CN102709704B - A kind of MRI magnetic signal enhancement device - Google Patents
A kind of MRI magnetic signal enhancement device Download PDFInfo
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Abstract
The invention provides a kind of MRI magnetic signal enhancement device, MRI magnetic signal enhancement device is arranged between the magnetic signal receiving coil of detected part and MRI imaging device, at least one deck negative-magnetic-permeability meta-material that MRI magnetic signal enhancement device comprises shell and arranges in the enclosure, this negative-magnetic-permeability meta-material is the low frequency negative-magnetic-cometamaterial metamaterial through particular design, when the negative-magnetic-permeability meta-material in MRI magnetic signal enhancement device is when magnetic permeability is for bearing, and resonance frequency identical with MRI operating frequency when, the receiving coil of negative-magnetic-permeability meta-material and MRI equipment produces and responds, strengthen the magnetic signal of receiving coil, and then the image quality of Contrast-enhanced MRI system, simultaneously, the image quality of MRI system strengthens, can make the receiving coil of MRI equipment need not near detected part, increase the comfortableness of MRI equipment use.
Description
Technical field
The present invention relates to MRI field, relate to a kind of MRI magnetic signal enhancement device particularly.
Background technology
The principle of nulcear magnetic resonance (NMR) (MRI) imaging system utilizes coil to remove the radio wave pulses energy detecting nuclear spin absorption and launch, and this coil, as receiving coil, is being gone back simultaneously as transmitting coil sometimes.Under the help of radio wave pulses energy, Magnetic resonance imaging scanner can a very little point in position patient body, then determines that this is the tissue of which kind of type.Magnetic resonance imaging machine device adopts the radio frequency pulse specific to hydrogen atom.The body region that will check is aimed in System guides pulse, and causes the proton uptake in this region to make them with the energy needed for different directions rotation or precession.This is NMR imaging device " resonance " part.Radio frequency pulse forces their (refer to unnecessary in each 1,000,000 proton a pair or two to unmatched proton) to rotate according to specific direction under characteristic frequency.The characteristic frequency causing resonance is called as Rameau that frequency, and this value draws according to wanting the magnetic field intensity of the particular organization of imaging and main field to calculate.Radio frequency pulse utilizes a coil to provide usually, and this coil is called transmitting coil.The receiving coil of existing magnetic resonance imaging device must quite near-earth close to detected part, to obtain the magnetic signal discharged by detected part.Definition and the main field strength of MRI imaging device are proportionate, and main magnetic field magnet system is the major part of MRI imaging device, and in order to promote the image quality of MRI imaging system, generally need to change whole MRI imaging device, cost is very high.
Meta Materials refers to some artificial composite structures with the extraordinary physical property not available for natural material or composite material.By the structurally ordered design on the key physical yardstick of material, the restriction of some apparent natural law can be broken through, thus obtain the meta-materials function exceeding the intrinsic common character of nature.The character of Meta Materials and function mainly come from the structure of its inside but not form their material.At present, the geometry of existing metal man-made microstructure is the open annular of " work " font or similar " recessed " font as shown in Figure 1, but this structure all can not realize magnetic permeability μ and be significantly less than 0 or make meta-material resonant frequency reduce, isotropism can not be realized, only has the metal man-made microstructure by design with special geometric figure, just can make this artificial electromagnetic material in special frequency channel, reach magnetic permeability μ value and be less than 0, and there is lower resonance frequency.
At present, international community has large quantifier elimination to magnetic permeability aspect, research wherein for positive magnetic permeability has been tending towards ripe, research for negative-magnetic-permeability meta-material is the focus of research both at home and abroad now, negative magnetoconductivity has quantum polarization, polarization can be produced to incident wave, therefore sphere of action is very large, as the mr imaging technique in medical imaging field, negative magnetic-inductive capacity material can strengthen electromagnetic imaging effect, negative magnetic-inductive capacity material also plays an important role in lens research in addition, at engineering field, magnetic permeability all refers to relative permeability usually, for absolute permeability μ and the magnetic constant μ of material
0the ratio of (also known as permeability of vacuum), μ
r=μ/μ
0, dimensionless number.Usually " relatively " two word and symbol subscript r be all removed.Magnetic permeability is when representing that material is subject to magnetizing field H effect, the increase (μ > 1) of inner true magnetic field relative to H or the degree of minimizing (μ < 1).So far, in the already present material of the nature found, μ is generally greater than 0.
