CN102772716A - Nano-silver system itching-relieving skin calming tincture for antibiosis, delousing and killing parasites and mites - Google Patents

Abstract

The invention discloses a nano-silver system itching-relieving skin calming tincture for antibiosis, delousing and killing parasites and mites, which belongs to the field of a production technology for preparing an external preparation for the skin diseases. The phthiriasis can be divided into three types according to the different parasitic sites of the lice, namely pubic louse, body louse and head louse. The phthiriasis is a contact pruritic skin disease and simultaneously exists with mite infection. According to the nano-silver system itching-relieving skin calming tincture, a radix stemonae sulphur which is traditional Chinese medicine razor clam killing medicine, fructus carpesii etc. and a broad spectrum powerful silver are taken as a represent for contact antibiosis, TiO2 is taken as a represent for photocatalytic contact antibiosis, Al2O2 is taken as a represent for far infrared radiant type antibiosis, and a chitin natural antibacterial agent and the mite preventing antibacterial agents SCG-999 and SCJ-998 are jointly utilized for clearing heat and expelling damp, killing parasites to relieve itching, and diminishing swelling and removing stasis, thereby achieving the aims of quick and high-efficient antibiosis, killing parasites and mites, delousing, relieving itching and calming the skin.

Description

Nanometer silver is that antibiotic parasite killing delousing kills the antipruritic easypro skin tincture of demodicid mite

Technical field:

Nanometer silver of the present invention is that antibiotic parasite killing delousing kills the antipruritic easypro skin tincture of demodicid mite, is to belong to dermatosis external preparation preparation and production field.

Background technology:

Pediculosis is to be parasitized human body and bitten the caused a kind of itching skin disease of skin by louse.Can be divided into three kinds of head louses, body louse, pubic louse according to the parasitic site difference of louse.The pediculosis pilosity is born among the relatively poor crowd of sanitary condition, through interpersonal direct contact or mediate contact, like medicated clothing, bedding, shoes and hats etc., after louse stings, invades in skin injury, the toxin, hinders in skin, causes erythra and pruritus.Its clinical manifestation: one, head louse: head louse often parasitizes women and child's head with dishevelled hair, especially for can there be erythema, pimple in the head louse place of biting, and violent pruritus.Chang Yin select grab and scratch, blood crusts, sepage, even secondary infection is causing hair adhesion bunchy, and with stink.Two, body louse or title clothing louse: clothing louse and worm's ovum are hidden in the fold place of underwear, clothing seam or bedding more, and locate to suck human blood at the omoplate back of the body, waist etc., and red pimple, speckle or louse group can take place the skin that bites.Often can see bite mark in the erythra, conscious play is itched, can scratch because of selecting, blood crusts, sepage, even secondary infection.Three, pubic louse: mainly be that louse parasitizes human body pubes root and genital skin.Normal do as one likes life contagion, and with other sexually transmitted disease (STD) and deposit, be to belong to one of sexually transmitted disease.Motherland's medical literature is put down in writing already, and like " Waike Zhengzong, Orthodox Manual of External Diseases " cloud: " pubic louse has another name called the octal worm also." the infectivity of this worm, this person does not get better, near then good person promptly gives birth to this worm also.Can not be careless.By pubic louse bite visible pimple in place or livid purple color depth brown speckle, pruritus is unbearable, and the traditional Chinese medical science is thought: this is sick how unclean because of sexual life, dyed by insect poison, so that excessive the having an itch of worm and send out and be primary disease.Though the pubic louse main parasitic, expands to anus hair place on every side sometimes at the pubes place, and also might involve armpit hair, eyebrow, eyelashes etc.Particularly the young men and women of property active phase are for seeing more, and exist simultaneously with mite infection.And acarid is very serious to the harm of human body.

