CN102727555A - Traditional Chinese medicine for treating gastritis, gastric ulcer and duodenal ulcer and preparation method - Google Patents
Traditional Chinese medicine for treating gastritis, gastric ulcer and duodenal ulcer and preparation method Download PDFInfo
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- 201000005917 gastric ulcer Diseases 0.000 title claims abstract description 17
- 208000007882 Gastritis Diseases 0.000 title claims abstract description 14
- 208000000718 duodenal ulcer Diseases 0.000 title claims abstract description 14
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 239000000203 mixture Substances 0.000 claims abstract description 46
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Abstract
The invention relates to a traditional Chinese medicine composition for treating gastritis, gastric ulcer and duodenal ulcer. The composition comprises the following raw materials by mass percent: 4 to 6% of frankincense, 4 to 6% of myrrh, 8 to 12% of cuttlebone, 8 to 12% of lumbricus and 65 to 75% of mixture a, wherein the mixture a is prepared by mixing fel bovis with gypsum powder in a proportion of 1ml: (7-9g) and then drying. The invention also discloses the preparation method of the traditional Chinese medicine composition for treating gastritis, gastric ulcer and duodenal ulcer. The preparation method comprises the steps of: mixing fel bovis with gypsum powder in a proportion of 1ml: (7-9g), and drying in the air to obtain the mixture a; and then mixing the mixture a with other medicaments, and crushing to obtain the composition. The composition can directly act on the gastric mucosa for treating; and the composition has the advantages of high seepage force, good treatment effect and high cure rate.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, relates to a traditional Chinese medicine composition for treating gastritis, gastric ulcer and duodenal ulcer, and also relates to a preparation method of the traditional Chinese medicine composition.
Background
Gastritis, gastric ulcer and duodenal ulcer, the incidence rate of the traditional Chinese medicine is close to 30% in the population at present. However, the patients can only relieve the symptoms of serious diseases and can not be eradicated completely after being treated by the traditional Chinese medicine, and most of the diseases are as long as 5-10 years. The traditional Chinese medicine has the theory that the congenital origin lies in the kidney, the acquired origin lies in the stomach, and other nutritional deficiency diseases are gradually formed along with the long-term gastropathy, so that the traditional Chinese medicine causes great harm to the health of human bodies.
The pathological changes in the stomach, firstly, are caused by the damage of mucous membranes caused by various factors, and the pathological changes cause obstacles to the absorption of food, including the absorption of medicines for treating stomach diseases. Since the gastric mucosa is the tissue organ that absorbs food. The diseased mucosa in the tissue chain of the mucosal barrier loses or completely loses its own function, thus causing problems with drug-dependent circulatory absorption for the treatment of gastric disorders. Therefore, any decoction or pill for treating the stomach is considered as the treatment principle of the traditional Chinese medicine, such as adjusting the balance of internal organs, conditioning cold, heat, deficiency and excess and the like; the indirect treatment has slow and incomplete mucosa recovery and low cure rate.
Because of the function of the mucosa barrier, the stomach is protected from being corroded by acid, and the mucosa barrier is tightly protected, so that all foods and medicaments are attached to the surface of the inner layer of the mucosa, the medicaments for treating the stomach diseases cannot invade the inner layer of the mucosa barrier, and the mucosa with deep pathological changes cannot contact the medicaments. The inability of drugs to treat the gastric mucosa to invade the inner layer of the mucosal barrier is a significant problem not addressed by the prior art. Therefore, the existing medicine for treating the stomach illness has poor effect, long treatment period and low cure rate, and the patient is easy to relapse after relieving the symptoms.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for treating gastritis, gastric ulcer and duodenal ulcer, which directly acts on gastric mucosa for treatment, and has the advantages of strong permeability, good treatment effect and high cure rate.
The invention also aims to provide a preparation method of the traditional Chinese medicine composition.