Summary of the invention
Technical problem to be solved by this invention is: provide a kind of MRI magnetic signal enhancement device, this MRI magnetic signal enhancement device is negative-magnetic-permeability meta-material, the image quality of Contrast-enhanced MRI imaging device, simultaneously, MRI equipment image quality strengthens, the receiving coil of MRI equipment can be made near detected part, the comfortableness of MRI equipment use need not to be increased.
The present invention is the technical scheme realizing goal of the invention employing: provide a kind of MRI magnetic signal enhancement device, this MRI magnetic signal enhancement device is arranged between the magnetic signal receiving coil of detected part and MRI imaging device, at least one deck negative-magnetic-permeability meta-material that MRI magnetic signal enhancement device comprises shell and arranges in the enclosure, negative-magnetic-permeability meta-material comprises substrate and is fixed on the man-made microstructure layer on substrate, the multiple man-made microstructure of periodic array arrangement on man-made microstructure layer, man-made microstructure forms by the helical wire that four length is equal is equidistantly nested, man-made microstructure is around its center of rotational symmetry half-twist, 180 °, overlap with initial man-made microstructure respectively after 270 °.
Preferably, negative-magnetic-permeability meta-material is laminated by two-layer substrate is alternate with two-layer man-made microstructure layer.
Preferably, two-layer substrate, the first substrate of one deck to be dielectric constant be 10-20, the second substrate of one deck to be dielectric constant be 5-10.
Preferably, the thickness of first substrate is 0.005-0.015mm.
Preferably, the thickness of second substrate is 0.10-0.30mm.
Preferably, the live width 0.05-0.15mm of helical wire.
Preferably, the distance between centers of tracks 0.05-0.15mm of helical wire.
Preferably, the thickness 0.015-0.020mm of helical wire.
Preferably, the cross section of helical wire is rectangle.
Preferably, the nested number of plies of helical wire is greater than 2.
The invention has the beneficial effects as follows: a kind of MRI magnetic signal enhancement device is provided, MRI magnetic signal enhancement device utilizes the magnetic permeability of negative-magnetic-permeability meta-material for this characteristic negative, reach the effect that signal strengthens, make MRI imaging device imaging effect better, simultaneously, MRI equipment image quality strengthens, and the receiving coil of MRI equipment can be made near detected part, need not to increase the comfortableness of MRI equipment use.
Accompanying drawing explanation
Fig. 1, prior art negative-magnetic-permeability meta-material man-made microstructure schematic diagram;
Fig. 2, MRI magnetic signal enhancement device schematic diagram;
Fig. 3, negative-magnetic-permeability meta-material man-made microstructure schematic diagram of the present invention;
Fig. 4, negative-magnetic-permeability meta-material structural representation of the present invention;
Fig. 5, prior art negative-magnetic-permeability meta-material simulated effect schematic diagram;
Fig. 6, negative-magnetic-permeability meta-material simulated effect schematic diagram of the present invention;
Fig. 7, MRI animal in vitro coronal-plane imaging effect comparison diagram;
In figure, 10 negative-magnetic-permeability meta-materials, 12 shells, 1 man-made microstructure layer, 2 first substrates, 3 second substrates.
Embodiment
Below in conjunction with drawings and Examples, the present invention is described in detail.
Figure 1 shows that the open annular man-made microstructure of similar " recessed " of the prior art font, the man-made microstructure of this shape can make Meta Materials magnetic permeability be negative, but the resonance frequency reaching negative magnetoconductivity is higher, shown in negative-magnetic-permeability meta-material technology simulated effect schematic diagram as existing in Fig. 5, it is that negative resonance frequency is more than 350MHz that above-mentioned man-made microstructure shape reaches magnetic permeability, simulation parameter is: man-made microstructure selects copper cash, copper cash live width 0.1mm, copper cash distance between centers of tracks 0.1mm, copper cash thickness 0.018mm, substrate Ceramics substrate, its thickness is 0.011mm, dielectric constant is 16, size 15mm × the 15mm of man-made microstructure.
