CN102772579B - Tincture for treating toothache and pulpitis and preparation method thereof - Google Patents
Tincture for treating toothache and pulpitis and preparation method thereof Download PDFInfo
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- CN102772579B CN102772579B CN201210138877.8A CN201210138877A CN102772579B CN 102772579 B CN102772579 B CN 102772579B CN 201210138877 A CN201210138877 A CN 201210138877A CN 102772579 B CN102772579 B CN 102772579B
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Abstract
The invention relates to a pure traditional Chinese medicine preparation prepared by lilac daphne root, cortex lycii radicis, radix scrophulariae and lithospermum. According to the preparation, a nozzle of an atomization device is utilized for directly spraying an affected gingiva lightly for administration or coating and smearing an affected tooth for administration, so that the medicine is directly absorbed by the gingiva so as to promote the blood circulation of the gingiva and eliminate the blood vessel stasis of the gingiva. Nutrition can be directly absorbed by the gingiva through active components, and the blood stasis of dental pulps is also solved readily, so that the nutrition can be directly absorbed by both of the gingiva and the dental pulps so as to eliminate the static blood stagnation in the blood vessels of the gingiva and the dental pulps and achieve double effects of promoting the blood circulation to remove the blood stasis and regulating the blood condition to alleviate pain. Therefore, the pulpitis is recovered, and the gingiva is regenerated. A loose tooth can be anew wrapped tightly by the regeneration and the expansion of an atrophied gingiva, which is beneficial to the health of periodontal tissues. Therefore, the toothache and the pulpitis are treated by the effects of promoting the blood circulation to remove the blood stasis and regulating the blood condition to alleviate the pain according to the pure traditional Chinese medicine preparation.
Description
Technical field:
The present invention relates to a kind of medicinal tincture and the process of preparing thereof with blood circulation promoting and blood stasis dispelling and treating blood disorders pain-relieving functions, particularly relate to a kind of to treatment toothache, the specific tincture of pulpitis and preparation method thereof.
Background technology:
" pearl in red water " rolls up three: " after tooth person bone, the mark of kidney is sent in gum, supports in QI and blood." pathological changes of gingiva is normal has substantial connection with stomach and kidney etc. are dirty; especially tooth firmly fill relevant with the QI and blood of gingiva; with advancing age; be engraved in change during the QI and blood of gingiva, gingival atrophy has become the serious condition of modern especially old people, falls tooth or hypodontia is of common occurrence especially; trace it to its cause or even dental pulp QI and blood is not smooth due to gingiva; cause gingiva dental pulp blood supply insufficiency, tooth loses the toothache of supporting and causing, and wind worm parasitism causes loss of tooth.
The external used medicine of existing treatment toothache; the BINGPENG SAN class preparation of external application Chinese medicine mainly based on Borneolum Syntheticum and Borax; chemical medicine is for oral administration or external preparation with anaerobism mushrooms such as metronidazoles; in the illness for specific adaptations disease is prevented and treated; there is the effect of taking stopgap measures preferably; but the alternate fundamentally not solving dental pulp, gingiva and tooth moistens foster basic physiological mechanism, initiative designs the medicine protected dental pulp, gingiva, fundamentally solve toothache.
Summary of the invention:
Object of the present invention, it is a kind of deficiency that can overcome prior art and cure the symptoms, not the disease of invention, foster basic physiological mechanism is moistened according to gingiva and dental pulp alternate, fundamentally solve the cause of disease causing toothache, the present invention is that one treats toothache, tincture of pulpitis and preparation method thereof, process is put on the skin by the painting of external mucosa, first by absorption and the transmission of mucosa, promote the sanguimotor speed of gingiva, eliminate in gingiva due to blood-vessel obstructive that insufficiency of vital energy and blood causes, active component further absorbs, diffusion, dental pulp gingiva is nourished, the blood circulation of gingiva and dental pulp and microcirculation normal circulation of qi and blood, the malaise symptoms that blood stasis blocking causes also is readily solved, allow gingiva and dental pulp directly can absorb nutrition, the blood stasis eliminated in gingiva and dental pulp blood vessels blocks, reach the double effects of blood circulation promoting and blood stasis dispelling and treating blood disorders pain relieving.
The medicine of blood circulation promoting and blood stasis dispelling of the present invention and treating blood disorders pain relieving, is characterized in that described medicine is made up of following component: Radix Genkwa 40-50%, Cortex Lycii 40-50%, Radix Scrophulariae 0-10%, Radix Arnebiae (Radix Lithospermi) 0-10%, and the percentage by weight sum of each component is 100%.
