CN102683878B - A kind of MRI magnetic signal enhancement device - Google Patents
A kind of MRI magnetic signal enhancement device Download PDFInfo
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- CN102683878B CN102683878B CN201210133046.1A CN201210133046A CN102683878B CN 102683878 B CN102683878 B CN 102683878B CN 201210133046 A CN201210133046 A CN 201210133046A CN 102683878 B CN102683878 B CN 102683878B
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Abstract
The invention provides a kind of MRI magnetic signal enhancement device, at least one deck negative-magnetic-permeability meta-material that this MRI magnetic signal enhancement device comprises shell and arranges in the enclosure, this negative-magnetic-permeability meta-material is the low frequency negative-magnetic-cometamaterial metamaterial through particular design, when the negative-magnetic-permeability meta-material in MRI magnetic signal enhancement device is when magnetic permeability is for bearing, and in resonance frequency and the approximately uniform situation of MRI operating frequency, the receiving coil of negative-magnetic-permeability meta-material and MRI imaging device produces and responds, strengthen the magnetic signal of receiving coil, and then the image quality of Contrast-enhanced MRI imaging device, simultaneously, the image quality of MRI imaging device strengthens, can make the receiving coil of MRI imaging device need not near detected part, increase comfortableness when MRI imaging device uses.
Description
[technical field]
The present invention relates to MRI field, relate to a kind of MRI magnetic signal enhancement device particularly.
[background technology]
The principle of nulcear magnetic resonance (NMR) (MRI) imaging system utilizes coil to remove the radio wave pulses energy detecting nuclear spin absorption and launch, and this coil, as receiving coil, is being gone back simultaneously as transmitting coil sometimes.Under the help of radio wave pulses energy, Magnetic resonance imaging scanner can a very little point in position patient body, then determines that this is the tissue of which kind of type.Magnetic resonance imaging machine device adopts the radio frequency pulse specific to hydrogen atom.The body region that will check is aimed in System guides pulse, and causes the proton uptake in this region to make them with the energy needed for different directions rotation or precession.This is NMR imaging device " resonance " part.Radio frequency pulse forces their (refer to unnecessary in each 1,000,000 proton a pair or two to unmatched proton) to rotate according to specific direction under characteristic frequency.The characteristic frequency causing resonance is called as Rameau that frequency, and this value draws according to wanting the magnetic field intensity of the particular organization of imaging and main field to calculate.Radio frequency pulse utilizes a coil to provide usually, and this coil is called transmitting coil.The receiving coil of existing magnetic resonance imaging device must quite near-earth close to detected part, to obtain the magnetic signal discharged by detected part.Definition and the main field strength of MRI imaging device are proportionate, and main magnetic field magnet system is the major part of MRI imaging device, and in order to promote the image quality of MRI imaging system, generally need to change whole MRI imaging device, cost is very high.
Meta Materials refers to some artificial composite structures with the extraordinary physical property not available for natural material or composite material.By the structurally ordered design on the key physical yardstick of material, the restriction of some apparent natural law can be broken through, thus obtain the meta-materials function exceeding the intrinsic common character of nature.The character of Meta Materials and function mainly come from the structure of its inside but not form their material.At present, the geometry of existing metal man-made microstructure is the open annular of " work " font or similar " recessed " font as shown in Figure 1, but this structure all can not realize magnetic permeability μ and be significantly less than 0 or make meta-material resonant frequency reduce, isotropism can not be realized, only has the metal man-made microstructure by design with special geometric figure, just can make this artificial electromagnetic material in special frequency channel, reach magnetic permeability μ value and be less than 0, and there is lower resonance frequency.
At present, international community has large quantifier elimination to magnetic permeability aspect, research wherein for positive magnetic permeability has been tending towards ripe, research for negative-magnetic-permeability meta-material is the focus of research both at home and abroad now, negative magnetoconductivity has quantum polarization, polarization can be produced to incident wave, therefore sphere of action is very large, as the mr imaging technique in medical imaging field, negative magnetic-inductive capacity material can strengthen electromagnetic imaging effect, negative magnetic-inductive capacity material also plays an important role in lens research in addition, at engineering field, magnetic permeability all refers to relative permeability usually, for absolute permeability μ and the magnetic constant μ of material
0the ratio of (also known as permeability of vacuum), μ r=μ/μ
0, dimensionless number.Usually " relatively " two word and symbol subscript r be all removed.Magnetic permeability is when representing that material is subject to magnetizing field H effect, the increase (μ > 1) of inner true magnetic field relative to H or the degree of minimizing (μ < 1).So far, in the already present material of the nature found, μ is generally greater than 0.
