CN102813758A - Anorectal administration drug - Google Patents
Anorectal administration drug Download PDFInfo
- Publication number
- CN102813758A CN102813758A CN2012103308693A CN201210330869A CN102813758A CN 102813758 A CN102813758 A CN 102813758A CN 2012103308693 A CN2012103308693 A CN 2012103308693A CN 201210330869 A CN201210330869 A CN 201210330869A CN 102813758 A CN102813758 A CN 102813758A
- Authority
- CN
- China
- Prior art keywords
- extract
- anorectal
- anorectal plug
- plug filling
- filling medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to an anorectal administration drug which belongs to the technical field of medical preparation. The drug is prepared by mixing the following ingredients according to mass percent: 38-45% of chitin, 28-32% of Chinsee clinopodium herb extract, 22-28% of cattail pollen extract and the 1-5% of skin penetrant, wet storage agent and curing agent totally, wherein the chitin, the Chinsee clinopodium herb extract and the cattail pollen extract are active ingredients. After the drug of the invention is adopted, post-operation wound hemorrhage and pain can be quickly, effectively reduced, and the drug can exert the efficacy for 24 hours, prevents post-operation adhesion, diminishes swelling and inflammation, and accelerates healing; and moreover, and the drug can be used for avoiding pathogen damage and nerve fiber lesion.
Description
Technical field
The present invention relates to a kind of human body surgical incision especially hemostasis, pain relieving, short slow-releasing agent that more reaches antiinflammatory of anal-surgery wound of being used for, belong to the medicinal preparation technical field.
Background technology
Existing be used for that local hemostatic product mainly contains Fibrin Glue, absorbability gelfoam, collagen protein sponge and oxidized cellulose in the body, these hemostatic materials have different haemostatic effects and function.But main still lean on long-time compressing to reach hemostatic function, the effect of quick-acting haemostatic powder is not very desirable.Wherein clinical practice comparatively widely Fibrin Glue be the protein biological product that from animal blood slurry, extract, haemostatic effect is fair, but exists the danger of certain antigenicity and blood disease sexual disease transmission.
With common petrolatum oil gauze anus is clogged often for postoperative treatment of wounds methods of anorectal disease such as human body surgical operation such as anus hemorrhoid, anal fistula in the hospital at present.Its effect is anti, filling hemostasis by compression, and is also both economical.But owing to the blood vessel of human anus and anorectal inwall is very abundant, external perceptibility is also very responsive, adopts the gauze filling, and pullling when changing dressings can cause having an intense pain with hemorrhage of patient, and the while wound surface is difficult to coating and wound healing time prolongs.After petrolatum oil gauze, also use macromolecular material, calcium alginate etc. that wound is handled successively, improve though have in various degree; But still exist anthemorrhagic speed slow, fill in, get inconvenience, the disadvantage of no analgesic antiphlogistic effect.
Summary of the invention
The technical problem that the present invention solves is: proposes a kind of both can be fast effectively minimizing anorectal postoperative wound hemorrhage, ease the pain; Can bring into play lasting drug effect in 24 hours again, prevent tissue adhesion, detumescence antiinflammatory, healing acceleration, and can avoid the medical of pathogen injury and nerve fiber pathological changes.
In order to solve the problems of the technologies described above, the technical scheme that the present invention proposes is: a kind of anorectal plug filling medicament is mainly mixed by following component:
Wherein, said chitin, Herba Clinopodii extract and Pollen Tyjphae extract are active component.
The perfect of technique scheme is: the main component of said chitin comprises chitosan, and said chitosan is through binary linearity polymer that β-(1 → 4) glycosidic bond is connected by 2-acetylaminohydroxyphenylarsonic acid 2-deoxidation-D-Glucopyranose. and 2-amino-2-deoxidation-D-Glucopyranose.; The main component of said Herba Clinopodii extract comprises that herb contains Herba Clinopodii Polycephali Saponin and dandelion match-9,12,17-triolefin 3 β, 23-glycol; The main component of said Pollen Tyjphae extract comprises flavonoid, naringenin, Quercetin, rutinoside, isorhamnetin, isorhamnetin neohesperidose glycoside, methyl hexadecanoate, kaempferol neohesperidoside and sitosterol.
