CN102743308A - Skin care product combining rosewood extractive with nitric oxide - Google Patents
Skin care product combining rosewood extractive with nitric oxide Download PDFInfo
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- CN102743308A CN102743308A CN2011101025981A CN201110102598A CN102743308A CN 102743308 A CN102743308 A CN 102743308A CN 2011101025981 A CN2011101025981 A CN 2011101025981A CN 201110102598 A CN201110102598 A CN 201110102598A CN 102743308 A CN102743308 A CN 102743308A
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- nitric oxide
- lignum pterocarpi
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- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 title claims abstract description 42
- 235000009984 Pterocarpus indicus Nutrition 0.000 title abstract description 5
- 241000533793 Tipuana tipu Species 0.000 title abstract 4
- 239000002537 cosmetic Substances 0.000 claims abstract description 17
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 42
- 239000003795 chemical substances by application Substances 0.000 claims description 39
- 239000000284 extract Substances 0.000 claims description 22
- 229910052757 nitrogen Inorganic materials 0.000 claims description 21
- 238000000605 extraction Methods 0.000 claims description 19
- 238000003756 stirring Methods 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 17
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 15
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 13
- 235000011470 Adenanthera pavonina Nutrition 0.000 claims description 12
- 239000002904 solvent Substances 0.000 claims description 11
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 9
- 239000012567 medical material Substances 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 8
- 235000010323 ascorbic acid Nutrition 0.000 claims description 5
- 229960005070 ascorbic acid Drugs 0.000 claims description 5
- 239000011668 ascorbic acid Substances 0.000 claims description 5
- 235000015165 citric acid Nutrition 0.000 claims description 5
- 235000006408 oxalic acid Nutrition 0.000 claims description 5
- 230000037394 skin elasticity Effects 0.000 claims description 4
- 230000008961 swelling Effects 0.000 claims description 4
- 230000002792 vascular Effects 0.000 claims description 4
- 239000003125 aqueous solvent Substances 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 230000001186 cumulative effect Effects 0.000 claims description 3
- 238000002481 ethanol extraction Methods 0.000 claims description 3
- 239000012530 fluid Substances 0.000 claims description 3
- 230000004927 fusion Effects 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 claims description 2
- 240000001606 Adenanthera pavonina Species 0.000 claims 3
- 230000001737 promoting effect Effects 0.000 claims 1
- 238000005728 strengthening Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 17
- 239000006071 cream Substances 0.000 abstract description 5
- 230000004060 metabolic process Effects 0.000 abstract description 2
- 230000009758 senescence Effects 0.000 abstract 2
- 239000000686 essence Substances 0.000 abstract 1
- 230000037384 skin absorption Effects 0.000 abstract 1
- 231100000274 skin absorption Toxicity 0.000 abstract 1
- 230000036560 skin regeneration Effects 0.000 abstract 1
- 241000750718 Pterocarpus santalinus Species 0.000 description 10
- 230000001815 facial effect Effects 0.000 description 7
- 239000002253 acid Substances 0.000 description 5
- 241000700159 Rattus Species 0.000 description 4
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical group [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 3
- -1 homopterocarpine Natural products 0.000 description 3
- 230000008439 repair process Effects 0.000 description 3
- 230000032683 aging Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- IOYHCQBYQJQBSK-UHFFFAOYSA-N orobol Chemical compound C=1C(O)=CC(O)=C(C2=O)C=1OC=C2C1=CC=C(O)C(O)=C1 IOYHCQBYQJQBSK-UHFFFAOYSA-N 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 235000010288 sodium nitrite Nutrition 0.000 description 2
