CN102727732B - Traditional Chinese medicine composition for treating immunoiogical sterility and application of traditional Chinese medicine composition in preparing medicine for treating immunoiogical sterility - Google Patents
Traditional Chinese medicine composition for treating immunoiogical sterility and application of traditional Chinese medicine composition in preparing medicine for treating immunoiogical sterility Download PDFInfo
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- CN102727732B CN102727732B CN201210248473.4A CN201210248473A CN102727732B CN 102727732 B CN102727732 B CN 102727732B CN 201210248473 A CN201210248473 A CN 201210248473A CN 102727732 B CN102727732 B CN 102727732B
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Abstract
The invention relates to a traditional Chinese medicine composition for treating immunoiogical sterility and an application of the traditional Chinese medicine composition in preparing a medicine for treating immunoiogical sterility. The technical scheme provided by the invention is that the traditional Chinese medicine composition for treating immunoiogical sterility comprises the materials in parts by weight as follows: 5 parts of capillary Artemisia, 3-5 parts of scutellaria baicalensis, 0.5-1.5 parts of prepared rhubarb, 3-5 parts of angelica sinensis, 2-4 parts of radix paeoniae alba, 1.5-2.5 parts of rhizoma atractylodis macrocephalae, 4-6 parts of leonurus, 2-4 parts of ligusticum wallichii, 2-4 parts of rhizoma anemarrhenae, 2-4 parts of golden cypress, 1-3 parts of common andrographis herb, 4-6 parts of semen cuscutae. The traditional Chinese medicine composition and the application can be applied to production of the traditional Chinese medicine composition for treating immunoiogical sterility.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of immune infertility, relate in particular to the Chinese medicine composition for the treatment of the immune infertility causing because of Positive Anti-sperm Antibody reaction, the invention still further relates to the application of this Chinese medicine composition in preparation treatment immune infertility medicament.
Background technology
Cause the reason of infertility to be divided into: 1. genitals's abnormal (comprising sex genital structure).2. sexual dysfunction (comprising cryptorrhea).3. smart ovum is in conjunction with obstacle.Front two classes shared clinical ratio in male accounts for 5% left and right, and in women, shared clinical ratio is about 10% left and right.And because a variety of causes causes Infertile couples proportion in clinical infertility that smart ovum causes in conjunction with obstacle to reach 95%, wherein approximately 35% Mr. and Mrs find Positive Anti-sperm Antibody because bridegroom's or husband's side serum (or seminal fluid) or wife's side serum (or cervical mucus) detect, sperm loses mobility or limitation of activity, or stop sperm further to move about through cervix uteri arrival women's fallopian tube position, thereby make smart ovum in conjunction with forming germ cell, cause the wife's side infertile.Chinese patent document CN101569670B discloses a kind of pharmaceutical composition for the treatment of infertility; but the Squama Manis containing in its formula watches for animals from country more than two; also contain toxic components such as thering is Scolopendra, Hirudo; and its mainly for women's obstruction of fallopian tube, menoxenia, do not ovulate and that uterine hypoplasia causes is infertile, be not suitable for the infertility that Mr. and Mrs both sides or folk prescription cause because of Positive Anti-sperm Antibody.
Summary of the invention
One of technical problem to be solved by this invention is to provide a kind of Chinese medicine composition, and its infertility that Mr. and Mrs both sides or folk prescription are caused because of Positive Anti-sperm Antibody has the feature of good therapeutic effect.
Two of the technical problem to be solved in the present invention is that the Chinese medicine composition that one of above-mentioned technical problem provides is treated the application in immune infertility medicament in preparation.
For one of solving the problems of the technologies described above, the technical solution used in the present invention is as follows: a kind of Chinese medicine composition for the treatment of immune infertility, represents to comprise with weight portion: 5 parts of Herba Artemisiae Scopariaes, 3～5 parts of Radix Scutellariaes, 0.5～1.5 part of Radix et Rhizoma Rhei (processed), 3～5 parts of Radix Angelicae Sinensis, 2～4 parts of the Radix Paeoniae Albas, 1.5～2.5 parts of the Rhizoma Atractylodis Macrocephalaes, 4～6 parts of Herba Leonuris, 2～4 parts of Rhizoma Chuanxiongs, 2～4 parts of the Rhizoma Anemarrhenaes, 1～3 part of 2～4 parts of Herba Andrographis of Cortex Phellodendri, 4～6 parts of Semen Cuscutae.