[summary of the invention]
Technical problem to be solved by this invention is: provide a kind of MRI magnetic signal enhancement device, this MRI magnetic signal enhancement device is negative-magnetic-permeability meta-material, the image quality of Contrast-enhanced MRI imaging device, simultaneously, the image quality of MRI imaging device strengthens, the receiving coil of MRI imaging device can be made near detected part, the comfortableness that MRI imaging device uses need not to be increased.
The present invention is the technical scheme realizing goal of the invention employing: provide a kind of MRI magnetic signal enhancement device, at least one deck negative-magnetic-permeability meta-material that this MRI magnetic signal enhancement device comprises shell and arranges in the enclosure, negative-magnetic-permeability meta-material comprises the first man-made microstructure and the second man-made microstructure that substrate and multiple cyclic array are arranged in substrate two sides, first man-made microstructure is connected by a metallic vias with the second man-made microstructure, first man-made microstructure and the second man-made microstructure are square torus, square torus winding turns is 3 circles, first man-made microstructure and the second man-made microstructure are of a size of 19.5mm × 19.5mm, described first man-made microstructure and described second man-made microstructure press row-column arrangement, and line space and column pitch are not more than 1/4th of the wavelength of wanted corresponding incident electromagnetic wave respectively, substrate is placed with the magnetic signal receiving coil of two sides perpendicular to MRI imaging device of the first man-made microstructure and the second man-made microstructure, the resonance frequency of described negative-magnetic-permeability meta-material and the magnetic signal operating frequency of MRI imaging device close.
Preferably, MRI magnetic signal enhancement device is of a size of 300mm × 300mm.
Preferably, the field intensity of MRI imaging device is 1.5T.
Preferably, the live width of the first man-made microstructure and the second man-made microstructure is 0.50-1.50mm.
Preferably, the distance between centers of tracks of the first man-made microstructure and the second man-made microstructure is 0.05-0.15mm.
Preferably, the line thickness of the first man-made microstructure and the second man-made microstructure is 0.03-0.05mm.
Preferably, substrate comprises first substrate and second substrate, and first substrate and second substrate are FR-4 organic polymer substrate or ceramic substrate.
Preferably, first substrate thickness is 0.15-0.20mm.
Preferably, the thickness of second substrate is 0.05-0.10mm.
Preferably, the aperture of metallic vias is 0.50-0.90mm.
The invention has the beneficial effects as follows: a kind of MRI magnetic signal enhancement device is provided, MRI magnetic signal enhancement device utilizes the magnetic permeability of negative-magnetic-permeability meta-material for this characteristic negative, reach the effect that signal strengthens, make MRI imaging device imaging effect better, simultaneously, the image quality of MRI imaging device strengthens, and the receiving coil of MRI imaging device can be made near detected part, need not to increase MRI imaging device comfort.
[accompanying drawing explanation]
Fig. 1, prior art negative-magnetic-permeability meta-material man-made microstructure schematic diagram;
Fig. 2, MRI magnetic signal enhancement device schematic diagram;
Fig. 3, negative-magnetic-permeability meta-material structural representation of the present invention;
Fig. 4, the present invention first man-made microstructure schematic diagram;
Fig. 5, the present invention second man-made microstructure schematic diagram;
Fig. 6, prior art negative-magnetic-permeability meta-material simulated effect schematic diagram;
Fig. 7, negative-magnetic-permeability meta-material simulated effect schematic diagram of the present invention;
Fig. 8, without MRI magnetic signal enhancement device spherical moisture film sagittal plane design sketch;
Fig. 9, has MRI magnetic signal enhancement device spherical moisture film sagittal plane design sketch;
Figure 10, without the in vitro coronal-plane design sketch of MRI magnetic signal enhancement device animal;
Figure 11, has the in vitro coronal-plane design sketch of MRI magnetic signal enhancement device animal;
Figure 12, MRI magnetic signal enhancement device-receiving coil-detected part position view;
In figure, 10 negative-magnetic-permeability meta-materials, 12 shells, 1 first man-made microstructure, 2 second man-made microstructure, 3 metallic vias, 4 first substrates, 5 second substrates, 6 syndetons, 101MRI magnetic signal enhance device, 102 receiving coils, 103 detected part.
