CN102772355A - Skin care composition with light aging resisting effect - Google Patents
Skin care composition with light aging resisting effect Download PDFInfo
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- CN102772355A CN102772355A CN2012102901535A CN201210290153A CN102772355A CN 102772355 A CN102772355 A CN 102772355A CN 2012102901535 A CN2012102901535 A CN 2012102901535A CN 201210290153 A CN201210290153 A CN 201210290153A CN 102772355 A CN102772355 A CN 102772355A
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Abstract
The invention discloses a skin care composition with a light aging resisting effect. The skin care composition consists of the following components in parts by weight: 1 to 10 parts of ginseng, 1 to 10 parts of liquorice, 1 to 10 parts of lucid ganoderma, 1 to 10 parts of astragalus mongholicus, 1 to 10 parts of rhodiola rosea, 1 to 10 parts of sophora flower and 1 to 10 parts of scutellaria baicalensis. A test result shows that the composition can obviously enhance the super oxygen dehydrogenises (SOD) activity of the skin tissue of a light aging mice and reduce the methane dicarboxylic aldehyde (MDA) content, namely the composition can enhance the anti-oxidization capacity of the skin tissue and reduce the radical content in the skin tissue and has the effect of delaying light aging of the skin; after being used for a long time, the composition can prevent light aging and enhance the resistance of the skin to the outside.
Description
Technical field
The present invention relates to a kind of skin care compositions, particularly relate to a kind of skin care compositions that has the anti-light aging effect.
Background technology
Human skin aging is divided into the aging and exogenous photoaging of endogenous physiological, and intrinsic aging can not stop, and is merely able to delay.But photoaging just can be protected.Photoaging is owing to skin is exposed to the chronic injury that causes under the ultraviolet.Ultraviolet B radiation (being called for short UVB) can directly act on DNA, makes it absorb energy, undergos mutation; The reactive oxygen species (ROS) that UVB and long wave ultraviolet (be called for short UVA) produce can indirect injury nucleus and mitochondrial DNA, causes the unusual or apoptosis of cell function.Oxidable injury protein matter of ROS and lipid that the UV irradiation produces cause the unusual of corresponding function and structure.Ultraviolet radiation can influence the skin pigment metabolism: immediate reaction is that the reactivity of melanocyte is synthetic to be increased and redistribution; Late response increases for the melanocyte number and vigor raises.Ultraviolet can make the up-regulated of vascular endothelial cell growth factor, thereby causes the hypertrophy and the expansion of blood capillary; Simultaneously, ultraviolet has immunosuppressive action, the change that causes immunocyte quantity, vigor and relevant cell factor to be expressed, but with photoaging performance dependency maximum be the change of UV-induced hypodermal cell epimatrix components in proportions, quality and function.The principal character of photoaging skin is clinically: pachylosis is dry, and irregular pigmentation, elasticity reduce and dark wrinkle in property.The characteristic of photoaging skin changes: collagen fiber elastic fibers organizational structure disappearance, and the deposition of amorphous elastin appearance material.
Modern western medical treatment skin photoage is mainly according to its pathogeny, and reduction, antioxidation, the stimulation dermal collagen hypertrophy that the collagen protein due to inducing through degraded, the protection UV that suppresses collagen fiber is expressed, the approach such as mRNA that increase some cytokine IL-1B, TNF-α, TGF-B1 carry out.Common drug has tretinoin, hydroxyacetic acid, iron chelating agent, Botulinum toxin, ubiquinone etc.Use the laser therapy skin photoage, can also reverse the photoaging change of epidermis and corium from ultrastructure, using always has CO
2Laser, YAG laser, novel C O
2Laser etc. also have dermabrasion, chemistry Therapeutic Method such as to strip off.Theory of Chinese medical science think skin photoage mainly be since deficient five internal organs, insufficiency of vital energy and blood can not go up flourish in face, body fluid not cloth be not enough to moisten and phlegm-turbidity and blood stasis resistance skin space between skin and muscles due to; So advocate that dispel turbid with kidney tonifying, essence replenishing, strengthening the spleen and tonifying the lung QI invigorating, promoting flow of QI and blood, blood stasis dispelling is main method of treatment, apply in a flexible way balance internal organs negative and positive, QI and blood regulating through square medicine reach function in delaying senility.It is closely related that modern study thinks that traditional Chinese medical science defying age mechanism and Chinese medicine can be removed interior free yl.And Chinese medicine is of a great variety, it is natural to draw materials, and favored by people because of its toxic and side effects is little again.
