CN102755306A - Application of hydroxytyrosol in medicine used for preventing and curing obesity - Google Patents
Application of hydroxytyrosol in medicine used for preventing and curing obesity Download PDFInfo
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- CN102755306A CN102755306A CN2012102129785A CN201210212978A CN102755306A CN 102755306 A CN102755306 A CN 102755306A CN 2012102129785 A CN2012102129785 A CN 2012102129785A CN 201210212978 A CN201210212978 A CN 201210212978A CN 102755306 A CN102755306 A CN 102755306A
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Abstract
The invention relates to an application of hydroxytyrosol in a medicine used for preventing and curing obesity. The hydroxytyrosol is capable of effectively reducing the increment of weight, as well as accumulation of epididymis fat and perirenal fat during the generating process of obesity. Moreover, the hydroxy tyrosol can reduce the contents of triglyceride, free fatty acid and hunger insulinum in blood; and in addition, the hydroxy tyrosol is capable of obviously restraining the generation of fatty liver, reducing the weight of the liver, and restraining the accumulation of the triglyceride and cholesterol in the liver. Therefore, the hydroxy tyrosol has the function of promoting fat metabolism and cholesterol metabolism, can effectively protect the liver function, and cure and prevent the occurrence of obesity, and belongs to a drug with high curative effect, safety and simplicity.
Description
Technical field
The present invention relates to biology and medicine and pharmacology field, the particularly application of hydroxytyrosol in the fat medicine that takes place of control.
Background technology
Obesity is a kind of chronic disease, estimates according to World Health Organization (WHO), and it is the most out in the cold to be that the mankind face at present, but sickness rate is but in a kind of disease that rises rapidly.It shows that mainly obvious overweight and fat deposit to a certain degree is blocked up, is especially a kind of state of excessively causing of the accumulation of triglyceride of body fat.
The generation of obesity can cause the generation of multiple physiology and mental illness such as diabetes, cancer, cardiovascular disease, non-alcoholic fatty liver disease, osteoarthritis, obstructive sleep apnea syndrome, human communication disorders etc.Obesity is one of topmost preventability lethal factor simultaneously.The research of a large amount of US and Europeans shows that fat fatality rate increases along with the increase of IC, and the annual death toll that increases because of obesity of the U.S. is between 111,999 to 365,000.Obesity makes life expectancy decreased average 6-7, and wherein serious obesity makes male's life expectancy reduce 20 years, and the women reduces 5 years.
Obesity be defined in continuous variation, one of method of the body fat content of the most frequently used mensuration of obesity is exactly a people's a Body Mass Index (BMI) at present, the computational methods of BMI are BMI=body weight (kg)/height
2(m).The international science association China office of giving birth to has organized " Chinese problem of obesity working group " be made up of several subject experts; Related data to 240,000 people such as 21 provinces and cities of China, regional crowd BMI, waistline, blood pressure, blood glucose, blood fat carries out Macro or mass analysis; And Chinese BMI standard proposed in view of the above; BMI=24 is the overweight boundaries of Chinese, and BMI=28 is fat boundary.Nineteen eighty-two, 7% of Chinese population was identified as overweight, by 2006; This ratio rises to 15%, one research report of delivering in 2010 to be claimed, China's population of being obese at present reaches 3.25 hundred million people; Amplification surpasses the U.S., Britain and Australia, and this numeral also possibly double at following 20 years.
At present, the fat concrete mechanism that takes place it be unclear that, and Most scholars thinks that excessive energy is taken in and the life style of silent oscillation is the main cause that causes fat disease.And the main treatment means that is directed against obesity is exactly diet control and physical training.Diet control can make body weight obviously descend in a short time; But how keeping afterwards is a problem of making us perplexing; Often need the long-term life style that keeps physical training to cooperate dietary restrictions simultaneously; Investigation finds to have only 20% people to keep body weight not rebound for a long time, and the therefore new fat method of treatment is the direction that present researcher is made great efforts research.
Summary of the invention
Treat the deficiency that fat method exists in order to overcome prior art; The object of the present invention is to provide the application of hydroxytyrosol in the fat medicine that takes place of control; Through taking in effective natural nutrient-hydroxytyrosol under the situation of normal diet; Promote body function, increase fat combustion and consumption, under the situation that does not influence food intake, accomplish the purpose of fat-reducing.
Hydroxytyrosol is a kind of native compound that derives from Fructus Canrii Albi extract; Has remarkable antioxidation; To good facilitations such as bone growth and development and cardiovascular functioies; The effect that simultaneously cancer such as pulmonary carcinoma, breast carcinoma, uterus carcinoma and carcinoma of prostate etc. is had good promotion treatment, belong to curative effect high, safely, the medicine of simplifying.
In order to achieve the above object, the technical scheme that the present invention adopted is:
The application of hydroxytyrosol in the fat medicine that takes place of control; It is characterized in that; Hydroxytyrosol is to the inductive fat inhibitory action that takes place of high fat diet, and described hydroxytyrosol structural formula is
Hydroxytyrosol can effectively improve the metabolism disorder in the fat generating process.