In technique scheme, described Chinese medicine composition, represents to preferably include 6～8 parts of 6～8 parts of Radix Codonopsis and/or the Radixs Astragali with weight portion, more preferably further comprises 0.5～1.5 part, Radix Glycyrrhizae.
In technique scheme, described Chinese medicine composition, preferably 5 parts of Herba Artemisiae Scopariaes, 4 parts of Radix Scutellariaes, 1 part of Radix et Rhizoma Rhei (processed), 4 parts of Radix Angelicae Sinensis, 3 parts of the Radix Paeoniae Albas, 2 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Herba Leonuris, 3 parts of Rhizoma Chuanxiongs, 3 parts of the Rhizoma Anemarrhenaes, 2 parts of 3 parts of Herba Andrographis of Cortex Phellodendri, 5 parts of Semen Cuscutae; But can be 5 parts of Herba Artemisiae Scopariaes, 3 parts of Radix Scutellariaes, 0.5 part of Radix et Rhizoma Rhei (processed), 3 parts of Radix Angelicae Sinensis, 2 parts of the Radix Paeoniae Albas, 1.5 parts of the Rhizoma Atractylodis Macrocephalaes, 4 parts of Herba Leonuris, 2 parts of Rhizoma Chuanxiongs, 2 parts of the Rhizoma Anemarrhenaes, 2 parts of Cortex Phellodendris, 1 part of Herba Andrographis, 4 parts of Semen Cuscutae; Can also be 5 parts of Herba Artemisiae Scopariaes, 5 parts of Radix Scutellariaes, 1.5 parts of Radix et Rhizoma Rhei (processed), 5 parts of Radix Angelicae Sinensis, 4 parts of the Radix Paeoniae Albas, 2.5 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Herba Leonuris, 4 parts of Rhizoma Chuanxiongs, 4 parts of the Rhizoma Anemarrhenaes, 4 parts of Cortex Phellodendris, 3 parts of Herba Andrographis, 6 parts of Semen Cuscutae.
In technique scheme, the title of all components all adopts the standard of < < Pharmacopoeia of People's Republic of China > > (version in 2010), particularly, Herba Artemisiae Scopariae is feverfew Artemisia scoparia Waldst. et Kit. (latin name Artemisias coparia Waldst.etKit) or Herba Artemisiae Scopariae (latin name Artemisia capillaries Thunb.) dry aerial parts, what gather spring is " capillary wormwood ", and what tap autumn is " flower Herba Artemisiae Scopariae ", Radix Scutellariae is the dry root of labiate Radix Scutellariae (latin name Scutellaria baicalensis Georgi), concocts as scutellaria tablet, this programme Radix et Rhizoma Rhei (processed) used is that Chinese herb rhubarb (latin name Rhei radix et rhizoma) is picked up clean rear clear water immersion 6 to 8 hours, in the water elimination silt impurity impouring pot soaking, every 100 kilograms of former dry medicines add adjuvant (10 kilograms of bright Herba Plantaginiss, 10 kilograms of fresh Cacumen Platycladi), put into pot with Radix Et Rhizoma Rhei layering, boil with high heat 4 to 6 hours, boil while nearly doing to water, add 10 kilograms of Chinese liquor to mix thoroughly, simmer in water again 10 to 20 minutes, suck dry moisture, take out, remove Herba Plantaginis, Cacumen Platycladi, Radix Et Rhizoma Rhei shines while doing to 5 one-tenth, be cut into 7 to 10 millimeters of blockages, shine or dry, it has the effect of obvious blocking-up antigen antibody reaction in this programme, used when being classified as the decoction pieces of the dry root process of preparing Chinese medicine of umbelliferae angelica (latin name angelica sinensis (Oliv.) Diels.), the Radix Paeoniae Alba used is the decoction pieces that the dry root of cohosh Radix Paeoniae (latin name Paeonia lactiflora Pall.) is concocted, and the Rhizoma Atractylodis Macrocephalae used is the decoction pieces that the dry stem of the feverfew Rhizoma Atractylodis Macrocephalae (latin name Atractylodes macrocephala Koidz.) is concocted, Herba Leonuri used is the dry aerial parts of labiate Herba Leonuri (latin name Leonurus japonicus Houtt.), Rhizoma Chuanxiong used is the decoction pieces that samphire Rhizoma Chuanxiong (latin name Ligusticum chuanxiong Hort.) dry root is concocted, the Rhizoma Anemarrhenae used is the decoction pieces that the dry rhizome of the liliaceous plant Rhizoma Anemarrhenae (latin name Anemarrhena asphodeliodes Beg.) is concocted, Cortex Phellodendri used is the decoction pieces that the dry bark of rutaceae wampee (latin name Phllodendron chinense Schneid.) is made, Herba Andrographis used is the decoction pieces that the dry aerial parts of acanthaceous plant Herba Andrographis (latin name Andrographis paniculata (Burm.f.) Nees) are made, Radix Glycyrrhizae used is the dry root of glycyrrhizic legume (latin name Glycyrrhiza uralensisi Fish.), Glycyrrhiza inflata Bat. (latin name Glycyrrhiza inflata Bat.) or Glycyrrhiza glabra L. (latin name Glycyrrhiza glabra L.) and the decoction pieces that rhizome is made, Radix Codonopsis used is Campanulaceae Radix Codonopsis (latin name Codonapsis pilosola (French.) Nannf.), the element flower Radix Codonopsis (decoction pieces that the dry root of latin name Codonapsis pilosola Nannf. Var.modesta (Nannf.) L.T.Shen or radix codonpsis tangshen (latin name Codonapsis tangshen Oliv.) is made, the Radix Astragali used is the decoction pieces that the dry root of leguminous plant Radix Astagali (latin name Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsia) or Radix Astragali (Astragalus membranaceus (Fisch.) Bge.) is made, Semen Cuscutae used is the dry mature seed of convolvulaceous plant south Semen Cuscutae (latin name Cuscuta auatrulis R.Br.) or Semen Cuscutae (latin name Cuscuta chinensis Lam.).
In technique scheme, the preferred capillary wormwood of described Herba Artemisiae Scopariae.
For solve the problems of the technologies described above two, technical scheme of the present invention is as follows: the application of above-mentioned Chinese medicine composition in preparation treatment immune infertility medicine.
In technique scheme, the dosage form of described medicine can be decoction, granule, capsule, the watered pill or tablet, preferably decoction.
The preparation method of described Chinese medicine composition, comprises the steps:
A, in the container of boiling medicine by aequum component and 2～4 times to the water soaking of composition total weight 20～60 minutes;
B, 55～100 ℃ heating 20～40 minutes;
C, isolate the decoction that liquid obtains described compositions.
Granulation, capsule, the watered pill, tablet, oral liquid after decoction further can also being concentrated.One skilled in the art will appreciate that for dosage form figuration, improve the needs such as taste, abnormal smells from the patient, can add the applicable excipient in this area, sweetener, thickening agent, aromatic etc. according to practical situation.
Clinical test results to immune infertility shows, Chinese medicine composition of the present invention up to 90.3%, up to 96.7%, has been obtained good therapeutic effect to the effective percentage of women's immune infertility to the effective percentage of male's immune barrenness.
Below in conjunction with the specific embodiment, the present invention will be further described.
The specific embodiment
[embodiment 1]
(1) preparation of compositions
Take 1 weight portion as 4 grams, according to the proportioning of table 1, each component is weighed in decocting medicine pot, add the clear water that is equivalent to 3 times of weights of compositions gross weight, soak 40 minutes, then, 85 ℃ of heating 30 minutes, the liquid that filtered through gauze obtains is that potion decoction is standby.
(2) clinical trial
The selection of Positive Anti-sperm Antibody case: check the standard with diagnosis handbook > > (1995) according to the < < of World Health Organization (WHO) (WHO) infertile couples standard, select regular risk sexual life conceived Mr. and Mrs and bridegroom's or husband's side semen volume>=2.0ml, liquefying time≤30 minute, sperm concentration>=20.0 * 10 not yet after 1 year
6sperm>=25% of/milliliter, proal sperm (category-A and category-B)>=50% or category-A motion, eupyrene sperm form>=30% and wife's side menstrual cycle are normal, ovulation rule, hysterosalpingography show without abnormal and unobstructed Infertile couples, the factor of getting rid of the impact fertilities such as other systemic diseases, carry out antisperm antibody assay, the patient of Positive Anti-sperm Antibody reaction is carried out to clinical clinical trial as Positive Anti-sperm Antibody case.