Summary of the invention
The purpose of this invention is to provide a kind of skin care compositions that has the anti-light aging effect.
Technical scheme of the present invention is summarized as follows:
A kind of skin care compositions that has the anti-light aging effect is made up of following component: Radix Ginseng 1-10 part, Radix Glycyrrhizae 1-10 part, Ganoderma 1-10 part, Radix Astragali 1-10 part, Radix Rhodiolae 1-10 part, Flos Sophorae 1-10 part, Radix Scutellariae 1-10 part by weight.
Preferably: said Radix Ginseng is that 3 parts, Radix Glycyrrhizae are that 8 parts, Ganoderma are that 5 parts, the Radix Astragali are that 5 parts, Radix Rhodiolae are 5 parts, and Flos Sophorae is 2 parts, and Radix Scutellariae is 2 parts.
Said Radix Ginseng, Radix Glycyrrhizae, Ganoderma, the Radix Astragali and Radix Rhodiolae are preferably concocted with following method and are formed: get Radix Ginseng, Radix Glycyrrhizae, Ganoderma, the Radix Astragali and Radix Rhodiolae and use the distilled water moistening; Steamed 0.5-3 hour; Dry or dry, so obtain the processed product of above-mentioned medical material repeatedly for 1-9 time.
Experimental result shows; It is active that the present composition can obviously strengthen photoaging mouse skin tissue SOD, reduces MDA content, shows that the present composition can strengthen the oxidation resistance of skin histology; Reduce the skin histology free-radical contents, the effect of performance delaying skin photoaging.Life-time service can prevent the generation of photoaging, and strengthens skin resistance to external world.
The specific embodiment
Below in conjunction with specific embodiment the present invention is further described.
Embodiment 1
A kind of skin care compositions that has the anti-light aging effect is made up of following component: 3 parts of Radix Ginsengs, 8 parts in Radix Glycyrrhizae, 5 parts of Ganodermas, 5 parts of the Radixs Astragali, 5 parts of Radix Rhodiolaes, 2 parts in Flos Sophorae, 2 parts of Radix Scutellariaes by weight.
Embodiment 2
A kind of skin care compositions that has the anti-light aging effect is made up of following component: 1 part of Radix Ginseng, 10 parts in Radix Glycyrrhizae, 5 parts of Ganodermas, 1 part of the Radix Astragali, 10 parts of Radix Rhodiolaes, 2 parts in Flos Sophorae, 1 part of Radix Scutellariae by weight.
Embodiment 3
A kind of skin care compositions that has the anti-light aging effect is made up of following component: 3 parts of Radix Ginsengs, 1 part in Radix Glycyrrhizae, 10 parts of Ganodermas, 5 parts of the Radixs Astragali, 1 part of Radix Rhodiolae, 10 parts in Flos Sophorae, 2 parts of Radix Scutellariaes by weight.
Embodiment 4
A kind of skin care compositions that has the anti-light aging effect is made up of following component: 10 parts of Radix Ginsengs, 8 parts in Radix Glycyrrhizae, 1 part of Ganoderma, 10 parts of the Radixs Astragali, 5 parts of Radix Rhodiolaes, 1 part in Flos Sophorae, 10 parts of Radix Scutellariaes by weight.
Embodiment 5
A kind of skin care compositions that has the anti-light aging effect is made up of following component: 3 parts of Radix Ginsengs, 8 parts in Radix Glycyrrhizae, 5 parts of Ganodermas, 5 parts of the Radixs Astragali, 5 parts of Radix Rhodiolaes, 2 parts in Flos Sophorae, 2 parts of Radix Scutellariaes by weight.
