CN102802674B - 手消毒剂 - Google Patents
手消毒剂 Download PDFInfo
- Publication number
- CN102802674B CN102802674B CN201080032200.5A CN201080032200A CN102802674B CN 102802674 B CN102802674 B CN 102802674B CN 201080032200 A CN201080032200 A CN 201080032200A CN 102802674 B CN102802674 B CN 102802674B
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- Prior art keywords
- foam
- alcohol
- hand disinfectant
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- described part
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical compound OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000004155 Chlorine dioxide Substances 0.000 claims abstract description 5
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Classifications
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
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- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
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- A—HUMAN NECESSITIES
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- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
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- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
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Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
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- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
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Abstract
一种手消毒剂(2),其包含:(a)第一部分,所述第一部分包含处于醇介质中的亚氯酸盐,其中溶解有第一泡沫促进剂,所述第一部分装在第一泡沫分配器(4)内,由此作为第一泡沫进行分配;和(b)第二部分,所述第二部分包含处于醇介质中的酸,其中溶解有第二泡沫促进剂,所述第二部分装在第二泡沫分配器(6)内,由此作为第二泡沫进行分配;其中,当所述第一泡沫与所述第二泡沫混合时,所述亚氯酸盐和所述酸反应而提供二氧化氯,且其中等量的所述第一部分和所述第二部分的混合物(18)含有至少50重量%的醇。
Description
背景技术
本发明涉及一种手消毒剂。
诸如耐甲氧西林金黄色葡萄球菌(MRSA)和艰难梭状芽孢杆菌(Clostridium difficile)的医院获得性感染的增加强调了对于清洁的需要。特别地,在临床环境中工作的人们需要有效的手消毒。
发明内容
本发明的各方面描述在独立权利要求中。优选技术特征描述在从属权利要求中。
本发明提供了具有杀孢子性质的二氧化氯(ClO2)的抗菌醇手清洗消毒剂的益处。
本发明使用的术语“醇介质”指含有醇的液体,通常是醇的水溶液。所述醇可以是乙醇、异丙醇、正丙醇或它们的混合物。在一种实施方式中,所述醇为或含有3-甲氧基-3-甲基-1-丁醇(MMB),我们发现与乙醇相比其提供快速干燥时间和改善皮肤感觉。
我们惊奇地发现,在大量醇存在下,ClO2的生成不会明显导致令人不愉快的醇的氧化产物,如源自乙醇的乙醛或醋酸。不希望受理论的束缚,我们认为,当泡沫混合时,ClO2与醇短暂接触,不会使得醇的氧化达到其中氧化产物的气味显著的水平。此外,我们惊奇地发现,尽管亚氯酸钠为一种氧化剂,但长期其在醇介质中是稳定的。
泡沫分配器可以在普通的外罩中提供和使用普通驱动器进行分配,如WO 2006/079822中所描述,其全部内容通过引用并入本文。