Medication and clinical efficacy standard: each case is taken above-mentioned potion decoction every day, early, respectively take half agent evening.During treatment, patient Mr. and Mrs all adopt condom contraception.Take 24 doses of decoctions as 1 course for the treatment of, after every 1 course for the treatment of, check serum antisperm antibody 1 time, antisperm antibody assay transfers negative patient to be cut out and adds up as effectively, or still keep Positive Anti-sperm Antibody 6 courses for the treatment of of taking medicine continuously, and person also cuts out and adds up as invalid.
Table 2 has provided the clinical testing data of traditional Chinese medicine composition for treating Positive Anti-sperm Antibody of the present invention.
[embodiment 2]～[embodiment 9], [comparative example 1] and [comparative example 2]
(1) preparation of compositions
Except the formula proportion difference adopting, other are all identical with embodiment 1, and the formula proportion of each embodiment and comparative example is in Table in 1.
(2) clinical trial
Except participating in the positive case sex of clinical trial,, to participate in the positive case number of clinical trial different, and take outside the decoction of corresponding embodiment and comparative example separately, all identical with embodiment 1, for ease of relatively clinical test results being listed in to table 2.
From the data that table 1 and table 2 provide, can find out, in the present composition, Herba Artemisiae Scopariae and Radix et Rhizoma Rhei (processed) have obvious synergism aspect treatment immune infertility; And in relating to the preferred invention that comprises Radix Codonopsis, the Radix Astragali and Radix Glycyrrhizae, between Radix Codonopsis, the Radix Astragali and Radix Glycyrrhizae three, also there is certain synergism.
The effective percentage of table 2 Chinese medicine composition treatment of the present invention Positive Anti-sperm Antibody
Claims (9)
1. treat a Chinese medicine composition for immune infertility, with weight portion, represent composed of the following components: 5 parts of Herba Artemisiae Scopariaes, 3～5 parts of Radix Scutellariaes, 0.5～1.5 part of Radix et Rhizoma Rhei (processed), 3～5 parts of Radix Angelicae Sinensis, 2～4 parts of the Radix Paeoniae Albas, 1.5～2.5 parts of the Rhizoma Atractylodis Macrocephalaes, 4～6 parts of Herba Leonuris, 2～4 parts of Rhizoma Chuanxiongs, 2～4 parts of the Rhizoma Anemarrhenaes, 2～4 parts of Cortex Phellodendris, 1～3 part of Herba Andrographis, 4～6 parts of Semen Cuscutae.
2. Chinese medicine composition as claimed in claim 1, is characterized in that 5 parts of Herba Artemisiae Scopariaes, 4 parts of Radix Scutellariaes, 1 part of Radix et Rhizoma Rhei (processed), 4 parts of Radix Angelicae Sinensis, 3 parts of the Radix Paeoniae Albas, 2 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Herba Leonuris, 3 parts of Rhizoma Chuanxiongs, 3 parts of the Rhizoma Anemarrhenaes, 3 parts of Cortex Phellodendris, 2 parts of Herba Andrographis, 5 parts of Semen Cuscutae.
3. Chinese medicine composition as claimed in claim 1, is characterized in that 5 parts of Herba Artemisiae Scopariaes, 3 parts of Radix Scutellariaes, 0.5 part of Radix et Rhizoma Rhei (processed), 3 parts of Radix Angelicae Sinensis, 2 parts of the Radix Paeoniae Albas, 1.5 parts of the Rhizoma Atractylodis Macrocephalaes, 4 parts of Herba Leonuris, 2 parts of Rhizoma Chuanxiongs, 2 parts of the Rhizoma Anemarrhenaes, 2 parts of Cortex Phellodendris, 1 part of Herba Andrographis, 4 parts of Semen Cuscutae.
4. Chinese medicine composition as claimed in claim 1, is characterized in that 5 parts of Herba Artemisiae Scopariaes, 5 parts of Radix Scutellariaes, 1.5 parts of Radix et Rhizoma Rhei (processed), 5 parts of Radix Angelicae Sinensis, 4 parts of the Radix Paeoniae Albas, 2.5 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Herba Leonuris, 4 parts of Rhizoma Chuanxiongs, 4 parts of the Rhizoma Anemarrhenaes, 4 parts of Cortex Phellodendris, 3 parts of Herba Andrographis, 6 parts of Semen Cuscutae.