Summary of the invention:

Louse stings disease (Pediculosis) and on skin, bites caused dermatosis because of louse, claims pediculosis again in the past.Louse inhales blood of human body and parasitism with thorn on human body skin.Both can cause the pruritus erythra, influence is slept and routine work, can become the Vector of infection of some spreading venereal diseases again.Louse is the parasite that does not throughout one's life break away from the host, and is all very sensitive to temperature and humidity, both is afraid of cold, To Be Protected from Heat, is afraid of that again humidity is high.Primary disease mainly is to be infected by direct contact, and the sexual life contact is common, but also can infect through mediate contact (like comb, scarf, medicated cap, clothing etc.).This suitable warm, moist nonventilated shady place has also been created the numerous condition of planting of good growth for acarid simultaneously.Acarid has 100 kinds more than approximately, and common acarid surpasses kind more than 10, and maximum is dirt demodicid mite, indoor first demodicid mite and pawl demodicid mite, and flour mite, meat demodicid mite etc.Human body exuviae every day bits, enough 1,000,000 acarids of fed to appetite, acarid about 4 months in indoor survival, during this period, it can produce 200 times to the feces of body weight and incubate following 300 ovum, and the harm of visible acarid is how serious.

Microorganisms such as silver can killing bacteria, virus, fungus, but harmless to the human normal cell, be a kind of natural inorganic antiseptic.Silver ion all has very good effect to treatment gastritis, malaria, parasitic infection, psoriasis, the infection of eye ear oral area, yeast infection, mite infection.Silver can kill 650 kinds of pathogenic organisms bodies, does not find still up to now that under lab any microorganism can not killed by silver in 6min.Nanometer silver is that a kind of wide spectrum is imitated antibacterial by force, and the antibacterial action effect is lasting, and the multiple harmful bacterium that comprises antibacterial, fungus, infusorian, acarid, mycoplasma is all had good restraining and killing action, and antibiotic rate reaches 99.9%.

Common far infrared radiation material is arranged, Al in Maifanitum and the tourmaline ₂O ₃, TiO ₂, SiO ₂, Fe ₂O ₃They can go deep into subcutaneous tissue 3-5mm makes its heating activation tissue that heats up automatically, enhances metabolism enhancing human immune, TiO simultaneously ₂Be to represent the antibacterial of photocatalysis formula, Al ₂O ₃Be to represent the antibacterial of far infrared radiation formula.Like this from being that three kinds of antibacterial forms of contact antibacterial of representative all exist with the silver ion.Like silver is that antibacterial performance effect needs about 24h, and TiO ₂The germ-resistant bactericidal action of photocatalysis formula only needs about 1h.The present invention is with the composite effect antibacterial with three kinds of effects, and its bactericidal action is more obviously outstanding.Its principle is: at nano-TiO ₂In carry silver, exactly silver ion is embedded TiO ₂Lattice constitutes with TiO ₂With inertia silver be the short circuit micro cell of electrode.TiO ₂The hole that electrode produced is with the antibacterial oxidation operation, and silver ion is effective acceptor of electronics, with the reduction of oxidation state component, thereby reduces the compound of hole and electronics, significantly improves TiO ₂Light-catalyzed reaction efficient; On the other hand, silver ion can be at TiO ₂Lattice in stable existence, can realize the slow release of silver ion in the use, also increase the antibiotic property of photocatalyst so simultaneously at the dark place of light." silver-carrying nano titanium oxide (AT) antibacterial " produced by the Chenzhou City Jingui Nonferrous Metal Co., Ltd---" AT nano antibacterial agent " to the escherichia coli of those serious threat human healths, staphylococcus aureus killing rate up to 99.99%.The silicon dioxide SiO that is contained in Maifanitum, tourmaline, marine mineral, coral fossil, bottom sediment, the Sargassum carbon ₂, titanium dioxide TiO ₂, aluminium sesquioxide Al ₂O ₃, iron sesquioxide Fe ₂O ₃, various trace elements such as calcium Ca, nickel, zinc Zn, molybdenum Mu, cobalt Co, silicon Si, copper Cu, stannum Sn, manganese Mn, vanadium V, selenium Se, germanium Ge, fluorine F, iodine l, potassium K, magnesium Mg, sodium Na, chromium Cr, lithium Li, strontium Sr all is that human body is necessary; After these nano-elements and the contact skin; Spark with regard to producing, ionisation effect is H with the hydrone electrolysis ⁺And OH ^-H ⁺With tourmaline, marine mineral deposit or coral fossil, the electronics that discharges combines and is neutralized into the H atom, and OH ^-With other water molecules, can generate hydroxyl anion H continuously ₃O ₂ ^-It is how stuffy that louse often parasitizes head, axil, pudendum, hair, and the shady place of warm moist again not only provides the breeding parasitic conditions of louse, and the also very suitable killing indoor mite of this good humiture is bred the condition created fast simultaneously.Acarid is extremely harmful to health, can transmitted virus, antibacterial, and the heat that can cause bleeding, dermatitis, folliculitis, scabies, eczema, abnormality Herba Urticae Cannabinae such as examine at anaphylactic disease.Purify water air negative ion purifying air, silver ion for sterilization sterilization with Maifanitum.