附图说明
现在仅通过实施例的方式参照下列附图对本发明进行进一步说明:
图1显示根据本发明的一种实施方式的手消毒剂;以及
图2显示使用中的图1所示的手消毒剂。
具体实施方式
除非另有说明,在本说明书中,所有部分都以重量计。
本实施例中的手消毒剂使用源自Airspray International BV的双道发泡(Dual Foamer)泡沫分配器。手消毒剂2具有夹扣于第二分配器室6的第一分配器室4。所述分配器室4和分配器室6为两个小的泡沫泵系统部件,当压挤各自活塞元件14、16时,喷出其作为泡沫的内容物。通过操作单一驱动器8挤压活塞14、16,引起一定体积(在该实施例中为0.8ml)的液体从分配器室4、6分别同时泵出并与空气组合而形成泡沫。来自分配器室4的液体转化为第一泡沫,来自分配器室6的液体转化为第二泡沫。所述第一和第二泡沫通过位于驱动器8中的各自独立的喷口10、12而分配。
第一分配器室4包含第一部分,所述第一部分包含处于水性介质中的亚氯酸盐,其中溶解有第一泡沫促进剂,所述第一部分装在第一泡沫分配器内,由此作为第一泡沫进行分配。所述第一部分的例示配方显示于表1A和表2A。
第二分配器室6包含第二部分,所述第二部分包含处于醇介质中的酸,其中溶解有第二泡沫促进剂,所述第二部分装在第二泡沫分配器内,由此作为第二泡沫进行分配。所述第二部分的例示配方显示于表1B和表2B。
表1A
第二部分 | % | |
1 | 脱盐水 | 平衡 |
2 | 乙醇-B | 80 |
3 | 柠檬酸(ANH) | 1 |
4 | 山梨酸 | 0.01 |
5 | 硼酸 | 0.01 |
6 | 甘油(植物) | 0.5 |
7 | 苯甲酸钠 | 0.2 |
8 | 表面活性剂(聚二甲基硅氧烷共聚醇) | 0.5 |
9 | 羟乙基纤维素 | 0.25 |
10 | 醋酸钠 | 0.2 |
表1B
在第一部分和第二部分中,应用聚二甲基硅氧烷共聚醇表面活性剂作为泡沫促进剂。在其它实施方式中,我们发现,包含等份聚二甲基硅氧烷共聚醇、聚二甲基硅氧烷敌草快(polydimethylsiloxane diquat)、烷基氨基羧酸盐和烷基甜菜碱的混合物的表面活性剂在水性介质和醇介质中具有良好的泡沫稳定性。
第一部分 | % | |
1 | 脱盐水 | 平衡 |
2 | 亚氯酸钠溶液 | 0.5 |
3 | 表面活性剂(聚二甲基硅氧烷共聚醇) | 0.5 |
4 | 乙醇-B | 30 |
5 | 羟乙基纤维素 | 0.25 |
表2A
第二部分 | % | |
1 | 脱盐水 | 平衡 |
2 | 乙醇-B | 70 |
3 | 柠檬酸(ANH) | 1 |
4 | 山梨酸 | 0.01 |
5 | 硼酸 | 0.01 |
6 | 甘油(植物) | 0.5 |
7 | 苯甲酸钠 | 0.2 |
8 | 表面活性剂(聚二甲基硅氧烷共聚醇) | 0.5 |
9 | 羟乙基纤维素 | 0.25 |
10 | 醋酸钠 | 0.2 |
表2B
参考图2,通过使用者的手指22对驱动器8的作用,将来自各个喷口的泡沫喷在使用者的手20上。泡沫混合以提供含有醇和ClO2的消毒泡沫组合物18。使用者揉搓双手以使泡沫彻底混合,并用消毒泡沫组合物18覆盖其手。
任选地,可将抗生素、抗病毒剂或其他的抗微生物剂掺入至第一部分和/或第二部分。适合的试剂是本领域普通技术人员公知的。其实例包括阳离子型表面活性剂、两性表面活性剂和酚醛树脂。
在使用者的双手通过用泡沫混合物18覆盖并揉搓而彻底消毒后,使用者可以洗除混合物18。然而,所述醇含量使得泡沫混合液极具挥发性,使用者可简单地选择通过蒸发使其手得到干燥。
表1的实施方式提供一种泡沫,该泡沫含有80%醇,我们发现,当其与二氧化氯组合用作手消毒剂时提供良好的消毒特性,比单独的传统醇手消毒剂或二氧化氯手消毒剂更为有效。
表2A和2B的实施方式在第一部分中具有30%醇,在第二部分具有70%醇第二。当以泡沫分配和等份混合时,所组合的泡沫具有50%醇,也提供了有效的手消毒。
如本领域自身公知,任选地,第一部分或第二部分(优选地)可以含有保湿剂、增湿剂以及芳香剂。
为改善包装和保护分配器,第一部分和/或第二部分可以含有腐蚀抑制剂。
我们发现,为了实现具有合适稳定性和“快速爆破”特性的醇泡沫,期望掺入增稠剂或成膜剂(在表1和2实施例中的羟乙基纤维素)。成膜剂的最适范围为0.01-1%,优选为0.1-0.25%。当使用手消毒剂而未清洗时,限制成膜剂的浓度至约0.25%,有助于减少非期望的残留物。
第一部分
材料 | % | |
脱盐水 | 平衡 | |
亚氯酸钠 | 0.50 | |
* | 表面活性剂 | 0.50 |
*** | 醇 | 80.00 |
** | 成膜剂 | 0.25 |
表3A
第二部分
材料 | % | |
脱盐水 | 平衡(Balance) | |
亚氯酸钠 | 0.50 | |
* | 表面活性剂 | 0.50 |
*** | 醇 | 30.00 |
** | 成膜剂 | 0.25 |
表3B
* | 表面活性剂组合: |
聚二甲基硅氧烷共聚醇 | |
聚二甲基硅氧烷敌草快 | |
烷基氨基羧酸盐+烷基甜菜碱 |
** | 成膜剂-参考如下列表 |
*** | 乙醇、异丙醇、正丙醇 |
第一部分