- 238000000638 solvent extraction Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- YMHOBZXQZVXHBM-UHFFFAOYSA-N 2,5-dimethoxy-4-bromophenethylamine Chemical compound COC1=CC(CCN)=C(OC)C=C1Br YMHOBZXQZVXHBM-UHFFFAOYSA-N 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- YLZYAUCOYZKLMA-UHFFFAOYSA-N O-Methyl-maackiain Natural products O1C2=CC=3OCOC=3C=C2C2C1C1=CC=C(OC)C=C1OC2 YLZYAUCOYZKLMA-UHFFFAOYSA-N 0.000 description 1
- SLEPYIDGMPDTFO-UHFFFAOYSA-N Pterocarpin Natural products COc1ccc2C3Oc4c5OCOc5ccc4C3COc2c1 SLEPYIDGMPDTFO-UHFFFAOYSA-N 0.000 description 1
- XZXBGGYJQALVAW-UHFFFAOYSA-N Pterocarpol Natural products C1C(O)CC(=C)C2CC(C(C)(O)C)CCC21C XZXBGGYJQALVAW-UHFFFAOYSA-N 0.000 description 1
- 244000086363 Pterocarpus indicus Species 0.000 description 1
- 244000104426 Sandoricum koetjape Species 0.000 description 1
- 235000016012 Sandoricum koetjape Nutrition 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 241000545067 Venus Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- FIUXTXZNWKOFPH-UHFFFAOYSA-N beta-Chenopodiol Natural products CC(C)(O)C1CCC2(C)CCCC(=C)C2C1O FIUXTXZNWKOFPH-UHFFFAOYSA-N 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
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- 238000006243 chemical reaction Methods 0.000 description 1
- 210000000589 cicatrix Anatomy 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
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- 230000023597 hemostasis Effects 0.000 description 1
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- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- YLZYAUCOYZKLMA-SJCJKPOMSA-N pterocarpin Chemical compound O1C2=CC=3OCOC=3C=C2[C@H]2[C@@H]1C1=CC=C(OC)C=C1OC2 YLZYAUCOYZKLMA-SJCJKPOMSA-N 0.000 description 1
- VLEUZFDZJKSGMX-ONEGZZNKSA-N pterostilbene Chemical compound COC1=CC(OC)=CC(\C=C\C=2C=CC(O)=CC=2)=C1 VLEUZFDZJKSGMX-ONEGZZNKSA-N 0.000 description 1
- VLEUZFDZJKSGMX-UHFFFAOYSA-N pterostilbene Natural products COC1=CC(OC)=CC(C=CC=2C=CC(O)=CC=2)=C1 VLEUZFDZJKSGMX-UHFFFAOYSA-N 0.000 description 1
- 238000013441 quality evaluation Methods 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000000194 supercritical-fluid extraction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
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- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 210000003556 vascular endothelial cell Anatomy 0.000 description 1
Abstract
The invention provides a skin care product combining rosewood extractive with nitric oxide, which is applied to anti-senescence aspects. The skin care product not only has the effects in facilitating skin regeneration and resisting skin senescence of rosewood and the nitric oxide, but also increases skin absorption of effective components in traditional cosmetics. The skin care product of the invention not only has the effects in skin decorating and skin moistening of traditional essences and face creams, but also fully playing effects of the rosewood extractive and the nitric oxide, thereby comprehensively reaching effects of facilitating skin metabolism, tenderizing skin, resisting senescence, and the like.
Description
Technical field
The present invention relates to a kind of cosmetics, be meant the skin care item that a kind of Lignum pterocarpi indici extract combines with nitric oxide especially.
Background technology
The Lignum pterocarpi indici formal name used at school is a red sandalwood, has been commonly called as Lignum pterocarpi indici, lobule Lignum pterocarpi indici, narra, Venus Lignum pterocarpi indici etc.At present the chemical constitution study to Lignum pterocarpi indici shows, it is rich in various active compositions such as pterostilbene, pterocarpin, homopterocarpine, pterocarpol, Lignum pterocarpi indici alkane, Lignum pterocarpi indici are red, desoxysantalin, Santol.Nineteen ninety-five, version " once recorded pulse family Lignum pterocarpi indici Pterocarpus santalinus woody part in the Chinese pharmacopoeia appendix.Lignum pterocarpi indici has " detumescence, hemostasis, analgesic therapy.Control toxic swelling, incised wound is hemorrhage " effect.
