CN102764271B - 双组分口腔护理产品 - Google Patents
双组分口腔护理产品 Download PDFInfo
- Publication number
- CN102764271B CN102764271B CN201210249396.4A CN201210249396A CN102764271B CN 102764271 B CN102764271 B CN 102764271B CN 201210249396 A CN201210249396 A CN 201210249396A CN 102764271 B CN102764271 B CN 102764271B
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- Prior art keywords
- component
- salt
- phosphate
- fluoride
- weight
- Prior art date
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- 230000009977 dual effect Effects 0.000 title description 7
- 239000000203 mixture Substances 0.000 claims abstract description 69
- 150000003839 salts Chemical group 0.000 claims abstract description 23
- 150000001413 amino acids Chemical class 0.000 claims abstract description 22
- 210000004268 dentin Anatomy 0.000 claims abstract description 14
- 208000002193 Pain Diseases 0.000 claims abstract description 5
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 21
- 239000004475 Arginine Substances 0.000 claims description 18
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 17
- -1 phosphate anion Chemical class 0.000 claims description 16
- 229910052791 calcium Inorganic materials 0.000 claims description 13
- 239000011575 calcium Substances 0.000 claims description 13
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 12
- 229910019142 PO4 Inorganic materials 0.000 claims description 8
- 150000002500 ions Chemical class 0.000 claims description 6
- 230000007935 neutral effect Effects 0.000 claims description 6
- 239000010452 phosphate Substances 0.000 claims description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 229940085991 phosphate ion Drugs 0.000 claims description 4
- 239000002244 precipitate Substances 0.000 claims description 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 3
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- 238000007599 discharging Methods 0.000 claims 1
- 230000008030 elimination Effects 0.000 claims 1
- 238000003379 elimination reaction Methods 0.000 claims 1
- YRWWOAFMPXPHEJ-OFBPEYICSA-K sodium L-ascorbic acid 2-phosphate Chemical compound [Na+].[Na+].[Na+].OC[C@H](O)[C@H]1OC(=O)C(OP([O-])([O-])=O)=C1[O-] YRWWOAFMPXPHEJ-OFBPEYICSA-K 0.000 claims 1
- 229940048058 sodium ascorbyl phosphate Drugs 0.000 claims 1
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- 230000002708 enhancing effect Effects 0.000 abstract description 6
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- 229940091249 fluoride supplement Drugs 0.000 description 17
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 16
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- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 10
- 239000003795 chemical substances by application Substances 0.000 description 10
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 10
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 238000000034 method Methods 0.000 description 9
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
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- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 5
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- RYJDNPSQBGFFSF-WCCKRBBISA-N (2s)-2-amino-5-(diaminomethylideneamino)pentanoic acid;carbonic acid Chemical compound OC(O)=O.OC(=O)[C@@H](N)CCCNC(N)=N RYJDNPSQBGFFSF-WCCKRBBISA-N 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 4
- 241000590002 Helicobacter pylori Species 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
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- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 4
- 229910052700 potassium Inorganic materials 0.000 description 4
- 239000011591 potassium Substances 0.000 description 4
- 229960003975 potassium Drugs 0.000 description 4
- 239000000377 silicon dioxide Substances 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 3
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- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000003082 abrasive agent Substances 0.000 description 3
- ORILYTVJVMAKLC-UHFFFAOYSA-N adamantane Chemical compound C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 description 3
- 229910001573 adamantine Inorganic materials 0.000 description 3
- 229910052783 alkali metal Inorganic materials 0.000 description 3
- 150000001340 alkali metals Chemical class 0.000 description 3
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 3
- 150000001450 anions Chemical class 0.000 description 3
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- 150000001875 compounds Chemical class 0.000 description 3
- 238000000586 desensitisation Methods 0.000 description 3
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 3
- 230000009429 distress Effects 0.000 description 3
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- 229910052588 hydroxylapatite Inorganic materials 0.000 description 3
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- 208000015181 infectious disease Diseases 0.000 description 3
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 3
