CN102755626B - 一种治疗病态窦房结综合症的中药组合物及制备方法 - Google Patents
一种治疗病态窦房结综合症的中药组合物及制备方法 Download PDFInfo
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Abstract
本发明涉及一种治疗病态窦房结综合症的药物，特别是一种治疗病态窦房结综合症的中药及其制备方法。该中药是由麻黄、生石膏、白芥子、干姜、熟附子、白术、细辛、枳壳、阿胶、麦门冬、当归、郁金、生地、丹参、淫羊藿、枸杞子、桔梗、山茱萸、黄芪和玉竹制成。本发明与现有技术相比，具有疗效可靠，无毒副作用的优点，并且生产工艺简单，对病态窦房结综合症患者疗效显著。
Description
技术领域
本发明涉及中医中药领域，特别是一种治疗病态窦房结综合症的中药及制备方法。
背景技术
病态窦房结综合症简称病窦综合症，是由窦房结及其邻近组织病变引起窦房结起搏功能和窦房传导障碍，从而产生多种心律失常和临床症状，病窦综合症的主要特点是窦房结功能衰竭，而且可以合并心房、房室交接处及心脏全传导系统的病理改变，各种年龄都可发病，年龄越大发病率越高。其临床表现轻重不一，也呈间歇发作，轻者乏力、头昏、眼花、失眠、记忆力差、反应迟钝或易激动等，重者可引起短暂黑蒙、近乎晕厥、晕厥或阿斯综合征发作。
公开号102309726A （申请号201110277744.4 ）的中国专利文献公开的一种治疗病态窦房结综合症的中药组合物，该中药组合物是由黄芪、炙麻黄、党参、山茱萸、鹿角胶、补骨脂、淫羊藿、麦冬、玄参、女贞子、枸杞子、川穹、枳壳、郁金、地龙、甘草、附子制成。公开号CN 102526452 A（申请号201210016958.0 ）的中国专利文献公开的治疗病态窦房结综合症的中药汤剂，该中药汤剂由如下原料按重量份配比：黄芪9 ~30 份，知母 6 ~12 份，柴胡3 ~10 份，桔梗3 ~10 份，升麻 3 ~10 份，党参9 ~30 份，山萸肉5 ~20 份，桂 枝3 ~10 份，炙甘草1 ~10 份 ；同时，该发明专利还公开了中药汤剂的制备方法，将上述原料置于净器并用加冷水浸泡半小时，用武火煮开锅，后改用小火，保持微沸状态煎煮半小时后将药汁倒出并过滤；重新在容器内加冷水至超过药物3 ～5 厘米，用武火煮开锅，后改用小火，保持微沸状态煎煮半小时后，将药汁倒出并过滤后与前述倒出的药汁混合，即得中药汤剂。
现代西医学对本病尚无特效药物治疗，常用药有阿托品、麻黄素和异丙肾上腺素，病态窦房结综合症心力衰竭患者则安装人工心脏起搏器，人工心脏起搏器费用高，并且还不能根治。中医药在治疗本病方面取得了较好疗效，但还存在一定不足，中药治疗病态窦房结综合症的研究还有待于进一步提高。
发明内容
本发明的目的在于克服现有技术不足而提供一种治疗病态窦房结综合症的中药。
本发明的另一目的在于提供一种治疗病态窦房结综合症中药的制备方法。
本发明采用如下技术方案：
一种治疗病态窦房结综合症的中药及其制备方法。该中药是由麻黄、生石膏、白芥子、干姜、熟附子、白术、细辛、枳壳、阿胶、麦门冬、当归、郁金、生地、丹参、淫羊藿、枸杞子、桔梗、山茱萸、黄芪和玉竹制成。
一种治疗病态窦房结综合症的中药组合物，是由如下原料药制备而成，均为重量份：麻黄3~10份，生石膏9~30份，白芥子3~9份，干姜1~3份，熟附子3~9份，白术6~12份，细辛5~15份，枳壳3~9份，阿胶6~12份，麦门冬6~15份，当归5~12份，郁金2~8份，生地3~9份，丹参3~9份，淫羊藿3~9份，枸杞子5~15份，桔梗5~10份，山茱萸6~12份，黄芪5~10份，玉竹1~3份。
所述的治疗病态窦房结综合症的中药组合物，优选的方案中，是由如下原料药制备而成，均为重量份：麻黄5~8份，生石膏12~20份，白芥子4~8份，干姜1.5~2份，熟附子4~6份，白术8~10份，细辛8~12份，枳壳4~6份，阿胶8~10份，麦门冬8~12份，当归6~10份，郁金4~6份，生地4~8份，丹参4~8份，淫羊藿4~8份，枸杞子8~12份，桔梗6~8份，山茱萸8~10份，黄芪7~9份，玉竹1.5~2份。
