CN102791879A - 用于诊断乳癌侵袭性和遗传不稳定性的标记 - Google Patents

用于诊断乳癌侵袭性和遗传不稳定性的标记 Download PDF

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Publication number
CN102791879A
CN102791879A CN2010800565327A CN201080056532A CN102791879A CN 102791879 A CN102791879 A CN 102791879A CN 2010800565327 A CN2010800565327 A CN 2010800565327A CN 201080056532 A CN201080056532 A CN 201080056532A CN 102791879 A CN102791879 A CN 102791879A
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polq
breast cancer
gene
patient
expression level
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Pending
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CN2010800565327A
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English (en)
Chinese (zh)
Inventor
C·卡佐
J-S·霍夫曼
J-C·布尔东
A·马沙多达西尔瓦
H·罗什
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Centre National de la Recherche Scientifique CNRS
INSTITUT CLAUDIUS REGAUD
Universite de Toulouse
Original Assignee
Centre National de la Recherche Scientifique CNRS
INSTITUT CLAUDIUS REGAUD
Universite Toulouse III Paul Sabatier
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Application filed by Centre National de la Recherche Scientifique CNRS, INSTITUT CLAUDIUS REGAUD, Universite Toulouse III Paul Sabatier filed Critical Centre National de la Recherche Scientifique CNRS
Publication of CN102791879A publication Critical patent/CN102791879A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN2010800565327A 2009-11-13 2010-11-12 用于诊断乳癌侵袭性和遗传不稳定性的标记 Pending CN102791879A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09306096A EP2322658A1 (en) 2009-11-13 2009-11-13 Signature for the diagnosis of breast cancer aggressiveness and genetic instability
EP09306096.0 2009-11-13
PCT/EP2010/067401 WO2011058143A1 (en) 2009-11-13 2010-11-12 Signature for the diagnosis of breast cancer aggressiveness and genetic instability

Publications (1)

Publication Number Publication Date
CN102791879A true CN102791879A (zh) 2012-11-21

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CN2010800565327A Pending CN102791879A (zh) 2009-11-13 2010-11-12 用于诊断乳癌侵袭性和遗传不稳定性的标记

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Country Link
US (1) US8865408B2 (enExample)
EP (2) EP2322658A1 (enExample)
CN (1) CN102791879A (enExample)
AU (1) AU2010317877A1 (enExample)
BR (1) BR112012011247A2 (enExample)
CA (1) CA2780479A1 (enExample)
ES (1) ES2522992T3 (enExample)
IL (1) IL219697A0 (enExample)
IN (1) IN2012DN04944A (enExample)
PT (1) PT2499258E (enExample)
WO (1) WO2011058143A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106011262A (zh) * 2016-06-29 2016-10-12 北京泱深生物信息技术有限公司 子宫内膜癌诊治标志物及其应用
CN112646864A (zh) * 2020-12-30 2021-04-13 杭州联川基因诊断技术有限公司 一种检测esr1基因表达的引物、探针、试剂盒和检测方法
CN112725444A (zh) * 2020-12-30 2021-04-30 杭州联川基因诊断技术有限公司 一种检测pgr基因表达的引物、探针、试剂盒和检测方法

