CN102742727A - Glycosaminoglycan and vitamin mixed ecological growth-promoting and immune-modulating agent used in aquaculture - Google Patents
Glycosaminoglycan and vitamin mixed ecological growth-promoting and immune-modulating agent used in aquaculture Download PDFInfo
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- CN102742727A CN102742727A CN2012101590647A CN201210159064A CN102742727A CN 102742727 A CN102742727 A CN 102742727A CN 2012101590647 A CN2012101590647 A CN 2012101590647A CN 201210159064 A CN201210159064 A CN 201210159064A CN 102742727 A CN102742727 A CN 102742727A
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- glycosaminoglycan
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- immunomodulator
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Abstract
The invention discloses a glycosaminoglycan and vitamin mixed ecological growth-promoting and immune-modulating agent used in aquaculture. The agent comprises 0.1-22% of a glycosaminoglycan active component, and an acid solution with a solvent concentration of 0.1-30%. The molecular weight of glycosaminoglycan is 2000-4000000. A deacetylation degree is higher than 50%. 100-2500mg/L of vitamin C, 1-100 mg/L of vitamin B1, 1-100 mg/L of vitamin B2, and 1-100mg/L of vitamin B6 are added into the agent. The solvent prepared with the above mixed substances is mixed into various aquaculture feeds, wherein the solvent accounts for 0.1-1% of the feed by weight. The components are scientifically formulated. With the agent, fast growth of various aquatic animals can be ecologically promoted, various drug residues and toxin accumulations in aquatic animal bodies can be degraded, and aquatic animal immunity and disease resistances can be improved. The glycosaminoglycan and vitamin mixed agent provided by the invention is safe, highly efficient, and stable. The agent does not contain antibiotic and hormone components. With the agent, yield and quality of aquatic animals are improved.
Description
Technical field:
The present invention design is in aquaculture field, and a kind of glycosaminoglycan mixes ecological growth promotion and immunomodulator with vitamin, processes bait in the middle of joining this compounding substances in the feeds of various aquatic livestocks.
Background technology:
Glycosaminoglycan be by chitin through the deacetylated and macromolecule active material that obtains, the source is very abundant, is mainly derived from the crusts of aquatic livestocks such as sea water and fresh water shrimp, crab to extract.Glycosaminoglycan has good biocompatibility, and is biodegradable, and catabolite is nontoxic, harmless, with and antitoxin, antibacterial characteristics; It is reported, anticancer, raising immunity that glycosaminoglycan has, antithrombotic, anti-oxidant; Reducing blood lipid, anti-arrhythmia cordis, prevents multiple effect such as cell proliferation at the protection endothelial cell; In medicines and health protection, food fresh keeping obtains broad research in the multiple industry such as agricultural and has a good application prospect.
In aquaculture field; The Along with people's growth in the living standard; Consumption figure for various aquatic livestocks is also more and more; It also is increasingly high particularly requiring for the consumption of high-grade aquatic livestocks such as sea cucumber, prawn, crab, soft-shelled turtle, swamp eel, and this has promoted the development of culture fishery to a great extent, still, current culture fishery still is in the chaotic evolution.Vast aquaculture practitioner, has but ignored medicines such as high-quality, a large amount of low-quality feed, hormone, antibiotic and has been used in the middle of the aquaculture high density that covets, high yield.The use of these products though temporarily improved economic benefit, has seriously hindered the development of culture fishery.Culture fishery is in the middle of the high risk, cultures high density and makes aquatic livestock that the danger of hypoxia death arranged all the time, a large amount of uses of low-quality feed and hormone; Quality, passive protective physical fitness and the immunity of aquatic livestock are weakened greatly, resistance against diseases very a little less than, the very easily sick death of aquatic livestock; This has just caused antibiotic a large amount of use, and antibiotic a large amount of uses have worsened the quality of aquatic livestock more; Antibiotic residue exceeds standard, and the resistance to the action of a drug of aquatic livestock strengthens gradually, and antibiotic using dosage is increasing; Effect but worse and worse; The medicament residue of high-load has hindered the normal growth of aquatic livestock, has improved aquaculture cost, and the quality of aquatic livestock is low.The aquatic livestock product that high medicine is residual may cause great food-safety problem, and people more and more do not accept, and the annual example that aquatic products can't be exported because of the medicament residue problem also is of common occurrence.
