CN102727735A - Xuanmai Ganjie puffed particulate granules and preparation method thereof - Google Patents
Xuanmai Ganjie puffed particulate granules and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the medicine field, particularly to Xuanmai Ganjie puffed granules and a preparation method thereof. The invention provides Xuanmai Ganjie puffed granules with good flowing characteristics and a ball-like shape. The extraction or decocting technology can be performed according to the present method during the granulating process. The main difference between the method in the invention and the present method is making the granules in a compressed state. In the process of drying the granules, the moisture of the granules is controlled at 4-5 percent, then the granules are heated at high temperature to become puffed and the finished products of the granules are obtained by drying the puffed granules. The preparation method of the invention can form ball-like granules with smooth surfaces and compact texture. The interiors of the granules have a phenomenon of cavitation expansion which enables the granules to have good shape and not-easily-broken property, An angle of repose of a granule is between 10 degree to 25 degree. The granules prepared by the method have characteristics that the granules have good fluidity, do not easily absorb moisture and require less auxiliary material. Besides, the paste material is hard to appear when the granules are mixed with water, so that the mixing is very easy. The Xuanmai Ganjie puffed granules of the invention can be used as a raw material for preparing tablets and capsules according to the ordinary technology of compressing tablets and stuffing capsules.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to Xuanmai Ganju swelling granular agent and preparation method thereof.
Background technology
At present, for the ease of Application of TCM Chinese medicine, the common mode dosage form that herbal mixture is common is a granule, tablet, and capsules etc. also have processing granule after the single medicinal material extraction.The Xuanmai Ganju granule has the heat clearing away YIN nourishing, the effect of dispelling phlegm and relieving sore-throat.Be applicable to hyperactivity of fire caused by deficiency of YIN, mouth and nose are dry, diseases such as laryngopharynx swelling and pain.
The Xuanmai Ganju granule obtains extractum after normally crude drug being adopted organic solvent extraction such as decocte with water or ethanol, add then adjuvant process behind the soft material granulate, granulate, obtain granule.Could figurations but need add a large amount of adjuvants usually, and coating of particles is generally indefinite form according to the granule of existing method preparation, granule looses, broken, and profile is poor, and is mobile poor, and the easy moisture absorption is unfavorable for preserving packing and preservation.In order to improve existing method, the inventor desires to provide a kind of brand-new Xuanmai Ganju granule.
Summary of the invention
It is fine and close that the technical problem that the present invention solved provides a kind of smooth-shaped; Good fluidity, type spheric Xuanmai Ganju swelling granular agent, its extraction or decocting process; All can carry out with reference to existing method during granulation, main difference is: the granule of compressive state is processed in (1); (2) during dried particles, adopting first low temperature to be controlled to moisture is 4-5%, and heated particle makes it expanded under hot conditions again, drying.
Xuanmai Ganju swelling granular of the present invention agent is to be got by following method preparation:
A, take by weighing following raw materials by weight proportions: Radix Scrophulariae 300-500 part, Radix Ophiopogonis 300-500 part, Radix Glycyrrhizae 300-500 part, Radix Platycodonis 300-500 part, adopt conventional method to be prepared into extractum;
B, extractum processed soft material after, granulate, granulate is to crossing the 14-24 mesh sieve;
C, dried particles;
The improvements of Xuanmai Ganju swelling granular agent method for preparing of the present invention are:
1, step B prepares bulk density greater than 0.78g/cm
3Granule.The inventor will " bulk density be greater than 0.78g/cm
3Granule " be called " granule of compressive state ", the granulation mass density of this compressive state is at least greater than 0.78g/cm
3, with this understanding, just can carry out second committed step of the present invention, realize expanded purpose; The present invention prepares gained " granule of compressive state " bulk density and is generally 0.78-0.90g/cm
3
2, step C dried particles is to adopt following method:
(1) earlier under 40-60 ℃ cryogenic conditions dried particles to water content 4-5%;
(2) it is expanded under 65-95 ℃ hot conditions, to be heated to granule then;
(3) keep 65-95 ℃ hot conditions again, below the dried particles moisture to 2%, promptly get granule.
Cooperate above-mentioned technology, need were processed soft material after extractum is processed dry extract again when extractum was processed soft material, and so processing can reduce supplementary product consumption, reduced and took in unnecessary adjuvant, reduced production costs.