Further improving of technique scheme is: said skin penetrant is azone, Moschus or water, and the percentage ratio that its consumption accounts for said anorectal plug filling medicament gross mass is 0.2%-1.1%.
Further improving of technique scheme is: said wetting agent is glycerol, propylene glycol or sorbitol, and the percentage ratio that its consumption accounts for said anorectal plug filling medicament gross mass is 1%-5%.
Further improving again of technique scheme is: said firming agent is an active aluminium hydroxide, and the percentage ratio that the consumption of said active aluminium hydroxide accounts for said anorectal plug filling medicament gross mass is 0.001%-0.005%.
The one of further perfect again of technique scheme is: described Herba Clinopodii extract can extract from positions such as the root of Herba Clinopodii, stem, leaf, flowers.
Further perfect again two of technique scheme is: said Pollen Tyjphae extract can extract from the pollen of Herba Typhae.
Beneficial effect of the present invention is to adopt chitin, Herba Clinopodii extract and Pollen Tyjphae extract to make up; Make the effect of each composition produce synergism; Thereby can effectively reduce postoperative wound hemorrhage, ease the pain, lasting medicine, prevent that tissue adhesion, detumescence antiinflammatory, healing are fast, and can avoid pathogen injury and nerve fiber pathological changes.The effect of each composition of wherein selecting for use is:
1) chitin has very strong affinity to human body cell, and getting into when chitin is broken down into ultimate unit in the human body is exactly the intravital composition of people; Because chitosan is cationic natural polymer, and the good effect of controlling germs/bacteria/mycete is arranged; Chitin is native cellulose (an animal food fiber); There are not toxicity and side effect; Its safety and Saccharum Sinensis Roxb. are approximate, owing to have undersaturated cation group in its molecular structure, thereby electronegative all kinds of harmful substances are had powerful adsorption; It also can remove people's intravital " rubbish " equally, reaches the purpose of prevent disease, life lengthening; The chitin chemical property is stable, does not change with body fluid, and is nontoxic to can not organizing foreign body reaction, has antithrombotic, characteristics such as high temperature-resistant disinfected.
2) Herba Clinopodii has good anastalsis, antiinflammatory, bacteriostasis.
3) Pollen Typhae numbness and the detumescence of dispelling of invigorating blood circulation all has inhibitory action to escherichia coli.
The method for preparing of anorectal plug filling medicament of the present invention is: chitin, Herba Clinopodii extract, Pollen Tyjphae extract, azone, glycerol and firming agent are weighed respectively by mass percentage; The said components of weighing is added mix homogeneously in the vacuum response still, be heated to 60 ± 5 degree, heated 10-30 minute; Take out material in reactor after stopping heating and being cooled to room temperature.
The specific embodiment
Embodiment one
The anorectal plug filling medicament of present embodiment is mixed by following component:
Wherein, Main component as the chitin of one of active component is a chitosan, and said chitosan is through binary linearity polymer that β-(1 → 4) glycosidic bond is connected by 2-acetylaminohydroxyphenylarsonic acid 2-deoxidation-D-Glucopyranose. and 2-amino-2-deoxidation-D-Glucopyranose.;
Main component as two Herba Clinopodii extract of active component has: herb contains Herba Clinopodii Polycephali Saponin and dandelion match-9,12,17-triolefin 3 β, 23-glycol.Herba Clinopodii extract can extract from positions such as the root of Herba Clinopodii, stem, leaf, flowers.
Main component as three Pollen Tyjphae extract of active component has: flavonoid, naringenin, Quercetin, rutinoside, isorhamnetin, isorhamnetin neohesperidose glycoside, methyl hexadecanoate, kaempferol neohesperidoside and sitosterol.Pollen Tyjphae extract can extract from the pollen of Herba Typhae.
Skin penetrant is selected azone for use, and consumption is that the percentage ratio that accounts for whole anorectal plug filling medicament gross mass is 1.1%; Wetting agent is selected glycerol for use, and consumption is that the percentage ratio that accounts for whole anorectal plug filling medicament gross mass is 2.895%; Firming agent is selected active aluminium hydroxide for use, and consumption is that the percentage ratio that accounts for whole anorectal plug filling medicament gross mass is 0.005%.