Said Radix Ginseng, Radix Glycyrrhizae, Ganoderma, the Radix Astragali and Radix Rhodiolae are to concoct with following method to form: get Radix Ginseng, Radix Glycyrrhizae, Ganoderma, the Radix Astragali and Radix Rhodiolae and use the distilled water moistening, and steamed 2 hours, dry, so obtain the processed product of above-mentioned medical material repeatedly for 9 times.
Embodiment 6
A kind of skin care compositions that has the anti-light aging effect is made up of following component: 1 part of Radix Ginseng, 10 parts in Radix Glycyrrhizae, 5 parts of Ganodermas, 1 part of the Radix Astragali, 10 parts of Radix Rhodiolaes, 2 parts in Flos Sophorae, 1 part of Radix Scutellariae by weight.
Said Radix Ginseng, Radix Glycyrrhizae, Ganoderma, the Radix Astragali and Radix Rhodiolae are to concoct with following method to form: get Radix Ginseng, Radix Glycyrrhizae, Ganoderma, the Radix Astragali and Radix Rhodiolae and use the distilled water moistening, and steamed 0.5 hour, oven dry, the processed product that obtains above-mentioned medical material repeatedly for 7 times like this.
Embodiment 7
A kind of skin care compositions that has the anti-light aging effect is made up of following component: 3 parts of Radix Ginsengs, 1 part in Radix Glycyrrhizae, 10 parts of Ganodermas, 5 parts of the Radixs Astragali, 1 part of Radix Rhodiolae, 10 parts in Flos Sophorae, 2 parts of Radix Scutellariaes by weight.
Said Radix Ginseng, Radix Glycyrrhizae, Ganoderma, the Radix Astragali and Radix Rhodiolae are to concoct with following method to form: get Radix Ginseng, Radix Glycyrrhizae, Ganoderma, the Radix Astragali and Radix Rhodiolae and use the distilled water moistening, and steamed 1 hour, dry, so obtain the processed product of above-mentioned medical material repeatedly for 5 times.
Embodiment 8
A kind of skin care compositions that has the anti-light aging effect is made up of following component: 10 parts of Radix Ginsengs, 8 parts in Radix Glycyrrhizae, 1 part of Ganoderma, 10 parts of the Radixs Astragali, 5 parts of Radix Rhodiolaes, 1 part in Flos Sophorae, 10 parts of Radix Scutellariaes by weight.
Said Radix Ginseng, Radix Glycyrrhizae, Ganoderma, the Radix Astragali and Radix Rhodiolae are to concoct with following method to form: get Radix Ginseng, Radix Glycyrrhizae, Ganoderma, the Radix Astragali and Radix Rhodiolae and use the distilled water moistening, and steamed 3 hours, oven dry, the processed product that obtains above-mentioned medical material repeatedly for 1 time like this.
A kind of preparation and use that has the skin care compositions of anti-light aging effect:
Get raw material Radix Ginseng, Radix Glycyrrhizae, Ganoderma, the Radix Astragali, Radix Rhodiolae among the embodiment 1-8, Flos Sophorae, Radix Scutellariae was pulverized the 80-200 mesh sieve, mixed well with water.
The said goods evenly was applied in facial 20-60 minute, and clear water is cleaned facial, gets final product.
Experimental data
1 material
1.1 animal.100 of Kunming mouses, body weight 20 ± 2g, ♀ ♂ half and half.
1.2 material and reagent.Compositions of the present invention; SOD mensuration test kit, MDA measure test kit, the hydroxyproline determination test kit builds up bio-engineering research by Nanjing and provides.
1.3 key instrument.Ultraviolet lamp tube (the Nanjing China limited department of forceful electric power, 80WUVA lamp and 160W UVB lamp); Uitraviolet intensity analyzer (Mei Ying Pu, Shanghai instrument and meter Manufacturing Co., Ltd, model: the ZQJ-254 type); Ultra-violet and visible spectrophotometer (east of a river, Suzhou precision instrument company limited, model: 752N); (magnetoelectricity scarabaeidae skill company limited, model: the T10 type) are got in Shanghai in tissue refiner.
2 methods
2.1 animal divides into groups and administration.
