CN102727555A - Traditional Chinese medicine for treating gastritis, gastric ulcer and duodenal ulcer and preparation method - Google Patents

Abstract

The invention relates to a traditional Chinese medicine composition for treating gastritis, gastric ulcer and duodenal ulcer. The composition comprises the following raw materials by mass percent: 4 to 6% of frankincense, 4 to 6% of myrrh, 8 to 12% of cuttlebone, 8 to 12% of lumbricus and 65 to 75% of mixture a, wherein the mixture a is prepared by mixing fel bovis with gypsum powder in a proportion of 1ml: (7-9g) and then drying. The invention also discloses the preparation method of the traditional Chinese medicine composition for treating gastritis, gastric ulcer and duodenal ulcer. The preparation method comprises the steps of: mixing fel bovis with gypsum powder in a proportion of 1ml: (7-9g), and drying in the air to obtain the mixture a; and then mixing the mixture a with other medicaments, and crushing to obtain the composition. The composition can directly act on the gastric mucosa for treating; and the composition has the advantages of high seepage force, good treatment effect and high cure rate.

Description

The Chinese medicine and the method for preparing of treatment gastritis, gastric ulcer, duodenal ulcer

Technical field

The invention belongs to technical field of Chinese medicines, relate to a kind of Chinese medicine composition of treating gastritis, gastric ulcer, duodenal ulcer, the invention still further relates to the method for preparing of this Chinese medicine composition.

Background technology

Gastritis, gastric ulcer, duodenal ulcer, at present in the crowd sickness rate near 30%.But these patients adopt existing treatment by Chinese herbs can only the person of weight to alleviate, can not thoroughly eradicate later, most ill 5-10 that reach.The traditional Chinese medical science has opinion, and the congenital foundation is kidney, and the foundation of acquired constitution is stomach, owing to suffer from gastropathy for a long time, forms other malnutrition disease gradually again, so health is caused very big harm thereupon.

Gastric generation pathological changes at first is because various factors has damaged mucosa, and mucosa generation pathological changes to the absorption of food, comprises that the absorption of medicine to treatment gastropathy brings obstacle.Because the gastric mucosa is the histoorgan that assimilates food.At the mucosa that pathological changes takes place in the chain of organizing of mucosal barrier, lose or completely lose the function of itself, so just cause problem to the drug dependence circulation absorption of treatment gastropathy.Infer that thus any decoction and pill of controlling stomach just thinks that the treatment principle is adjustment internal organs balances, the Therapeutic Principle of the traditional Chinese medical science such as regulating cold and heat deficiency and excess; This indirect treatment mucosa recovers slow, and not thorough, cure rate is low.

Again because of the function of mucosal barrier; The corrosion of protection gastric acid and alkali, this mucosal barrier protection simultaneously is tight, causes all food, medicine all attached to mucosa internal layer surface; The medicine of treatment gastropathy can not be invaded the internal layer of mucosal barrier, and the mucosa of deep layer pathological changes does not reach medicine.The medicine of treatment gastric mucosa can not be invaded the internal layer of mucosal barrier, and this is a great problem that prior art does not have solution.So the effect of drugs of existing treatment gastropathy is poor, treatment cycle is long, and cure rate is low, and the patient alleviates easy relapse after the disease.

Summary of the invention

The purpose of this invention is to provide a kind of Chinese medicine composition of treating gastritis, gastric ulcer, duodenal ulcer, medicine directly effect is treated with gastric mucosa, and penetrating power is strong, and therapeutic effect is good, and cure rate is high.

Another object of the present invention provides the method for preparing of above-mentioned Chinese medicine composition.

The technical scheme that the present invention adopted is, a kind of Chinese medicine composition of treating gastritis, gastric ulcer, duodenal ulcer is made up of following raw material according to mass percent:

Olibanum 4%-6%, Myrrha 4%-6%, Os Sepiae 8%-12%, Pheretima 8%-12%, mixture a65%-75%; More than the mass percent sum of each component be 100%, wherein mixture a is Fel Bovis seu Bubali and gypsum powder according to the 1ml Fel Bovis seu Bubali: the mixed drying of 7 ~ 9g gypsum powder makes.

Another technical scheme that the present invention adopted is, the method for preparing of the Chinese medicine composition of above-mentioned treatment gastritis, gastric ulcer, duodenal ulcer is specifically carried out according to following steps:

Step 1

With Fel Bovis seu Bubali and gypsum powder according to the 1ml Fel Bovis seu Bubali: the mixed of 7 ~ 9g gypsum powder, air-dry, make mixture a;

And then take by weighing the Olibanum of 4%-6%, the Myrrha of 4%-6%, the Os Sepiae of 8%-12%, the Pheretima of 8%-12%, the mixture a of 65%-75% according to mass percent, more than the mass percent sum of each component be 100%;

Step 2

Get step 1 claim Pheretima soaked in the suitable quantity of water 15-20 minute, cook oven dry then, be ground into Earthworm; Then mixture a, Earthworm, Olibanum, Myrrha, Os Sepiae are mixed, pulverize, promptly get.