The detailed process of the anorectal plug filling medicament method for preparing of present embodiment is:
1) chitin, Herba Clinopodii extract, Pollen Tyjphae extract, slow releasing agent are weighed respectively by mass percentage;
2) said components that will weigh adds mix homogeneously in the vacuum response still, is heated to 60 degree, heats 20 minutes;
3) stop the heating and be cooled to room temperature after take out material in reactor.
With the anorectal plug filling medicament of present embodiment stop blooding respectively, antibiotic, clinical experiment.
One, hemostasis experiment
Get healthy rabbits carotid artery otch, femoral artery otch, the normal saline solution of present embodiment anorectal plug filling medicament and the normal saline solution of YUNNAN BAIYAO are injected in tame rabbit liver, hind leg skin, muscle cutting respectively, and experimental data is as shown in table 1.
Table 1
The data show of table 1, the anastalsis of present embodiment anorectal plug filling medicament is better than YUNNAN BAIYAO.
Two, antibacterial experiment
After staphylococcus aureus, escherichia coli, bacillus pyocyaneus, Candida albicans carried out activation, separation, cultivation, be prepared into 10
9The bacterium liquid of individual cell/ml, subsequent use.The dressing that anorectal plug filling medicament is prepared into, common gauze (blank group) are cut into the square of 8mm * 8mm, are immersed in the sterilized water of 500ml, place 4 ℃ of refrigerators, after 1-7 days, take out, and natural drying, subsequent use.
The bacterium liquid for preparing is examined and determine culture medium in 1% ratio adding, shake up, fall by dull and stereotyped (15ml culture medium/flat board); After waiting to solidify flat board is put in dressing for preparing and gauze, compacting gently drips small amount of aseptic water; 4 ℃ of refrigerators spread 2 hours; Put 37 ℃ and cultivated 24 hours, measure antibacterial circle diameter (mm), measure the result and see table 2.
Table 2
Annotate: "-" expression does not have.
Can draw such conclusion from the statistical data of table 2 is: anorectal plug filling medicament all has obvious inhibitory action to escherichia coli, staphylococcus aureus, bacillus pyocyaneus and Candida albicans; Anorectal plug filling medicament after soaking through 1 day to 7 days still has bacteriostasis, its fungistatic effect with compare no significant difference without the sample of immersion.
Three, clinical experiment
Picked at random 68 examples are carried out anus patient (male patient's 39 examples of operation on anus; Female patient 29 examples, the mean age is 42 years old), type of surgery is hemorrhoidectomy 14 examples; Anal fistulectomy 30 examples; Perianal abscess radical correction 10 examples, excision of anal fissure 14 examples, more than every kind of patient be equally divided into experimental group and matched group.
Patient's normal diet, defecation, clinical routine laboratory examination hematuria are just conventional, blood coagulation is conventional, rabat, electrocardiogram are all normal, and examination of sugar in urine is all negative before the art.Two groups of patients all adopt lumbar anesthesia, routine disinfection skin and anal canal; Art formula mixed hemorrhoid is carried out in the outer stripping and is pricked art, and anal fistula is carried out anal fistulectomy, and perianal abscess is carried out the perianal abscess radical correction, and anal fissure is carried out excision of anal fissure, and matched group is carried out anal fistulectomy.The postoperative experimental group adopts anorectal plug filling medicament filling anus, applies gauze again, gives antiinflammatory, hemostasis, fluid-supplement therapy simultaneously; Matched group adopts conventional hemostasis method, gives antiinflammatory, hemostasis, fluid-supplement therapy simultaneously.
Through the hemorrhage situation of record postoperative wound, wound healing time, observation patient pain situation etc. the therapeutic effect that uses anorectal plug filling medicament and common haemostatic medicament is analyzed.
(1) the hemorrhage situation of postoperative wound:, count blood volume through observing blood volume and the used gauze piece number on the different time gauze of operation back.SS is an absorbent carbasus (7.5cm * 7.5cm; 8 layers) be full of blood and represent hemorrhage 4-5ml (an above gauze then multiply by gauze quantity); The hemorrhage 2-2.5ml of 1/2 congested expression of gauze; The hemorrhage 1-1.5ml of 1/4 congested expression of gauze.The hemorrhage situation statistics of postoperative wound is seen table 3.
