. The capsule shell comprises 1-50wt% of L-arabinose. The capsule shell is conductive to relieving irritation of drugs to intestinal tracts and shortening the drug absorption time.
Description
Technical field
The present invention relates to a kind of capsule shells, be specifically related to a kind of capsule shells that contains L-arabinose.
Background technology
Capsule shells is a kind of splendid attire pressed powder, particulate ovum shape hollow casing of being used for, and it has good bioavailability, can dissolve rapidly, reliably and safely, is mainly used in medicine, pharmaceutical industry.The medical capsule shell is mainly used in the splendid attire solid drugs, like self-control powder, health product, medicament etc.Capsule shells adopts gelatin to form through precision processing and manufacturings such as auxiliary material such as starch mostly.If have the medicine of big stimulation to incapsulate the shell the inside to stomach some, because stomach does not absorb starch, capsule is taken and directly is absorbed after medicine gets into small intestinal, has avoided the stimulation of medicine to stomach.But after the capsule shells dissolving, medicine is inevitable to the stimulation of intestinal.Publication number is that the patent documentation of CN1839803 has openly been introduced a kind of plant fiber hard softgel shell and preparation method thereof, and the hard-shell capsule main component of the method preparation is a plant source hydroxypropyl emthylcellulose and as the agar and the glycerol of adjuvant.Publication number is the manufacturing approach that the patent documentation of CN1565411 has openly been introduced a kind of Capsules shell that will use, and the capsule shells main component of this invention is chitin, acetic acid and water.Though above method has replaced the gelatin composition in original technology with plant source hydroxypropyl emthylcellulose and chitin respectively, medicine itself is not but avoided the stimulation of intestinal, and the bitterness property that capsule shell produces in the process of swallowing also can't be avoided.
Summary of the invention
In order to overcome above-mentioned defective, the present invention provides a kind of capsule shells that helps cushion intestinal to be stimulated, shortens the drug absorption time.
Capsule shells of the present invention contains the L-arabinose of 1% ~ 50% weight percentage; The L-arabinose that preferably contains 1% ~ 25% weight percentage; Especially preferably the L-arabinose that contains 1% ~ 10% weight percentage; Be more preferably the L-arabinose that contains 3% ~ 5% weight percentage.
As preferred capsule shell formulation content, capsule shells of the present invention mainly comprises each composition of following weight percent:
Said capsule shells preferably mainly comprise each composition of following weight percent:
Said capsule shells is more preferably each composition that mainly comprises following weight percent:
Said capsule shells especially preferably mainly comprise each composition of following weight percent:
Wherein, said gel major ingredient comprises one or more in gelatin, hydroxy methocel, agar, Colla Corii Asini, the starch.
In addition, said adjuvant comprises glycerol, acetic acid, white titanium pigment, dehydrated alcohol, 1, one or more in the 2-propylene glycol.
The present invention also provides a kind of method for preparing of said capsule shells, and it comprises the steps:
(1) with the even post-heating to 80 of each composition raw materials mix ~ 90 ℃ of formation glue;
(2), and after 30 ~ 40 ℃ of oven dry, obtain capsule shells through dipping in glue method, dropping preparation method or pressing molding.
Can improve the activity of enzyme on the intestinal wall through the L-arabinose that contains in the capsule shells of the present invention, improve the absorption efficiency of medicine effectively, shorten the drug absorption time, make the faster and better effect of playing of medicine.In addition, the L-arabinose in the capsule shells of the present invention has the effect that sugar absorbs that suppresses, and it suppresses saccharide and absorbs in intestinal; Accelerate drug absorption; But also in intestinal, formed one deck saccharide protecting film, and slow down the stimulation of medicine to intestinal, do not influence the activity of enzyme.In addition, the raw material of preparation capsule shells of the present invention is all without any side effects.Capsule shells of the present invention can be used for taking up medicine or food of various powder or solid granular etc.And the L-arabinose in the capsule shells of the present invention is a sweeting agent, can improve the mouthfeel of said capsule shell.
The specific embodiment
Following examples are used to explain the present invention, but are not used for limiting scope of the present invention.
Embodiment 1
Get 37g gelatin, 12.5g water, 50g L-arabinose, 0.5g glycerol mix homogeneously post-heating to 80 ℃ formation glue; Through dipping in the molding of glue method, and in 30 ℃ of oven dry, obtain capsule shells, the capsule shells The performance test results is as shown in table 1.