Nitric oxide is a kind of diatomic molecule, is the interior physiology amboceptor of a lot of biological functions.Since finding that the mammal vascular endothelial cell can synthesize endogenous nitric oxide in 1987; This simple diatomic molecule free radical of nitric oxide just begins to show its infinite charm to common people, is chosen as " star molecule " (Molecule of the Year) in 1992 by U.S.'s " science " (" Science ") magazine.Nitric oxide is except that aspects such as cardiovascular disease, tumor treatment play a role, produces because of it can promote skin microcirculation and collagen protein, so in the reparation of burn and scald treatment, wound surface and suppress the effect that many-side such as cicatrix generation has uniqueness.
At present, Shang Weijian combines with nitric oxide based on the Lignum pterocarpi indici extract and is used for the report of skin care item.
Summary of the invention
In view of this, main purpose of the present invention is to provide a kind of Lignum pterocarpi indici extract to combine to be applied to the skin care item of defying age aspect with nitric oxide.Said skin care item can not only be brought into play Lignum pterocarpi indici, nitric oxide itself to the promotion regeneration of skin, the good effects of opposing aging, can also increase the absorption of skin to traditional cosmetics effective ingredient, are the research of a novelty.
Technical scheme
At common facial treatment repair and skin protection facial cream cosmetics is on the basis of carrier, adds the Lignum pterocarpi indici extract, and makes two product can produce nitric oxide when priority is used successively.
That is, the purpose of this invention is to provide a kind of Lignum pterocarpi indici extract and nitric oxide and produce the defying age skin care item that agent is formed.
Preferably, cosmetics of the present invention contain Lignum pterocarpi indici extract and nitric oxide generation agent.
Preferably, nitric oxide generation agent of the present invention is sour agent and nitrogen agent.
Preferably, nitrogen agent of the present invention contains nitrite 0.02%-2% mass percent.
Preferably, sour agent of the present invention contains one or more combination of citric acid, oxalic acid, ascorbic acid, and the mass percent of said citric acid, oxalic acid, ascorbic acid is 0.2-6%.
Preferably, the mass percent 0.1%-10% of Lignum pterocarpi indici extract of the present invention.
Another object of the present invention provides a kind of method for preparing of above-mentioned cosmetics.
Preferably, nitrogen agent according to the invention is prepared by following method:
Add material among the A successively under stirring, be heated to 80 ℃, kept 30 minutes, be cooled to 60 ℃ and add the good B components of mixing swelling in advance; Be cooled to 50 ℃ after stirring and dissolving is complete, add the C component successively, after the stirring and dissolving, add good D, the E component of dissolving in advance; Continue to be cooled to below 35 ℃, add the good F component of dissolving in advance, and the G component; Stirred 15 minutes, and then leave standstill 24h, under aseptic condition, carry out canned;
Preferably, sour agent according to the invention is prepared by following method:
A, B component are heated to 80 ℃ respectively, are stirred to fusion fully, B is stirred adding A down; Homogenized 3 minutes, cooling while stirring is to 50 ℃; Homogenized 1 minute, stirring is cooled to below 35 ℃, adds in advance respectively and dissolves back D material and E material homogenizing 1 minute; Continue to stir 5 minutes, and then leave standstill 24h, under aseptic condition, carry out canned.
Preferably, Lignum pterocarpi indici preparation method of extract of the present invention is:
1) it is dry the red sandalwood heartwood to be placed on the place, cool place, pulverizes with pulverizer, crosses 40 mesh sieves, and it is subsequent use to get the red sandalwood powder;
2) the red sandalwood powder is with aqueous solvent or ethanol extraction, and concentration of ethanol is the 40%-80% percent by volume, and solvent load is a 4-10 times of volume of medical material amount; Extraction time is 1-3 time, and extraction time is each 1-3 hour, merge extractive liquid; Filter, be concentrated into 1.00-1.20g/ml, make extractum.
More preferably, Lignum pterocarpi indici preparation method of extract of the present invention is: the 6-8 times of volume that said alcohol solvent consumption is the medical material amount, and extraction time is 1-3 time; Extraction time is each 1-3 hour, and merge extractive liquid, filters; Be concentrated into 1.00-1.20g/ml, make extractum.