Be divided into 10 groups at random
Matched group (being normal group): do not carry out ultra-vioket radiation and not administration;
Distilled water group (model group): ultra-vioket radiation is also smeared the equivalent distilled water;
Of the present invention group (embodiment 1-8): ultra-vioket radiation and the compositions of smearing 2g/ embodiment of the invention 1-8 respectively.Mice was smeared compositions of the present invention in preceding 10 minutes carrying out ultraviolet radiation.(compositions of the present invention was pulverized 100 mesh sieves, add water mix well be suitable for using)
2.2 modeling
Except that normal group, all the other respectively organize mice with 10%Na
2S solution is got center, back skin depilatory, exposes 2cm * 2cm size skin.Simulation UV irradiation.Radiation source: UVA lamp 80W, UVB lamp 160W.Light source is shining apart from the about 40cm of mice place.Shine 1 the 1st every day in week, each 1h, and the 2nd week rose and shines 2 times every day, each 40min, prolonged exposure to accumulative total exposure dose reaches UVA 304.5J/cm
2, UVB 6.3J/cm
2
2.3 draw materials.
Behind the 60th day last irradiation 2h, take off cervical vertebra and put to death mice, get the about 1cm of depilation position skin
2, the work done in the manner of a certain author hydroxyproline content detects; Get about surplus depilation skin of back 0.1g, work done in the manner of a certain author MDA and SOD detect.
2.4 hydroxyproline content detects.
Accurately take by weighing the 0.050g skin histology, add hydrolysis 40min in 95～100 ℃ of hydrolyzed solutions, centrifugal 10min gets the supernatant strictness and detects by hydroxyproline determination test kit operating instruction.
2.5MDA, the SOD content detection.
Got the skin histology about 0.1 with the rinsing of pre-cooling normal saline, remove connective tissue and subcutaneous fat, filter paper is wiped away dried weighing; In pouring into after tissue shredded in the cut homogenate pipe; Measure the pre-cooling normal saline of 9 times of these skin histology weight, take a morsel earlier to pour into homogenate 15min in the frozen water is housed in the piece of tissue homogenizer; Pour the residue normal saline then into, process 10% tissue homogenate.It is subsequent use that 10% tissue homogenate is got supernatant with the centrifugal 10min of 3000r/min.MDA is pressed in strictness, SOD test kit operating instruction detects.
2.6 statistical method.
(X ± S) expression is carried out check between variance analysis and group with SPSS11.5 software to the result with mean ± standard deviation.
3 results
3.1 mouse skin general state.
Normal group mouse skin smooth surface is flexible, and texture is clear, no wrinkle; There is obvious erythema on model group mouse skin surface, follows the string and gloss, and keratinization of epidermis, coarse companion's desquamation have dark fold; Of the present invention group of mouse skin wrinkle is not obvious, near the normal group mouse skin.
3.2 the present composition is to the influence of mouse skin SOD, MDA.
See table 1.With normal group relatively, active significantly reduce (P＜0.01) of model group skin SOD, MDA level significantly raise (P＜0.01).Compare with model group for of the present invention group, the skin SOD activity all obviously raises (P＜0.01), MDA content obviously reduces (P＜0.01).
3.3 the present composition is to the influence of mouse skin hydroxyproline content.
See table 1.With normal group relatively, model group skin hydroxyproline content significantly descend (P＜0.01).Of the present invention group of embodiment 5-8 group compared skin hydroxyproline content rising (P＜0.05) with model group.Of the present invention group of embodiment 1-4 group compared with model group, and the skin hydroxyproline content raises, but does not possess statistical significance.
Table 1 pharmaceutical composition of the present invention to mouse skin SOD, MDA, hydroxyproline content influence (X ± S, N=10)
Annotate: compare with model group
*P＜0.05,
*P＜0.01.
In this experimental result; It is active that the present composition can obviously strengthen photoaging mouse skin tissue SOD, reduces MDA content, shows that the present composition can strengthen the oxidation resistance of skin histology; Reduce the skin histology free-radical contents, the effect of performance delaying skin photoaging.
Claims (3)
1. a skin care compositions that has the anti-light aging effect is characterized in that being made up of following component by weight: Radix Ginseng 1-10 part, Radix Glycyrrhizae 1-10 part, Ganoderma 1-10 part, Radix Astragali 1-10 part, Radix Rhodiolae 1-10 part, Flos Sophorae 1-10 part, Radix Scutellariae 1-10 part.