Therefore, under current culture environment of aquatic products, the development of aquatic products industry is had difficulty in taking a step; Human beings'health and living environment in serious threat; People are hung back for homemade aquatic products, restricted the fast development of culture fishery, caused enormous economic loss and social concern.
Summary of the invention:
The objective of the invention is to; A kind of aquaculture process that is used for is provided; The antibiotic residue and the toxin that can reach ecological growth promotion, never contain in hormone, the degraded aquatic products animal body are accumulated; Strengthen immunity and the premunition of aquatic livestock, improve the glycosaminoglycan and the vitamin mixed solvent of aquatic products quality.
The objective of the invention is to realize through following technical proposal:
A kind of used for aquiculture glycosaminoglycan mixes ecological growth promotion and immunomodulator with vitamin; It comprises 0.1～22% glycosaminoglycan active component; And solvent strength is 0.1～30% acid solution, and the glycosaminoglycan molecular weight is 2000～4000000, and deacetylation is higher than 50%; Add vitamin C 100～2500mg/L in addition, Cobastab
11～100mg/L, Cobastab
21～100mg/L, Cobastab
61～100mg/L.
Glycosaminoglycan solution is 2～11% glycosaminoglycan active components according to percentage by weight, and the molecular weight of glycosaminoglycan is 10000～500000, and the concentration of acid solution is 1～5%.
The used for aquiculture glycosaminoglycan that is mixed and made into by above-mentioned substance mixes ecological growth promotion and immunomodulator with vitamin, be mixed in the various aquatic feeds, accounts for 0.1～1% of feed percentage by weight.
Used for aquiculture glycosaminoglycan solution of the present invention and vitamin mixed solvent add the bait of processing in the middle of the feed to has following advantage:
1, after glycosaminoglycan got in the aquatic livestock body, multiple antibiotic residue and toxin in the aquatic products animal body of can degrading were accumulated, and recover the ecosystem state of aquatic livestock; Immunity and the premunition of aquatic livestock have been improved; Digestion of the aquatic livestock that also makes and absorption function reach better state, improve the digestion and the absorptivity of food, promote the growth of aquatic livestock; The also corresponding effect that has improved next stage aquatic products medicine use promotes the health of aquaculture to carry out.
2, vitamin C is a kind of vitamin(e) supplement that in the aquaculture process, generally uses, and functions such as the collagen of promotion is synthetic, anti-oxidant, anti-scurvy that it has are widely used in the aquatic livestock growth promotion, resist aspects such as stress, improving immunity.
3, vitamin B complex vitamin is the required essential amino acid of aquatic animal to grow, has the metabolism of adjusting, keeps the health of skin and muscle, promotes immune system and nervous system, promotes the function of cell growth and division, is widely used in the middle of the aquaculture.
4, these article are used for the aquaculture process after mixing, and have had the growth of promotion aquiculture animal; Improve anti-stress ability; Improve immunity and premunition, antibiotic residue and toxin are accumulated in the degraded aquatic products animal body, reduce the function of feed coefficient; Improve the yield and quality of aquatic livestock, be of value to the healthy of people.
The specific embodiment:
Further specify the present invention below in conjunction with the practical implementation instance, and the present invention is not limited.
Embodiment 1
With mean molecule quantity is 80000, and deacetylation is 55% glycosaminoglycan 50g, and acetic acid 40g joins in the 910g water, and fully stirring and dissolving after treating to dissolve fully, adds the 1g vitamin C, the 10mg Cobastab again
1, Cobastab
210mg/L, Cobastab
610mg/L processes the used for aquiculture glycosaminoglycan and mixes ecological growth promotion and immunomodulator with vitamin.
Get feed 200kg, the used for aquiculture glycosaminoglycan is mixed ecological growth promotion and immunomodulator be sprayed on the feed with vitamin, after the sprinkling evenly, can make bait after drying.
Embodiment 2
With average mark strength is 200000, and deacetylation is 65% glycosaminoglycan 100g, and acetic acid 100g joins in the 800g water, and fully stirring and dissolving after treating to dissolve fully, adds the 1.5g vitamin C, the 15mg Cobastab again
1, Cobastab
215mg/L, Cobastab
615mg/L processes the used for aquiculture glycosaminoglycan and mixes ecological growth promotion and immunomodulator with vitamin.