[embodiment]
Below in conjunction with drawings and Examples, the present invention is described in detail.
Figure 1 shows that the open annular man-made microstructure of similar " recessed " of the prior art font, the man-made microstructure of this shape can make Meta Materials magnetic permeability be negative, but the resonance frequency reaching negative magnetoconductivity is higher, as Fig. 6 shows, it is that negative resonance frequency is more than 350MHz that above-mentioned man-made microstructure shape reaches magnetic permeability.
Fig. 2 is MRI magnetic signal enhancement device 101 schematic diagram, and MRI magnetic signal enhancement device 101 of the present invention comprises shell 12 and is arranged at least one deck negative-magnetic-permeability meta-material 10 in shell 12.Should be appreciated that shell 12 of the present invention plays the effect of support, protection internal layer negative-magnetic-permeability meta-material 10, when measuring some privileged sites as leg, neck, conformal design can be carried out to shell 12 and Meta Materials 10, being convenient to user and using according to specific needs.If there is two-layer above negative-magnetic-permeability meta-material 10 shell 12 inside, can be coaxial parallel fixing by it.
Fig. 3 shows negative-magnetic-permeability meta-material structural representation of the present invention, negative-magnetic-permeability meta-material of the present invention comprises substrate and multiple cyclic array and is arranged in the first man-made microstructure 1 of substrate both sides and the second man-made microstructure 2, first man-made microstructure 1 is connected by a metallic vias 3 with the second man-made microstructure 2.First man-made microstructure 1 is connected by metallic vias 3 with the second man-made microstructure 2, the aperture of metallic vias 3 is 0.50-0.90mm, the connected mode of the first man-made microstructure 1 and the second man-made microstructure 2 is as follows: the first man-made microstructure 1 and the second man-made microstructure 2 all have syndeton 6, two syndetons 6 are connected by metallic vias 3, syndeton 6 is electric conducting material, as metallic copper, argent, conductive plastics etc.
Be to be understood that, first man-made microstructure 1 and the second man-made microstructure 2 are periodic arrangement on the surface of substrate 4, as shown in Figure 3, such as rectangular array arrangement, namely with an x direction be row, with perpendicular to x direction y direction be row arrange, and each line space, each column pitch are equal respectively, even line space equals column pitch.Preferred line space, column pitch are not more than 1/4th of the wavelength of the incident electromagnetic wave that will respond, the i.e. electromagnetic wave of such as operational environment to be wavelength be λ, Meta Materials is needed to be present negative magnetoconductivity to this electromagnetic electromagnetic property, when then designing man-made microstructure, above-mentioned line space, column pitch are selected to be not more than quarter-wave, be preferably 1/10th wavelength.
Fig. 4 is the present invention first man-made microstructure schematic diagram, Fig. 5 is the present invention second man-made microstructure schematic diagram, first man-made microstructure 1 and the second man-made microstructure 2 are square torus, as shown in Figure 4, Figure 5, square torus is generally metal wire, as copper cash, silver-colored line, copper alloy, or even gold thread, also can be by least two kinds of metal alloys, or even nonmetallic electric conducting material, as conductive plastics, ITO (indium tin oxide), carbon nano-tube, graphite etc.The square torus winding turns of the present invention is 3 circles, and the first man-made microstructure 1 and the second man-made microstructure 2 are of a size of 19.5mm × 19.5mm.
Be to be understood that, the live width of the present invention first man-made microstructure 1 and the second man-made microstructure 2 is 0.05-0.15mm, the distance between centers of tracks of the first man-made microstructure 1 and the second man-made microstructure 2 is 0.03-0.05mm, and the line thickness of the first man-made microstructure 1 and the second man-made microstructure 2 is 0.05-0.15mm.
Should be appreciated that a circle herein, refer to as shown in Figure 4, any of the ring-shaped inner part surrounded with split ring resonator is polar limit O
e, from limit O in split ring resonator two distal point
enear distal point line is to the extreme this polar pole axis, and getting is positive direction counterclockwise, then use polar coordinates (ρ successively along the every bit on split ring resonator
e, θ) represent, every one 360 degree is a circle, until reach split ring resonator from another distal point away from limit.