Hydroxytyrosol can effectively suppress the generation of the fatty liver that obesity causes.
Hydroxytyrosol can suppress the accumulation of increase, reduction epididymal adipose tissues and the perirenal fat of body weight.
Hydroxytyrosol can significantly reduce in the blood content of insulin under the triglyceride and FFA content and starvation.
Hydroxytyrosol can effectively reduce the liver weight increase that high fat diet causes, reduces triglyceride and content of cholesterol in the liver simultaneously.
Advantage of the present invention: hydroxytyrosol is the natural nutrient that derives from Fructus Canarii albi, and health is had no side effect, and has good safety.Simultaneously in edible hydroxytyrosol, need not carry out dietary restrictions, for keeping health and health at heart all has good result.The application of hydroxytyrosol has the market prospect of extensive use, can open up a new medical approach for the treatment and the prevention of obesity.
Description of drawings
Fig. 1 is the inhibitory action of hydroxytyrosol to the inductive weight increase of high fat diet.Wherein: abscissa is the absorption concentration of hydroxytyrosol, and vertical coordinate is the body weight of mouse.
Fig. 2 is the inhibitory action of hydroxytyrosol to inductive epididymal adipose tissues of high fat diet and the increase of perirenal fat tissue.Fig. 2 A is the inhibitory action to epididymal adipose tissues, and Fig. 2 B is the inhibitory action to perirenal fat.Wherein: abscissa is the absorption concentration of hydroxytyrosol, and vertical coordinate is the weight of mouse fatty tissue.
Fig. 3 is the influence coordinate diagram of hydroxytyrosol to content of triglyceride in the serum.Wherein: abscissa is the absorption concentration of hydroxytyrosol, and vertical coordinate is the content of triglyceride in the serum.
Fig. 4 is the influence coordinate diagram of hydroxytyrosol to FFA content in the serum.Wherein: abscissa is the absorption concentration of hydroxytyrosol, and vertical coordinate is the content of FFA in the serum.
Fig. 5 is the influence coordinate diagram of hydroxytyrosol to serum insulin content.Wherein: abscissa is the absorption concentration of hydroxytyrosol, and vertical coordinate is the content of serum insulin.
Fig. 6 is the influence coordinate diagram of hydroxytyrosol to liver weight.Wherein: abscissa is the absorption concentration of hydroxytyrosol, and vertical coordinate is the weight of mouse liver.
Fig. 7 is the influence coordinate diagram of hydroxytyrosol to content of triglyceride in the liver.Wherein: abscissa is the absorption concentration of hydroxytyrosol, and vertical coordinate is the content of triglyceride in the mouse liver.
Fig. 8 is the influence coordinate diagram of hydroxytyrosol to total cholesterol level in the liver.Wherein: abscissa is the absorption concentration of hydroxytyrosol, and vertical coordinate is a content of cholesterol in the mouse liver.
The specific embodiment
1. animal feeding
The C57 male mice is that Si Laike animal Co., Ltd buys from Shanghai.Mice is raised in the room of controllable temperature (22 spend to 28 degree) and humidity (60%), and the light in room maintains in the circulation at 12 hour daytime, 12 hour night, and mice can ad lib and water inlet in experiment is carried out.
2. the foundation of fat model
Experiment mice is divided into four groups altogether, 10 every group.Four groups are respectively: (1) normal diet group; (2) high fat diet group; (3) high fat diet group is irritated the hydroxytyrosol of stomach 10mg/kg simultaneously every day; (4) high fat diet group is irritated the hydroxytyrosol of stomach 50mg/kg simultaneously every day.Be 4 months experimental period.
3. correlated results
(1) hydroxytyrosol is to the inductive fat inhibitory action that takes place of high fat diet
Respectively the body weight of mouse is measured before the experiment beginning with after finishing; Use the mice body weight after experiment finishes to cut the body weight when testing beginning; Gained is the body weight of mice increase in four months; Fig. 1 can find out obviously that high fat diet induced tangible weight increase as a result, and under the situation of taking in hydroxytyrosol, the weight increase of mouse can be by effective inhibition.
Fig. 2 A and Fig. 2 B show epididymal adipose tissues and a large amount of accumulation of perirenal fat in the fat process simultaneously, and the absorption of hydroxytyrosol can effectively reduce the accumulation of fat.The result representes that with Mean ± S.E.M form the statistical result of 10 mouse is represented in statistical result; Data analysis uses One Way-ANOVA analytical method, significantly statistical significance be * p 0.05, * * p < 0.01.
(2) hydroxytyrosol can effectively improve the metabolism disorder in the fat generating process.
Fat formation is accompanied by a series of metabolism disorder, mainly shows a large amount of risings of triglyceride in the blood, FFA and hungry insulin content.As shown in Figure 3, high fat diet significantly increases the content of triglyceride in the blood, and the hydroxytyrosol of two kinds of dosage can both effectively reduce the content of triglyceride.As shown in Figure 4, high fat diet has significantly increased the content of FFA in the blood, and the hydroxytyrosol of two kinds of dosage has effectively reduced its content in blood equally.And as shown in Figure 5, the hydroxytyrosol of two kinds of dosage has all effectively suppressed the rising of insulin under the hungry situation.These results explain effectively that hydroxytyrosol can effectively improve the metabolism disorder in the fat generating process.The result representes that with Mean ± S.E.M form the statistical result of 10 mouse is represented in statistical result; Data analysis uses One Way-ANOVA analytical method, significantly statistical significance be * p 0.05, * * p < 0.01.