The beneficial effect that the present invention treats the Chinese medicine composition of gastritis, gastric ulcer, duodenal ulcer is, solved general medicine and can not invade mucosal barrier, is deposited under the exocuticle, reach this difficult problem of contact treatment, and therapeutic effect is good, not repeatedly.

The specific embodiment

Through the specific embodiment the present invention is elaborated below.

The Chinese medicine composition of treatment gastritis of the present invention, gastric ulcer, duodenal ulcer, form by following raw material according to mass percent:

Olibanum 4%-6%, Myrrha 4%-6%, Os Sepiae 8%-12%, Pheretima 8%-12%, mixture a65%-75%; More than the mass percent sum of each component be 100%, wherein mixture a is Fel Bovis seu Bubali and gypsum powder according to the 1ml Fel Bovis seu Bubali: the mixed drying of 7 ~ 9g gypsum powder makes.

Wherein,

Gypsum Fibrosum, hot, sweet, Great Cold.Attach to the lung and stomach meridians.The expelling pathogenic factors from muscles for clearing heat pathogenic fire purging, relieving restlessness is quenched the thirst, and the convergence granulation promoting has the effect of the skin ulcer of holding back closing in to ulcer surface.

Fel Bovis seu Bubali, bitter in the mouth, in Great Cold, power of impregnation is strong, removing toxic substances and promoting subsidence of swelling, parasite killing heat clearing away.

Fel Bovis seu Bubali and Gypsum Fibrosum make up in the ability and gastric acid, stick on pathological changes mucosa or ulcer surface, immerse the mucosal barrier internal layer, are all monarch drug.

Os Sepiae is held back skin ulcer and is closed up gastric acid inhibitory, astringing to arrest bleeding.Be used for Peptic Ulcers, hyperchlorhydria, hematemesis and epistaxis, metrorrhagia is had blood in stool, the stomachache acid regurgitation.Because mucosa infection, the ulcer surface mucosa comes off, and it is subcutaneous that gastric acid directly corrodes ulcer surface, suppressed gastric acid, makes gastric keep gentle, is ministerial drug among the we.

Pheretima, cold in nature, the heat clearing away arresting convulsion, collateral dredging has the function that granulation promoting is put on flesh, and has superpower regeneration power, plays the effect of regenerated mucosa.

Olibanum, arduous, temperature.Have more significantly invigorate blood circulation, the effect of granulation promoting, analgesic.

Myrrha, the blood blood stasis removing that looses, subduing swelling and relieving pain has effects such as promoting blood circulation and stopping pain, detumescence and promoting granulation.

Pheretima, Olibanum, Myrrha are all supplementary drug.

The method for preparing of the Chinese medicine composition of treatment gastritis of the present invention, gastric ulcer, duodenal ulcer, specifically carry out according to following steps:

Step 1

With Fel Bovis seu Bubali and gypsum powder according to the 1ml Fel Bovis seu Bubali: the mixed of 7 ~ 9g gypsum powder, air-dry, make mixture a;

And then take by weighing the Olibanum of 4%-6%, the Myrrha of 4%-6%, the Os Sepiae of 8%-12%, the Pheretima of 8%-12%, the mixture a of 65%-75% according to mass percent, more than the mass percent sum of each component be 100%;

Step 2

Get step 1 claim Pheretima soaked in the suitable quantity of water 15-20 minute, cook oven dry then, be ground into Earthworm; Then mixture a, Earthworm, Olibanum, Myrrha, Os Sepiae are mixed, pulverize, promptly get.

Pharmacodynamic experiment:

1. analgesic test

Get 75 of mices, public mother half and half, quality 18-22g.Divide 5 groups at random by body weight, 15 every group, be respectively matched group (giving water) with volume; The aspirin group, the high, medium and low dose groups of Chinese medicine electuary of the present invention is respectively at 1h after the mouse stomach administration; Every Mus lumbar injection 0.7% glacial acetic acid, the 0.1ml/10g body weight causes pain; Observe and record injection algogen after in the 15min every group of each Mus turn round the body number of times, each administration group and matched group comparison.

Experimental result shows:

Aspirin has significant analgesia role, and the mouse writhing number of times obviously is less than matched group.Chinese medicine electuary of the present invention is similar with aspirin analgesic activity under test dose, and height of the present invention, middle dose groups and matched group more all have utmost point significant difference, and analgesic activity is clear and definite, and strengthens with dosage increase effect.

