CN102723039A - Model for demonstrating tumor vascular dissemination - Google Patents
Model for demonstrating tumor vascular dissemination Download PDFInfo
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- CN102723039A CN102723039A CN2012102094678A CN201210209467A CN102723039A CN 102723039 A CN102723039 A CN 102723039A CN 2012102094678 A CN2012102094678 A CN 2012102094678A CN 201210209467 A CN201210209467 A CN 201210209467A CN 102723039 A CN102723039 A CN 102723039A
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Abstract
The invention relates to a teaching aid for medical teaching, in particular to a model for demonstrating a tumor vascular, which can be used for vividly demonstrating a tumor vascular dissemination process to students, and has the technical scheme that the device comprises a base and a demonstrating plate, wherein a primary cancer model, a basement membrane model, an extracellular matrix model, a vascular model and a tissue space model are arranged on the demonstrating plate; the basement membrane model is arranged under the primary cancer model; the extracellular matrix model is arranged under the basement membrane model; the vascular model is located between the extracellular matrix model and the tissue space model; the extracellular matrix model is provided with an extracellular matrix channel; and an opening is arranged in the basement membrane model. Adjusting switches are respectively arranged on the lower ends of the primary cancer model and the basement membrane model. The model provided by the invention is visual, and is simple to operate, and medical students can completely understand an occurrence and development process of tumor vascular dissemination through demonstration.
Description
Technical field
The present invention relates to a kind of medical teaching and use teaching aid, particularly tumour blood road diffusion demonstrating model.
Background technology
In the pathology teaching, malignant tumour be the most important reason that malignant tumour is difficult to effect a radical cure and cause death, and the process that the blood road shifts is complicated, its each link of student's indigestion through local infiltration and the diffusion of blood road.Teaching material only provides static signal figure, and the multimedia animation does not have the visual stimulus effect of ocular demonstration in kind, and the teacher says that time service also is difficult to the demonstration that true process is complete with simple language description or plate figure and comes out, and is difficult to attract student's notice.
Summary of the invention
Summary of the invention:
The present invention is directed to prior art to malignant tumour blood road shift show existence not intuitively, not vivid; Its pathologic process of student's indigestion and provide a kind of simulation tumour blood road of simple in structure, visual pattern to shift demonstrating model; For achieving the above object, the present invention adopts following technical scheme: simulation tumour blood road shifts demonstrating model, comprises base and demonstration board; Demonstration board is provided with primary tumor model, basilar memebrane model, extracellular matrix model, basement membrane of blood vessel model, vascular pattern and tissue space model; It is characterized in that: said primary tumor below is set to the basilar memebrane model, and extracellular matrix model top is the basilar memebrane model, and the below is the basement membrane of blood vessel model; Vascular pattern is provided with the extracellular matrix passage in the said extracellular matrix model between basement membrane of blood vessel model and tissue space model.Said basilar memebrane and basement membrane of blood vessel are provided with opening, and primary carcinoma model, basement membrane of blood vessel model are connected the lower end with the blood vessel slit and are provided with by-pass cock.
According to technique scheme, the present invention can demonstrate pathologic process-tumour cell of shifting in tumour blood road intuitively from primary tumor fall-breaks through basilar memebrane-pass extracellular matrix-penetrate blood vessel-knurl bolt form-to pass blood vessel-metastatic tumor formation.Can bring following beneficial effect:
(1) breaks through focal points, difficult point that tumour blood road shifts, improved teaching efficiency;
(2) rational in infrastructure, simple to operate, make things convenient for the student to operate in person;
(3) through the incidence and development process of demonstration ability complete understanding tumour blood road diffusion, make the student darker understanding arranged to the biological property of malignant cell.
Description of drawings:
Accompanying drawing 1 is a structural representation of the present invention.
Among the figure:
1, primary tumor model
2, primary tumor cell model
3, primary tumor cell separation
4, primary tumor by-pass cock
5, basilar memebrane model
6, basilar memebrane opening
7, extracellular matrix model
8, extracellular matrix passage
9, basement membrane of blood vessel opening
10, basement membrane of blood vessel model
11, vascular pattern
12, basement membrane of blood vessel by-pass cock
13, lumen of vessels
14, tumor cell embolus
15, vascular wall slit
16, vascular wall slit by-pass cock
17, tissue space model
18, metastatic tumor
19, base
20, demonstration board
Embodiment:
In order to make the present invention realize technological means, creation characteristic, to reach purpose and effect and be easy to understand and understand,, further set forth the present invention below in conjunction with concrete demonstration.
Invasion and attack and transfer are the topmost biological markers of malignant tumour, can be divided into local infiltration and the blood road is sent out.Malignant cell can be divided into following a few step for the invasion and attack of extracellular matrix: (1) tumour cell is separated from one another; (2) stick together with basilar memebrane; (3) extracellular matrix degradation; (4) migration of tumour cell; The blood road is sent out and is divided into: basement membrane of blood vessel is passed in (1); (2) penetrate blood vessel; (3) the knurl bolt forms; (4) pass blood vessel; (5) form metastatic tumor.