2. a kind of skin care compositions that has the anti-light aging effect according to claim 1 is characterized in that said Radix Ginseng is that 3 parts, Radix Glycyrrhizae are that 8 parts, Ganoderma are that 5 parts, the Radix Astragali are that 5 parts, Radix Rhodiolae are 5 parts, and Flos Sophorae is 2 parts, and Radix Scutellariae is 2 parts.
3. a kind of skin care compositions that has the anti-light aging effect according to claim 1 and 2; It is characterized in that said Radix Ginseng, Radix Glycyrrhizae, Ganoderma, the Radix Astragali and Radix Rhodiolae are to concoct with following method to form: get Radix Ginseng, Radix Glycyrrhizae, Ganoderma, the Radix Astragali and Radix Rhodiolae and use the distilled water moistening; Steamed 0.5-3 hour; Dry or dry, so obtain the processed product of above-mentioned medical material repeatedly for 1-9 time.
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| CN 201210290153 CN102772355B (en) | 2012-08-15 | 2012-08-15 | Skin care composition with light aging resisting effect |
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| CN 201210290153 CN102772355B (en) | 2012-08-15 | 2012-08-15 | Skin care composition with light aging resisting effect |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103251721A (en) * | 2013-05-08 | 2013-08-21 | 山西省肿瘤研究所 | Radiation-proof skin-care gel and preparation method thereof |
| CN103690434A (en) * | 2013-12-18 | 2014-04-02 | 郑州市嘉蓓丽生物科技有限公司 | Pu' er tea anti-aging cream and preparation method thereof |
| CN103720622A (en) * | 2013-12-25 | 2014-04-16 | 张艳 | Traditional Chinese medicine formula extract for inhibiting skin photoaging |
| CN105434266A (en) * | 2015-12-20 | 2016-03-30 | 青岛海特新蓝生物科技有限公司 | Whitening cosmetic containing rhodiola-rosea extractive, ginseng extractive and ganoderma-lucidum extractive |
| CN109200005A (en) * | 2018-11-26 | 2019-01-15 | 谢成家 | A kind of Chinese medicine sun cream formula |
| CN112353836A (en) * | 2020-11-23 | 2021-02-12 | 李沐宸 | Anti-aging whitening traditional Chinese medicine mask and preparation method thereof |
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| WO2009133998A1 (en) * | 2008-05-02 | 2009-11-05 | Amorepacific Corporation | Medicinal plants extract using processing of herbal medicine and composition of skin external application comprising the same |
| CN102406580A (en) * | 2011-11-19 | 2012-04-11 | 大连得达科技发展有限公司 | Acne-removing nourishing cream |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1410045A (en) * | 2001-09-29 | 2003-04-16 | 焦柏忠 | Cosmetics made of nano natural material |
| WO2009133998A1 (en) * | 2008-05-02 | 2009-11-05 | Amorepacific Corporation | Medicinal plants extract using processing of herbal medicine and composition of skin external application comprising the same |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103251721A (en) * | 2013-05-08 | 2013-08-21 | 山西省肿瘤研究所 | Radiation-proof skin-care gel and preparation method thereof |
| CN103690434A (en) * | 2013-12-18 | 2014-04-02 | 郑州市嘉蓓丽生物科技有限公司 | Pu' er tea anti-aging cream and preparation method thereof |
| CN103720622A (en) * | 2013-12-25 | 2014-04-16 | 张艳 | Traditional Chinese medicine formula extract for inhibiting skin photoaging |
| CN105434266A (en) * | 2015-12-20 | 2016-03-30 | 青岛海特新蓝生物科技有限公司 | Whitening cosmetic containing rhodiola-rosea extractive, ginseng extractive and ganoderma-lucidum extractive |
| CN109200005A (en) * | 2018-11-26 | 2019-01-15 | 谢成家 | A kind of Chinese medicine sun cream formula |
| CN112353836A (en) * | 2020-11-23 | 2021-02-12 | 李沐宸 | Anti-aging whitening traditional Chinese medicine mask and preparation method thereof |
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| CN102772355B (en) | 2013-09-04 |
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