所述的治疗病态窦房结综合症的中药组合物，优选的方案中，是由如下原料药制备而成，均为重量份：麻黄6份，生石膏18份，白芥子6份，干姜1.8份，熟附子5份，白术9份，细辛10份，枳壳5份，阿胶9份，麦门冬10份，当归8份，郁金5份，生地6份，丹参6份，淫羊藿6份，枸杞子10份，桔梗7份，山茱萸9份，黄芪8份，玉竹1.8份。
所述的治疗病态窦房结综合症的中药组合物的制备方法，步骤如下：
（1） 将生石膏和阿胶之外的各原料药粉碎，过90－100目筛，得细粉；
（2）将生石膏与步骤（1）所得细粉混合均匀，置于棉布袋内，用温度为20℃的凉开水浸泡6-8小时，用水量为所述细粉重量的6-7倍；
（3） 加热至沸腾，持续50分钟后取出棉布袋，所得液体经浓缩至原体积的1/2－1/3，得浓缩液；
（4）将阿胶烊化，加入到步骤（3）所得浓缩液，于105－120℃杀菌10－20分钟后无菌封装，即得中药组合物。
所述的制备方法，优选的方案在于：步骤（1）中粉碎后过95目筛，得细粉。
所述的制备方法，优选的方案在于：步骤（2）用凉开水浸泡7小时，用水量为所述细粉重量的6.5倍。
所述的制备方法，优选的方案在于：步骤（4）于110℃杀菌15分钟后无菌封装，即得。
本发明与现有技术相比，具有疗效可靠，无毒副作用的优点，生产工艺简单。
麻黄，出自《神农本草经》，辛、微苦、温。归肺、膀胱经。其功效在于发汗散寒，宣肺平喘，利水消肿。麻黄为宣肺利尿之药，该品发汗利水，有助于消散水肿，与干姜、白术等同用；
白芥子，出自《得配本草》，性温、味辛、无毒。功能温肺豁痰利气，散结通络止痛，主治寒痰喘咳，胸胁胀痛，痰滞经络，关节麻木、疼痛，痰湿流注，阴疽肿毒；
熟附子，大辛、大热、有毒，其功用在于回阳救逆，温补脾肾，散寒止痛。大辛大热，温阳逐寒。熟附子和干姜相配治疗寒少阳病，阴寒内盛，阳气欲脱，而有腹痛下利，四肢厥冷，脉微细欲绝；
白术，苦、甘，温。归脾、胃经。健脾益气、燥湿利水、止汗、安胎。用于脾虚食少、腹胀泄泻、痰饮眩悸、水肿、自汗、胎动不安；白术健脾燥湿，白芥子善祛皮里膜外之痰水，两药合用，则健脾化饮，治疗饮停胸胁之证。
细辛，功效在于解表散寒，祛风止痛，通窍，温肺化饮， 解热、利尿、镇痛、镇静药，治头痛，有发汗、祛痰；
枳壳，功效在于理气宽中，行滞消胀。用于胸胁气滞，胀满疼痛，食积不化，痰饮内停；胃下垂，脱肛，子官脱垂；
阿胶， 补血；止血；滋阴；润燥；
麦门冬，甘；微苦；寒，滋阴润肺；益胃生津；清心除烦。肺燥干咳，吐血，咯血，肺痿，肺痈，虚劳烦热，消渴，热病津伤，咽干口燥，便秘。
当归，性温，味甘、辛。归肝、心、脾经。补血活血，调经止痛，润肠通便。用于血虚萎黄、眩晕心悸、月经不调、经闭痛经、虚寒腹痛、肠燥便秘、风湿痹痛、跌扑损伤、痈疽疮疡。
郁金，性辛、苦，寒。归肝、心、肺经。可行气化瘀，清心解郁，利胆退黄。一般用于经闭痛经，胸腹胀痛、刺痛，热病神昏，癫痫发狂，黄疸尿赤。
生地，生地黄味甘、苦,性寒。归心、肝、肺经。清热、生津、润燥、滑肠、破瘀、生新、止痛、调经、金疮瘀、凉血、止血；
淫羊藿，辛、甘，温。归肝、肾经主治功能：补肾阳，强筋骨，祛风湿； 丹参，性味苦，性微寒。能活血化瘀，凉血，安神。入心、脾二经。据《本草求真》：丹参具有入心包络破瘀之功效。现代医学研究证实，其能扩张冠状动脉，增加冠脉流量，改善心肌缺血、梗塞和心脏功能，调节心律，并能扩张外周血管，改善微循环；能提高机体耐缺氧能力；有抗凝血，促进纤溶，抑制血小板凝聚，抑制血栓形成的作用；能降低血脂，抑制冠脉粥样硬化形成；能缩短红细胞及血色素的恢复期，使网织细胞增多，能促进组织的修复，加速骨折的愈合；有中枢神经有抑制作用；有抗肿瘤作用；能增强机体免疫功能；能降低血糖；对结核杆菌等多种细菌有抑制作用。