Table 3
Table 3 statistical data shows: experimental group patient postoperative adopts anorectal plug filling medicament to stop blooding, and effect is better than matched group, and wound bleeding is few than the matched group patient in the body, has the obviously hemorrhage time short than the matched group patient.
Table 4
Annotate: the high explanation of A value amount of bleeding is many, and haemostatic effect is poor.
Table 4 is a Hb range absorption data table.According to table 4 data computation, the meansigma methods of control group A value is 1.9447 ± 0.62384, and the meansigma methods of experimental group A value is 0.9695 ± 0.71777 (P＜0.01).To take advantage of the t check analysis of group design, experimental group and control group A value comparing difference significance (P＜0.01) explain that anorectal plug filling medicament truly has good anastalsis for the anorectal postoperative hemorrhage.
(2) wound healing time: 3-5 week is observed the wound healing situation after surgery respectively, the record wound healing time.Wound healing time is seen table 5.
Table 5
Annotate: table empty place representes not have patient's healing.
Table 5 statistical data shows: the experimental group patient uses anorectal plug filling medicament that the postoperative wound healing rate is obviously accelerated, and healing time is than few 1-2 week of matched group patient.
(3) pain is observed: adopt the NRS assessment method, with the digitized representation pain in various degree of 0-10, the grading standard is: 0 is painless; The 1-3 mild pain; The 4-6 moderate pain; The 7-10 moderate pain.
The data of NRS method are carried out simple process, and data are seen table 6.
Table 6
Annotate: * representes that statistical significance is arranged.
Data through table 6 can find that the average pain sensation scoring of the 1st, 2,3,5 day experimental group significantly is lower than matched group, P＞0.05.Through how far returning discovery, age, sick kind, Body Mass Index and pain sensation scoring are irrelevant, have only the different dressing of use influential to postoperative pain.
Can be drawn as drawing a conclusion by this clinical experiment: anorectal plug filling medicament goes for the postoperative filling of all kinds of anal-surgeries, can prevent the postoperative stickup, and the ability liquid-absorbent hemostatic, alleviates the patient suffering, promotes healing.
Because there is its special dissect physiology property at the anus position; Determined this regional operation agglutination directly to receive sphincteral lax and the influence of shrinking and the influence of fecal pollution, though to be the operative incision at anus position little and healing time is longer than the reason of other otch for this.Therefore, the hemostasis of the auxiliary anus position of selection wound healing, antiinflammatory material are particularly difficult.The anorectal plug filling medicament of present embodiment just can be used as the inside stuffing of medical anorectal plug.As after adopting the anorectal plug of being with the slow release hole to fill in anal; The anus endocrine gets in the anorectal plug through the slow release hole and dissolves the anorectal plug filling medicament of present embodiment; Under the contraction of anal sphincter, dissolved present embodiment anorectal plug filling medicament promptly is extruded the slow release hole and coats on the otch wound surface at anus position simultaneously, after rapid hemostasis, pain relieving; The otch wound surface plays detumescence, antiinflammatory, prevents the effect of skin and flesh adhesion longer, and curative effect was 24 hours.
The amino positive charge ion that the anorectal plug filling medicament of present embodiment includes; The negative charge that has on its positive charge ion and the bacterium surface is inhaled mutually, thereby punctures cell wall, causes bacterial death; The regeneration of hemostasis and cellular matrix be can effectively promote simultaneously, blood crusts healing, skin regeneration and recovery promoted; Simultaneously; Possess effects such as blood compatibility, histocompatibility and immunity, satisfy the basic demand of medical material, can be in organism the enzymolysis Cheng Yi small-molecule substance that absorbed, have no side effect by live body; Can not remain in vivo, be one type of biodegradation absorption-type macromolecular material.
Embodiment two
The anorectal plug filling medicament of present embodiment is the variation on embodiment one basis, and different is except identical with embodiment one: (1) anorectal plug filling medicament heat time heating time in the preparation is 12 minutes; (2) mass percent of its component is following:
(3) skin penetrant is selected Moschus for use, and consumption is to account for 0.2% of whole anorectal plug filling medicament gross mass; (4) wetting agent is selected propylene glycol for use, and consumption is to account for 2.797% of whole anorectal plug filling medicament gross mass; (5) firming agent is selected active aluminium hydroxide for use, and consumption is to account for 0.003% of whole anorectal plug filling medicament gross mass.
