CN102823672A - Puerh tea compound for controlling blood lipid - Google Patents
Puerh tea compound for controlling blood lipid Download PDFInfo
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- CN102823672A CN102823672A CN2012103371979A CN201210337197A CN102823672A CN 102823672 A CN102823672 A CN 102823672A CN 2012103371979 A CN2012103371979 A CN 2012103371979A CN 201210337197 A CN201210337197 A CN 201210337197A CN 102823672 A CN102823672 A CN 102823672A
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Abstract
The invention relates to a Puerh tea compound which comprises the following components in weight portions: 3 portions to 8 portions of Puerh tea, 6 portions to 12 portions of gynostemma pentaphylla, 3 portions to 8 portions of dates, and 3 portions to 8 portions of dried tangerine or orange peel; the components are the Puerh tea and the ingredient cornflour or the extraction equivalent to the Puerh tea and the ingredient quantity; and the Puerh tea compound can be used for controlling blood lipid and other diseases.
Description
Technical field
The present invention relates to a kind of Pu'er tea composition, specifically, is a kind of Pu'er tea composition that is used to regulate disease such as blood fat, and the component of said composition can be directly to be ground into the food materials of powder and/or through extracting the food materials extract that obtains.
Background technology
Along with improving constantly of living standard, people's dietary structure also changes gradually, and hyperlipemia is just threatening human beings'health.High fat of blood is meant blood cholesterol (TC) and/or triglycerides (TG) is too high or HDL-C (HDL-C) is low excessively, and modern medicine is referred to as dyslipidemia.Because cholesterol deposition on arterial wall, forms atherosclerotic plaque, vessel wall thickening, endangium become coarse, and luminal stenosis makes and is easy to generate thrombus in the lumen of vessels, even stop up tube chamber.If betide in the coronary artery, can cause deficiency myocardial blood supply, angina pectoris takes place, even myocardial infarction.If occur in brain, headstroke will appear; If the obstruction optical fundus blood vessel will cause eyesight to descend, lose one's sight; If occur in kidney, will cause renal arteriosclerosis, renal failure; Occur in lower limb, limb necrosis can occur, fester etc.In addition, high fat of blood can cause hypertension, brings out gall stone, pancreatitis, increases the weight of hepatitis, causes male sexual disfunction, disease such as senile dementia.
Investigation shows that China has 9,000 ten thousand people to suffer from high fat of blood approximately.During high fat of blood has become, common complaint among the elderly, and the various cardiovascular and cerebrovascular diseases that cause have thus become in the threat, the chief culprit of the elderly's life.
It is a lot of to be used to treat the medicine of regulating blood fat now; As: owing to can not take for a long time, so develop a kind of integration of drinking and medicinal herbs, take for a long time, determined curative effect, sophisticated technologies, the stay-in-grade food that is used to regulate blood fat by market in urgent need in clinical practice for statins in the Western medicine.
Summary of the invention
The inventor comes from theory of traditional Chinese medical science, sums up many years of experience, carries through the daily life practical experienceization to form.The present invention is the Pu'er tea composition, is to extract the health food that makes by food materials such as Pu'er tea, gynostemma pentaphylla, date, dried orange peel process, has the blood fat of adjusting effect, and determined curative effect, and safety is stable.
The object of the present invention is to provide a kind of Pu'er tea composition and comprise the food of said composition, this food can be regulated disease illness such as blood fat.
The present invention also aims to provide the preparation method of above-mentioned composition and food,, can obtain being used for evident in efficacy, the sophisticated technologies of illnesss such as dyslipidemia, stay-in-grade food compositions through this method.
The present invention also aims to provide above-mentioned food compositions to be used to regulate the purposes of blood fat.
In order to achieve the above object, the invention provides a kind of Pu'er tea composition, said composition comprises the food materials component of following weight portion: Pu'er tea 3-8 part, gynostemma pentaphylla 6-12 part, date 3-8 part, dried orange peel 3-8 part; Said food materials component is above-mentioned food materials fecula or be equivalent to the extract of above-mentioned food materials amount.