The technical scheme adopted by the invention is that a traditional Chinese medicine composition for treating gastritis, gastric ulcer and duodenal ulcer is prepared from the following raw materials in percentage by mass:
4-6% of frankincense, 4-6% of myrrh, 8-12% of cuttle bone, 8-12% of earthworm and 65-75% of a mixture a, wherein the sum of the mass percentages of the components is 100%, and the mixture a is the weight ratio of oxgall to gypsum powder according to 1ml of oxgall: and 7-9 g of gypsum powder are mixed and dried to obtain the gypsum powder.
The invention adopts another technical scheme that the preparation method of the traditional Chinese medicine composition for treating gastritis, gastric ulcer and duodenal ulcer specifically comprises the following steps:
step 1
Mixing oxgall and gypsum powder according to the proportion of 1ml oxgall: mixing 7-9 g of gypsum powder in proportion, and air-drying to obtain a mixture a;
then weighing 4-6% of frankincense, 4-6% of myrrh, 8-12% of cuttle bone, 8-12% of earthworm and 65-75% of mixture a according to the mass percentage, wherein the sum of the mass percentages of the components is 100%;
step 2
Soaking the earthworms weighed in the step 1 in a proper amount of water for 15-20 minutes, then steaming, drying and grinding into earthworm powder; mixing the mixture a, Lumbricus powder, Olibanum, Myrrha, and Os Sepiae, and pulverizing.
The traditional Chinese medicine composition for treating gastritis, gastric ulcer and duodenal ulcer has the advantages of solving the problem that common medicines cannot invade mucosal barriers and precipitate under the outer surface skin to achieve contact treatment, along with good treatment effect and no relapse.
Detailed Description
The present invention will be described in detail below with reference to specific embodiments.
The traditional Chinese medicine composition for treating gastritis, gastric ulcer and duodenal ulcer comprises the following raw materials in percentage by mass:
4-6% of frankincense, 4-6% of myrrh, 8-12% of cuttle bone, 8-12% of earthworm and 65-75% of a mixture a, wherein the sum of the mass percentages of the components is 100%, and the mixture a is the weight ratio of oxgall to gypsum powder according to 1ml of oxgall: and 7-9 g of gypsum powder are mixed and dried to obtain the gypsum powder.
Wherein,
gypsum, Gypsum Fibrosum, pungent and sweet in flavor and cold in nature. It enters lung and stomach meridians. Relieving muscles and skin, clearing heat, purging fire, relieving restlessness, quenching thirst, astringing, promoting granulation, and healing ulcer.
Ox bile is bitter in taste, cold in nature, strong in penetration, capable of detoxifying and reducing swelling, and capable of killing parasites and clearing heat.
The combination of ox bile and gypsum can neutralize gastric acid, and is applied to the affected mucosa or ulcer surface and soaked in the inner layer of mucosa barrier, which is also used as monarch drug.
The cuttlefish bone can heal wound, inhibit gastric acid, and stop bleeding. Can be used for treating ulcer, hyperchlorhydria, hematemesis, epistaxis, metrorrhagia, hematochezia, gastralgia, and acid regurgitation. The mucosa of the ulcer surface falls off due to mucosal lesion, gastric acid directly erodes the subcutaneous part of the ulcer surface, the gastric acid is inhibited, and the stomach is kept mild, so the formula is a ministerial drug.
Earthworm, being cold in nature, clearing heat and arresting convulsion, dredging collaterals, having the functions of promoting tissue regeneration and promoting granulation, having super-strong regenerative power and playing a role in regenerating mucosa.
Ru Xiang is pungent and bitter with warm taste. Has the obvious functions of promoting blood circulation, promoting tissue regeneration and relieving pain.
Myrrh, has the functions of dissipating blood stasis, eliminating swelling and relieving pain, promoting blood circulation to stop pain, eliminating swelling and promoting granulation.
Earthworm, frankincense and myrrh are used as adjuvant drugs.