(3) hydroxytyrosol can effectively suppress the generation of the fatty liver that obesity causes.
The formation of fatty liver is with fat inseparable, and the influence to the crowd of caused hepatic injury of fatty liver and peripheral diseases is more extensive, therefore in treatment and prevention of obesity generation, more should note treatment and prevention to fatty liver.As shown in Figure 6, high fat diet has significantly increased the weight of liver, and like Fig. 7 and shown in Figure 8, high fat diet has equally also increased triglyceride and content of cholesterol in the liver, and these indexs have all disclosed the formation of the inductive fatty liver of high fat diet.And taking under the situation of hydroxytyrosol, the hydroxytyrosol of two kinds of dosage can both effectively reduce liver weight and triglyceride, content of cholesterol.These all disclose the generation that hydroxytyrosol can effectively suppress fatty liver.The result representes that with Mean ± S.E.M form the statistical result of 10 mouse is represented in statistical result; Data analysis uses One Way-ANOVA analytical method, significantly statistical significance be * p 0.05, * * p < 0.01.
Can effectively suppress the formation of the inductive fat generation of high fat diet, metabolism disorder and fatty liver through above experimental result proof hydroxytyrosol.Hydroxytyrosol is as a kind of natural component, and its useful effect concentration is low, and safety is without any side effects.Taking for a long time has remarkable effect to clinical treatment obesity and fatty liver etc., is the effective ways that effect a permanent cure, and has the market prospect of extensive use.This has opened up a new medical approach for hydroxytyrosol in clinical extensive use.
Claims (6)
1. the application of hydroxytyrosol in the fat medicine that takes place of control; It is characterized in that; Hydroxytyrosol is to the inductive fat inhibitory action that takes place of high fat diet, and described hydroxytyrosol structural formula is
2. application according to claim 1 is characterized in that, hydroxytyrosol can effectively improve the metabolism disorder in the fat generating process.
3. application according to claim 1 is characterized in that, hydroxytyrosol can effectively suppress the generation of the fatty liver that obesity causes.
4. application according to claim 1 is characterized in that, hydroxytyrosol can suppress the accumulation of increase, reduction epididymal adipose tissues and the perirenal fat of body weight.
5. application according to claim 2 is characterized in that, hydroxytyrosol can significantly reduce in the blood content of insulin under the triglyceride and FFA content and starvation.
6. application according to claim 3 is characterized in that, hydroxytyrosol can effectively reduce the liver weight increase that high fat diet causes, reduces triglyceride and content of cholesterol in the liver simultaneously.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103550332A (en) * | 2013-11-15 | 2014-02-05 | 天津市尖峰天然产物研究开发有限公司 | Capsule and preparation containing rich hydroxytyrosol, lycium barbarum polysaccharide and apple polyphenol and used for protecting liver |
| CN105592852A (en) * | 2013-09-30 | 2016-05-18 | 太阳星光齿磨公司 | Anti-obesity composition |
| CN107158025A (en) * | 2017-05-05 | 2017-09-15 | 山东省药学科学院 | A kind of blood-fat reducing composition containing hydroxytyrosol and its application |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101035594A (en) * | 2004-08-09 | 2007-09-12 | 酶学技术有限公司 | Food products for diabetics |
-
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- 2012-06-26 CN CN2012102129785A patent/CN102755306A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101035594A (en) * | 2004-08-09 | 2007-09-12 | 酶学技术有限公司 | Food products for diabetics |
Non-Patent Citations (2)
| Title |
|---|
| JIEJIE HAO ETC.: "Hydroxytyrosol promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes", 《JOURNAL OF NUTRITIONAL BIOCHEMISTRY》 * |
| 王芳等: "羟基酪醇的作用机制及研究进展", 《食品工业科技》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105592852A (en) * | 2013-09-30 | 2016-05-18 | 太阳星光齿磨公司 | Anti-obesity composition |
| CN105592852B (en) * | 2013-09-30 | 2019-07-19 | 太阳星光齿磨公司 | Fat composite inhibiting |
| US10603332B2 (en) | 2013-09-30 | 2020-03-31 | Sunstar Inc. | Anti-obesity composition |
| CN103550332A (en) * | 2013-11-15 | 2014-02-05 | 天津市尖峰天然产物研究开发有限公司 | Capsule and preparation containing rich hydroxytyrosol, lycium barbarum polysaccharide and apple polyphenol and used for protecting liver |
| CN107158025A (en) * | 2017-05-05 | 2017-09-15 | 山东省药学科学院 | A kind of blood-fat reducing composition containing hydroxytyrosol and its application |
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Application publication date: 20121031 |