Committed step of the present invention is at first to adopt the compressing grains machine to process the granule of compressive state; In low temperature-pyritous processing mode, make granule at drying stage again, especially expansible phenomenon (expanded) appears in granule during high-temperature process; Make and form smooth in appearance fine and close sphere or spherical particle; Granule interior has the expanded phenomenon of cavity, and granule is not fragmentary, and profile is good; Granule scope angle of repose is 10-25 °, and good fluidity is difficult for the moisture absorption; Supplementary product consumption is few; Be not prone to pasty masses when brewing at the bottom of the cup, be prone to brew.Xuanmai Ganju granule of the present invention can also be pressed common process tabletting or encapsulated getting final product as the raw material of preparation tablet or capsule.
Description of drawings
Fig. 1 is the sketch map of compressing grains machine of the present invention.
Fig. 2 is the front view that the present invention gathers charging tray.
Fig. 3 is the left view of Fig. 2.
Fig. 4 is the front view of splitter section of the present invention.
Fig. 5 is the rearview of Fig. 4.
Fig. 6 is the A-A profile of Fig. 5.
Fig. 7 is the B-B profile of Fig. 5.
Fig. 8 is the front view of extrusion die of the present invention.
Fig. 9 is the left view of Fig. 8.
Figure 10 is the structure chart that existing screw rod is extruded the pay-off screw rod.
Figure 11 is the sketch map of screw rod cooling structure of the present invention.
Figure 12 is the front view of rotary-cut cutter of the present invention.
Figure 13 is the vertical view of Figure 12.
Be labeled as among the figure, the 1-head, the 2-discharge barrel, the 3-extrusion die, 4-gathers charging tray, 5-by-passing parts, 6-rotary-cut cutter; The 7-screw rod, 8-dynamical system, 9-rotary-cut system, 10-water collar, 30-discharge opening, 31-macropore, 32-aperture; The 40-centre bore, the 51-splitter box, 52-shunts ridge, and 53-blow tank, 54-gather the charging tray bayonet socket, 55-central boss, 56-back-up block; The 60-elastic, 61-sword limit, the 70-blind hole, the 71-inner cool tube, 72-cools off lid, the 73-nut, 74-cools off inlet; The 75-coolant outlet, 76-front end fixed disk, 77-gear shaft part, the 78-thread segment, the 700-cooling duct, 720-cools off cover cavity.
The specific embodiment
Below through to the description of specific embodiment of the invention explanation but do not limit the present invention.
Xuanmai Ganju swelling granular of the present invention adopts following method preparation:
A, take by weighing following raw materials by weight proportions: Radix Scrophulariae 300-500 part, Radix Ophiopogonis 300-500 part, Radix Glycyrrhizae 300-500 part, Radix Platycodonis 300-500 part, adopt conventional method to be prepared into dry extract;
B, dry extract processed soft material after, granulate, granulate is to crossing the 14-24 mesh sieve;
C, dried particles;
It is characterized in that:
Step B processes bulk density greater than 0.78g/cm
3Granule;
Step C dried particles is to adopt following method:
(1) earlier under 40-60 ℃ cryogenic conditions dried particles to water content 4-5% (w/w);
(2) it is expanded under the hot conditions of 65-95 ℃ (preferred 75-95 ℃), to be heated to granule then;
(3) keep the hot conditions of 65-95 ℃ (preferred 75-95 ℃) again, below the dried particles moisture to 2% (w/w), promptly get granule.
Wherein, preferred feedstock medicine weight proportion is: 400 parts of Radix Scrophulariaes, 400 parts of Radix Ophiopogonis, 400 parts in Radix Glycyrrhizae, 400 parts of Radix Platycodoniss.
In the past according to the granulation mass density of existing method preparation usually at 0.55-0.7g/cm
3Even adopt first low temperature-pyritous again drying mode also can't realize expanded purpose.And granule of the present invention prepares bulk density greater than 0.78g/cm in step B
3" granule of compressive state ", should " granule of compressive state " bulk density be generally 0.78-0.90g/cm
3, be to realize one of expanded key parameter.
Further, the conventional method that steps A prepares extractum has, decocte with water, and collecting decoction filters, and filtrating is left standstill, and getting supernatant concentration to relative density is the extractum of 1.32～1.35 (80～85 ℃).Also find during preparation, use method for preparing of the present invention extractum is processed refabrication soft material behind the extract powder, can obviously reduce supplementary product consumption, reduce the absorption of unnecessary adjuvant, reduce production costs.