Fig. 2 is MRI magnetic signal enhancement device schematic diagram, and MRI magnetic signal enhancement device of the present invention comprises shell 12 and is arranged at least one deck negative-magnetic-permeability meta-material 10 in shell 12.Should be appreciated that shell 12 of the present invention plays the effect of support, protection internal layer negative-magnetic-permeability meta-material 10, at some privileged sites of measurement, during as leg, neck, conformal design can be carried out to shell 12, be convenient to user and use according to specific needs.If there is two-layer above negative-magnetic-permeability meta-material 10 shell 12 inside, can be coaxial parallel fixing by it.
Fig. 3 shows man-made microstructure schematic diagram of the present invention, to be that helical wire that four length is equal is equidistantly nested form man-made microstructure of the present invention, and man-made microstructure overlaps with initial man-made microstructure respectively around its center of rotational symmetry half-twist, after 180 °, 270 °.Multiple man-made microstructure array arrangement is at substrate surface, and form man-made microstructure layer 1, first substrate 2, second substrate 3 stacked composition negative-magnetic-permeability meta-material 10 alternate with two-layer man-made microstructure layer 1, see Fig. 4.
Be to be understood that, man-made microstructure is periodic arrangement on the surface of first substrate 2, second substrate 3, such as rectangular array arrangement, namely with an x direction be row, with perpendicular to x direction y direction be row arrange, and each line space, each column pitch are equal respectively, even line space equals column pitch.Preferred line space, column pitch are not more than 1/4th of the wavelength of the incident electromagnetic wave that will respond, the i.e. electromagnetic wave of such as operational environment to be wavelength be λ, Meta Materials is needed to be present negative magnetoconductivity to this electromagnetic electromagnetic property, when then designing man-made microstructure, above-mentioned line space, column pitch are selected to be not more than quarter-wave, be preferably 1/10th wavelength.
Should be appreciated that the helical wire material of man-made microstructure of the present invention is copper cash, silver-colored line, or even gold thread.The distance between centers of tracks 0.05-0.15mm of helical wire, the thickness 0.015-0.020mm of helical wire, the cross section of helical wire is rectangle, and the nested number of plies of helical wire is greater than 2.
Should be appreciated that the dielectric constant of first substrate 2 is 10-20, the thickness of first substrate 2 is 0.005-0.015mm; The dielectric constant of second substrate 3 is 5-10, and the thickness of second substrate 3 is 0.10-0.30mm.The dielectric constant of first substrate 2 is higher, thickness is thinner; the resonance frequency of negative-magnetic-permeability meta-material is lower; the general Ceramics substrate of first substrate 2 or pottery-organic polymer composite base plate; second substrate 3 plays protection man-made microstructure, reduces the effect of Meta Materials overall losses; general selection thickness is comparatively large, the organic polymer substrate that loss is less.
Fig. 6 is negative-magnetic-permeability meta-material simulated effect schematic diagram of the present invention, the simulation software that simulation software and Fig. 5 use is CSTMICROWAVESTUDIO2010, simulation parameter is: spiral metal line options copper cash, copper cash live width 0.1mm, copper cash distance between centers of tracks 0.1mm, copper cash thickness 0.018mm, first substrate is ceramic substrate, thickness 0.011mm, dielectric constant 16, second substrate is polypropylene substrate, thickness 0.139mm, dielectric constant 7.7, man-made microstructure size 15mm × 15mm, from simulation result, it is that the resonance frequency of-1 is at below 150MHz that negative-magnetic-permeability meta-material of the present invention realizes magnetic permeability, compared with prior art, greatly reduce the resonance frequency of negative-magnetic-permeability meta-material.