Based on above-mentioned principle, the present invention provides demonstrating model as shown in the figure:
Simulation metastases demonstrating model of the present invention; Comprise base 19 and demonstration board 20; Demonstration board 20 is provided with primary carcinoma model 1, basilar memebrane model 5, extracellular matrix model 7, basement membrane of blood vessel model 10, vascular pattern 11 and tissue space model 17, and said primary carcinoma model 1 below is set to basilar memebrane model 5, and basilar memebrane model 5 belows are set to extracellular matrix model 7; Extracellular matrix model 7 belows are basement membrane of blood vessel model 10; Vascular pattern 11 is between basement membrane of blood vessel model 10 and tissue space model 17, and said extracellular matrix model 7 is provided with extracellular matrix passage 8, and the basilar memebrane model is provided with opening 6,9.Said primary tumor model 1, basement membrane of blood vessel model 10 are connected 15 lower ends and are respectively arranged with by- pass cock 4,12,16 with the blood vessel slit.
Being provided with two layers of substrate membrane modle (basilar memebrane model 5 and basement membrane of blood vessel model 10) between primary tumor model and the vascular pattern, is extracellular matrix model 7 between the two layers of substrate film, with the normal tissues structure of emulation tumor cell migration process.Extracellular matrix passage 8 and by- pass cock 4,12,16 are set, the speed of scalable tumor cell migration, clearer observation transition process.The present invention combines displaying with tumour cell local infiltration and the transfer of blood road, makes the student to the whole process that tumour blood road shifts darker understanding arranged.
The concrete presentation process of exemplary model according to technique scheme is following:
Primary tumor oncocyte 2 adhesions descend and separate 3 and move down through soaking and attack substrate mould model 6 and move into extracellular matrix passages 8, and this moment, scalable primary tumor model by-pass cock 4 was with the descending speed of control oncocyte migration.Oncocyte penetrates in the lumen of vessels 13 of vascular pattern 11 through passing basement membrane of blood vessel opening 9; Form tumor cell embolus 14; Because action of gravity is moved down forward along vascular pattern 11, passes blood vessel slit 15 at last, invade tissue space model 17 and formation metastatic tumor 18.
Accomplished the pathologic process that tumour blood road shifts through above simulation.
Claims (2)
1. simulation tumour blood road shifts demonstrating model; Comprise base and demonstration board; Demonstration board is provided with primary tumor model, basilar memebrane model, extracellular matrix model, basement membrane of blood vessel model, vascular pattern and tissue space model; It is characterized in that: said primary tumor below is set to the basilar memebrane model, and extracellular matrix model top is the basilar memebrane model, and the below is the basement membrane of blood vessel model; Vascular pattern is provided with the extracellular matrix passage in the said extracellular matrix model between basement membrane of blood vessel model and tissue space model.
2. according to claim 1, described simulation tumour blood road shifts demonstrating model, and it is characterized in that: said basilar memebrane and basement membrane of blood vessel are provided with opening, and primary carcinoma model, basement membrane of blood vessel model are connected the lower end with the blood vessel slit and are provided with by-pass cock.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102094678A CN102723039A (en) | 2012-06-25 | 2012-06-25 | Model for demonstrating tumor vascular dissemination |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102094678A CN102723039A (en) | 2012-06-25 | 2012-06-25 | Model for demonstrating tumor vascular dissemination |
Publications (1)
| Publication Number | Publication Date |
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| CN102723039A true CN102723039A (en) | 2012-10-10 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2012102094678A Pending CN102723039A (en) | 2012-06-25 | 2012-06-25 | Model for demonstrating tumor vascular dissemination |
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| CN (1) | CN102723039A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102124096A (en) * | 2008-07-16 | 2011-07-13 | 儿童医疗中心有限公司 | Organ mimic device with microchannels and methods of use and manufacturing thereof |
| CN102385811A (en) * | 2011-12-01 | 2012-03-21 | 关真民 | Demonstration model for simulating pathological change of acute glomerulonephritis |
| CN202694659U (en) * | 2012-06-25 | 2013-01-23 | 关真民 | Tumor blood channel diffusion demonstration model |
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2012
- 2012-06-25 CN CN2012102094678A patent/CN102723039A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102124096A (en) * | 2008-07-16 | 2011-07-13 | 儿童医疗中心有限公司 | Organ mimic device with microchannels and methods of use and manufacturing thereof |
| CN102385811A (en) * | 2011-12-01 | 2012-03-21 | 关真民 | Demonstration model for simulating pathological change of acute glomerulonephritis |
| CN202694659U (en) * | 2012-06-25 | 2013-01-23 | 关真民 | Tumor blood channel diffusion demonstration model |
Non-Patent Citations (1)
| Title |
|---|
| 冷静 等: "《病理学》", 31 August 2001 * |
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Application publication date: 20121010 |