Above-mentioned food materials component comprises that Pu'er tea, gynostemma pentaphylla, date, dried orange peel are the aqueous extract of these food materials.
In a preferred embodiment of the invention, above-mentioned Pu'er tea composition is made up of the food materials component of following weight portion: Pu'er tea 4-6 part, gynostemma pentaphylla 6-10 part, date 4-6 part, dried orange peel 4-6 part; Said food materials component is above-mentioned food materials fecula or be equivalent to the food materials extract of above-mentioned food materials amount.
In another preferred embodiment of the present invention, above-mentioned food materials composition is made up of the food materials component of following weight portion: 5 parts of Pu'er teas, 10 parts of gynostemma pentaphylla, 5 parts in date, 5 parts of dried orange peels; Said food materials component can be above-mentioned food materials fecula or the food materials extract that is equivalent to the amount of above-mentioned food materials.
The present invention also provides a kind of food of regulating blood fat, comprising above-mentioned food materials composition and food acceptable auxiliary.
Food provided by the invention, its component comprises: Pu'er tea 3-8 part, gynostemma pentaphylla 6-12 part, date 3-8 part, dried orange peel 3-8 part; Said food materials component is above-mentioned food materials powder or be equivalent to the food materials extract of above-mentioned food materials amount, and the food acceptable auxiliary; Above-mentioned food materials component is extract or the powder that is equivalent to above-mentioned food materials amount.
Wherein, make a living article or ripe article of above-mentioned Pu'er tea.
Preferred Pu'er tea, gynostemma pentaphylla, date, dried orange peel are the aqueous extract of these food materials.
The medicine of above-mentioned adjusting blood fat is preferably peroral dosage form, comprises formulations such as granule, powder, paste, oral liquid or syrup; This medicine is granule, paste, oral liquid or syrup more preferably.
In a preferred embodiment of the invention; A kind of food of regulating blood fat is provided; This food is granule, paste, oral liquid or syrup; This food comprises food materials composition and food acceptable auxiliary, and wherein, described food materials composition is the food materials component that is equivalent to the weight portion of following food materials amount: Pu'er tea 3-8 part, gynostemma pentaphylla 6-12 part, date 3-8 part, dried orange peel 3-8 part; Pu'er tea, gynostemma pentaphylla, date, dried orange peel are the aqueous extract of these food materials; Described food acceptable auxiliary is arbitrary or its combination in the brown powdered sugar that accounts for this drug weight 0.15-45%, microcrystalline cellulose, starch, the dextrin.
The present invention also provides and has prepared a kind of method of regulating the food of blood fat, and this method comprises: Pu'er tea, gynostemma pentaphylla, date, dried orange peel are the aqueous extract of these food materials, and it is Pu'er tea, gynostemma pentaphylla, date, dried orange peel boiling; The weight that adds water is 1-30 times of this food materials weight, and decocting liquid filters, and relative density was 1.20～1.25 when filtrating was concentrated into 60 ℃; Drying is pulverized, and gets extract powder; Add arbitrary or its combination in the brown powdered sugar account for this drug weight 0.15-45%, microcrystalline cellulose, starch, the dextrin, mixing is granulated; Drying promptly obtains this food of granule formulation.
Through experiment, the food acceptable auxiliary that screening obtains is preferably arbitrary or its combination in brown powdered sugar, microcrystalline cellulose, starch, the dextrin, and more preferably brown powdered sugar, microcrystalline cellulose, starch or dextrin most preferably are brown powdered sugar; The weight of this food acceptable auxiliary accounts for the 0.15-45% of this drug weight.
Pu'er tea composition of the present invention and food have the adjusting blood fat function.The characteristics that the present invention uses according to its daily life have at first been selected mixture, and technology is easy, taking convenience, but reflection and find the less stable of mixture in the practice process; The inventor preferably meets the oral solid formulation granule of modern health idea better again according to modern's eating habit, because of each food materials component of the present invention is the formal representation with the aqueous extract that obtains through extraction; The clothes back absorbs fast; And easy and simple to handle, preparation stabilization, finished-product volume is few; Taking convenience, low cost of manufacture.Through experimental study, preparation technology is easy, steady quality, controlled, safety, effectively, verification the verifying results is also good, so in a preferred embodiment of the invention, the formulation of food of the present invention is most preferably confirmed as granule.
