CN102713919B - 用于使用聚类来检测生物学状态的存在的系统和方法 - Google Patents

用于使用聚类来检测生物学状态的存在的系统和方法 Download PDF

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Publication number
CN102713919B
CN102713919B CN201080051528.1A CN201080051528A CN102713919B CN 102713919 B CN102713919 B CN 102713919B CN 201080051528 A CN201080051528 A CN 201080051528A CN 102713919 B CN102713919 B CN 102713919B
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genetic factor
sample
input value
mrsa
input
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CN102713919A (zh
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陆久留
子华·王
安东尼奥·阿雷瓦洛·雷耶斯
埃里克·艾伦·古斯塔夫森
约翰·史蒂文·赖利
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Beckman Coulter Inc
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Beckman Coulter Inc
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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/30—Unsupervised data analysis

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Databases & Information Systems (AREA)
  • Physiology (AREA)
  • Artificial Intelligence (AREA)
  • Bioethics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Data Mining & Analysis (AREA)
  • Epidemiology (AREA)
  • Evolutionary Computation (AREA)
  • Public Health (AREA)
  • Software Systems (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201080051528.1A 2009-11-13 2010-11-12 用于使用聚类来检测生物学状态的存在的系统和方法 Expired - Fee Related CN102713919B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26114709P 2009-11-13 2009-11-13
US61/261,147 2009-11-13
PCT/US2010/056455 WO2011060222A2 (en) 2009-11-13 2010-11-12 Systems and methods for detecting the presence of a biological status using clustering

Publications (2)

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CN102713919A CN102713919A (zh) 2012-10-03
CN102713919B true CN102713919B (zh) 2016-07-06

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Country Status (8)

Country Link
US (3) US8442924B2 (enExample)
EP (1) EP2499591A2 (enExample)
JP (2) JP5907880B2 (enExample)
KR (1) KR20120101065A (enExample)
CN (1) CN102713919B (enExample)
BR (1) BR112012011262A2 (enExample)
RU (1) RU2012124051A (enExample)
WO (1) WO2011060222A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110269138A1 (en) * 2008-12-30 2011-11-03 Qiagen Hamburg Gmbh Method for detecting methicillin-resistant staphylococcus aureus (mrsa) strains
WO2011060222A2 (en) 2009-11-13 2011-05-19 Beckman Coulter, Inc. Systems and methods for detecting the presence of a biological status using clustering
EP2617836A1 (en) * 2012-01-23 2013-07-24 Steffen Mergemeier Method for detecting a methicillin resistant coagulase positive Staphylococcus aureus strain
EP2887245A1 (en) * 2013-12-20 2015-06-24 Dassault Systèmes A computer-implemented method for designing a biological model
CN117425932A (zh) * 2021-06-09 2024-01-19 国立大学法人京都大学 信息处理装置、信息处理方法以及程序

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US6156507A (en) * 1996-02-23 2000-12-05 Kainos Laboratories, Inc. Method of identifying methicillin-resistant Staphylococcus aureus or methicillin-resistant coagulase-negative staphylococci
EP1529847A1 (en) * 2003-11-07 2005-05-11 Federal Rep. of Germany repr. by the Ministry of Health & Soc. Security, the latter repr. by the Pres. of the Robert Koch Ins. Method for detecting methicillin resistant Staphylococcus aureus (MRSA)
CN101147067A (zh) * 2005-03-04 2008-03-19 布雷兹创业科技有限公司 用于细菌取样的方法和装置
WO2008050041A1 (fr) * 2006-10-18 2008-05-02 Biomerieux Procede de diagnostic in vitro des staphylococcus aureus producteurs de pvl