组分 | % | |
脱盐水 | 平衡 | |
*** | 醇 | 80.00 |
柠檬酸 | 1.00 | |
山梨酸 | 0.01 | |
硼酸 | 0.01 | |
甘油 | 0.50 | |
苯甲酸钠 | 0.20 | |
* | 表面活性剂 | 0.50 |
** | 成膜剂 | 0.25 |
醋酸钠 | 0.20 |
表4A
第二部分
材料 | % | |
脱盐水 | 平衡 | |
*** | 醇 | 70.00 |
柠檬酸 | 1.00 | |
山梨酸 | 0.01 | |
硼酸 | 0.01 | |
甘油 | 0.50 | |
苯甲酸钠 | 0.20 | |
* | 表面活性剂 | 0.50 |
** | 成膜剂 | 0.25 |
醋酸钠 | 0.20 |
表4B
适合的成膜剂包括:藻酸盐、烷基纤维素和羟烷基纤维素、羧甲基纤维素、角叉菜胶(carrageenan)、古尔胶(guar gum)、琼脂胶(gum agar)、阿拉伯胶(gum Arabic)、茄替胶(gum ghatti)、刺梧桐胶(Gum karaya)、黄芪胶(gum tragacanth)、羟乙基纤维素、羟丙基纤维素、刺槐豆胶(locustbean gum)、果胶、聚丙烯酰胺、聚丙烯酸和其同系物、聚乙二醇、聚氧化乙烯、聚乙烯醇、聚乙烯吡咯烷酮淀粉和其改性物、罗望子胶(tamarind gum)、黄原胶(Xanthan gum)。
应理解,可以使用本领域技术人员公知的可选成膜剂,条件是它们可溶于醇介质。另外,可以使用可选的表面活性剂,特别是有助于泡沫稳定性的表面活性剂。其非限制性实例包括:羧酸盐、磺酸盐(例如线性或非线性烷基苯磺酸盐、甲酯-α-磺酸盐、α-烯烃磺酸盐)、硫酸酯盐、烷基硫酸盐、乙氧基化烷基硫酸盐、三乙醇胺烷基硫酸盐、二乙醇酰胺、烷基乙氧基化物、烷基苯基乙氧基化物、烷基三甲基铵盐、氯化二烷基三甲基铵、氯化烷基吡啶、烷基羧基甜菜碱、磷酸酯和多聚磷酸酯、氟化阴离子、长链胺及其盐、酰化二胺和聚乙烯亚胺及其盐、季铵盐、聚氧乙烯化(POE)长链胺、氧化胺、聚氧乙烯化烷基酚、烷基酚“乙氧基化物”、聚氧乙烯化直链醇,醇“乙氧基化物”、聚氧乙烯化聚丙二醇、聚氧乙烯化硫醇、长链羧酸酯,烷醇胺“缩合物”、烷醇酰胺、叔炔二醇和它们的“乙氧基化物”聚氧乙烯化聚硅氧烷、正烷基吡咯烷酮、烷基聚糖苷、pH敏感两性离子表面活性剂(zwitterionics)、pH值不敏感两性离子表面活性剂、α-磺基脂肪酸甲酯(SME)、酰化氨基酸、N-酰基L-谷氨酸盐、N-酰基甘氨酸盐、N-酰基DL-丙氨酸盐(alananinates)、其他酰化氨基酸、烷氧基化诺卜醇(Nopol alkoxylates)。
在本发明的另一种实施方式中,我们发现,与乙醇相比,MMB用作部分或全部的醇成分可提供快速干燥和显著改善皮肤感觉的益处。MMB还具有优于乙醇的益处,就是其基本上为非易燃的。通过泰克闭口闪点仪(TagClosed Cup)测定,纯MMB的闪点为68℃,而MMB与10%以上的水的混合物无闪点。MMB被认为是非常安全的,没有危险警语和安全警语(R andS phrases)和职业暴露限值(Occupational Exposure Limit)。
表5归纳了MMB和水的混合物与乙醇和水的混合物的干燥速度的比较。在每种情况下,0.1ml样品用于目测评估干燥速度。通过将样品放置到标准的滤纸并测量彻底蒸发的时间而检测蒸发速率。二乙醚蒸发的时间作为整体,对于各样品所引述的数字是相对于二乙醚而表示的。
表5
上述证明了,乙醇水溶液与MMB的水溶液的相当溶液具有类似的蒸发速率。定性测试证明,与乙醇相比,MMB大大改善皮肤的感觉。
Claims (9)
1.一种手消毒剂,其包含:
(a)第一部分,所述第一部分包含处于醇介质中的亚氯酸盐,其中溶解有第一泡沫促进剂,所述第一部分装在第一泡沫分配器内,由此作为第一泡沫进行分配;和
(b)第二部分,所述第二部分包含处于醇介质中的酸,其中溶解有第二泡沫促进剂,所述第二部分装在第二泡沫分配器内,由此作为第二泡沫进行分配;
其中,当所述第一泡沫与所述第二泡沫混合时,所述亚氯酸盐和所述酸反应而提供二氧化氯,且其中等量的所述第一部分和所述第二部分的混合物含有至少50重量%的醇。
2.如权利要求1所述的手消毒剂,其中,当等量的所述第一部分和所述第二部分混合时,所述醇的浓度为50-80重量%。
3.如权利要求1所述的手消毒剂,其中,所述第一部分和所述第二部分分别还包含0.01重量%至1重量%的增稠剂或成膜剂。
4.如权利要求3所述的手消毒剂,其中,所述增稠剂或成膜剂的浓度为0.1重量%至0.25重量%。
5.如权利要求1所述的手消毒剂,其中,所述醇包括乙醇、异丙醇、正丙醇或它们的混合物。
6.如权利要求1所述的手消毒剂,其中,所述醇的至少一部分含有3-甲氧基-3-甲基-1-丁醇(MMB)。
7.如权利要求6所述的手消毒剂,其中,所述醇是MMB。
8.如权利要求1所述的手消毒剂,其中,所述泡沫促进剂为聚二甲基硅氧烷共聚醇、聚二甲基硅氧烷敌草快、烷基氨基羧酸盐和烷基甜菜碱中的任意一种或几种成分的混合物。
9.一种消毒手的方法,其包括取权利要求1所述的手消毒剂,将所述第一泡沫和所述第二泡沫分配在使用者手上,一起揉搓所述使用者的手,以混合所述泡沫并使所混合的泡沫覆盖所述使用者的手。