With the anorectal plug filling medicament of present embodiment stop blooding respectively, antimicrobial experiment.
One, hemostasis experiment
1, adopts the normal saline solution of normal saline solution, medical saline and the YUNNAN BAIYAO of present embodiment anorectal plug filling medicament respectively, mice is irritated stomach, irritate stomach mice is docked.Observe docking place bleeding time, amount of bleeding and clotting time, experimental result is seen table 7.
Table 7
Table 7 data show, behind the use present embodiment anorectal plug filling medicament, bleeding time, the amount of bleeding of mice docking are compared obvious minimizing with normal saline; Compare difference with YUNNAN BAIYAO not remarkable; Can obviously shorten the mice docking bleeding time, reduce amount of bleeding, and shorten clotting time.
The heavy dose of 10mgkg of rabbit
-1With middle dosage 5mgkg
-1(quite the clinic trial amount is 3.34 times and 1.67 times) can make the multiple calcium clotting time (PRT) of blood plasma shorten; 10mgkg
-1Also can obviously shorten prothrombin time (SPT) and KPTT (KPTT); But the rat euglobulin lysis time there is not obvious influence; Show that these article can promote fibrin to form and blood coagulation through activating blood coagulation system, thus performance hemostasis drug effect.
Two, antibacterial experiment
Select the yellow coccus of 5-6 cash equivalent, escherichia coli, Pseudomonas aeruginosa, Candida albicans for use, prepare bacteria suspension with PBS, the bacteria containing amount of this bacteria suspension is 5 * 10
5～5 * 10
6Cfu/ml; Under 19～21 ℃, carry out 3 time antibacterial tests with anorectal plug filling medicament according to " disinfection technology standard " (version in 2002) 2.1.8: with diameter is that the anorectal plug filling medicament disk of 5mm is affixed on the microbiological contamination flat board; The bacteriostatic diameter of staphylococcus aureus, escherichia coli, Pseudomonas aeruginosa and Candida albicans is respectively 18.2mm, 14.8mm, 21.5mm and 25.3mm after cultivating in 17 hours, and experimental result is seen table 8.
Table 8
Annotate: (1) inhibition zone diameter has been judged to bacteriostasis greater than 7mm person; (2) negative control does not all have antibacterial ring generation.
Table 8 data show: anorectal plug filling medicament all has bacteriostasis to above-mentioned four kinds of strains.
Embodiment three
The anorectal plug filling medicament of present embodiment is the variation on embodiment one basis, and different is except identical with embodiment one: (1) anorectal plug filling medicament heat time heating time in the preparation is 25 minutes, and the mass percent of (2) its component is following;
(3) skin penetrant is selected water for use, and consumption is to account for 0.8% of whole anorectal plug filling medicament gross mass; (4) wetting agent is selected sorbitol for use, and consumption is to account for 2.198% of whole anorectal plug filling medicament gross mass; (5) firming agent is selected active aluminium hydroxide for use, and consumption is to account for 0.002% of whole anorectal plug filling medicament gross mass.
With the anorectal plug filling medicament of present embodiment stop blooding respectively, antimicrobial experiment in the body.
One, hemostasis experiment
Get 8 of rabbit, with the rabbit ear blood vessel perfusion method test of exsomatizing of 20% aqueous solution of the normal saline solution of anorectal plug filling medicament, each administration 0.5ml measures that blood flow changes in the 20min, with before the administration relatively.The result checks through F; The Chinese herbal medicine extract that anorectal plug filling medicament includes can make perfusion flow obviously reduce; Get 24 of rats and be divided into 4 groups; 0.8% aqueous solution of the normal saline solution of anorectal plug filling medicament carries out rat at body kidney perfusion experiment, and each administration 0.1ml observes administration front and back perfusion pressure difference and perfusion pressure raising value.The result checks through F, and the normal saline solution of anorectal plug filling medicament obviously improves perfusion pressure, and the perfusion pressure difference is 78.66 ± 0.4mmHg before and after the administration, and flow is pressed and improved 13.11814%.The normal saline solution anastalsis of this experimental result anorectal plug filling medicament mainly is vasoconstrictive.