Embodiment 2
Get 70g hydroxy methocel, 17.5g water, 1gL-arabinose, 11.5g acetic acid mix homogeneously post-heating to 90 ℃ formation glue; Through dipping in the molding of glue method, and in 40 ℃ of oven dry, obtain capsule shells, the capsule shells The performance test results is as shown in table 1.
Embodiment 3
Get 55g agar, 15g water, 25g L-arabinose, 5g white titanium pigment mix homogeneously post-heating to 85 ℃ formation glue; Through dipping in the molding of glue method, and in 35 ℃ of oven dry, obtain capsule shells, the capsule shells The performance test results is as shown in table 1.
Embodiment 4
Get 70g Colla Corii Asini, 15g water, 10g L-arabinose, 5g dehydrated alcohol mix homogeneously post-heating to 80 ℃ formation glue; Through the dropping preparation method molding, and in 40 ℃ of oven dry, obtain capsule shells, the capsule shells The performance test results is as shown in table 1.
Embodiment 5
Get 70g starch, 17g water, 3g L-arabinose, 10g white titanium pigment mix homogeneously post-heating to 90 ℃ formation glue; Through the dropping preparation method molding, and in 30 ℃ of oven dry, obtain capsule shells, the capsule shells The performance test results is as shown in table 1.
Embodiment 6
Get 35g Colla Corii Asini, 30g gelatin, 15g water, 5g L-arabinose, 15g1, the even post-heating to 80 of 2-mixed with propylene glycol ℃ formation glue; Through the pressing molding, and in 35 ℃ of oven dry, obtain capsule shells, the capsule shells The performance test results is as shown in table 1.
Embodiment 7
Get 48g agar, 20g hydroxy methocel, 13g water, 8g L-arabinose, 11g glycerol mix homogeneously post-heating to 85 ℃ formation glue; Through the pressing molding, and in 35 ℃ of oven dry, obtain capsule shells, the capsule shells The performance test results is as shown in table 1.
Embodiment 8
Capsule shells performance to embodiment 1 ~ 7 makes is tested.
Zest test: 28 experimenters are divided into 7 groups at random, every group 4 people; The capsule shells that makes with embodiment 1 ~ 7 takes up vitamin C; The corresponding one group of experimenter of each embodiment, experimenter's every day an oral vitamin C capsule, time remaining one month, whether the experimenter knows from experience has gastrointestinal stimulation property or inappetence phenomenon after taking the vitamin C capsule.
Disintegration time test: according to 2010 editions gelatin Capsuleses of Chinese Pharmacopoeia method of testing, test capsule disintegration time.
The The performance test results of the capsule shells that table 1, embodiment 1 ~ 7 make
| Outward appearance | Mouthfeel | Zest | Disintegration time (h) | |
| Embodiment 1 | Smooth, flexible | Little sweet | Non-stimulated no inappetence | 0.5 |
| Embodiment 2 | Smooth, flexible | Little sweet | Non-stimulated no inappetence | 0.6 |
| Embodiment 3 | Smooth, flexible | Little sweet | Non-stimulated no inappetence | 0.6 |
| Embodiment 4 | Smooth, flexible | Little sweet | Non-stimulated no inappetence | 0.7 |
| Embodiment 5 | Smooth, flexible | Little sweet | Non-stimulated no inappetence | 0.5 |
| Embodiment 6 | Smooth, flexible | Little sweet | Non-stimulated no inappetence | 0.6 |
| Embodiment 7 | Smooth, flexible | Little sweet | Non-stimulated no inappetence | 0.6 |
Can know by table 1, capsule shells smooth in appearance of the present invention, flexible, non-stimulated to human body, and the capsule disintegration time is short, help the fast Absorption of medicine, and taste is little sweet.
Claims (10)
1. a capsule shells is characterized in that, contains the L-arabinose of 1% ~ 50% weight percentage.
2. capsule shells according to claim 1 is characterized in that, contains the L-arabinose of 1% ~ 25% weight percentage.
3. capsule shells according to claim 1 is characterized in that, contains the L-arabinose of 1% ~ 10% weight percentage.
4. capsule shells according to claim 1 is characterized in that, contains the L-arabinose of 3% ~ 5% weight percentage.