Optimally, Lignum pterocarpi indici preparation method of extract of the present invention is: said alcohol solvent consumption is 7 times of volumes of medical material amount, and extraction time is 3 times; Extraction time is each 2 hours; Merge extractive liquid, filters, and is concentrated into 1.10g/ml; Make extractum, obtain total extractives and be the Lignum pterocarpi indici treatment fluid originally cumulative volume 21.20%.
Another object of the present invention is to provide a kind of above-mentioned cosmetics in the purposes that reduces skin microgroove, enhancing skin elasticity and promotion skin capillary vascular expansion.
By on can find out; Product of the present invention not only has the modification of traditional essence and facial cream, the effect of skin care; Can also give full play to Lignum pterocarpi indici extract and nitric oxide production effect, thereby play effects such as the metabolism that promotes skin, tenderization skin, opposing aging comprehensively.
The specific embodiment
(1), nitrogen agent (facial treatment repair):
Wherein, " surplus " of component water is meant the weight after in nitrogen agent gross weight, removing other components, makes gross mass reach 100% quality.What play the effect of nitrogen element donor in the nitrogen agent is sodium nitrite; As long as those of ordinary skills can confirm other any nitrogen element donors; It can with the acid reaction in the sour agent; Generate the organic or inorganic nitrogen-containing compound of NO, all can be used as nitrogen element donor---the equivalents of sodium nitrite in the nitrogen agent of the present invention.Other components are the chemical compound of using always in the skin care item in this area in the above nitrogen agent, and its component and ratio those skilled in the art can carry out the selection and the adjustment of routine property according to prior art.Preferably, use above-claimed cpd of the present invention and ratio, because experiment proof said components and ratio can obtain the effect of best skin protection defying age.Specifically referring to the experimental example 1 of rear section.
Nitrogen agent of the present invention (essence) preparation technology: add material among the A successively under stirring, be heated to 80 ℃, kept 30 minutes, be cooled to 60 ℃ and add the good B components of mixing swelling in advance; Be cooled to 50 ℃ after stirring and dissolving is complete, add the C component successively, after the stirring and dissolving, add good D, the E component of dissolving in advance; Continue to be cooled to below 35 ℃, add the good F component of dissolving in advance, and the G component; Stirred 15 minutes, and then leave standstill 24h, under aseptic condition, carry out canned.
(2), sour agent (skin protection facial cream):
Wherein, " surplus " of component water is meant the weight after in nitrogen agent gross weight, removing other components, makes gross mass reach 100% quality.Acting in the acid agent is citric acid, oxalic acid and ascorbic acid; As long as those of ordinary skills can confirm other any sour agent; It can with the nitrogen element donor effect in the nitrogen agent, generate the organic or inorganic nitrogen-containing compound of NO, all can be used as the equivalents of the present invention's acid agent.Other components are the chemical compound of using always in the skin care item in this area in the above sour agent, and its component and ratio those skilled in the art can carry out the selection and the adjustment of routine property according to prior art.Preferably, use above-claimed cpd of the present invention and ratio, because experiment proof said components and ratio can obtain the effect of best skin protection defying age.Specifically referring to the experimental example 1 of rear section.
The preparation technology of acid agent: A, B component are heated to 80 ℃ respectively, are stirred to fusion fully, B is stirred adding A down; Homogenized 3 minutes, cooling while stirring is to 50 ℃; Homogenized 1 minute, stirring is cooled to below 35 ℃, adds in advance respectively and dissolves back D material and E material homogenizing 1 minute; Continue to stir 5 minutes, and then leave standstill 24h, under aseptic condition, carry out canned.
Wherein the Lignum pterocarpi indici extract is an extraction of active ingredients thing in the Lignum pterocarpi indici, preferably, uses this area method for distilling commonly used to extract, and like organic solvent extraction, chromatograph is extracted or CO
2Supercritical extraction etc.More preferably, select following organic solvent extraction method:
1) preparation of raw material: it is dry that the red sandalwood heartwood is placed on the place, cool place, pulverizes with pulverizer, crosses 40 mesh sieves, and it is subsequent use to get the red sandalwood powder;
2) the red sandalwood powder is with aqueous solvent or ethanol extraction, and concentration of ethanol is the 40%-80% percent by volume, and solvent load is a 4-10 times of volume of medical material amount; Extraction time is 1-3 time, and extraction time is each 1-3 hour, merge extractive liquid; Filter, be concentrated into 1.00-1.20g/ml, make extractum.