The preparation method of the traditional Chinese medicine composition for treating gastritis, gastric ulcer and duodenal ulcer comprises the following steps:
step 1
Mixing oxgall and gypsum powder according to the proportion of 1ml oxgall: mixing 7-9 g of gypsum powder in proportion, and air-drying to obtain a mixture a;
then weighing 4-6% of frankincense, 4-6% of myrrh, 8-12% of cuttle bone, 8-12% of earthworm and 65-75% of mixture a according to the mass percentage, wherein the sum of the mass percentages of the components is 100%;
step 2
Soaking the earthworms weighed in the step 1 in a proper amount of water for 15-20 minutes, then steaming, drying and grinding into earthworm powder; mixing the mixture a, Lumbricus powder, Olibanum, Myrrha, and Os Sepiae, and pulverizing.
Pharmacodynamic experiments:
1. analgesic test
75 mice are taken, half of each mouse is male and female, and the mass is 18-22 g. The traditional Chinese medicine granule is divided into 5 groups according to weight, 15 groups are respectively a control group (giving water with the same volume) and an aspirin group, the high, medium and low dose groups of the traditional Chinese medicine granule are respectively injected with 0.7 percent of glacial acetic acid and 0.1ml/10g of body weight 1h after the mice are subjected to gastric lavage administration to cause pain, the times of body twisting of each group of mice within 15min after the injection of the pain-causing agent are observed and recorded, and each administration group is compared with the control group.
The experimental results show that:
aspirin has obvious analgesic effect, and the body twisting frequency of the mice is obviously less than that of a control group. The traditional Chinese medicine granule has similar analgesic effect with aspirin under experimental dose, and compared with a control group, the high and medium dose groups of the traditional Chinese medicine granule have very significant difference, have definite analgesic effect and have strengthened effect along with the increase of the dose.
2. Therapeutic effect on acetic acid burning gastric ulcer of rat
Taking 50 rats, half of the male and the female, taking the rat with the mass of 180-. Cutting a small opening on the stomach wall, inserting a steel tube with an inner diameter of 6mm into the stomach from the incision until the steel tube is abutted against the glandular stomach part of 1cm on the opposite side close to the pylorus, tapping the steel tube tightly, dripping 0.1ml of glacial acetic acid solution into a 0.25ml syringe to be in contact with the stomach in a sticking mode for 1min, then sucking the glacial acetic acid in the tube by using a dry cotton ball, washing the tube with proper amount of physiological saline for 2-3 times by using the dry cotton ball, then suturing the incision in a bag-shaped manner, covering the wound surface by using the omentum giganteum, suturing the abdominal wall, and normally feeding. After operation, animals are randomly divided into 5 groups according to male and female, 10 animals in each group, and three dose groups of water, dele granules and the medicinal granules of the invention with equal volume are respectively administered by intragastric administration. After 10 days of continuous administration, fasting for 18h, cervical dislocation and sacrifice, laparotomy, ligation of pylorus and cardia of stomach, injection of 10ml physiological sodium chloride solution into stomach, taking out and placing in 10% formaldehyde solution for fixation for 30min, cutting along the greater curvature of stomach, measuring ulcer surface of each mouse, calculating area, and comparing each administration group with a control group.
The experimental results show that:
compared with a control group, the Chinese medicinal granule has obvious and extremely obvious difference on each administration group of the ulcer area of the acetic acid gastric ulcer model after continuous intragastric administration for 10 days; and presents a dose-effect relationship, and the protective treatment effect of the high-dose and medium-dose groups is better than that of the dele electuary group. The medicine has the function of promoting the healing of gastric ulcer.
Acute toxicity test:
the Chinese medicinal composition is orally taken by 40 healthy people with the dosage of 2-3 times, toxic reaction is not found, and no toxic reaction or anaphylactic reaction is caused after 2-48 hours of observation.
The taking method comprises the following steps: fasting once every night, 6-8 g.
Example 1
Mixing oxgall and gypsum powder according to the proportion of 1ml oxgall: mixing 7g of raw gypsum powder in a ratio, and air-drying to obtain a mixture a; then weighing 5% of frankincense, 4% of myrrh, 8% of cuttle bone, 8% of earthworm and 75% of mixture a according to the mass percentage, weighing the earthworm, soaking the earthworm in a proper amount of water for 15 minutes, then steaming, drying and grinding into earthworm powder; mixing the mixture a, Lumbricus powder, Olibanum, Myrrha, and Os Sepiae, and pulverizing.