For effectively blocking-up louse and acarid parasitized breeding condition, the environment that makes its warm moist makes purification of water quality, purification mineralising with the characteristic of Maifanitum porous cave brute force adsorption cleaning water quality, and can discharge the various trace elements to the human body beneficial.Because of having far infrared radiation thing Al again ₂O ₃, TiO ₂, SiO ₂, Fe ₂O ₃Deng going deep into subcutaneous tissue 3-5mm, make its automatization's temperature heating, activating cell, enhance metabolism, strengthen cell viability, improve body immunity, the ability of enhances human body resist the disease, thus reach the purpose of killing louse and acarid fast.

Producing several kinds of SCJ-999 and SCJ-998 by clean your the refreshing High Seience Technology Co., Ltd. in Beijing has acarid and efficiently kills fast and the anti-acarid antibacterial of broad-spectrum high efficacy of repellent action; To anti-demodicid mite, anti-demodicid mite, deodorant, mildew-resistant, itching relieving effect, the scattering ratio of acarid is reached 99%.And kill various bacillus, coccus, mycete, funguses such as touching staphylococcus aureus, gonococcus, streptococcus, streptococcus pneumoniae, meningococcus, escherichia coli, dysentery bacillus and typhoid fever, pneumonia, green pus, hay, worm person shape spore fully.And mosquito proof finishing agent

main component has mosquito, fly, flea, louse, frog worm etc. and efficiently knocks down and killing effect for being master's nanoscale microcapsule with the pyrethrin compounds.

The natural generator material of a kind of anion tourmaline mainly is to belong to the silicates porous material.It has the effect of permanent spontaneous electrode.When the slight friction of skin and medicated clothing just can cause between the negative ion powder crystal up to 1.0X10 ⁶The ev electrostatic potential is poor; Thereby form the electric field high voltage and make the air ionization in the electric field, the permanent positive and negative polarity that the electronics that is hit is had through anion crystalline powder two ends contacts the back with the hydrone of common water, airborne hydrone or skin surface just can produce the instantaneous discharge ionisation effect.Thereby can continuously produce anion, thus purifying ambient air and with air in positively charged harmful mixture neutralization, cleaning surrounding air quality.Negative aeroion is a kind of material to the human body beneficial, is called as " airborne vitamin ", " the long-lived element of human body ".The cell that can excite nerve produces good effect; By contact skin, be penetrated in the body radianting capacity that absorbs surrounding and human body self, make blood circulation accelerate telangiectasis by pore, sweat pore; Strengthen the motion of microcirculation self-disciplining; Thereby microcirculation improvement promotes human body metabolism and body normal physiological function, in time gets rid of the microcirculatory multiple disease that does not freely cause.