The granule of Xuanmai Ganju swelling granular of the present invention agent is in profile, flowability, and moisture absorption brews and all is superior to the Xuanmai Ganju granule for preparing than existing methods on the complexity.
To prepare bulk density at least greater than 0.78g/cm in the method for preparing of the present invention
3Granule; When step B granulates, need use following compressing grains mechanism and be equipped with granule; This compressing grains machine such as Fig. 1～Fig. 9, Figure 11～shown in Figure 13 comprise that the double-screw type in the head 1 is extruded pay-off and extruded the discharge barrel 2 that pay-off cooperates with this, and the exit of discharge barrel 2 is provided with the extrusion die 3 that has discharge opening 30; In the discharge barrel 2; Extrude between pay-off and the extrusion die 3 at twin screw and to be provided with by-passing parts 5, twin screw extrude be provided with between pay-off and the by-passing parts 5 with by-passing parts 5 each other by touch have a centre bore 40 gather charging tray 4, the supplied materials side of by-passing parts 5 is evenly equipped with splitter box 51; Splitter box 51 converges at the blow tank 53 of by-passing parts exit side, and blow tank 53 is corresponding with the discharge opening 30 of extrusion die 3.The hollow charging tray 4 that gathers of the present invention can be extruded Double Circle stock column that pay-off sees off with twin screw and assembles and change over mono-cylindrical and water conservancy diversion before by-passing parts 5; Supplied materials side at by-passing parts 5 is evenly equipped with splitter box 51 as material channel; Guarantee to assemble the mono-cylindrical material bar that forms and evenly to be branched to extrusion die 3; Make material evenly to extrude,, be generally 0.78-0.90g/cm thereby obtain bulk density through its powerful extrusion capability
3Granule, and even particle size, good looking appearance obviously improves the particle appearance quality.The squeeze pressure scope of compressing grains machine can be floated at 45000N～150000N; When feeding at first; The feeding amount adopts less relatively squeeze pressure 45000N-6000N more at least; After feeding gets into normality, then adopt relatively large pressure 70000N～120000N extruding,, also can suitably increase squeeze pressure if the feeding amount is big.
Like Fig. 4, Fig. 5, Fig. 6 and shown in Figure 7, for further improving granular mass, said splitter box 51 is the sector diffuence groove, is shunting ridge 52 between the adjacent two sector diffuence grooves; Shunting ridge 52 is as separation between the sector diffuence groove and by-passing parts and gather the contacted part of charging tray, plays the effect of transmitting extruding force, and the sector diffuence groove is more shallow near the degree of depth of the part groove at middle part; Area is less, and extruding force is bigger, and corresponding material flow is less; And darker near the degree of depth of the part groove of circumference, area is bigger, and extruding force is less; Help giving full play to the homogenization of by-passing parts, make that the material bar linear velocity of extruding is more consistent, granule is more even.
For taking into account uniformity and easy to process, the number of sector diffuence groove is generally 4-7.
Like Fig. 5 and shown in Figure 6,, avoid template 3 local pressures excessive and damage for extruding force is delivered to extrusion die 3 uniformly; Should be provided with central boss 55 at the center of the exit side of said by-passing parts 5, be provided with back-up block 56 around the exit side, central boss 55 and back-up block 56 respectively with the center of extrusion die 3 with contact all around; Blow tank 53 is between central boss 55 and back-up block 56; Like this, the suffered pressure ratio of template is more even, also makes material to extrude more equably.
Like Fig. 4 and shown in Figure 6, for making things convenient for the location of by-passing parts 5, can be provided with in the supplied materials side of said by-passing parts 5 with centre bore 40 adaptive gather charging tray bayonet socket 54.
Shown in figure 11; Among the present invention; The screw rod 7 that double-screw type is extruded pay-off is provided with cooling structure; Said cooling structure be included in offer on the screw rod 7 with concentric blind hole of screw axis 70 and the inner cool tube 71 that is provided with cooling inlet 74; The cooling lid 72 that inner cool tube 71 passes this blind hole 70 of sealing stretch in the said blind hole 70 and its built-in length less than blind hole 70 degree of depth, cooling cover 72 and is had the cooling cover cavity 720 that is provided with coolant outlet 75, the cooling duct 700 that forms between inner cool tube 71 and the blind pore wall with cool off cover cavity 720 and be communicated with.This structure can feed cooling medium screw rod 7 is cooled off in running; Cooling medium is got into by cooling inlet 74, and the inner cool tube 71 of flowing through is flowed out by coolant outlet 75 with cooling duct 700, cooling cover cavity 720 backs, temperature arrising caused by friction in the time of can avoiding the equipment operation and the material viscosity that causes increases; Be prone to problems such as bonding; Guarantee normal discharging, for mechanical pelletizing provides precondition, the equipment that also makes can be applicable to the material extrusion granulator that viscosity is big.