枸杞子，其味甘、性平具有补肝益肾之功效，《本草纲目》中说“久服坚筋骨，轻身不老，耐寒暑。”中医常用它来治疗肝肾阴亏、腰膝酸软、头晕、健忘、目眩、目昏多泪、消渴、遗精等病症；
桔梗，出自《神农本草经》：味辛，微温。主治胸胁痛如刀刺，腹满，肠鸣幽幽，惊恐悸气；
山茱萸，酸、涩，微温。归肝、肾经。补益肝肾，收敛固涩 、固精缩尿止带止崩 、止汗、 此外还有生津止渴 。用于腰膝酸痛、 头晕耳鸣，健忘 、遗精滑精，遗尿尿频，崩漏带下月经不调，大汗虚脱 、内热消渴；
黄芪，性甘，微温。归肺、脾、肝、肾经。有益气固表、敛汗固脱、托疮生肌、利水消肿之功效。一般用于治疗气虚乏力，中气下陷，久泻脱肛，便血崩漏，表虚自汗，痈疽难溃，久溃不敛，血虚萎黄，内热消渴，慢性肾炎，蛋白尿，糖尿病等。
玉竹，性味: 甘，微寒。归经: 归肺、胃经。功效: 养阴润燥，生津止渴。主治: 用于肺胃阴伤，燥热咳嗽，咽于口渴，内热消渴。
中医认为心气不足，肾阳衰退是本病最重要的病机。肾阳为诸阳之本，心肾
阳虚则直接影响到心跳的快慢，故此方益气升阳，活血化疲。方中黄芪、郁金、丹参补益心气；淫羊藿、玉竹、枸杞子补肾壮阳；阿胶、当归滋阴补血；麻黄、熟附子、积壳具有兴奋窦房结、提高窦房结频率、改善窦房结周围组织的功能；生地能够改善心肌脏功能及血液循环；麦门冬、山茱萸制燥热伤阴，二则滋阴与温阳同用，使阴阳互根，则阴生阳长。诸药合用益气升阳、活血祛疲，具有明显改善窦房结心率的功能。
具体实施方式
下面结合实施例和试验例详细说明本发明的技术方案，但保护范围不被此限制。
实施例：一种治疗病态窦房结综合症的中药组合物，原料药分别是麻黄6g，生石膏18g，白芥子6g，干姜1.8g，熟附子5g，白术9g，细辛10g，枳壳5g，阿胶9g，麦门冬10g，当归8g，郁金5g，生地6g，丹参6g，淫羊藿6g，枸杞子10g，桔梗7g，山茱萸9g，黄芪8g，玉竹1.8g。
前述中药组合物的制备方法，其特征在于：步骤如下：
（1） 将生石膏和阿胶之外的各原料药粉碎，过95目筛，得细粉；
（2）将生石膏与步骤（1）所得细粉混合均匀，置于棉布袋内，用温度为20℃的凉开水浸泡7小时，用水量为所述细粉重量的6.5倍；
（3） 加热至沸腾，持续50分钟后取出棉布袋，所得液体经浓缩至原体积的1/4，得浓缩液；
（4）将阿胶烊化，加入到步骤（3）所得浓缩液，于110℃杀菌15分钟后无菌封装，即得中药组合物。
典型病例1：xxx，男性，57岁。心前区疼痛已4年余；数月来加重，每日疼痛发作5次，含硝酸甘油才能缓解。有胸闷、怕冷、心悸、四肢欠温暖，疲乏无力，腿肿腰酸，胸痛彻背等症。脉沉迟，苔薄白。心电图示冠状动脉供血不足，患病态窦房结综合症。
服用本实施例所得治疗病态窦房结综合症的中药组合物，7天一个疗程。患者服用后症状立即缓解。服用1个月，心前区疼痛明显减轻，疲乏无力亦减轻，纳量增，精神可，服用3个月，心电图示冠状动脉供血明显改善，继服6个月，患者痊愈。
典型病例2：xxx，年龄：63岁；性别：男性；有冠心病史，患者6小时前出现无明显诱因胸痛，为胸骨后闷痛，呈持续性，伴后背部放射，无腹胀，无腹痛，无恶心呕吐，无畏寒发热，无咳嗽咳痰。讨论：心电图示冠状动脉供血不足，经过检查基本排除其他原因导致的胸痛，冠心病所致病态窦房结综合症、心肌缺血诊断明确。
服用本实施例所得治疗病态窦房结综合症的中药组合物，7天一个疗程。患者服用片刻，自感症状缓解。服用21天之后，胸痛明显减轻，心中烦乱亦减轻，纳量增，精神可，服用3个月，症状消除，夜眠安，心烦除，力气增，纳食可，继服8个月，患者服用时未出现任何不适，痊愈。
实验例：本发明治疗病态窦房结综合症的中药于2005年至2012年治疗患者100例，基本资料如下：100例患者中，女性45例，男性55例，年龄在36—60岁之间，发病时间多在2—4年。对照组服用其他治疗病态窦房心脏病的药物（中药、西药）
表1:服用实施例1产品38－62病态窦房结患者治疗结果。