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US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US6335184B1 (en) * 1993-07-23 2002-01-01 Bio-Rad Laboratories, Inc. Linked linear amplification of nucleic acids
US5702895A (en) 1995-01-19 1997-12-30 Wakunaga Seiyaku Kabushiki Kaisha Method and kit for detecting methicillin-resistant Staphylococcus aureus
US6358519B1 (en) * 1998-02-16 2002-03-19 Ruth S. Waterman Germ-resistant communication and data transfer/entry products
US6356845B1 (en) * 1999-08-04 2002-03-12 Pharmacia & Upjohn Company Crystallization and structure determination of Staphylococcus aureus UDP-N-acetylenolpyruvylglucosamine reductase (S. aureus MurB)
DE60217837T2 (de) * 2001-03-15 2007-10-25 Jacques Schrenzel Nachweis von methicillin-resistenten staphylococcus aureus bakterien (mrsa)
US20030014420A1 (en) * 2001-04-20 2003-01-16 Jessee Charles B. Method and system for data analysis
FR2844807B1 (fr) * 2002-09-23 2005-11-11 Rambach Alain Procede de detection de microorganismes resistants a la meticilline
EP1603674B1 (en) * 2003-02-05 2016-01-06 Iquum, Inc. Sample processing
EP1541696A1 (en) 2003-12-09 2005-06-15 Institut Pasteur A DNA macro-array for staphylococcus aureus identification and typing
JP2008510456A (ja) * 2004-07-30 2008-04-10 アジェンコート バイオサイエンス コーポレーション 多官能基コート化固相担体を用いる核酸の単離方法
US7368422B2 (en) * 2005-02-28 2008-05-06 Novartis Vaccines And Diagnostics Inc. Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
US20070196820A1 (en) * 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US7838221B2 (en) * 2005-10-11 2010-11-23 Geneohm Sciences, Inc. Sequences for detection and identification of methicillin-resistant Staphylococcus aureus (MRSA)
JP5346801B2 (ja) 2006-05-12 2013-11-20 セフィード Ｄｎａ組換え接合部の検出
JP2010524454A (ja) * 2007-04-19 2010-07-22 モレキュラー ディテクション インコーポレーテッド 抗生物質耐性細菌の検出および分析のための方法、組成物、およびキット
WO2009018000A1 (en) * 2007-07-31 2009-02-05 Quest Diagnostics Investments Incorporated Detection of methicillin-resistant and methicillin-sensitive staphylococcus aureus in biological samples
US8229678B2 (en) * 2008-07-25 2012-07-24 Beckman Coulter, Inc. Methods and systems for transforming particle data
US8000940B2 (en) * 2008-10-08 2011-08-16 Beckman Coulter, Inc. Shape parameter for hematology instruments
US8154273B2 (en) * 2008-10-10 2012-04-10 Beckman Coulter, Inc. Detecting and handling coincidence in particle analysis
US8581927B2 (en) * 2008-11-04 2013-11-12 Beckman Coulter, Inc. Multidimensional particle analysis data cluster reconstruction
US8192995B2 (en) * 2008-11-13 2012-06-05 Beckman Coulter, Inc. Method of correction of particle interference to hemoglobin measurement
WO2011060222A2 (en) 2009-11-13 2011-05-19 Beckman Coulter, Inc. Systems and methods for detecting the presence of a biological status using clustering

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6156507A (en) * 1996-02-23 2000-12-05 Kainos Laboratories, Inc. Method of identifying methicillin-resistant Staphylococcus aureus or methicillin-resistant coagulase-negative staphylococci
EP1529847A1 (en) * 2003-11-07 2005-05-11 Federal Rep. of Germany repr. by the Ministry of Health & Soc. Security, the latter repr. by the Pres. of the Robert Koch Ins. Method for detecting methicillin resistant Staphylococcus aureus (MRSA)
CN101147067A (zh) * 2005-03-04 2008-03-19 布雷兹创业科技有限公司 用于细菌取样的方法和装置
WO2008050041A1 (fr) * 2006-10-18 2008-05-02 Biomerieux Procede de diagnostic in vitro des staphylococcus aureus producteurs de pvl

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Publication number Publication date
US20130196334A1 (en) 2013-08-01
JP2015165413A (ja) 2015-09-17
EP2499591A2 (en) 2012-09-19
BR112012011262A2 (pt) 2019-09-24
WO2011060222A2 (en) 2011-05-19
US8442924B2 (en) 2013-05-14
CN102713919A (zh) 2012-10-03
JP2013510579A (ja) 2013-03-28
WO2011060222A9 (en) 2011-07-14
US20110131159A1 (en) 2011-06-02
JP5907880B2 (ja) 2016-04-26
US20170140096A1 (en) 2017-05-18
RU2012124051A (ru) 2013-12-20
US9519751B2 (en) 2016-12-13
KR20120101065A (ko) 2012-09-12

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Termination date: 20171112