The present invention has the preparation method of the medicine of blood circulation promoting and blood stasis dispelling and treating blood disorders pain-relieving functions, it is characterized in that its step is as follows:
(1) get Radix Genkwa, Cortex Lycii, Radix Scrophulariae, Radix Arnebiae (Radix Lithospermi), removing impurity and silt, washing, shine or dry, being ground into coarse powder respectively for subsequent use.
(2) get above-mentioned coarse powder by charge ratio, mixing, adds the solvent of medicated powder 1.5 times amount, mixes thoroughly, airtight placement 15 minutes to 2 hours, with medicated powder uniform wet and degree of being expanded to fully.
(3) medicated powder of moistening is loaded percolator equably, answer degree of tightness consistent.Use 75% ethanol as solvent, should get rid of the air in medicated powder gap when adding solvent to greatest extent, solvent is submergence medicated powder surface all the time, according to the percolation (annex I N) under ingredients item, floods after 24 hours, slowly percolation;
(4) collect the liquid 1000ml that filters, leave standstill, clarification of waiting, filter, obtain filtrate for subsequent use;
(5) percolate obtained in (4) is loaded with in the container of atomising device or in common container and get final product.
The invention belongs to the natural prodcuts that Wild Medicinal refines extraction, be also at present known to effectively treat toothache, the related indication pure Chinese medicinal preparation product of pulpitis.
Radix Genkwa, be the root of Isolated From Thymelaeaceae Species Flos Genkwa, autumn excavates, and removing earth, dries.Arduous, temperature, poisonous.Enter spleen, lung meridian.Effect is harnessed the river swollen, scrofula, acute mastitis, hemorrhoid flaccidity, scabies.Functional component is: separate cupreol, the overgrown with weeds root glycoside of flavonoid glycoside and a kind of yellow crystal (B prime) C15H14O6 in root bark, fusing point 192 DEG C
Cortex Lycii is the root bark of eggplant kind of plant Fructus Lycii etc.Sweet in the mouth, cold in nature." enter lung, liver, kidney channel, effect heat clearing away, removing heat from blood.Functional component is: containing root bark containing cinnamic acid and volume aldehydes matter, betanin.Still containing the material suppressing thiamine activity in root, this inhibitory action can be removed by cysteine and vitamin C.Cupreol, linoleic acid, linolenic acid, 1 acid etc. are still separated to obtain in Cortex Lycii.
Radix Scrophulariae, this product is the dry root of dicotyledon profound section Scrophulariaceae Radix Scrophulariae Scrophularia ningpoensis Hemsl..Sweet in the mouth, hardship, salty; Cold nature.Return lung, stomach, kidney channel.Have pathogenic warmth to join the army, cave in pericardium, maculae caused by violent heat pathogen, and consumption of YIN caused by febrile disease, crimson tongue excessive thirst, Tianjin hinder constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus.Functional component is: containing alkaloid, saccharide, sterol (Phy-tosterol), aminoacid (left-handed agedoite L-Asparagine etc.), fatty acid (mainly oleic acid, linolenic acid, stearic acid), volatile oil, carotene and retinoid material.
Radix Arnebiae (Radix Lithospermi), be Boraginaceae herbaceos perennial, tuber is used as medicine.Cold, sweet in the mouth, salty.There is removing heat from blood, invigorate blood circulation, the function of rash of detoxifying.Main component: Radix Arnebiae (Radix Lithospermi) contains Acetyl-shikonin Acetylshikonin, shikonin, alkannan, isobutyryl shikonin, β, beta-dimethyl-acryloyl shikonin, β-hydroxyl isovaleryl shikonin, 3,4-dimethyl pentene-3-acyl group shikonins.The false Radix Arnebiae (Radix Lithospermi) in Xinjiang-Tibet is containing β-Hydroxyisovalerylshikonin, 3,4-dimethyl pentene-3-acyl group shikonins.
Medicine of the present invention utilizes the spout of atomising device spray delivery or painting are put on the skin and suffered from tooth administration gently directly to ill gingiva, gingiva is made directly to absorb the drug, promote gingiva blood circulation, eliminate the blood-vessel obstructive of gingiva, active component directly can absorb nutrition by gingiva, and the blood stasis blocking of dental pulp is also readily solved, and allows gingiva and dental pulp directly can absorb nutrition, the blood stasis eliminated in gingiva and dental pulp blood vessels blocks, and reaches the double effects of blood circulation promoting and blood stasis dispelling and treating blood disorders pain relieving.Thus pulpitis is fully recovered, gingiva is regenerated, and the gingiva of atrophy can be allowed to regenerate expansion and again pack tightly loosening tooth, be beneficial to periodontal tissue and keep fit.Therefore, the present invention treats toothache and pulpitis by effect of blood circulation promoting and blood stasis dispelling and treating blood disorders pain relieving.