5. according to the arbitrary described capsule shells of claim 1 ~ 4, it is characterized in that, mainly comprise each composition of following weight percent:
6. capsule shells according to claim 5 is characterized in that, mainly comprises each composition of following weight percent:
7. capsule shell according to claim 6 is characterized in that, mainly comprises each composition of following weight percent:
8. capsule shell according to claim 7 is characterized in that, mainly comprises each composition of following weight percent:
9. according to the arbitrary described capsule shells of claim 5 ~ 8, it is characterized in that said gel major ingredient comprises one or more in gelatin, hydroxy methocel, agar, Colla Corii Asini, the starch; Said adjuvant comprises glycerol, acetic acid, white titanium pigment, dehydrated alcohol, 1, one or more in the 2-propylene glycol.
10. according to the method for preparing of the arbitrary said capsule shells of claim 1 ~ 9, it is characterized in that, comprise the steps:
(1) with the even post-heating to 80 of each composition raw materials mix ~ 90 ℃ of formation glue;
(2), and after 30 ~ 40 ℃ of oven dry, obtain capsule shells through dipping in glue method, dropping preparation method or pressing molding.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210277699 CN102824640A (en) | 2012-08-06 | 2012-08-06 | Capsule shell and preparation method thereof |
| CN201310330266.8A CN103520727B (en) | 2012-08-06 | 2013-07-31 | A kind of capsule shells and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210277699 CN102824640A (en) | 2012-08-06 | 2012-08-06 | Capsule shell and preparation method thereof |
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| CN102824640A true CN102824640A (en) | 2012-12-19 |
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| CN 201210277699 Pending CN102824640A (en) | 2012-08-06 | 2012-08-06 | Capsule shell and preparation method thereof |
| CN201310330266.8A Active CN103520727B (en) | 2012-08-06 | 2013-07-31 | A kind of capsule shells and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106074440A (en) * | 2016-08-04 | 2016-11-09 | 浙江益立胶囊股份有限公司 | A kind of capsule and preparation method thereof |
| CN107496510A (en) * | 2017-09-07 | 2017-12-22 | 凯里市千户金钱柳种植有限公司 | A kind of blue or green money willow capsule and preparation method thereof |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103990150B (en) * | 2014-05-08 | 2016-06-22 | 青岛市中心医院 | A kind of Aerogenic capsule for Barium meal examination and preparation method thereof |
| CN104432058B (en) * | 2014-12-19 | 2016-05-25 | 山东福胶集团有限公司 | A kind of agate coffee capsule and preparation method thereof |
| CN106667950A (en) * | 2016-11-29 | 2017-05-17 | 四川旭华制药有限公司 | Pharmaceutical capsule material |
| CN106692103A (en) * | 2016-11-29 | 2017-05-24 | 四川旭华制药有限公司 | Preparation method of medicinal capsule material |
| CN115992120A (en) * | 2023-02-13 | 2023-04-21 | 中山市南方新元食品生物工程有限公司 | Enzyme preparation special for caramel treats and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0212951A (en) * | 2001-09-28 | 2004-10-26 | Mcneil Ppc Inc | Composite Dosage Forms |
| JP5421126B2 (en) * | 2008-01-10 | 2014-02-19 | 武田薬品工業株式会社 | Capsule formulation |
-
2012
- 2012-08-06 CN CN 201210277699 patent/CN102824640A/en active Pending
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2013
- 2013-07-31 CN CN201310330266.8A patent/CN103520727B/en active Active
Non-Patent Citations (2)
| Title |
|---|
| 《食品与发酵工业》 20111231 朱道辰 等 L-阿拉伯糖的最新应用进展 127页右栏 1-10 第37卷, 第2期 * |
| 《食品研究与开发》 20110131 邱泼 等 L-阿拉伯糖的研究进展及应用现状 162页右栏 1-10 第32卷, 第1期 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106074440A (en) * | 2016-08-04 | 2016-11-09 | 浙江益立胶囊股份有限公司 | A kind of capsule and preparation method thereof |
| CN106074440B (en) * | 2016-08-04 | 2019-06-21 | 浙江益立胶囊股份有限公司 | A kind of capsule and preparation method thereof |
| CN107496510A (en) * | 2017-09-07 | 2017-12-22 | 凯里市千户金钱柳种植有限公司 | A kind of blue or green money willow capsule and preparation method thereof |
| CN107496510B (en) * | 2017-09-07 | 2021-02-26 | 凯里市千户金钱柳种植有限公司 | Cyclocarya paliurus capsule and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103520727B (en) | 2016-02-10 |
| CN103520727A (en) | 2014-01-22 |
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