Based on above-mentioned low resonant frequency negative-magnetic-permeability meta-material, make MRI magnetic signal enhancement device as shown in Figure 2, between the receiving coil that this magnetic signal enhance device is placed in MRI equipment and user, when the negative-magnetic-permeability meta-material in MRI magnetic signal enhancement device is when magnetic permeability is for bearing, and resonance frequency identical with MRI operating frequency when, the receiving coil of negative-magnetic-permeability meta-material and MRI equipment produces and responds, strengthen the magnetic signal of receiving coil, and then the image quality of Contrast-enhanced MRI system, as shown in Figure 7, left figure is the in vitro coronal-plane effect contrast figure of animal not adding MRI magnetic signal enhancement device, in figure, animal is the fresh in vitro leg of pork in vitro, right figure is the image that the same leg of pork uses identical MRI equipment after adding MRI magnetic signal enhancement device of the present invention, known by contrasting, after adding MRI magnetic signal enhancement device, the muscle that animal is in vitro, bone texture display more clear, image is brighter, MRI imaging effect significantly improves, be convenient to doctor diagnose.Meanwhile, the image quality of Contrast-enhanced MRI system, can make the receiving coil of MRI equipment near detected part, need not increase the comfortableness of MRI equipment use.
Above-described embodiment in the present invention has only done exemplary description, and those skilled in the art can carry out various amendment to the present invention without departing from the spirit and scope of the present invention after reading present patent application.
Claims (6)
1. a MRI magnetic signal enhancement device, it is characterized in that, described MRI magnetic signal enhancement device is arranged between the magnetic signal receiving coil of detected part and MRI imaging device, at least one deck negative-magnetic-permeability meta-material that described MRI magnetic signal enhancement device comprises shell and arranges in the enclosure, described negative-magnetic-permeability meta-material comprises substrate and is fixed on the man-made microstructure layer on substrate, the multiple man-made microstructure of periodic array arrangement on described man-made microstructure layer, described man-made microstructure forms by the helical wire that four length is equal is equidistantly nested, described man-made microstructure is around its center of rotational symmetry half-twist, 180 °, overlap with initial man-made microstructure respectively after 270 °, the live width 0.05-0.15mm of described helical wire, distance between centers of tracks 0.05-0.15mm, thickness 0.015-0.020mm, described negative-magnetic-permeability meta-material is laminated by two-layer described substrate is alternate with two-layer described man-made microstructure layer, man-made microstructure is at the rectangular array arrangement in the surface of first substrate, second substrate, and line space, column pitch are not more than 1/4th of the wavelength of the incident electromagnetic wave that will respond.
2. MRI magnetic signal enhancement device according to claim 1, is characterized in that, described two-layer substrate, the first substrate of one deck to be dielectric constant be 10-20, the second substrate of one deck to be dielectric constant be 5-10.
3. MRI magnetic signal enhancement device according to claim 2, is characterized in that, the thickness of described first substrate is 0.005-0.015mm.
4. MRI magnetic signal enhancement device according to claim 3, is characterized in that, the thickness of described second substrate is 0.10-0.30mm.
5. MRI magnetic signal enhancement device according to claim 1, is characterized in that, the cross section of described helical wire is rectangle.
6. MRI magnetic signal enhancement device according to claim 1, is characterized in that, the nested number of plies of described helical wire is greater than 2.
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| CN104409863A (en) * | 2014-11-27 | 2015-03-11 | 骆柳春 | MRI magnetic signal enhancing device |
| CN106410420B (en) * | 2016-10-25 | 2022-08-12 | 华南理工大学 | Novel metamaterial with negative equivalent dielectric constant and negative equivalent magnetic permeability |
| CN108267698B (en) * | 2018-01-08 | 2020-07-14 | 上海交通大学 | Method for improving sensitivity of laminated composite magnetic sensor |
| WO2020176857A1 (en) * | 2019-02-28 | 2020-09-03 | American University Of Beirut | Biomarker monitoring sensor and methods of use |
| CN109841960B (en) * | 2019-03-18 | 2020-12-25 | 南京邮电大学 | Low-permeability metamaterial based on metal coil array |
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