Hubei stomatological hospital in February, 1985, to the beginning of April two months, has carried out the observation of clinical analgesic effect and desensitization effect with toothache drops to 40 routine acute pulpitiss and Dentine autopath.Wherein acute pulpitis 22 example, (totally 23 teeth) male 12 example, women 10 example, (totally 18 teeth, comprise wearing and tearing 5 example-7 teeth to dentin hypersensitiveness 18 example, contract shape defect 13 example-15 teeth, male 11 example, women 7 example.In 40 examples, the range of age is 19-64 year.
One, case selection: the object of observation is that acute pulpitis and essence are irritated, and the clinical criteria of acute pulpitis is: tooth damages+caloric stimulation pain+spy pain+spontaneous pain hypnalgia.The clinical criteria of dentin hypersensitiveness's (comprising wearing and tearing, contract shape defect and cervical region irritated) is: dentin exposure+caloric stimulation allergy+metallic weapon is irritated.
Two, using method
1, all medications when the spontaneous pain outbreak of acute pulpitis, first every wet, dry hole with sterilization dry cotton ball, in order to avoid saliva dilution medicinal liquid, then soak " spirit " toothache drops to protection and state with sterilization cotton pellet.Be placed in hole, observe pain and disappear or the situation of alleviation.
2, tooth is suffered to dentin hypersensitiveness, first every wet, drying facing with sterilized cotton ball, then with there being the sterilized cotton ball of " spirit " toothache drops to be placed on irritated facing, rubbing facing back and forth for several times, or dip in " spirit " medicinal liquid with probe and be placed in irritated facing, rub back and forth for several times by probe head end or key end again, after being disposed, use cold water stimulating affected part immediately, and detect affected part with probe, observe its allergic conditions.
Three, criterion of therapeutical effect:
1, acute pulpitis:
(1) effective: after medication, immediately without responsive needle-like or obviously alleviate.
(2) effective: after medication, condition susceptible alleviates.
(3) invalid: unchanged after medication.
Four, observed result:
In 22 routine acute pulpitiss, effective 3 examples, effective 16 examples (18 teeth), invalid 8 examples, total effectively number of cases 19 example, effective percentage reaches 86%, in 18 routine Dentine allergy, effective 16 examples (18 teeth), effective 2 examples, without nonresponder, effective percentage reaches 100%.
Five, model case:
Example 1: Yuan Honge, female, 26 years old,
Examine and tell, lower-left backteeth paroxysmal pain, hypnalgia.Cold and hot aggravation three days.
Check: suffer from painful expression.
Process: put toothache drops, cotton pellet is pain relieving immediately in hole.
Example 2: permitted Jinhua, man, 51 years old.
Main suit, upper right backteeth is met cold and hot and is eaten saccharic acid pain, February.
Check: facing matter is worn and torn, dentin exposes, dentin intersection extreme sensitivity.
Process: be positioned over allergy place, face with toothache drops cotton pellet, with tweezers clamping, rub back and forth on the whole (15 second) for several times detects allergy from probe again, and anacidity is keenly felt.
Six, brief summary
Observation shows: toothache drops has obviously and rapidly analgesic effect to acute pulpitis, and have 15 examples spontaneous pain within half a minute to disappear in 22 examples, only 3 examples are invalid, this drug use is convenient, energy quickly alleviating pain, does not find side effect in Clinical practice, can for acute pulpitis patient emergency processing.To the more remarkable effect of dentin hypersensitiveness, generally after coating, allergic symptom is eliminated immediately.There is no the irritated specific medicine of pulpitis essence at present clinically, toothache drops is very remarkable to the curative effect of dentin hypersensitiveness, is the promising medicine of effect for the treatment of dentin hypersensitiveness.
Seven, the observation of toothache drops pinprick pain effect and stability
By the holder of the Xianning State Scientific and Technological Commission, we carry out the observation of analgesic effect and stability to a record quick-acting liquid preparation for toothache, and by the pain simulation experiment to animals such as Mus, rabbit, Canis familiaris L.s, the biological electric degree of following alveolus spirit, nervus lingualis and mental nerve turns to index, finds:
One, this medicine (841110) has good Peripheral Analgesic Effect, and its effect time-histories is: after medication, namely 1 minute current potential starts to change, and change in 10-15 minute is the most remarkable, and progressively recover thereafter, acting duration can reach 2-3 hour.