Below in conjunction with examples of implementation the present invention is further illustrated:

Embodiment one: nanometer silver is that antibiotic parasite killing delousing kills the antipruritic easypro skin tincture of demodicid mite, forms % by following drug quality composition proportion

Hundred step 120g account for 22.2%;

Sulfur 60g accounts for 11.1%;

Fructus Carpesii, Radix Sophorae Flavescentis, Cortex Dictamni, the Fructus Kochiae, Galla Chinensis, Fructus Cnidii, Liu Jishuan, Radix Et Rhizoma Rhei, each 40g of zinc sulfate respectively account for 7.4%.Be total to 540g.

Effect: the treatment that is mainly used in pediculosis

The pediculosis main parasitic is in human body head, armpit, pudendum, and hair is many and the dark moist improper ventilation place of seldom washing hair mainly is communicated by contact.Simultaneously brought good condition also for the acarid parasitism, brought convenience, so in removing lice, also it should be noted that and kill acarid so there is the patient of louse also to survive generally to acarid in this warm dark moist place.This in recent years contagious disease is along with the development of reforming and opening up to the outside world, going sightseeing, and sickness rate slightly rises.Common people are ashamed of nibbling mouth, be reluctant to go to the hospital, but violent pruritus are unbearable; Have to regard to rash, the state of an illness is not in time controlled caused complication, use insecticide in the treatment usually; Curative effect is not good enough, can not solve root problem, uses inconvenient; And skin had stimulation, and and brought many sequela, caused many worried and painful.

Embodiment two: nanometer silver is that antibiotic parasite killing delousing kills the antipruritic easypro skin tincture of demodicid mite, forms % by following mass component proportioning

(1) with silver ion etc. is the dry powder body 12% of contact antibacterial nanometer of representative;

(2) with TiO ₂Deng photocatalysis formula antibacterial nanometer drying powder body 10% for representative;

(3) with Al ₂O ₃Deng far infrared radiation formula antibacterial nanometer drying powder body 10% for representative;

(4) with chitin or the dry powder body 12% of chitosan natural antibacterial agent nanometer;

(5) the dry powder body 10% of mite-proofing and antimicrobial agent SCJ-999 or SCJ-998 nanometer;

(6) the dry powder body 12% of Maifanitum nanometer;

(7) the dry powder body 10% of tourmaline nanometer;

(8) marine mineral deposit, the dry powder body 10% of coral fossil nanometer;

(9) Chinese medicinal formulae is promptly implemented the dry powder body 14% of a nanometer.

Amount to 100%

Nanometer silver of the present invention is that Chinese medicine element medicine integrated use that antibiotic delousing kills demodicid mite reaches the purpose that delousing rapidly and efficiently kills demodicid mite.Use the parasite killing panacea Radix Stemonae, sulfur, Fructus Carpesii commonly used over the years at all times in the Chinese medicine, assistant has the effect of clearing heat and expelling damp, killing parasites for relieving itching, detumescence with Radix Sophorae Flavescentis, Galla Chinensis, Cortex Dictamni, Fructus Cnidii, Radix Et Rhizoma Rhei, zinc sulfate etc.Reasonable compatibility strengthens the effect that delousing kills demodicid mite, to warmly make a bet, worm-eaten becomes skin ulcer, with the folliculitis pruritus special effect arranged unbearably, delousing kills demodicid mite anti-inflammation determined curative effect, short treating period does not have irritated non-stimulated to skin.

Above-mentioned prescription is made the operating procedure method of the dry powder body of nanometer:

(1) with raw materials used by after drafting formulated, the vibration batch mixer fully mix pulverizing, each raw material all can be mixed equably;

(2) with mixed uniformly raw material briquetting and place container under 1050-1250 ℃ temperature, high-temperature calcination is synthetic;

(3) be cooled to room temperature, in the rolling grinding machine for grinding;

(4) powder body behind the mixed grinding, corundum ball, water are mixed with 1: 1: 4 serosity, in the rolling grinder, roughly grind;

(5) serosity after will roughly grinding is squeezed in the vibrator, grinds and adds an amount of dispersant with zirconia ball, grinds again;

(6) ground after with the serosity oven drying at low temperature;

(7) mill of the combination drying powder body reuse steam flow after the oven dry is pulverized and is separated;

(8) or simply cross 1000 mesh sieves with nanoscale particle diameter superfine treatment technology, medium particle diameter is 0.1-5 μ m.The dry powder body of nanometer is immersed in the 60% medical alcohol 2000ml solution subsequent use after two weeks of sealing, and the time spent is coated with cotton rod and puts the affected part on the skin 1d3 time, and 1 week of logotype is a course of treatment.