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103827314A (zh) * 2011-05-18 2014-05-28 国家科学研究中心 用于诊断癌侵袭性和遗传不稳定性的标记
CN104145030B (zh) 2012-01-05 2016-10-12 国家科学研究中心 用于诊断肺癌侵袭性和遗传不稳定性的标记
CN102994627B (zh) * 2012-06-21 2015-04-15 宁波海尔施基因科技有限公司 一种肿瘤用药个体化指导的检测方法
US9157124B2 (en) 2012-09-18 2015-10-13 Institute For Cancer Research Systems and methods for diagnosing a predisposition to develop colon cancer
FR3019821A1 (fr) * 2014-04-14 2015-10-16 Centre Nat Rech Scient Nouveaux anticorps utiles pour le diagnostic et le pronostic du cancer
US10724100B2 (en) 2015-09-16 2020-07-28 Institute For Cancer Research Systems and methods for treating patients having a genetic predisposition to develop prostate cancer
WO2017062754A1 (en) * 2015-10-07 2017-04-13 New York University Compositions and methods for enhancing crispr activity by polq inhibition
US20190055563A1 (en) * 2015-10-19 2019-02-21 Dana-Farber Cancer Institute, Inc. Polymerase q as a target in hr-deficient cancers
US12428663B2 (en) 2018-07-11 2025-09-30 The Johns Hopkins University Identification of DNA polymerase theta inactivation mechanism
JP7689494B2 (ja) * 2018-12-31 2025-06-06 テンパス・エーアイ・インコーポレイテッド 患者コホートの反応、増悪、および生存を予測し解析するための方法およびプロセス
US11875903B2 (en) 2018-12-31 2024-01-16 Tempus Labs, Inc. Method and process for predicting and analyzing patient cohort response, progression, and survival
US11599800B2 (en) * 2020-01-28 2023-03-07 Color Genomics, Inc. Systems and methods for enhanced user specific predictions using machine learning techniques

Citations (1)

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WO2008077165A1 (en) * 2006-12-22 2008-07-03 Austrian Research Centers Gmbh - Arc Set of tumor markers

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BRPI0408284B8 (pt) 2003-03-12 2021-05-25 Kudos Pharm Ltd compostos derivados de ftalazinona, seu uso e composição farmacêutica compreendendo os mesmos
WO2005053662A1 (en) 2003-12-01 2005-06-16 Kudos Pharmaceuticals Limited Dna damage repair inhibitors for treatment of cancer
US20090081119A1 (en) 2005-05-19 2009-03-26 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Inhibiting dna polymerase beta to enhance efficacy of anticancer agents
CA2674084C (en) 2006-12-26 2013-05-14 Pharmacyclics, Inc. Method of using histone deacetylase inhibitors and monitoring biomarkers in combination therapy
PL2209375T3 (pl) 2007-10-03 2014-12-31 Eisai Inc Związki, kompozycje i metody stosowania inhibitorów PARP

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008077165A1 (en) * 2006-12-22 2008-07-03 Austrian Research Centers Gmbh - Arc Set of tumor markers

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KAWAMURA ET AL.: "DNA polymerase θ is preferentially expressed in lymphoid tissues and upregulated in human cancers", 《INTERNATIONAL JOURNAL OF CANCER》 *
WANG ET AL.: "Mutational Analysis of Thirty-two Double-Strand DNA Break Repair Genes in Breast and Pancreatic Cancers", 《CANCER RESEARCH》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106011262A (zh) * 2016-06-29 2016-10-12 北京泱深生物信息技术有限公司 子宫内膜癌诊治标志物及其应用
CN112646864A (zh) * 2020-12-30 2021-04-13 杭州联川基因诊断技术有限公司 一种检测esr1基因表达的引物、探针、试剂盒和检测方法
CN112725444A (zh) * 2020-12-30 2021-04-30 杭州联川基因诊断技术有限公司 一种检测pgr基因表达的引物、探针、试剂盒和检测方法

Also Published As

Publication number Publication date
PT2499258E (pt) 2014-11-04
AU2010317877A1 (en) 2012-06-07
EP2499258B1 (en) 2014-08-06
IN2012DN04944A (enExample) 2015-09-25
CA2780479A1 (en) 2011-05-19
US8865408B2 (en) 2014-10-21
WO2011058143A1 (en) 2011-05-19
EP2499258A1 (en) 2012-09-19
EP2322658A1 (en) 2011-05-18
IL219697A0 (en) 2012-07-31
US20120021935A1 (en) 2012-01-26
BR112012011247A2 (pt) 2016-11-22
ES2522992T3 (es) 2014-11-20

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