Fig. 1 is the mental nerve current potential of Mus
(1) 3 minutes are contrasted after (2) medicine after 1 minute (3) medicine
(4) after medicine after 5 minutes (5) medicines after 10 minutes (6) medicines 15 minutes
(7) after medicine after 22 minutes (8) medicines after 30 minutes (9) medicines 60 minutes
(10) after medicine after 90 minutes (11) medicines after 120 minutes (12) medicines 162 minutes
Two, after finding that medicine (84612) stores half a year at normal temperatures, its analgesic effect does not change.
Fig. 2 is the nervus lingualis current potential of Mus
(1) (2) 1 minutes (3) 3 minutes are contrasted
(4) 5 minutes (5) 10 minutes (6) 30 minutes
Eight, medicament for treating toothache clinical observation and pharmacological evaluation are summed up
Toothache drops is through the attached stomatological hospital of Hubei medical college, unit clinical observation 225 examples such as each hospital of Wuhan City, total effective rate is 97.78%, and wherein obvious effective rate is 75.56%, treatment acute pulpitis effective percentage is 97.71%. chronic pulpitis is 96.15%, and dark dental caries companion pulp hyperemia is 100%.Male 148 example in 225 examples, women 77 example.Age 8-60 year between, prove that this medicine uses male woman is all-ages, after this medicine uses, effect is rapidly, and pain relieving speed to calculate second, and has long-acting.This medicine does not find any side effect in clinical.
Zoopery shows, this medical instrument has good peripheral nervous analgesic activity.Within after medication one minute, namely potential change occurs, acting duration reaches 2-3 hour, and bacteriostatic test shows, this medicine has good bacteriostasis.To green angle streptococcus, Candida albicans is extremely sensitive, and to a type streptococcus, bacteroides fragilis, to mucosa, Hemolytic streptococcus medium sensitivity, does not find that obvious stimulation is reacted, change without particular tissues dental pulp.
Detailed description of the invention:
Embodiment 1
Get Radix Genkwa 40%, Cortex Lycii 40%, Radix Scrophulariae 10%, Radix Arnebiae (Radix Lithospermi) 10%, removing impurity and silt, washing, shine or dry, being ground into coarse powder respectively.Get coarse powder by above-mentioned charge ratio, mixing, adds the solvent of medicated powder 1.5 times amount, mixes thoroughly, airtight placement 15 minutes to 2 hours, with medicated powder uniform wet and degree of being expanded to fully.The medicated powder of moistening is loaded percolator equably, answers degree of tightness consistent.Use 75% ethanol as solvent, should get rid of the air in medicated powder gap when adding solvent to greatest extent, solvent is submergence medicated powder surface all the time, according to the percolation (annex I N) under ingredients item, floods after 24 hours, slowly percolation; Collection is filtered liquid 1000ml, leaves standstill, clarification of waiting, filtration, obtains filter and to filter liquid; Obtained percolate loads with in the container of atomising device and get final product.
Embodiment 2
Get Radix Genkwa 50%, Cortex Lycii 40%, Radix Scrophulariae 10%, removing impurity and silt, washing, shine or dry, being ground into coarse powder respectively.Get coarse powder by above-mentioned charge ratio, mixing, adds the solvent of medicated powder 1.5 times amount, mixes thoroughly, airtight placement 15 minutes to 2 hours, with medicated powder uniform wet and degree of being expanded to fully.The medicated powder of moistening is loaded percolator equably, answers degree of tightness consistent.Use 75% ethanol as solvent, should get rid of the air in medicated powder gap when adding solvent to greatest extent, solvent is submergence medicated powder surface all the time, according to the percolation (annex I N) under ingredients item, floods after 24 hours, slowly percolation; Collection is filtered liquid 1000ml, leaves standstill, clarification of waiting, filtration, obtains filter and to filter liquid; Obtained percolate loads with in the container of atomising device and get final product.