Get feed 180kg, the used for aquiculture glycosaminoglycan is mixed ecological growth promotion and immunomodulator be sprayed on the feed with vitamin, after the sprinkling evenly, can make bait after drying.
Embodiment 3
With average mark strength is 1000000, and deacetylation is 60% glycosaminoglycan 160g, and acetic acid 40g joins in the 800g water, and fully stirring and dissolving after treating to dissolve fully, adds the 1g vitamin C, the 8mg Cobastab again
1, Cobastab
28mg/L, Cobastab
68mg/L processes the used for aquiculture glycosaminoglycan and mixes ecological growth promotion and immunomodulator with vitamin.
Get feed 160kg, the used for aquiculture glycosaminoglycan is mixed ecological growth promotion and immunomodulator be sprayed on the feed with vitamin, after the sprinkling evenly, can make bait after drying.
Embodiment 4
With average mark strength is 50000, and deacetylation is 60% glycosaminoglycan 150g, and acetic acid 50g joins in the 800g water, and fully stirring and dissolving after treating to dissolve fully, adds the 1g vitamin C, the 20mg Cobastab again
1, Cobastab
220mg/L, Cobastab
620mg/L processes the used for aquiculture glycosaminoglycan and mixes ecological growth promotion and immunomodulator with vitamin.
Get feed 150kg, the used for aquiculture glycosaminoglycan is mixed ecological growth promotion and immunomodulator be sprayed on the feed with vitamin, after the sprinkling evenly, can make bait after drying.
Embodiment 5
With average mark strength is 600000, and deacetylation is 60% glycosaminoglycan 100g, and acetic acid 30g joins in the 870g water, and fully stirring and dissolving after treating to dissolve fully, adds the 1.2g vitamin C, the 30mg Cobastab again
1, Cobastab
230mg/L, Cobastab
630mg/L processes the used for aquiculture glycosaminoglycan and mixes ecological growth promotion and immunomodulator with vitamin.
Get feed 110kg, the used for aquiculture glycosaminoglycan is mixed ecological growth promotion and immunomodulator be sprayed on the feed with vitamin, after the sprinkling evenly, can make bait after drying.
Embodiment 6
With average mark strength is 200000, and deacetylation is 60% glycosaminoglycan 160g, and acetic acid 40g joins in the 800g water, and fully stirring and dissolving after treating to dissolve fully, adds the 1.1g vitamin C, the 8mg Cobastab again
1, Cobastab
28mg/L, Cobastab
68mg/L processes the used for aquiculture glycosaminoglycan and mixes ecological growth promotion and immunomodulator with vitamin.
Get feed 120kg, the used for aquiculture glycosaminoglycan is mixed ecological growth promotion and immunomodulator be sprayed on the feed with vitamin, after the sprinkling evenly, can make bait after drying.
Embodiment 7
With average mark strength is 2000000, and deacetylation is 60% glycosaminoglycan 100g, and acetic acid 80g joins in the 820g water, and fully stirring and dissolving after treating to dissolve fully, adds the 1.2g vitamin C, the 18mg Cobastab again
1, Cobastab
218mg/L, Cobastab
618mg/L processes the used for aquiculture glycosaminoglycan and mixes ecological growth promotion and immunomodulator with vitamin.
Get feed 130kg, the used for aquiculture glycosaminoglycan is mixed ecological growth promotion and immunomodulator be sprayed on the feed with vitamin, after the sprinkling evenly, can make bait after drying.
Embodiment 8
With average mark strength is 1500000, and deacetylation is 60% glycosaminoglycan 150g, and acetic acid 50g joins in the 800g water, and fully stirring and dissolving after treating to dissolve fully, adds the 1.2g vitamin C, the 10mg Cobastab again
1, Cobastab
210mg/L, Cobastab
610mg/L processes the used for aquiculture glycosaminoglycan and mixes ecological growth promotion and immunomodulator with vitamin.
Get feed 120kg, the used for aquiculture glycosaminoglycan is mixed ecological growth promotion and immunomodulator be sprayed on the feed with vitamin, after the sprinkling evenly, can make bait after drying.
