CN102725410B - 来自檀香属的萜烯合酶 - Google Patents

来自檀香属的萜烯合酶 Download PDF

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Publication number
CN102725410B
CN102725410B CN201080038885.4A CN201080038885A CN102725410B CN 102725410 B CN102725410 B CN 102725410B CN 201080038885 A CN201080038885 A CN 201080038885A CN 102725410 B CN102725410 B CN 102725410B
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China
Prior art keywords
santalene
terpene synthase
nucleic acid
synthase
seqidno
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Expired - Fee Related
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CN201080038885.4A
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English (en)
Chinese (zh)
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CN102725410A (zh
Inventor
K·G·楚拉克
C·琼斯
J·莫尼奥迪斯
J·博尔曼
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University of Western Australia
Forest Products Commission
University of British Columbia
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University of Western Australia
Forest Products Commission
University of British Columbia
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Priority claimed from AU2009903016A external-priority patent/AU2009903016A0/en
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Publication of CN102725410A publication Critical patent/CN102725410A/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P15/00—Preparation of compounds containing at least three condensed carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/6895—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
    • C12Y402/03081—Exo-alpha-bergamotene synthase (4.2.3.81)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
    • C12Y402/03082—Alpha-santalene synthase (4.2.3.82)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
    • C12Y402/03083—Beta-santalene synthase (4.2.3.83)

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201080038885.4A 2009-06-29 2010-06-25 来自檀香属的萜烯合酶 Expired - Fee Related CN102725410B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2009903016A AU2009903016A0 (en) 2009-06-29 Novel Gene and Product
AU2009903016 2009-06-29
PCT/AU2010/000802 WO2011000026A1 (en) 2009-06-29 2010-06-25 Terpene synthases from santalum

Publications (2)

Publication Number Publication Date
CN102725410A CN102725410A (zh) 2012-10-10
CN102725410B true CN102725410B (zh) 2016-03-16