The present invention also provides above-mentioned food materials preparation of compositions method; This preparation method is in many-sided factors such as the moral character of comprehensive above-mentioned each food materials, life, productions; Consulting on the basis of documents and materials; In conjunction with physicochemical property, the pharmacologically active of the active ingredient of each food materials, through repetition test research, the process route of the product of the present invention of design.
The preferred for preparation method of above-mentioned food materials composition comprises: with the food materials boiling of Pu'er tea, gynostemma pentaphylla, date, dried orange peel three times, the heating decocting time was respectively 2 hours, and 1 hour, 1 hour; The weight that adds water is 1-30 times of this food materials weight, is respectively 12 times, 10 times, and 8 times; Collecting decoction can obtain food materials composition of the present invention.Also can this decocting liquid drying be obtained dried cream powder, be this solid-state food materials composition (or dried cream powder of title food materials composition).
General food materials are used with decoction in life basically, and the method that adopts decocting to boil just can extract it basically, but because active ingredient in the component of the present invention, so do not adopt alcohol precipitation process.Thereby guarantee the curative effect of food.
Extraction process of the present invention preferably obtains through Orthogonal Experiment and Design.
Through overtesting, investigate the factor that decocting boils that influences in many ways, select amount of water, extraction time, extraction time for to influence the main factor that decocting boils, and three reasonable level of corresponding selection make an experiment.Be to guarantee the controllability and the advance of product quality, to the main test data gallic acid of reflection product quality and paste-forming rate as the investigation index.
With food of the present invention is that granule is an example, needs in conjunction with food self-characteristic, moulding standard and big financial cost of producing, and adopts wet granulation, and drying promptly gets.
Mixed accessories with single auxiliary material, different cultivars, different proportion makes an experiment respectively, with auxiliary material and 90g dried cream powder mixing, sprays in right amount with 80% ethanol, and wet granulation, 12 mesh sieves are granulated, the whole grain of 16 mesh sieves, and drying is processed particle.Find out the auxiliary material kind and the consumption thereof of basic preparations shaping, select suitable pharmaceutical adjunct.According to result of the test, most preferably confirm to select for use the preparation condition of brown powdered sugar as auxiliary material, i.e. 90g dried cream powder adds brown powdered sugar 10g, mixing, spray an amount of with 80% ethanol, granulation, drying is processed particle, promptly gets.
According to this area routine techniques, composition of the present invention also can be made into oral liquid, paste nourishing agent, and its processing step is routine operation, and visual medicinal material situation difference takes the circumstances into consideration to change process conditions, and it is conventionally known to one of skill in the art.
Food materials dried orange peel, date, the gynostemma pentaphylla of being adopted in the composition of the present invention is the medicinal material that version pharmacopeia in 2010 is recorded, and through identifying, each item index all meets the pharmacopeia regulation; Pu'er tea meets national Pu'er tea standard.
The inspection of arsenic salt and heavy metal in the medicine of the present invention: press one one of Chinese Pharmacopoeia version in 2010, appendix IXE, IXF item be regulation down, the arsenic salt and the heavy metal of these article 3 lot sample article is checked the result is in prescribed limit.
Health examination in the food of the present invention:, meet pharmacopeia hygiene standard through health examination.
The present invention also provides the above-mentioned application of food materials composition in diseases such as preparation treatment adjusting blood fat.
And the present invention also provides the above-mentioned application of food in diseases such as preparation treatment adjusting blood fat.
Food of the present invention is example with the granule.
The food materials preparation that the present invention is made up of Pu'er tea etc. is used to regulate blood fat in the life.Having done hyperlipidemia population by the health food requirement tries out with experiment.
Experimenter person's standard: the standard when the national dyslipidemia of reference is prevented TC, LDL-C, the TG rising of formulating in the smelting suggestion and begun drug therapy.