One, therapeutic outcome

Transference cure can not find mite and nit and acarid; Skin lesion recovers.This group 30 example is all cured, the course of treatment the longest 7d, the shortest 3d, average 4d.

Two, model case

Zhao X, the man, 38 years old, the violent pruritus of pudendum more than 10 day was once with outer medicine treatment, poor effect.In on March 7th, 2011 with regard to rash, pubes place skin is seen big five rash of grain of rice appearance, blood crusts and scratch, pubes adhere to canescence like cuticle bits shape thing, use lens examination, observation has active pubic louse and nit and acarid, is diagnosed as pediculosis pubis and mite infection.Use further consultation behind the 4d by tincture of the present invention, pruritus disappears, and can not find active pubic louse and acarid and ovum, advises its sterilize its underwear, towel, bedding, notices simultaneously whether the live-in partner has this disease.

Experiment material method, result:

One, animal

Healthy rabbits, body weight 1.5kg-2.0kg; Healthy rat, body weight 200g-300g; Healthy guinea pig, body weight 250g-300g.

Above animal male and female half and half are provided by Nantong University animal field.

Two, method (1) skin irritation test

1. operational approach

Get 8 of healthy rabbits, male and female half and half are divided into two groups at random, are respectively intact skin group and damaged skin group, with sterilization syringe needle cut, with slight oozing of blood degree of being.24h sloughs rabbit spinal column both sides hair with 8% sodium sulfide gelatinized corn starch, the about 100cm of every side depilation scope before being tried ², divide cage to feed.Employing consubstantiality contrast, each is organized in the left side depilation district and smears antipruritic easypro skin tincture 1.0ml, and this medicine substrate 70% ethanol 1.0ml is smeared in depilation district in right side, with 1 layer of oilpaper and 2 layers of gauzes covering, uses the nonirritant immobilization with adhesive tape, and the rubber band of reuse suitable length is tied up.Repeat administration is 1 time behind the 6h, takes off fixingly behind the 24h, with wet gauze flush away medicine, observes medicine-feeding part respectively at 0h, 1h, 24h, 48h, 72h and has or not erythema and edema.

2. standards of grading

By do not have, reluctantly, moderate, severe, aubergine erythema and have eschar to form, meter 0-4 branch; By do not have, reluctantly, moderate and severe edema, meter 0-3 branch.Total mark 7 minutes.Skin irritation reaction grade form is seen table 1.

Table 1 skin irritation reaction grade form

3. result

Observe 72h, IRs such as erythema, edema all do not appear in intact skin group and damaged skin group, and the IR mean scores is 0, two group of relatively zero difference.Explain that antipruritic easypro skin tincture is all non-stimulated to intact skin and damaged skin.

(2) skin acute toxicity test

1. operational approach

Get 36 of healthy rats, male and female half and half are divided into 6 groups at random, 6 every group.Be intact skin high and low dose group and matched group; Injured skin high and low dose group and matched group.24h sloughs rat spine both sides hair with said method, the about 2cmX3cm of depilation scope before the administration.The antipruritic easypro skin tincture 1.5ml of high concentration is evenly smeared in the district in the high dose group depilation; Antipruritic easypro skin tincture 1.5ml is smeared in low dose group depilation district; 70% ethanol 1.5ml is smeared in matched group depilation district, and fixing means is with above-mentioned skin irritation test.Take off fixingly behind the 24h,, observe and the variation of the body weight of record animal, skin, hair, eye conjunctiva respectively at 0h, 1h, 24h, 48h, 72h with wet gauze flush away medicine, and breathing, circulation, central nervous system, movable and other poisoning manifestations of extremity.