Two, antibacterial experiment in the body
Anorectal plug filling medicament is tested the protection of infection of staphylococcus aureus mice: get 76 random packet of 18～22g ICR kind mice, be divided into 4 groups, 19 every group).(1) normal control group: equivalent NS 10ml/kg; (2) model control group: equivalent NS 10ml/kg; (3) SHUANGHUANLIAN group: equivalent NS 10ml/kg.(4) anorectal plug filling medicament group: equivalent NS10ml/kg.Below respectively organize the equal muscle administration of mice, administration capacity 10ml/kg, 1 time/day * 5 days.Administration 1 in the 2nd day is 0.5ml/ Mus of pneumoretroperitoneum injection staphylococcus aureus culture fluid (removing the blank group) as a child, continues administration 3 days, observes death condition in each treated animal 7 days.Experimental result is seen table 9.
Table 9
Table 9 data show: for the mice of infection of staphylococcus aureus, use anorectal plug filling medicament to carry out antibacterial experiment in the body, can obviously reduce the survival rate natural law that its mortality rate also can prolong infecting mouse.Experimental result has significant difference (P＜0.05), has explained that anorectal plug filling medicament is used for having antibacterial action preferably in the body.
The technical scheme that the described concrete technical scheme of the foregoing description that is not limited to of the present invention, all employings are equal to replacement formation is the protection domain that the present invention requires.
Claims (7)
1. anorectal plug filling medicament is characterized in that being mixed by following component by mass percentage:
Chitin 38-45%
Herba Clinopodii extract 28-32%
Pollen Tyjphae extract 22-28%
Skin penetrant, wetting agent and firming agent add up to 1-5%
Wherein, said chitin, Herba Clinopodii extract and Pollen Tyjphae extract are active component.
2. according to the said anorectal plug of claim 1 filling medicament; It is characterized in that: the main component of said chitin comprises chitosan, and said chitosan is through binary linearity polymer that β-(1 → 4) glycosidic bond is connected by 2-acetylaminohydroxyphenylarsonic acid 2-deoxidation-D-Glucopyranose. and 2-amino-2-deoxidation-D-Glucopyranose.; The main component of said Herba Clinopodii extract comprises that herb contains Herba Clinopodii Polycephali Saponin and dandelion match-9,12,17-triolefin 3 β, 23-glycol; The main component of said Pollen Tyjphae extract comprises flavonoid, naringenin, Quercetin, rutinoside, isorhamnetin, isorhamnetin neohesperidose glycoside, methyl hexadecanoate, kaempferol neohesperidoside and sitosterol.
3. according to the said anorectal plug of claim 1 filling medicament, it is characterized in that: said skin penetrant is azone, Moschus or water, and the percentage ratio that its consumption accounts for said anorectal plug filling medicament gross mass is 0.2%-1.1%; Said wetting agent is glycerol, propylene glycol or sorbitol, and the percentage ratio that its consumption accounts for said anorectal plug filling medicament gross mass is 1%-5%.
4. according to the said anorectal plug of claim 2 filling medicament, it is characterized in that: said skin penetrant is azone, Moschus or water, and the percentage ratio that its consumption accounts for said anorectal plug filling medicament gross mass is 0.2%-1.1%; Said wetting agent is glycerol, propylene glycol or sorbitol, and the percentage ratio that its consumption accounts for said anorectal plug filling medicament gross mass is 1%-5%.
5. according to claim 1 or 2 said anorectal plug filling medicaments, it is characterized in that: said firming agent is an active aluminium hydroxide, and the percentage ratio that the consumption of said active aluminium hydroxide accounts for said anorectal plug filling medicament gross mass is 0.001%-0.005%.
6. according to claim 1 or 2 said anorectal plug filling medicaments, it is characterized in that: described Herba Clinopodii extract can extract from positions such as the root of Herba Clinopodii, stem, leaf, flowers.