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KR102521748B1 (ko) | 2021-03-17 | 2023-04-17 | 주식회사 캠프런 | 전기분해 살균 세정 및 플라즈마 멸균 건조 시스템 |
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- 2010-03-29 CN CN201080032200.5A patent/CN102802674B/zh not_active Expired - Fee Related
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- 2010-03-29 KR KR1020117030623A patent/KR101653436B1/ko active IP Right Grant
- 2010-03-29 DK DK10711927.3T patent/DK2432506T3/da active
- 2010-03-29 NZ NZ596578A patent/NZ596578A/xx unknown
- 2010-03-29 AU AU2010250978A patent/AU2010250978B2/en not_active Ceased
- 2010-03-29 EP EP10711927A patent/EP2432506B1/en not_active Not-in-force
- 2010-03-29 WO PCT/GB2010/050525 patent/WO2010133855A1/en active Application Filing
- 2010-03-29 US US13/321,403 patent/US9072800B2/en not_active Expired - Fee Related
- 2010-03-29 SG SG2011086097A patent/SG176196A1/en unknown
- 2010-03-29 JP JP2012511345A patent/JP5587984B2/ja not_active Expired - Fee Related
- 2010-03-29 ES ES10711927T patent/ES2415332T3/es active Active
- 2010-03-29 CA CA2763063A patent/CA2763063A1/en not_active Abandoned
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CN1826142A (zh) * | 2003-07-23 | 2006-08-30 | 特里斯特尔有限公司 | 二氧化氯的制备 |
CN1907500A (zh) * | 2006-08-21 | 2007-02-07 | 天津生机集团有限公司 | 二氧化氯消毒剂 |
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WO2010133855A1 (en) | 2010-11-25 |
AU2010250978A1 (en) | 2011-12-22 |
HK1150434A1 (en) | 2011-12-30 |
ES2415332T3 (es) | 2013-07-25 |
GB0908849D0 (en) | 2009-07-01 |
EP2432506B1 (en) | 2013-03-27 |
US9072800B2 (en) | 2015-07-07 |
EP2432506A1 (en) | 2012-03-28 |
GB2470551B (en) | 2011-05-11 |
MY152717A (en) | 2014-11-28 |
US20120121461A1 (en) | 2012-05-17 |
CA2763063A1 (en) | 2010-11-25 |
BRPI1011051A2 (pt) | 2015-08-25 |
DK2432506T3 (da) | 2013-06-24 |
GB2470551A (en) | 2010-12-01 |
BRPI1011051A8 (pt) | 2017-01-10 |
JP5587984B2 (ja) | 2014-09-10 |
CN102802674A (zh) | 2012-11-28 |
NZ596578A (en) | 2013-03-28 |
JP2012527441A (ja) | 2012-11-08 |
KR101653436B1 (ko) | 2016-09-01 |
BRPI1011051B1 (pt) | 2017-07-18 |
KR20120026100A (ko) | 2012-03-16 |
AU2010250978B2 (en) | 2013-08-15 |
SG176196A1 (en) | 2011-12-29 |
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