For same purpose, as shown in Figure 1, can be on the such scheme basis, the barrel of extruding pay-off at double-screw type adds water collar 10 etc., and barrel is also lowered the temperature, and reaches better effect.
Shown in figure 11; Said inner cool tube 71 can be fixed on cooling through nut 73 and cover on 72, and said cooling lid 72 is fixedly connected with head 1, nut 73 and cooling off cover 72 can the while as the axial limiting structure of screw rod 7; Be limited to the axial displacement of extruding force screw rod 7 when excessive; Avoid two screw rods 7 to hang each other, improve the equipment reliability of operation, the equipment that also makes can be applicable to the material extrusion granulator that viscosity is big.
Be same purpose, on the such scheme basis, also can increase front end fixed disk 76 at the bearing side of screw rod 7, front end fixed disk 76 is fixedly connected with barrel, guarantees that screw rod 7 do not hang each other.
Like Fig. 8 and shown in Figure 9; For improving granular mass, said extrusion die 3 does not adopt common cylindrical hole, but at the supplied materials sidetracking macropore 31 of said extrusion die 3; The discharging sidetracking aperture 32 of extrusion die; Macropore 31 correspondences are communicated with one or two apertures 32 and form discharge opening 30, and material by further compression, obtains granule more closely through extrusion die 3 time like this.Consider the discharging uniformity; The aperture 32 of the exit side of extrusion die generally should be uniformly distributed with; Can be communicated with two apertures 32 with a macropore 31 more ground correspondences in the periphery of extrusion die 3, extrusion die 3 is communicated with an aperture 32 near the position at center with a macropore 31 more ground correspondences.
Usually, can bear bigger extruding force, guarantee that equipment also can normally move when the very big material of extruding viscosity for guaranteeing template; Give full play to the squeezing action in discharging hole 30 simultaneously; Said extrusion die 3 should have suitable thickness, and its thickness should reach more than the 30mm usually, considers the processing in hole; Thickness also should not be too thick, and its thickness generally is not more than 40mm.
Like Fig. 1, Figure 12 and shown in Figure 13; Since adopted extruding granulation mode, tightr from the material bar quality that extrusion die comes out, the rotary-cut cutter 6 cutting granulating that the exit side of available extrusion die 3 is provided with; Injure extrusion die 3 when avoiding rotary-cut cutter 6 operation and produce metal fillings; Its cutter hub is the elastic 60 that is convexly curved near the part on sword limit 61, then when feed is adjusted, make 61 two ends, sword limit can both with extrusion die 3 cutting of fitting well.
Be to increase extrusion pressure, said combination bore of gathering the centre bore 40 of charging tray 4 for taper hole and circular hole is promptly also pushed material gathering charging tray 4 places, and the equipment that makes can be applicable to the material extrusion granulator that viscosity is bigger.
Compressing grains facility of the present invention have powerful extrusion force (45000N～150000N); Reach 40～90% material for the dry extract amount; Also can mandatoryly extrude, cutting; Also can not influence the equipment operation too much, can't granulate owing to material contains extractum, the granulation mass density that obtains be at least greater than 0.78g/cm
3, scope is 0.78-0.9g/cm
3
Step B adopts compressing grains mechanism to be equipped with granule, and the granule that obtains through cold drying-high temperature puffing, dried then is in profile, flowability, and moisture absorption brews and all is superior to the granule for preparing than existing methods on the complexity; And preparation the time also finds, uses method for preparing of the present invention, can obviously reduce supplementary product consumption, and the minimizing patient takes in unnecessary adjuvant, reduces production costs.
Below prove beneficial effect of the present invention through the preparation instance, all adopt compressing grains of the present invention mechanism grain during granulation.
Get Radix Scrophulariae 400g, Radix Ophiopogonis 400g, Radix Glycyrrhizae 400g, Radix Platycodonis 400g, decocte with water three times, 1.5 hours for the first time; Second and third time each 1 hour; Collecting decoction filters, and filtrating was left standstill 12 hours; Getting supernatant concentration to relative density is the extractum of 1.32～1.35 (80～85 ℃), is dried to dry extract.The dry extract of following embodiment all adopts method for preparing.