2. rat acetic acid is burnt the therapeutical effect of gastric ulcer

Get 50 of rats, public mother half and half, quality 180-220g, fasting 24h is defending under the barbital sodium anesthesia, and the sterile working cuts the abdominal cavity open and exposes stomach.Cut an osculum at coat of the stomach, internal diameter 6mm estimation of biological potency is inserted gastric with steel pipe by otch, direct reach the glandular stomach portion of offside, steel pipe is kowtowed tightly near 1cm on the pylorus; Splash into glacial acetic acid solution 0.1ml with the 0.25ml syringe, make with sticking the touching of stomach and contact 1min, glacial acetic acid exhaustion in then will managing with dry cotton ball; Wash 2 ~ 3 times with an amount of normal saline with dry cotton ball, the pocket shape is sewed up the incision then again, the topped face of hindering of omentum majus; Sew up stomach wall,, the normal raising.Operation back 24h is divided into 5 groups with animal by public mother at random, 10 every group, irritates stomach respectively and gives isopyknic water, three dose groups of DELE CHONGJI and medicine instant of the present invention.Behind the successive administration 10 days, fasting 18h, dislocation of cervical vertebra is put to death, and cuts open the belly; With stomach pylorus, cardia ligation, gastric injects the 10ml physiological sodium chloride solution, takes out and puts into fixedly 30min of 10% formalin, cuts off along greater gastric curvature; Measure the ulcer surface of each Mus, calculate its area, each administration group and matched group are relatively.

Experimental result shows:

Each administration group of ulcer area of Chinese medicine electuary continuous irrigation stomach 10d Dichlorodiphenyl Acetate gastric ulcer model of the present invention and matched group more all have significantly and utmost point significant difference; And be dose-effect relationship, protectiveness therapeutical effect high, middle dose groups is better than DELE CHONGJI group.Explain that this medicine has the effect that promotes gastric ulcer healing.

Anxious poison experiment:

It is oral to carry out for 40 healthy subjects with the Chinese medicine composition of the present invention of 2-3 times of consumption, does not find toxic reaction, observes no toxic reaction in 2-48 hour, does not have irritated reaction.

Instructions of taking: every night once on an empty stomach, a 6-8 gram.

Embodiment 1

With Fel Bovis seu Bubali and gypsum powder according to the 1ml Fel Bovis seu Bubali: the mixed of 7g gypsum powder, air-dry, make mixture a; And then take by weighing 5% Olibanum, 4% Myrrha, 8% Os Sepiae, 8% Pheretima, 75% mixture a according to mass percent, claim Pheretima soaked in the suitable quantity of water 15 minutes, cook oven dry then, be ground into Earthworm; Then mixture a, Earthworm, Olibanum, Myrrha, Os Sepiae are mixed, pulverize, promptly get.

Embodiment 2

With Fel Bovis seu Bubali and gypsum powder according to the 1ml Fel Bovis seu Bubali: the mixed of 9g gypsum powder, air-dry, make mixture a; And then take by weighing 6% Olibanum, 5% Myrrha, 12% Os Sepiae, 12% Pheretima, 65% mixture a according to mass percent, claim Pheretima soaked in the suitable quantity of water 20 minutes, cook oven dry then, be ground into Earthworm; Then mixture a, Earthworm, Olibanum, Myrrha, Os Sepiae are mixed, pulverize, promptly get.

Embodiment 3

With Fel Bovis seu Bubali and gypsum powder according to the 1ml Fel Bovis seu Bubali: the mixed of 8g gypsum powder, air-dry, make mixture a; And then take by weighing 4% Olibanum, 6% Myrrha, 10% Os Sepiae, 10% Pheretima, 70% mixture a according to mass percent, claim Pheretima soaked in the suitable quantity of water 17 minutes, cook oven dry then, be ground into Earthworm; Then mixture a, Earthworm, Olibanum, Myrrha, Os Sepiae are mixed, pulverize, promptly get.

Claims (2)

1. a Chinese medicine composition of treating gastritis, gastric ulcer, duodenal ulcer is characterized in that, is made up of following raw material according to mass percent:

Olibanum 4%-6%, Myrrha 4%-6%, Os Sepiae 8%-12%, Pheretima 8%-12%, mixture a65%-75%; More than the mass percent sum of each component be 100%, wherein mixture a is Fel Bovis seu Bubali and gypsum powder according to the 1ml Fel Bovis seu Bubali: the mixed drying of 7 ~ 9g gypsum powder makes.

2. a method for preparing of treating the Chinese medicine composition of gastritis, gastric ulcer, duodenal ulcer is characterized in that, specifically carries out according to following steps:

Step 1

With Fel Bovis seu Bubali and gypsum powder according to the 1ml Fel Bovis seu Bubali: the mixed of 7 ~ 9g gypsum powder, air-dry, make mixture a;

And then take by weighing the Olibanum of 4%-6%, the Myrrha of 4%-6%, the Os Sepiae of 8%-12%, the Pheretima of 8%-12%, the mixture a of 65%-75% according to mass percent, more than the mass percent sum of each component be 100%;

Step 2

Get step 1 claim Pheretima soaked in the suitable quantity of water 15-20 minute, cook oven dry then, be ground into Earthworm; Then mixture a, Earthworm, Olibanum, Myrrha, Os Sepiae are mixed, pulverize, promptly get.