Study subject: select 40-60 year the elderly 30 people, 52.2 years old mean age, wherein, and the male sex 10 people, women 20 people try out time 30 ± 2d.During trying out, try out preceding 3 the week and try out during withdraw the medicine that influences blood lipid metabolism.
Test material: transfer the fat Pu'er tea, lot number: 20091001, the resource medicine engineering research center preparation of the Ministry of Education of Beijing Normal University, every bag of 6g, every bag contains food materials 25g;
Observation index: routine blood test (red blood cell, hemoglobin, leucocyte, blood platelet), blood fat (TG, TC, HDL-C, LDL-C), blood sugar (BS), liver function (total protein, albumin, globulin, glutamic-pyruvic transaminase GPT), renal function (blood uric acid; Creatinine, urea nitrogen).Each item index is taked each test of venous blood once on an empty stomach in trying out experiment when beginning and finishing.Lipids detection is used Japanese 01ympus, and 1000 automatic clinical chemistry analyzers are measured.
Try out method: drink 3 bags every day, divide morning, noon, evening to drink.Take 30 ± 2d continuously.
Statistical method: t check.
Result and discussion thereof: after hyperlipidemia person tried out the test of Fu tea beverage, the experimenter all had no adverse reaction, all no abnormal variation of routine blood test, blood sugar, hepatic and renal function.It is as shown in the table for its blood fat biochemical indicator.Show in the table that experimenter TC, TG and LDL-C level all descend, and HDL-C raises.Wherein, LDL-C descends to some extent, but there was no significant difference; TG descends significantly (P＜0.05), and HDL-C rising remarkable (P＜0.05); TC descend extremely significantly (P \ 0.01).
Blood Lipid comparison before and after the table person of trying out (X ± S)
*：P＜0.05；**：P＜0.01
The specific embodiment
For more clear explanation goal of the invention and technical scheme, further detail by following embodiment.
Embodiment:
The prescription of composition of the present invention (weight portion):
5 parts of Pu'er teas, 10 parts of gynostemma pentaphylla, 5 parts in date, 5 parts of dried orange peels.
The preparation method:
Above flavour of a drug boiling three times was respectively 2 hours heat time heating time, and 1 hour, 1 hour; The weight that adds water is 1-30 times of this food materials weight, is respectively 12 times, 10 times, and 8 times; Collecting decoction filters, and it is 1.20～1.25 (60 ℃) that filtrating is concentrated into relative density, spray-drying, (160 ℃ of intake air temperatures; 85 ℃ of air outlet temperature, inlet amount 50ml/min), get extract powder; Adding is with respect to 10% brown powdered sugar of extract powder weight, sprays in right amount with 80% ethanol, granulates; Drying is processed particle, is composition.
The result shows: the present composition meets the relevant each item regulation under the granule item.
More than described the preferred embodiment for the present invention, so it is not in order to limit the present invention.Those skilled in the art can not depart from the improvement and the variation of category of the present invention and spirit to embodiment disclosed herein.
Claims (9)
1. Pu'er tea composition, said composition comprises the food materials component of following weight portion: Pu'er tea 3-8 part, gynostemma pentaphylla 6-12 part, date 3-8 part, dried orange peel 3-8 part; Said component is Pu'er tea, gynostemma pentaphylla, date, dried orange peel food materials powder or the extract that is equivalent to above-mentioned food materials powder.
2. Pu'er tea composition as claimed in claim 1, wherein, in the described Pu'er tea component, Pu'er tea, gynostemma pentaphylla, date, dried orange peel are the aqueous extract of those food materials.
3. Pu'er tea composition as claimed in claim 1, wherein, described Pu'er tea composition is made up of the food materials component of following weight portion: Pu'er tea 3-8 part, gynostemma pentaphylla 6-12 part, date 3-8 part, dried orange peel 3-8 part; Said Pu'er tea, gynostemma pentaphylla, date, dried orange peel are the aqueous extract of those food materials.
4. Pu'er tea of regulating blood fat, it comprises claim 1-3 each described Pu'er tea composition and food acceptable auxiliary, this Pu'er tea is an oral formulations.