Wherein, more preferably following method for distilling:
3) the red sandalwood powder extracts with etoh solvent, and concentration of ethanol is the 60%-80% percent by volume, and solvent load is a 6-8 times of volume of medical material amount; Extraction time is 1-3 time, and extraction time is each 1-3 hour, merge extractive liquid; Filter, be concentrated into 1.00-1.20g/ml, make extractum.Wherein, most preferably following method for distilling:
4) the red sandalwood powder extracts with etoh solvent, and concentration of alcohol is 80% percent by volume, and solvent load is 7 times of volumes of medical material amount; Extraction time is 3 times, and extraction time is each 2 hours, merge extractive liquid; Filter; Be concentrated into 1.10g/ml, make extractum, obtain total extractives and be the Lignum pterocarpi indici treatment fluid originally cumulative volume 21.20%.
The method for using of skin care item of the present invention does, gets 0.1-10.0g facial treatment repair (nitrogen agent) earlier and uses, and re-uses the skin protection facial cream (sour agent) of 0.1-10.0g, with the two abundant applied getting final product on skin.
Be the experimental example of the result of use of skin care item of the present invention below
Experimental example 1
Use the skin care item of embodiment 1,2,3,4 and 5 preparations in 18 volunteers and 30 rats, to use effect such as following table:
Wherein practical implementation effect such as the following table of embodiment:
Microgroove and elasticity project make the data that apply some make up and obtained later in month continuously for the volunteer, and skin capillary vascular expansion is that rat once makes the data of obtaining after applying some make up 30 minutes; Experimental animal is a female rats, body weight 130 ± 17 grams; The volunteer is 20-55 year, masculinity and femininity half and half.Subjects is equally divided into 6 groups, and data are the meansigma methods of subjects in the group in the table.
Used negative control is meant the cosmetics that do not add containing of Lignum pterocarpi indici extract of sour agent and nitrogen agent, and wherein the component ratio of this negative control is with composition and the ratio of embodiment 1, and method for preparing is with the method for preparing of the present invention's acid agent and nitrogen agent cosmetics.Mean roughness records with instrument dermal imaging analytical system, and the high more expression of numerical value is coarse more; * number expression significant difference, P＜0.05.Microscopic examination scoring scoring is 3 fens systems, and expression in 0 fen is not compared with the recessiveness contrast and changed, and expression in 1 fen has slight improvement, and the expression moderate was improved in 2 minutes, and expression in 3 fens significantly improves.Evaluation effect is that experienced cosmetics quality evaluation personnel make in this area.
Skin elasticity records with the skin elasticity tester; * number expression significant difference, P＜0.05.The expansion of blood capillary is estimated with the increase of vascular flow amount, and blood flow unit is ml/min.Change with the zoodermic blood flow of laser-Doppler blood flow appearance determination test, static probe is (each rat position consistency) in the cosmetic applying position, obtains data.* number expression significant difference, P＜0.05.
The above is merely preferred embodiment of the present invention, and is in order to restriction the present invention, not all within spirit of the present invention and principle, any modification of being done, is equal to replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. Lignum pterocarpi indici extract and nitric oxide produce the defying age skin care item that agent is formed, and it is characterized in that, said cosmetics contain Lignum pterocarpi indici extract and nitric oxide generation agent.
2. skin care item according to claim 1 is characterized in that, it is sour agent and nitrogen agent that said nitric oxide produces agent.
3. skin care item according to claim 1 is characterized in that, said nitrogen agent contains nitrite 0.02%-2% mass percent.
4. skin care item according to claim 1 is characterized in that, said sour agent contains one or more combination of citric acid, oxalic acid, ascorbic acid, and the mass percent of said citric acid, oxalic acid, ascorbic acid is 0.2-6%.
5. skin care item according to claim 1 is characterized in that, the mass percent 0.1%-10% of said Lignum pterocarpi indici extract.