7. according to claim 1 or 2 said anorectal plug filling medicaments, it is characterized in that: said Pollen Tyjphae extract can extract from the pollen of Herba Typhae.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012103308693A CN102813758A (en) | 2012-09-07 | 2012-09-07 | Anorectal administration drug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012103308693A CN102813758A (en) | 2012-09-07 | 2012-09-07 | Anorectal administration drug |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102813758A true CN102813758A (en) | 2012-12-12 |
Family
ID=47298440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012103308693A Pending CN102813758A (en) | 2012-09-07 | 2012-09-07 | Anorectal administration drug |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102813758A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1626064A (en) * | 2003-12-13 | 2005-06-15 | 昆明紫健生物技术有限公司 | Aseptic dry powder spray agent and production method in use for stopping the blood and diminishing inflammation in wound |
| CN101455857A (en) * | 2007-12-11 | 2009-06-17 | 美国淀粉医疗公司 | Biocompatibility modified starch sponges |
| CN101596207A (en) * | 2008-06-04 | 2009-12-09 | 上海天龙药业有限公司 | Be used for rapid hemostatic Pharmaceutical composition and preparation method |
-
2012
- 2012-09-07 CN CN2012103308693A patent/CN102813758A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1626064A (en) * | 2003-12-13 | 2005-06-15 | 昆明紫健生物技术有限公司 | Aseptic dry powder spray agent and production method in use for stopping the blood and diminishing inflammation in wound |
| CN101455857A (en) * | 2007-12-11 | 2009-06-17 | 美国淀粉医疗公司 | Biocompatibility modified starch sponges |
| CN101596207A (en) * | 2008-06-04 | 2009-12-09 | 上海天龙药业有限公司 | Be used for rapid hemostatic Pharmaceutical composition and preparation method |
Non-Patent Citations (3)
| Title |
|---|
| 关月等: "壳聚糖_黄酮复合膜的抑菌止血促愈合作用研究", 《中国药房》, vol. 22, no. 11, 16 March 2011 (2011-03-16), pages 961 - 963 * |
| 张晶锐等: "医用壳聚糖创面修复膜凝胶在痔切除术中的应用", 《黑龙江医学》, vol. 34, no. 7, 10 July 2010 (2010-07-10), pages 504 - 505 * |
| 林琳: "医用伤口护理膜用于肛肠病术后换药的体会", 《现代中西医结合杂志》, vol. 19, no. 16, 1 June 2010 (2010-06-01), pages 2080 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105012993B (en) | A kind of cation Medical Living Creature Gum antiseptic dressing and preparation method thereof | |
| CN101879283B (en) | Novel membrane spraying preparation for skin trauma and preparation method | |
| CN103272153B (en) | Antibacterial gel and preparation method thereof | |
| CN103083713A (en) | Sterile polymerized covering dressing for wound surface | |
| JP6000976B2 (en) | Hemostatic formulation containing Takara-bi extract | |
| CN105169455B (en) | A kind of burn and scald external application first aid medical dressing and preparation method thereof | |
| CN105169456B (en) | A kind of medical bio hemorrhoid hydrogel functional dressing and preparation method thereof | |
| CN108578756A (en) | A kind of function sanitary pad and preparation method thereof | |
| CN111481498A (en) | Antibacterial gel for regulating microecological balance of female vagina and preparation method thereof | |
| CN105031708B (en) | A kind of wound rapid hemostasis powder and preparation method thereof | |
| CN104306324A (en) | Medical collagen gel and preparation method thereof | |
| CN103007337B (en) | Polymer dressing and dressing patch | |
| CN111297961A (en) | Dong medicine for promoting wound healing | |
| US20160051595A1 (en) | External-use medicament for cleaning and care of the ovaries, vagina and vulva | |
| CN108686103B (en) | Hemostatic traditional Chinese medicine composition and multifunctional emergency hemostatic composite material | |
| CN105169464B (en) | A kind of natural honey wound dressing and preparation method and application | |
| CN102274493A (en) | Bleeding-stopping, inflammation-diminishing and pain-relieving nano emulsion for use in minimally invasive beauty treatment therapy and preparation method thereof | |
| CN104524222B (en) | A kind of Chinese medicine promoting wound healing | |
| CN105560620A (en) | Trauma treatment traditional Chinese medicine preparation | |
| CN102813758A (en) | Anorectal administration drug | |
| CN105168629A (en) | Traditional Chinese medicine gel for treating qi-stagnation and blood stasis type decubitus | |
| CN105012992B (en) | A kind of medical bio vagina hydrogel functional dressing and preparation method thereof | |
| CN102028875A (en) | Medicament for treating open wound and preparation method thereof | |
| CN111514119A (en) | Adhesive bandage containing industrial hemp root extract and preparation method thereof | |
| CN105362292A (en) | Medicine composition for treating cervical erosion |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20121212 |