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US (3) US8569025B2 (enExample)
EP (1) EP2449107B1 (enExample)
CN (1) CN102725410B (enExample)
BR (1) BRPI1014137A2 (enExample)
CA (1) CA2766810C (enExample)
IL (1) IL217221A0 (enExample)
IN (1) IN2012DN00403A (enExample)
WO (1) WO2011000026A1 (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009240505B2 (en) 2008-04-23 2013-09-05 Danisco Us Inc. Isoprene synthase variants for improved microbial production of isoprene
AU2015201051B2 (en) * 2008-12-11 2017-03-02 Firmenich Sa Method for producing beta-santalene
ES2626456T3 (es) * 2008-12-11 2017-07-25 Firmenich Sa Procedimiento enzimático para producir beta-santaleno y la enzima correspondiente
CA2759700A1 (en) 2009-04-23 2010-10-28 Danisco Us Inc. Three-dimensional structure of isoprene synthase and its use thereof for generating variants
WO2011000026A1 (en) 2009-06-29 2011-01-06 The University Of Western Australia Terpene synthases from santalum
US9273298B2 (en) 2010-10-27 2016-03-01 Danisco Us Inc. Isoprene synthase variants for improved production of isoprene
AU2011320127B2 (en) 2010-10-29 2015-10-01 Evolva, Inc. Modified valencene synthase polypeptides, encoding nucleic acid molecules and uses thereof
EP2783004B1 (en) 2011-11-21 2019-08-07 The University of British Columbia Diterpene synthases and method for producing diterpenoids
US9550815B2 (en) 2012-01-23 2017-01-24 University Of British Columbia ABC terpenoid transporters and methods of using the same
US9163263B2 (en) 2012-05-02 2015-10-20 The Goodyear Tire & Rubber Company Identification of isoprene synthase variants with improved properties for the production of isoprene
CA2889945A1 (en) 2012-11-01 2014-05-08 The University Of British Columbia Cytochrome p450 and cytochrome p450 reductase polypeptides, encoding nucleic acid molecules and uses thereof
DK2970934T3 (da) 2013-03-14 2017-11-13 Evolva Inc Valencensynthasepolypeptider, nukleinsyremolekyler, der koder derfor, og anvendelser deraf
US9714418B2 (en) 2014-03-31 2017-07-25 Evolva, Inc. Modified santalene synthase polypeptides, encoding nucleic acid molecules and uses thereof
CN107001216B (zh) 2014-12-02 2020-12-01 弗门尼舍有限公司 制备檀木油结构单元的中间体和方法
CN108239630B (zh) * 2016-12-27 2021-07-16 武汉臻智生物科技有限公司 一种改造萜类合酶的方法
US20220315911A1 (en) * 2017-03-02 2022-10-06 Isobionics B.V. Santalene synthase
NL2018457B1 (en) 2017-03-02 2018-09-21 Isobionics B V Santalene Synthase
NL2019473B1 (en) 2017-09-01 2019-03-11 Isobionics B V Terpene Synthase producing patchoulol and elemol, and preferably also pogostol
CN110093329B (zh) * 2018-01-30 2023-07-04 深圳艾格鑫科技有限公司 萜类合酶及其应用
CN108660128B (zh) * 2018-05-18 2021-07-13 江苏省农业科学院 一种紫花苜蓿萜烯合成酶、其编码基因、载体、多克隆抗体及其应用
CN111434773B (zh) * 2019-01-15 2021-06-18 天津大学 一种高产檀香油的重组酵母菌及其构建方法与应用
CN111073941B (zh) * 2019-09-12 2022-10-14 天津芸熙生物技术有限公司 檀香多肽的制备工艺
CN112852650B (zh) * 2019-11-27 2023-04-14 暨南大学 一种高产檀香烯和檀香醇的酿酒酵母工程菌及其构建方法与应用
EP4058589A1 (en) * 2019-12-23 2022-09-21 Firmenich SA Biochemically produced sandalwood oil
CN115516102B (zh) * 2020-06-04 2025-10-31 艾瑟拜奥尼克斯公司 合成的檀香烯合酶
CN112410362A (zh) * 2020-11-06 2021-02-26 浙江万里学院 云锦杜鹃花tps基因、用于克隆云锦杜鹃花tps基因的引物及其克隆方法和应用
CN112831519B (zh) * 2020-12-28 2022-10-21 上海交通大学 一种利用青蒿制备檀香醇的方法
CN113025594B (zh) * 2021-03-04 2022-05-31 安徽农业大学 多肽、核酸及其在合成香叶醇上的应用
CN114457067B (zh) * 2022-02-10 2024-10-25 中国科学院天津工业生物技术研究所 一种低成本快速去除dna合成中错误的方法
CN118812684B (zh) * 2024-09-03 2025-06-13 广西壮族自治区农业科学院 檀香SaERF89基因及其在生物合成α-甜没药醇中的应用
CN119039411B (zh) * 2024-09-12 2025-12-12 广西壮族自治区农业科学院 檀香SaERF89基因及其在生物合成(Z)-α-反式-香柠檬醇中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102245778A (zh) * 2008-12-11 2011-11-16 弗门尼舍有限公司 用于生产β-檀香萜的方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3654090A (en) 1968-09-24 1972-04-04 Organon Method for the determination of antigens and antibodies
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US4016043A (en) 1975-09-04 1977-04-05 Akzona Incorporated Enzymatic immunological method for the determination of antigens and antibodies
US5837832A (en) 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
SE9602545L (sv) 1996-06-25 1997-12-26 Michael Mecklenburg Metod för att diskriminera komplexa biologiska prover
WO1998049557A1 (en) 1997-04-28 1998-11-05 B-E Safe, Inc. Taxonomic identification of microorganisms, proteins and peptides involved in vertebrate disease states
US6265639B1 (en) 1998-01-22 2001-07-24 Washington State University Foundation Gymnosperm nucleic acid molecules encoding sesquiterpene synthases and methods of use
EP2305825B1 (en) 1998-07-06 2015-01-14 DCV Inc. doing business as Bio-Technical Resourses Method of vitamin production
CN101914558B (zh) 2002-10-04 2013-05-29 弗门尼舍有限公司 倍半萜烯合成酶及其使用方法
FR2881143B1 (fr) 2005-01-27 2010-12-17 Librophyt Systeme de production de terpenoides dans les plantes
US7790413B2 (en) 2005-06-17 2010-09-07 Firmenich Sa Sesquiterpene synthases and methods of their use
WO2009044336A2 (en) 2007-10-05 2009-04-09 Firmenich Sa Method for producing diterpenes
EP2252691B1 (en) 2008-03-06 2013-03-27 Firmenich S.A. Method for producing alpha- santalene
WO2011000026A1 (en) 2009-06-29 2011-01-06 The University Of Western Australia Terpene synthases from santalum
EP2783004B1 (en) 2011-11-21 2019-08-07 The University of British Columbia Diterpene synthases and method for producing diterpenoids
US9550815B2 (en) 2012-01-23 2017-01-24 University Of British Columbia ABC terpenoid transporters and methods of using the same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102245778A (zh) * 2008-12-11 2011-11-16 弗门尼舍有限公司 用于生产β-檀香萜的方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EU798692;JONES, C. G.等;《GenBank》;20080713;全文 *

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Publication number Publication date
US9260728B2 (en) 2016-02-16
EP2449107A4 (en) 2013-01-02
CN102725410A (zh) 2012-10-10
US20120208173A1 (en) 2012-08-16
US8569025B2 (en) 2013-10-29
WO2011000026A1 (en) 2011-01-06
EP2449107A1 (en) 2012-05-09
EP2449107B1 (en) 2015-04-08
US8993284B2 (en) 2015-03-31
US20150167021A1 (en) 2015-06-18
IL217221A0 (en) 2012-02-29
CA2766810C (en) 2017-10-10
US20140196166A1 (en) 2014-07-10
IN2012DN00403A (enExample) 2015-08-21
CA2766810A1 (en) 2011-01-06
BRPI1014137A2 (pt) 2015-08-25

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