Example 2
Mixing oxgall and gypsum powder according to the proportion of 1ml oxgall: mixing 9g of raw gypsum powder in a ratio, and air-drying to obtain a mixture a; then weighing 6% of frankincense, 5% of myrrh, 12% of cuttle bone, 12% of earthworm and 65% of mixture a according to the mass percentage, weighing the earthworm, soaking the earthworm in a proper amount of water for 20 minutes, then steaming, drying and grinding into earthworm powder; mixing the mixture a, Lumbricus powder, Olibanum, Myrrha, and Os Sepiae, and pulverizing.
Example 3
Mixing oxgall and gypsum powder according to the proportion of 1ml oxgall: mixing 8g of raw gypsum powder in a ratio, and air-drying to obtain a mixture a; then weighing 4% of frankincense, 6% of myrrh, 10% of cuttle bone, 10% of earthworm and 70% of mixture a according to the mass percentage, weighing the earthworm, soaking the earthworm in a proper amount of water for 17 minutes, then steaming, drying and grinding into earthworm powder; mixing the mixture a, Lumbricus powder, Olibanum, Myrrha, and Os Sepiae, and pulverizing.
Claims (2)
1. A traditional Chinese medicine composition for treating gastritis, gastric ulcer and duodenal ulcer is characterized by comprising the following raw materials in percentage by mass:
4-6% of frankincense, 4-6% of myrrh, 8-12% of cuttle bone, 8-12% of earthworm and 65-75% of a mixture a, wherein the sum of the mass percentages of the components is 100%, and the mixture a is the weight ratio of oxgall to gypsum powder according to 1ml of oxgall: and 7-9 g of gypsum powder are mixed and dried to obtain the gypsum powder.
2. A preparation method of a traditional Chinese medicine composition for treating gastritis, gastric ulcer and duodenal ulcer is characterized by comprising the following steps:
step 1
Mixing oxgall and gypsum powder according to the proportion of 1ml oxgall: mixing 7-9 g of gypsum powder in proportion, and air-drying to obtain a mixture a;
then weighing 4-6% of frankincense, 4-6% of myrrh, 8-12% of cuttle bone, 8-12% of earthworm and 65-75% of mixture a according to the mass percentage, wherein the sum of the mass percentages of the components is 100%;
step 2
Soaking the earthworms weighed in the step 1 in a proper amount of water for 15-20 minutes, then steaming, drying and grinding into earthworm powder; mixing the mixture a, Lumbricus powder, Olibanum, Myrrha, and Os Sepiae, and pulverizing.
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| CN2012102481577A CN102727555B (en) | 2012-07-18 | 2012-07-18 | Traditional Chinese medicine for treating gastritis, gastric ulcer and duodenal ulcer and preparation method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104042693A (en) * | 2014-07-03 | 2014-09-17 | 陈延琼 | Traditional Chinese medicinal composition for treating gastritis, gastric and duodenal ulcer and preparation method thereof |
| CN105456595A (en) * | 2016-01-05 | 2016-04-06 | 丁勇剑 | Traditional Chinese medicine preparation for treating gastric ulcers and preparing method and application thereof |
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- 2012-07-18 CN CN2012102481577A patent/CN102727555B/en not_active Expired - Fee Related
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| CN1814159A (en) * | 2005-12-22 | 2006-08-09 | 陈宝贵 | Medicine for treating gastric and duodenal ulcer and preparing method |
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| Title |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104042693A (en) * | 2014-07-03 | 2014-09-17 | 陈延琼 | Traditional Chinese medicinal composition for treating gastritis, gastric and duodenal ulcer and preparation method thereof |
| CN105456595A (en) * | 2016-01-05 | 2016-04-06 | 丁勇剑 | Traditional Chinese medicine preparation for treating gastric ulcers and preparing method and application thereof |
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| CN102727555B (en) | 2013-09-18 |
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