Comparative Examples 1
(1) get extractum, press 1 part of dry extract, with 4.5 parts of sucrose, 1 part in dextrin, process granule, bulk density is about 0.60g/cm
3, drying gets granule 1000g, is distributed into 100 bags and promptly gets.。
(2) get extractum, add an amount of dextrin and sweeting agent, process granule, bulk density is about 0.62g/cm
3, drying is processed 300g (Sugarless type) granule, is distributed into 50 bags, promptly gets.
Embodiment 1
Get dry extract, pulverize, add appropriate amount of starch and sucrose, process granule, bulk density is about 0.86g/cm
3, earlier under 40-60 ℃ cryogenic conditions dried particles to water content 4-5%; Under 65-95 ℃ cryogenic conditions, kept at least 5 minutes then, expanded to granule; Keep the high-temperature condition again, below the dried particles moisture to 2%, get granule 250g, be distributed into 100 bags and promptly get.
Embodiment 2
Get dry extract, pulverize, add an amount of dextrin and sweeting agent, process granule, bulk density is about 0.88g/cm
3, dried particles was kept 5 minutes under 75-95 ℃ hot conditions to water content 4-5% then at least under 40-60 ℃ cryogenic conditions earlier, and is expanded to granule; Keep this hot conditions again, below the dried particles moisture to 2%, the dry granule 250g that gets is distributed into 100 bags, promptly gets.[this granule is a Sugarless type]
Embodiment 3
Get dry extract, pulverize, add an amount of dextrin, process granule, bulk density is about 0.83g/cm
3, dried particles was kept 5 minutes under 65-95 ℃ hot conditions to water content 4-5% then at least under 40-60 ℃ cryogenic conditions earlier, and is expanded to granule; Keep this hot conditions again, below the dried particles moisture to 2%, the dry granule 200g that gets is distributed into 100 bags, promptly gets.[this granule is a Sugarless type]
Get dry extract, pulverize, adding sucrose is an amount of, processes granule, and bulk density is about 0.86g/cm
3, first dried particles to water content 6% under 40-60 ℃ cryogenic conditions, then keep under 65-75 ℃ the hot conditions more than 15 minutes to below the pellet moisture to 2% yet for expanded situation occurring, granule 250g, be distributed into 100 bags.Particulate amorphous is prone to diffusing, broken, mobile relatively poor.
Embodiment 5
Get dry extract, pulverize, add an amount of dextrin, process granule, bulk density is about 0.88g/cm
3, first dried particles to water content 3% under 40-60 ℃ cryogenic conditions, then keep under 65-75 ℃ the hot conditions more than 15 minutes to below the pellet moisture to 2% yet for expanded situation occurring, granule 250g, be distributed into 100 bags, promptly get.Particulate amorphous is prone to diffusing, broken, mobile relatively poor.[this granule is a Sugarless type]
To sum up visible, the granule of existing prepared is an amorphous granular, is prone to diffusing, broken; Mobile relatively poor; And when adopting technology of the present invention if the cold drying water content exceeds the scope of 4-5%, under hot conditions, also can't reach expanded effect, like embodiment 4 and embodiment 5.And the obviously existing process shape of the profile of the Xuanmai Ganju swelling granular agent (embodiment 1-3) of prepared of the present invention is more attractive in appearance, and its smooth in appearance is fine and close, spherical particle, in the expanded phenomenon of cavity is arranged; Granule scope angle of repose is 10-25 °, and good fluidity is difficult for the moisture absorption; Supplementary product consumption is few; It is also easier to brew.
Claims (10)
1. the method for preparing of Xuanmai Ganju swelling granular agent, by following method preparation and get:
A, take by weighing following raw materials by weight proportions: Radix Scrophulariae 300-500 part, Radix Ophiopogonis 300-500 part, Radix Glycyrrhizae 300-500 part, Radix Platycodonis 300-500 part, adopt conventional method to be prepared into extractum;
B, extractum processed soft material after, granulate, granulate is to crossing the 14-24 mesh sieve;
C, dried particles;
It is characterized in that:
The said granulation of step B is for processing bulk density greater than 0.78g/cm
3Granule;
The described dried particles of step C is to adopt following method:
(1) earlier under 40-60 ℃ cryogenic conditions dried particles to water content 4-5%;
(2) it is expanded under 65-95 ℃ hot conditions, to be heated to granule then;
(3) keep 65-95 ℃ of hot conditions again, below the dried particles moisture to 2%, promptly get granule.