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Classifications
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- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/88—Two- or multipart kits
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| BR112012017707B1 (pt) * | 2010-01-29 | 2021-11-09 | Colgate-Palmolive Company | Composição para higiene oral para cuidado do esmalte sensível |
| WO2013036229A1 (en) | 2011-09-08 | 2013-03-14 | Colgate-Palmolive Company | Oral and skin care compositions based on a 3, 3 ' - dialkyl - 1, 1 ' - biphenyl - 2, 2 ' - diol or a 3, 3 ' -dialkenyl- 1, 1 ' -biphenyl- 2, 2 ' -diol |
| JP2013163656A (ja) * | 2012-02-10 | 2013-08-22 | Gc Corp | 歯磨剤 |
| RU2524614C1 (ru) * | 2013-08-01 | 2014-07-27 | Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") | Способ увеличения прочности цементов для медицины |
| JP6092751B2 (ja) * | 2013-10-25 | 2017-03-08 | ライオン株式会社 | 歯磨組成物 |
| CA2927611C (en) * | 2013-12-03 | 2020-11-17 | Colgate-Palmolive Company | Oral care compositions |
| CA2961376A1 (en) * | 2014-09-15 | 2016-03-24 | Vizuri Health Sciences Llc | Polyphenol/flavonoid compositions and methods of formulating oral hygienic products |
| WO2016105389A1 (en) | 2014-12-23 | 2016-06-30 | Colgate-Palmolive Company | Oral care compositions |
| BR112017012629B1 (pt) | 2014-12-23 | 2021-06-08 | Colgate-Palmolive Company | composição para higiene bucal e uso da mesma |
| AU2015374240B2 (en) | 2014-12-29 | 2021-11-11 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for delivering lypophilic agents to dental pulp and for enhancing dentin production |
| JP6523002B2 (ja) * | 2015-03-20 | 2019-05-29 | 東洋エアゾール工業株式会社 | ２液混合型エアゾール歯磨剤 |
| MX365971B (es) * | 2015-04-29 | 2019-06-21 | Colgate Palmolive Co | Composiciones para el cuidado bucal. |
| WO2017048617A1 (en) * | 2015-09-15 | 2017-03-23 | Vizuri Health Sciences Llc | Polyphenol/flavonoid compositions and methods of formulating oral hygienic products |
| WO2020252501A1 (en) * | 2019-06-13 | 2020-12-17 | The Procter & Gamble Company | Kits comprising unit-dose oral care compositions |
| CN110693724B (zh) * | 2019-11-05 | 2020-10-30 | 浙江大学 | 一种牙齿矿化液及其矿化方法 |
| CN112336634B (zh) * | 2020-11-02 | 2022-03-22 | 浙江大学 | 基于微环境诱导纳米粒子再沉积的牙本质粘接预处理组合物及用途 |
| EP4014948A1 (de) * | 2020-12-18 | 2022-06-22 | Ivoclar Vivadent AG | Zusammensetzung zur remineralisation von zähnen |
| CN114939073A (zh) * | 2022-06-07 | 2022-08-26 | 云南白药集团健康产品有限公司 | 一种提高牙釉质再矿化效率的口腔护理用品及其制备方法与应用 |
| EP4292665A1 (en) * | 2022-06-16 | 2023-12-20 | Koninklijke Philips N.V. | An instantly formed cationic acp gel for treatment of tooth hypersensitivity |
| CN119421699A (zh) * | 2022-06-16 | 2025-02-11 | 皇家飞利浦有限公司 | 用于治疗牙齿过敏症的原位形成的阳离子acp凝胶 |
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2009
- 2009-02-06 CA CA2710604A patent/CA2710604C/en not_active Expired - Fee Related
- 2009-02-06 RU RU2010137324/15A patent/RU2476200C2/ru not_active IP Right Cessation
- 2009-02-06 WO PCT/US2009/033295 patent/WO2009100268A2/en not_active Ceased
- 2009-02-06 TW TW098103784A patent/TWI457141B/zh not_active IP Right Cessation
- 2009-02-06 US US12/866,639 patent/US20110059029A1/en not_active Abandoned
- 2009-02-06 TW TW103121297A patent/TWI552762B/zh not_active IP Right Cessation
- 2009-02-06 AU AU2009212324A patent/AU2009212324B2/en not_active Ceased
- 2009-02-06 EP EP20090707335 patent/EP2249770A4/en not_active Ceased
- 2009-02-06 CN CN201210249396.4A patent/CN102764271B/zh not_active Expired - Fee Related
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2010
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2014
- 2014-07-18 JP JP2014147534A patent/JP2014221814A/ja active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5476647A (en) * | 1993-09-13 | 1995-12-19 | American Dental Association Health Foundation | Complex calcium and fluoride containing mouth rinses, dentifrices, and chewable tablets |
| GB2354441A (en) * | 1999-08-06 | 2001-03-28 | Mccormack Ltd | Composition for treating dentine hypersensitivity |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009212324B2 (en) | 2011-12-08 |
| BRPI0907102A2 (pt) | 2016-05-03 |
| EP2249770A2 (en) | 2010-11-17 |
| JP2014221814A (ja) | 2014-11-27 |
| TW201442734A (zh) | 2014-11-16 |
| CN101938975A (zh) | 2011-01-05 |
| WO2009100268A3 (en) | 2009-11-05 |
| CN101938975B (zh) | 2012-09-05 |
| JP5584629B2 (ja) | 2014-09-03 |
| CN102764271A (zh) | 2012-11-07 |
| AR070586A1 (es) | 2010-04-21 |
| EP2249770A4 (en) | 2014-02-19 |
| TWI457141B (zh) | 2014-10-21 |
| CA2710604A1 (en) | 2009-08-13 |
| TWI552762B (zh) | 2016-10-11 |
| AU2009212324A1 (en) | 2009-08-13 |
| TW200948385A (en) | 2009-12-01 |
| CA2710604C (en) | 2014-07-08 |
| RU2010137324A (ru) | 2012-03-20 |
| CO6300924A2 (es) | 2011-07-21 |
| WO2009100268A2 (en) | 2009-08-13 |
| MY157315A (en) | 2016-05-31 |
| JP2011511795A (ja) | 2011-04-14 |
| RU2476200C2 (ru) | 2013-02-27 |
| US20110059029A1 (en) | 2011-03-10 |
| MX2010007740A (es) | 2010-08-06 |
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