Method for using:
With the above bait of processing, throwing something and feeding comprises sea cucumber, prawn, river crab, soft-shelled turtle, six kinds of breed of eel kind, and each once connects and fed 15 days sooner or later.
Laboratory report:
1, Peng Lai, Shandong sea cucumber nursery pond:
Six the duplicate sea cucumber seedling of state ponds are selected in sea cucumber seedling pond, and one as contrasting original bait of throwing something and feeding, the different bait feedings in other 5 above-mentioned instances of selection.
Result: thrown something and fed and added glycosaminoglycan mixes ecological growth promotion and immunomodulator with vitamin ginseng pond; The seedling growing way obviously is superior to control group, particularly uses the ginseng pond of embodiment 1, and the growth promotion rate reaches 34%; The growth promotion rate is the highest; Also there is tangible growth promotion effect in other ginseng ponds, add glycosaminoglycan mixes ecological growth promotion and immunomodulator with vitamin ginseng pond and used, and the seedling state all obviously is better than control group; Corn has appearred in the control group seedling in breeding process sends out blunt, drags and just wait symptom, and growth conditions is relatively poor.
2, Zhanjiang, Guangdong shrimp culture pond
Three ponds are selected on the prawn culturing pool, and one as control group, in addition two bait feedings that use embodiment 1 and embodiment 8 respectively.
Result: thrown something and fed and added glycosaminoglycan mixes ecological growth promotion and immunomodulator with vitamin shrimp pond; The prawn growth conditions obviously is superior to control group, and shrimp seedling body colour green grass or young crops is bright, and spring and vigor all are superior to control group; The prawn speed of growth is faster than control group; Individual bigger than the shrimp body of control group, the pond of embodiment 1, the shrimp bulk-growth is more neat than embodiment 8.And the control group shrimp is recuperated and grows the later stage and the trip pool occurred, raise the nose above water to breathe to steal dead situation, and the shrimp body in two ponds not have appearance to steal dead situation in a large number in addition.
3, Changshu, Jiangsu culture of Chinese mitten crab pool
The culture of Chinese mitten crab pool is selected three, and one as control group, in addition two bait feedings that use embodiment 1 and embodiment 5 respectively.
The result: current culture of Chinese mitten crab pattern has had some changes more a few years ago, and aquaculture model is science more, the river crab disease seldom, topmost measure is a regulating and controlling water quality, is the quality of river crab and vast culture of Chinese mitten crab family is concerned about most, the quality price determination.Mix ecological growth promotion and immunomodulator with vitamin through adding glycosaminoglycan; River crab is being cultured the later stage, and the speed of growth obviously is superior to control group, and the proportion that crab oil and crab cream account for health is higher than control group; Promoted the river crab quality significantly, economic benefit obviously increases.
4, flat turtle culture pond is faced in Zhejiang
Breeding soft-shell turtle temperature canopy is selected three, a conduct contrast, two bait feedings that add embodiment 1 and embodiment 6 respectively in addition.
The result: current breeding soft-shell turtle much all is to take warm canopy to culture, and cultivation density is bigger, and the soft-shelled turtle disease is more serious, and the soft-shelled turtle quality is mutually far short of what is expected than the soft-shelled turtle that grows under the wild or imitative wild state on the outer pool.Through adding glycosaminoglycan mixes ecological growth promotion and immunomodulator with vitamin bait feeding, the speed of growth of soft-shelled turtle is obviously faster than contrast, and the approaching more wild body colour of soft-shelled turtle body colour, and disease seldom, and premunition and immunity obviously strengthen.
5, Shuande, Guangdong eel culture field
The eel factory in Shuande, because antibiotic and the toxin remains exceed standard and can't export, economic loss is bigger.Add glycosaminoglycan mixes ecological growth promotion and immunomodulator with vitamin bait through a period of time of throwing something and feeding, through check, antibiotic and the degraded gradually of the toxin remains quilt, content is step-down gradually, arrive big commercial specification after, reached export standard.