  |
实验组 | 对照组 |
| 例数 | 100 | 20 |
| 男性例数 | 55 | 10 |
| 女性例数 | 45 | 10 |
| 年龄(岁) | 36-60 | 38-62 |
| 临床治愈例数 | 75 | 5 |
| 有效例数 | 23 | 11 |
| 无效例数 | 2 | 4 |
| 总有效率 | 98% | 80% |
治疗效果：治愈75例（75%）， 有效23例（23%），无效1例（2%），总有效率98%。效果明显优于对照组。诊断标准：患者出现与心动过缓有关的心、脑等脏器供而不足的症状，如发作性晕眩、黑蒙、乏力等，严重者可发生晕厥。心电图主要表现包括：①持续而显著的窦性心动过缓(50次/min以下)，且并非由于药物引起；②窦性停搏与窦房传导阻滞；③窦房传导阻滞与房室传导阻滞同时存在；④心动过缓、心动过速综合征。服用方法：每次1剂，每日一次，10天为一疗程。服用期间自感症状及其体力精神变化如表2所示，由此可知，实验组明显优于对照组。
Claims (6)
1.一种治疗病态窦房结综合症中药组合物的制备方法，其特征在于：取如下原料药，均为重量份：麻黄3~10份，生石膏9~30份，白芥子3~9份，干姜1~3份，熟附子3~9份，白术6~12份，细辛5~15份，枳壳3~9份，阿胶6~12份，麦门冬6~15份，当归5~12份，郁金2~8份，生地3~9份，丹参3~9份，淫羊藿3~9份，枸杞子5~15份，桔梗5~10份，山茱萸6~12份，黄芪5~10份，玉竹1~3份；步骤如下：
（1）将生石膏和阿胶之外的各原料药粉碎，过90－100目筛，得细粉；
（2）将生石膏与步骤（1）所得细粉混合均匀，置于棉布袋内，用温度为20℃的凉开水浸泡6-8小时，用水量为所述细粉重量的6-7倍；
（3） 加热至沸腾，持续50分钟后取出棉布袋，所得液体经浓缩至原体积的1/2－1/3，得浓缩液；
（4）将阿胶烊化，加入到步骤（3）所得浓缩液，于105－120℃杀菌10－20分钟后无菌封装，即得中药组合物。
2.根据权利要求1所述的制备方法，其特征在于：各原料药如下：麻黄5~8份，生石膏12~20份，白芥子4~8份，干姜1.5~2份，熟附子4~6份，白术8~10份，细辛8~12份，枳壳4~6份，阿胶8~10份，麦门冬8~12份，当归6~10份，郁金4~6份，生地4~8份，丹参4~8份，淫羊藿4~8份，枸杞子8~12份，桔梗6~8份，山茱萸8~10份，黄芪7~9份，玉竹1.5~2份。
3.根据权利要求1所述的制备方法，其特征在于：各原料药如下：麻黄6份，生石膏18份，白芥子6份，干姜1.8份，熟附子5份，白术9份，细辛10份，枳壳5份，阿胶9份，麦门冬10份，当归8份，郁金5份，生地6份，丹参6份，淫羊藿6份，枸杞子10份，桔梗7份，山茱萸9份，黄芪8份，玉竹1.8份。
4.根据权利要求1所述的制备方法，其特征在于：步骤（1）中粉碎后过95目筛，得细粉。
5.根据权利要求1所述的制备方法，其特征在于：步骤（2）用凉开水浸泡7小时，用水量为所述细粉重量的6.5倍。
6.根据权利要求1所述的制备方法，其特征在于：步骤（4）于110℃杀菌15分钟后无菌封装，即得。
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| CN1136885C (zh) * | 2001-02-23 | 2004-02-04 | 邓万发 | 一种有效治疗咳喘病的中药 |
| CN102309726B (zh) * | 2011-09-19 | 2013-02-13 | 马爱芬 | 一种治疗病态窦房结综合症的中药组合物 |
| CN102526452A (zh) * | 2012-01-19 | 2012-07-04 | 唐山市中医医院 | 治疗病态窦房结综合症的中药汤剂 |
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