5. treat a Chinese medicine composition for immune infertility, with weight portion, represent composed of the following components: 6～8 parts of 5 parts of Herba Artemisiae Scopariaes, 3～5 parts of Radix Scutellariaes, 0.5～1.5 part of Radix et Rhizoma Rhei (processed), 3～5 parts of Radix Angelicae Sinensis, 2～4 parts of the Radix Paeoniae Albas, 1.5～2.5 parts of the Rhizoma Atractylodis Macrocephalaes, 4～6 parts of Herba Leonuris, 2～4 parts of Rhizoma Chuanxiongs, 2～4 parts of the Rhizoma Anemarrhenaes, 2～4 parts of Cortex Phellodendris, 1～3 part of Herba Andrographis, 4～6 parts of Semen Cuscutae and 6～8 parts of Radix Codonopsis and/or the Radixs Astragali.
6. treat a Chinese medicine composition for immune infertility, with weight portion, represent composed of the following components: 5 parts of Herba Artemisiae Scopariaes, 3～5 parts of Radix Scutellariaes, 0.5～1.5 part of Radix et Rhizoma Rhei (processed), 3～5 parts of Radix Angelicae Sinensis, 2～4 parts of the Radix Paeoniae Albas, 1.5～2.5 parts of the Rhizoma Atractylodis Macrocephalaes, 4～6 parts of Herba Leonuris, 2～4 parts of Rhizoma Chuanxiongs, 2～4 parts of the Rhizoma Anemarrhenaes, 2～4 parts of Cortex Phellodendris, 1～3 part of Herba Andrographis, 4～6 parts of Semen Cuscutae, 0.5～1.5 part, Radix Glycyrrhizae.
7. treat a Chinese medicine composition for immune infertility, with weight portion, represent composed of the following components: 6～8 parts of 5 parts of Herba Artemisiae Scopariaes, 3～5 parts of Radix Scutellariaes, 0.5～1.5 part of Radix et Rhizoma Rhei (processed), 3～5 parts of Radix Angelicae Sinensis, 2～4 parts of the Radix Paeoniae Albas, 1.5～2.5 parts of the Rhizoma Atractylodis Macrocephalaes, 4～6 parts of Herba Leonuris, 2～4 parts of Rhizoma Chuanxiongs, 2～4 parts of the Rhizoma Anemarrhenaes, 2～4 parts of Cortex Phellodendris, 1～3 part of Herba Andrographis, 4～6 parts of Semen Cuscutae, 0.5～1.5 part, Radix Glycyrrhizae and 6～8 parts of Radix Codonopsis and/or the Radixs Astragali.
8. the application of the Chinese medicine composition as described in any one in claim 1 to 7 in preparation treatment immune infertility medicine.
9. application as claimed in claim 7, is characterized in that the dosage form of described medicine is decoction, granule, capsule, the watered pill or tablet.
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| CN201210248473.4A CN102727732B (en) | 2012-07-18 | 2012-07-18 | Traditional Chinese medicine composition for treating immunoiogical sterility and application of traditional Chinese medicine composition in preparing medicine for treating immunoiogical sterility |
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| CN105943806A (en) * | 2016-05-31 | 2016-09-21 | 亳州市永博保健食品有限公司 | Traditional Chinese medicine health-care wine for treating infertility |
| CN113398191A (en) * | 2021-06-23 | 2021-09-17 | 天津中医药大学第一附属医院 | Yang warming and turbid removing traditional Chinese medicine composition for improving endometrial receptivity and preparation method and application thereof |
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| CN101049414A (en) * | 2007-05-16 | 2007-10-10 | 北京艺信堂医药研究所 | Preparation of Chinese traditional medicine for treating barrenness caused by chronic salpingitis |
| CN101428106B (en) * | 2008-12-24 | 2011-05-25 | 张铎 | Medicament composition for treating female infertility, and uses thereof |
| CN101513480B (en) * | 2009-04-07 | 2011-09-14 | 朱亚夫 | Pure traditional Chinese medicine composition for treating female sterility and pure traditional Chinese medicine preparation prepared thereby |
| CN101912534A (en) * | 2010-08-05 | 2010-12-15 | 重庆市南川区金佛山中药材品种培育研究所 | Chinese medicament for treating blood-heat barrenness of women |
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