Although relate to a kind of used for aquiculture glycosaminoglycan and mix ecological growth promotion and immunomodulator with vitamin and carried out special description disclosed with reference to embodiment; The embodiment of more than describing is illustrative rather than restrictive; Without departing from the spirit and scope of the present invention, all variations and revising all within the scope of the invention.
Claims (11)
1. a used for aquiculture glycosaminoglycan mixes ecological growth promotion and immunomodulator with vitamin; It is characterized in that comprising: 0.1～22% glycosaminoglycan active component; And solvent: concentration is 0.1～30% acid solution; The glycosaminoglycan molecular weight is 2000～4000000, and deacetylation is higher than 50%, and above percentage all is weight percentage.
2. according to claim 1, the used for aquiculture glycosaminoglycan mixes ecological growth promotion and immunomodulator with vitamin, it is characterized in that also comprising vitamin C 100～2500mg/L.
3. according to claim 1, the used for aquiculture glycosaminoglycan mixes ecological growth promotion and immunomodulator with vitamin, it is characterized in that also comprising Cobastab
11～100mg/L.
4. according to claim 1, the used for aquiculture glycosaminoglycan mixes ecological growth promotion and immunomodulator with vitamin, it is characterized in that also comprising Cobastab
21～100mg/L.
5. according to claim 1, the used for aquiculture glycosaminoglycan mixes ecological growth promotion and immunomodulator with vitamin, it is characterized in that also comprising Cobastab
61～100mg/L.
6. glycosaminoglycan mixes ecological growth promotion and immunomodulator with vitamin according to claim 1, it is characterized in that comprising: 2～11% glycosaminoglycan active components, the molecular weight of glycosaminoglycan is 10000～500000.
7. glycosaminoglycan mixes ecological growth promotion and immunomodulator with vitamin according to claim 1, and the concentration that it is characterized in that said acid solution is 1～5%.
8. mix ecological growth promotion and immunomodulator with vitamin like the said glycosaminoglycan of claim 7, it is characterized in that this acid solution is inorganic acid or organic acid.
9. mix ecological growth promotion and immunomodulator with vitamin like the said glycosaminoglycan of claim 8, it is characterized in that this inorganic acid is hydrochloric acid, phosphoric acid and sulfuric acid.
10. mix ecological growth promotion and immunomodulator with vitamin like the said glycosaminoglycan of claim 8, it is characterized in that this organic acid is formic acid, lactic acid, acetic acid and citric acid.
11. above requirement is characterised in that the used for aquiculture glycosaminoglycan mixes ecological growth promotion and immunomodulator with vitamin, is mixed in the various aquatic feeds, accounts for 0.1～1% of feed percentage by weight.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012101590647A CN102742727A (en) | 2012-05-22 | 2012-05-22 | Glycosaminoglycan and vitamin mixed ecological growth-promoting and immune-modulating agent used in aquaculture |
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| CN2012101590647A CN102742727A (en) | 2012-05-22 | 2012-05-22 | Glycosaminoglycan and vitamin mixed ecological growth-promoting and immune-modulating agent used in aquaculture |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102934761A (en) * | 2012-12-06 | 2013-02-20 | 山东新希望六和集团有限公司 | Feed for improving fish productivity and immunity |
| CN104206805A (en) * | 2014-07-22 | 2014-12-17 | 众合发(北京)生物科技发展有限公司 | Preparation for degrading vivotoxin and enhancing anti-stress capability of aquatic animals |
| CN111377546A (en) * | 2019-09-05 | 2020-07-07 | 环亚(天津)环保科技有限公司 | Biological activator for maintaining stable water quality of aquaculture |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102934761A (en) * | 2012-12-06 | 2013-02-20 | 山东新希望六和集团有限公司 | Feed for improving fish productivity and immunity |
| CN102934761B (en) * | 2012-12-06 | 2013-11-20 | 山东新希望六和集团有限公司 | Feed for improving fish productivity and immunity |
| CN104206805A (en) * | 2014-07-22 | 2014-12-17 | 众合发(北京)生物科技发展有限公司 | Preparation for degrading vivotoxin and enhancing anti-stress capability of aquatic animals |
| CN111377546A (en) * | 2019-09-05 | 2020-07-07 | 环亚(天津)环保科技有限公司 | Biological activator for maintaining stable water quality of aquaculture |
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Application publication date: 20121024 |