Embodiment 3
Get Radix Genkwa 40%, Cortex Lycii 50%, Radix Arnebiae (Radix Lithospermi) 10%, removing impurity and silt, washing, shine or dry, being ground into coarse powder respectively.Get coarse powder by above-mentioned charge ratio, mixing, adds the solvent of medicated powder 1.5 times amount, mixes thoroughly, airtight placement 15 minutes to 2 hours, with medicated powder uniform wet and degree of being expanded to fully.The medicated powder of moistening is loaded percolator equably, answers degree of tightness consistent.Use 75% ethanol as solvent, should get rid of the air in medicated powder gap when adding solvent to greatest extent, solvent is submergence medicated powder surface all the time, according to the percolation (annex I N) under ingredients item, floods after 24 hours, slowly percolation; Collection is filtered liquid 1000ml, leaves standstill, clarification of waiting, filtration, obtains filter and to filter liquid; Obtained percolate loads with in the container of atomising device and get final product.
Embodiment 4
Get Radix Genkwa 50%, Cortex Lycii 50%, removing impurity and silt, washing, shine or dry, being ground into coarse powder respectively.Get coarse powder by above-mentioned charge ratio, mixing, adds the solvent of medicated powder 1.5 times amount, mixes thoroughly, airtight placement 15 minutes to 2 hours, with medicated powder uniform wet and degree of being expanded to fully.The medicated powder of moistening is loaded percolator equably, answers degree of tightness consistent.Use 75% ethanol as solvent, should get rid of the air in medicated powder gap when adding solvent to greatest extent, solvent is submergence medicated powder surface all the time, according to the percolation (annex I N) under ingredients item, floods after 24 hours, slowly percolation; Collection is filtered liquid 1000ml, leaves standstill, clarification of waiting, filtration, obtains filter and to filter liquid; Obtained percolate loads with in the container of atomising device and get final product.
Claims (2)
1. have a medicine for blood circulation promoting and blood stasis dispelling and treating blood disorders pain-relieving functions, it is characterized in that described medicine is made up of following component: Radix Genkwa 40%, Cortex Lycii 40%, Radix Scrophulariae 10%, Radix Arnebiae (Radix Lithospermi) 10%, the percentage by weight sum of each component is 100%.
2. the preparation method of the medicine as described in right 1, is characterized in that its step is as follows:
(1) get Radix Genkwa, Cortex Lycii, Radix Scrophulariae, Radix Arnebiae (Radix Lithospermi), removing impurity and silt, washing, shine or dry, being ground into coarse powder respectively for subsequent use;
(2) get above-mentioned coarse powder by charge ratio, mixing, adds the solvent of medicated powder 1.5 times amount, mixes thoroughly, airtight placement 15 minutes to 2 hours, with medicated powder uniform wet and degree of being expanded to fully;
(3) medicated powder of moistening is loaded percolator equably, answer degree of tightness consistent, use 75% ethanol as solvent, the air in medicated powder gap should be got rid of to greatest extent when adding solvent, solvent is submergence medicated powder surface all the time, according to the percolation (annex I N) under ingredients item, flood after 24 hours, slowly percolation;
(4) collect the liquid 1000ml that filters, leave standstill, clarification of waiting, filter, obtain filtrate for subsequent use;
(5) percolate obtained in (4) is loaded with in the container of atomising device or in common container and get final product.
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| CN201210138877.8A CN102772579B (en) | 2012-07-03 | 2012-07-03 | Tincture for treating toothache and pulpitis and preparation method thereof |
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| CN102772579B true CN102772579B (en) | 2015-04-15 |
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Citations (3)
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|---|---|---|---|---|
| CN1096209A (en) * | 1993-06-09 | 1994-12-14 | 崇庆县中医院 | The prescription of medicine for treating toothache oral liquid and preparation technology |
| CN1698786A (en) * | 2005-05-26 | 2005-11-23 | 北京正大绿洲医药科技有限公司 | Quick acting toothache relieving dripping pills and its preparation method |
| CN101780229A (en) * | 2010-04-20 | 2010-07-21 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating gum bleeding and preparation method thereof |
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2012
- 2012-07-03 CN CN201210138877.8A patent/CN102772579B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1096209A (en) * | 1993-06-09 | 1994-12-14 | 崇庆县中医院 | The prescription of medicine for treating toothache oral liquid and preparation technology |
| CN1698786A (en) * | 2005-05-26 | 2005-11-23 | 北京正大绿洲医药科技有限公司 | Quick acting toothache relieving dripping pills and its preparation method |
| CN101780229A (en) * | 2010-04-20 | 2010-07-21 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating gum bleeding and preparation method thereof |
Non-Patent Citations (2)
| Title |
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| 中药药线治疗炎症性牙周炎72例报告;宋培智;《海军医学杂志》;19840228;68 * |
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