2. result

Observe 72h, each organizes all IRs such as show speckle, edema not of rat skin, and an eye conjunctiva does not have hyperemia, and physiological status is all normal, and the average weight of each treated animal increases, and does not cause and is poisoned to death, and explains that antipruritic easypro skin tincture does not have acute toxic reaction to skin.

(3) skin anaphylactic test

1. operational approach

Select 30 of Cavia porcelluss for use, be equally divided into 3 groups at random, divide cage to feed by male and female half and half.24h loses hair or feathers the guinea pig back both sides before being tried, depilation scope 3cmX3cm.Sensitization of skin contact: respectively at each depilation district, group Cavia porcellus left side be coated with antipruritic easypro skin tincture 0.5ml, 1% 2,4-dinitro-chloro-benzene 0.5ml, 70% ethanol 0.5ml fix with said method.Take off fixingly behind the 6h,, observe medicine-feeding part and have or not erythema and edema with wet gauze flush away medicine.In kind, in experiment the 7th day and the 14th day repeat administration 1 time.Skin excites contact: 2 weeks after the last administration, respectively at each the group depilation district, Cavia porcellus right side be coated with antipruritic easypro skin tincture 0.5ml, 1% 2,4-dinitro-chloro-benzene 0.5ml, 70% ethanol 0.5ml, the same skin irritation test of fixing means.Take off fixingly behind the 6h, warm water cleans, and 0h, 24h, 48h, 72h observe skin allergy.By do not have, light, in, severe edema's property erythema, meter 0-4 branch; By do not have, light, in and the severe edema, meter 0-3 branch.Total mark 7 minutes is calculated animal sensitization rate.Sensitization rate standard determination: 0-10%, weak sensitization; 11%-30%, slight sensitization; 31%-60%, the moderate sensitization;＞61%, the severe sensitization.

2. result

Experimental session is observed, and experimental group and negative control group are relatively receiving reactions such as erythema, edema not occur after examination district's administration, and two groups of mean scores are 0, and the sensitization rate is 0; Positive controls has the slight erythema of 7 examples, 2 routine moderate erythema, 5 routine Mild edema, average integral 1.6, sensitization rate 90%.Guinea pig skin anaphylaxis degree is seen table 2.

Table 2 guinea pig skin anaphylaxis table of degree

Claims (2)

1. nanometer silver is that antibiotic parasite killing delousing kills the antipruritic easypro skin tincture of demodicid mite, it is characterized in that: form % by following mass component proportioning

Hundred step 100-140g account for 18.5-25.9%;

Sulfur 40-80g accounts for 7.4-14.8%;

Fructus Carpesii, Radix Sophorae Flavescentis, Cortex Dictamni, the Fructus Kochiae, Galla Chinensis, Fructus Cnidii, Liu Jishuan, Radix Et Rhizoma Rhei, sulfur zinc

Each 20-60g respectively accounts for 3.7-11.1%.

2. according to claims, nanometer silver is that antibiotic parasite killing delousing kills the antipruritic easypro skin tincture of demodicid mite, it is characterized in that forming % by following mass component proportioning

(1) be the contact antibacterial 7-17% of representative with silver ion etc.;

(2) with TiO ₂Deng being the photocatalysis formula antibacterial 5-15% of representative;

(3) with Al ₂O ₃Deng being the far infrared radiation formula antibacterial 5-15% of representative;

(4) with chitin or chitosan nano powder body natural antibacterial agent 7-17%;

(5) the dry powder body 5-15% of mite-proofing and antimicrobial agent SCJ-999 or SCJ-998 nanometer;

(6) the dry powder body 7-17% of Maifanitum nanometer;

(7) the dry powder body 5-15% of tourmaline nanometer;

(8) marine mineral deposit, the dry powder body 5-15% of coral fossil nanometer;

(9) Chinese medicinal formulae is the dry powder body 9-19% of claim 1 nanometer.

Amount to 100%.