2. the method for preparing of Xuanmai Ganju swelling granular according to claim 1 agent is characterized in that: step B processes refabrication soft material behind the dry extract with extractum.
3. the method for preparing of Xuanmai Ganju swelling granular according to claim 3 agent is characterized in that: described granulation is to adopt compressing grains machine compressed granulate;
Said compressing grains machine; Comprise that the double-screw type in the head (1) extrudes pay-off and extrude the discharge barrel (2) that pay-off cooperates with this; The exit of discharge barrel (2) is provided with the extrusion die (3) that has discharge opening (30); In the discharge barrel (2), extrude between pay-off and the extrusion die (3) at twin screw and to be provided with by-passing parts (5);
Wherein, Twin screw extrude be provided with between pay-off and the by-passing parts (5) with by-passing parts (5) each other by touch have a centre bore (40) gather charging tray (4); The supplied materials side of by-passing parts (5) is evenly equipped with splitter box (51); Splitter box (51) converges at the blow tank (53) of by-passing parts exit side, and blow tank (53) is corresponding with the discharge opening (30) of extrusion die (3).
4. the method for preparing of Xuanmai Ganju swelling granular according to claim 3 agent is characterized in that: said splitter box (51) is the sector diffuence groove, is shunting ridge (52) between the adjacent two sector diffuence grooves.
5. according to the method for preparing of claim 3 or 4 described Xuanmai Ganju swelling granular decoction pieces; It is characterized in that: the center of the exit side of said by-passing parts (5) is provided with central boss (55); Be provided with back-up block (56) around the exit side; Central boss (55) and back-up block (56) respectively with the center of extrusion die (3) with contact all around, blow tank (53) is positioned between central boss (55) and the back-up block (56); Further preferably the supplied materials side of said by-passing parts (5) be provided with centre bore (40) adaptive gather charging tray bayonet socket (54).
6. according to the method for preparing of claim 3 or 4 described Xuanmai Ganju swelling granular agent; It is characterized in that: the screw rod (7) that said double-screw type is extruded pay-off is provided with cooling structure; Said cooling structure be included in offer on the screw rod (7) with the concentric blind hole of screw axis (70) and be provided with the inner cool tube (71) of cooling inlet (74); The cooling lid (72) that inner cool tube (71) passes this blind hole of sealing (70) stretch in the said blind hole (70) and its built-in length less than blind hole (70) degree of depth; Cooling lid (72) has the cooling cover cavity (720) that is provided with coolant outlet (75), the cooling duct (700) that forms between inner cool tube (71) and the blind pore wall with cool off cover cavity (720) and be communicated with; Further preferred said inner cool tube (71) is fixed on the cooling lid (72) through nut (73), and said cooling lid (72) is fixedly connected with head (1).
7. according to the method for preparing of claim 3 or 4 described Xuanmai Ganju swelling granular agent; It is characterized in that: the supplied materials side of said extrusion die (3) is macropore (31); The exit side of extrusion die is aperture (32), and a macropore (31) is corresponding to be communicated with one or two aperture (32) and formation discharge opening (30).
8. according to the method for preparing of claim 3 or 4 described Xuanmai Ganju swelling granular agent; It is characterized in that: the exit side of said extrusion die (3) is provided with rotary-cut cutter (6), and its cutter hub is the elastic (60) that is convexly curved near the part of sword limit (61).
9. according to the method for preparing of claim 3 or 4 described Xuanmai Ganju swelling granular agent, it is characterized in that: said combination bore of gathering the centre bore (40) of charging tray (4) for taper hole and circular hole.
Each described method for preparing preparation of claim 1-9 and the agent of Xuanmai Ganju swelling granular.
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| CN103636857A (en) * | 2013-11-21 | 2014-03-19 | 宁夏多维药业有限公司 | Herbaceous plant cool tea and preparation method thereof |
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| 高庆凌等: "膨化颗粒技术与应用", 《中国药业》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103300113A (en) * | 2013-06-27 | 2013-09-18 | 叶建斌 | Healthy food for dispelling wind and moistening dryness and preparation method |
| CN103636857A (en) * | 2013-11-21 | 2014-03-19 | 宁夏多维药业有限公司 | Herbaceous plant cool tea and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN102727735B (en) | 2014-05-28 |
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