6. the method for preparing like any said cosmetics of claim 1-5 is characterized in that,
Said nitrogen agent is prepared by following method:
Add material among the A successively under stirring, be heated to 80 ℃, kept 30 minutes, be cooled to 60 ℃ and add the good B components of mixing swelling in advance; Be cooled to 50 ℃ after stirring and dissolving is complete, add C successively and form branch, after the stirring and dissolving, add and dissolve good D, E component in advance; Continue to be cooled to below 35 ℃, add the good F component of dissolving in advance, and the G component; Stirred 15 minutes, and then leave standstill 24h, under aseptic condition, carry out canned;
Said sour agent is prepared by following method:
A, B component are heated to 80 ℃ respectively, are stirred to fusion fully, B is stirred adding A down; Homogenized 3 minutes, cooling while stirring is to 50 ℃; Homogenized 1 minute, stirring is cooled to below 35 ℃, adds in advance respectively and dissolves back D material and E material homogenizing 1 minute; Continue to stir 5 minutes, and then leave standstill 24h, under aseptic condition, carry out canned.
7. the method for preparing like any said cosmetics of claim 1-5 is characterized in that, said Lignum pterocarpi indici preparation method of extract is:
1) it is dry the red sandalwood heartwood to be placed on the place, cool place, pulverizes with pulverizer, crosses 40 mesh sieves, and it is subsequent use to get the red sandalwood powder;
2) the red sandalwood powder is with aqueous solvent or ethanol extraction, and concentration of ethanol is the 40%-80% percent by volume, and solvent load is a 4-10 times of volume of medical material amount; Extraction time is 1-3 time, and extraction time is each 1-3 hour, merge extractive liquid; Filter, be concentrated into 1.00-1.20g/ml, make extractum.
8. cosmetics method for preparing according to claim 7 is characterized in that, said Lignum pterocarpi indici preparation method of extract is: the 6-8 times of volume that said alcohol solvent consumption is the medical material amount; Extraction time is 1-3 time; Extraction time is each 1-3 hour, and merge extractive liquid, filters; Be concentrated into 1.00-1.20g/ml, make extractum.
9. cosmetics method for preparing according to claim 7 is characterized in that, said Lignum pterocarpi indici preparation method of extract is: said alcohol solvent consumption is 7 times of volumes of medical material amount; Extraction time is 3 times, and extraction time is each 2 hours, merge extractive liquid; Filter; Be concentrated into 1.10g/ml, make extractum, obtain total extractives and be the Lignum pterocarpi indici treatment fluid originally cumulative volume 21.20%.
10. one kind is being reduced the skin microgroove, strengthening skin elasticity and is promoting the purposes in the skin capillary vascular expansion like any said cosmetics of claim 1-5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110102598.1A CN102743308B (en) | 2011-04-22 | 2011-04-22 | The skin care product that rosewood extractive combines with nitrogen protoxide |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110102598.1A CN102743308B (en) | 2011-04-22 | 2011-04-22 | The skin care product that rosewood extractive combines with nitrogen protoxide |
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| CN102743308A true CN102743308A (en) | 2012-10-24 |
| CN102743308B CN102743308B (en) | 2016-06-15 |
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| CN201110102598.1A Active CN102743308B (en) | 2011-04-22 | 2011-04-22 | The skin care product that rosewood extractive combines with nitrogen protoxide |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101028229A (en) * | 2006-03-02 | 2007-09-05 | 北京尼奥克斯生物科技有限公司 | Cosmetics based on nitric oxide |
| CN101469296A (en) * | 2007-12-29 | 2009-07-01 | 北京富华安德生物医药科技开发有限公司 | Novel toilet soap based on red sandalwood and nitric oxide local release technology |
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2011
- 2011-04-22 CN CN201110102598.1A patent/CN102743308B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101028229A (en) * | 2006-03-02 | 2007-09-05 | 北京尼奥克斯生物科技有限公司 | Cosmetics based on nitric oxide |
| CN101469296A (en) * | 2007-12-29 | 2009-07-01 | 北京富华安德生物医药科技开发有限公司 | Novel toilet soap based on red sandalwood and nitric oxide local release technology |
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