5. Pu'er tea as claimed in claim 4, wherein, described oral formulations is oral liquid, granule, paste nourishing agent, powder, described food acceptable auxiliary is arbitrary or its combination in brown powdered sugar, microcrystalline cellulose, starch, the dextrin; The weight of described food acceptable auxiliary accounts for the 0.15-45% of this drug weight.
6. a food of regulating blood fat comprises Pu'er tea composition and food acceptable auxiliary, and wherein, this food compositions is the food materials component that is equivalent to the weight portion of following food materials: Pu'er tea 3-8 part, gynostemma pentaphylla 6-12 part, date 3-8 part, dried orange peel 3-8 part; Pu'er tea, gynostemma pentaphylla, date, dried orange peel are the aqueous extract of those food materials in the said food materials component; This food acceptable auxiliary is arbitrary or its combination in the brown powdered sugar that accounts for this drug weight 0.15-45%, microcrystalline cellulose, starch, the dextrin.
7. the preparation method of the described food of claim 6, wherein, this method comprises: the food materials boiling of Pu'er tea, gynostemma pentaphylla, date, dried orange peel; The weight that adds water is 1-30 times of this food materials weight, and decocting liquid filters, and relative density was 1.20～1.25 when filtrating was concentrated into 60 ℃, and drying gets extract powder, adding food acceptable auxiliary, and mixing, granulation, drying promptly obtains this food.
8. the preparation method of the food of the described adjusting blood fat of claim 7, this method comprises: the food materials boiling of Pu'er tea, gynostemma pentaphylla, date, dried orange peel; The weight that adds water is 1-30 times of this food materials weight, and decocting liquid filters, and relative density was 1.20～1.25 when filtrating was concentrated into 60 ℃; Drying, extract powder, add arbitrary or its combination in the brown powdered sugar account for this extract powder weight 0.15-45%, microcrystalline cellulose, starch, the dextrin; Mixing; Granulate, drying promptly obtains this food.
9. the described Pu'er tea composition of claim 1 is regulated the Application in Food of blood fat in preparation.
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| CN201210337197.9A CN102823672B (en) | 2012-09-13 | 2012-09-13 | A kind of puer tea composition for adjusting blood fat |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103300178A (en) * | 2013-06-13 | 2013-09-18 | 普洱淞茂制药股份有限公司 | Dry flower puer tea and preparation method thereof |
| CN103783189A (en) * | 2013-12-20 | 2014-05-14 | 芜湖金鹰机械科技开发有限公司 | Blood lipid reducing beverage for climacterium and preparation method thereof |
| CN104171137A (en) * | 2014-08-14 | 2014-12-03 | 刘本德 | Blood pressure-reducing and lipid-lowering tea |
| CN106819252A (en) * | 2017-02-13 | 2017-06-13 | 厦门茶天下茶叶有限公司 | Reducing blood lipid beauty tea and preparation method thereof |
| CN109090416A (en) * | 2018-08-07 | 2018-12-28 | 兰州大学 | A kind of solid tea and preparation method thereof with brain-tonifying healthcare function |
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| CN1935216A (en) * | 2006-06-09 | 2007-03-28 | 耿玉萍 | Composition containing gynostemma pentaphylla total aglycone and tea polyphenol |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103300178A (en) * | 2013-06-13 | 2013-09-18 | 普洱淞茂制药股份有限公司 | Dry flower puer tea and preparation method thereof |
| CN103783189A (en) * | 2013-12-20 | 2014-05-14 | 芜湖金鹰机械科技开发有限公司 | Blood lipid reducing beverage for climacterium and preparation method thereof |
| CN104171137A (en) * | 2014-08-14 | 2014-12-03 | 刘本德 | Blood pressure-reducing and lipid-lowering tea |
| CN106819252A (en) * | 2017-02-13 | 2017-06-13 | 厦门茶天下茶叶有限公司 | Reducing blood lipid beauty tea and preparation method thereof |
| CN109090416A (en) * | 2018-08-07 | 2018-12-28 | 兰州大学 | A kind of solid tea and preparation method thereof with brain-tonifying healthcare function |
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| CN102823672B (en) | 2018-06-08 |
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