Should be appreciated that substrate is FR-4 organic polymer substrate or ceramic substrate, the thickness of first substrate 4 is 0.15-0.20mm, and the thickness of second substrate 5 is 0.05-0.10mm.
Fig. 7 is negative-magnetic-permeability meta-material simulated effect schematic diagram of the present invention, the simulation software that simulation software and Fig. 6 use is CSTMICROWAVESTUDIO2010, simulation parameter is: square torus adopts copper cash, copper cash live width 1mm, copper cash distance between centers of tracks 0.1mm, copper cash line thickness 0.035mm, first substrate 4 is ceramic substrate, its thickness is 0.164mm, second substrate 5 is FR-4 epoxy resin base plate, its thickness is 0.06mm, first man-made microstructure 1 and the second man-made microstructure 2 are of a size of 19.5mm × 19.5mm, coiling 3 is enclosed, the aperture of metallic vias 3 is 0.7mm, from simulation result, it is that the resonance frequency of-1 is at 63.6MHz that negative-magnetic-permeability meta-material of the present invention realizes magnetic permeability, compared with prior art, greatly reduce the resonance frequency of negative-magnetic-permeability meta-material, the MRI system frequency of 1.5T and said frequencies close, thus resonance frequency is the image quality that the MRI magnetic signal enhancement device 101 of 63.6MHz can improve the MRI imaging device of 1.5T.
Based on above-mentioned low resonant frequency negative-magnetic-permeability meta-material, make MRI magnetic signal enhancement device 101 as shown in Figure 2, the substrate of the inner negative-magnetic-permeability meta-material of MRI magnetic signal enhancement device 101 is placed with the magnetic signal receiving coil 102 of two sides perpendicular to MRI imaging device of the first man-made microstructure 1 and the second man-made microstructure 2, when the negative-magnetic-permeability meta-material in MRI magnetic signal enhancement device 101 is when magnetic permeability is for bearing, and resonance frequency identical with MRI operating frequency when, the receiving coil of negative-magnetic-permeability meta-material and MRI imaging device produces and responds, strengthen the magnetic signal of receiving coil, and then the image quality of Contrast-enhanced MRI imaging device.
For proved invention MRI magnetic signal enhancement device 101 can the imaging effect of Contrast-enhanced MRI imaging device, do following experiment:
Test 1 hydraulic model experiment
A. spherical moisture film being placed in field intensity is between the MRI imaging device receiving coil 102 of 1.5T and transmitting coil, because spherical moisture film bottom is near receiving coil 102, the spherical moisture film sagittal view obtained evenly brightens from top to bottom, the average gray value of above-mentioned spherical moisture film sagittal view is 78.95, average snr value (signal to noise ratio) is 0.147, see Fig. 8.
B. MRI magnetic signal enhancement device 101 of the present invention is placed in spherical moisture film left hand position, see Figure 12, namely the substrate of the inner negative-magnetic-permeability meta-material of MRI magnetic signal enhancement device 101 is placed with the magnetic signal receiving coil 102 of two sides perpendicular to MRI imaging device of the first man-made microstructure 1 and the second man-made microstructure 2, and spherical moisture film (detected part 103) is placed between MRI magnetic signal enhancement device 101 and receiving coil 102.As shown in Figure 9, the image brightness of the spherical moisture film sagittal view obtained significantly improves, and recording its average gray value is 137.39, and average snr value is 0.173.
It can thus be appreciated that the average gray value of the spherical moisture film sagittal view obtained after adding MRI magnetic signal enhancement device 101 of the present invention adds 74%, and average snr value adds 17.9%.
Test 2 animal isolated experiments
A. the animal that animal isolated experiment is selected is fresh pig's feet in vitro, animal is placed in field intensity is the MRI imaging device of 1.5T in vitro between receiving coil 102 and transmitting coil, obtain the in vitro coronal-plane design sketch of animal as shown in Figure 10, recording its average gray value is 22.20, and standard deviation value is 30.81.
B. MRI magnetic signal enhancement device 101 is placed in the in vitro left hand position of animal, the substrate of the inner negative-magnetic-permeability meta-material of MRI magnetic signal enhancement device 101 is placed with the magnetic signal receiving coil 102 of two sides perpendicular to MRI imaging device of the first man-made microstructure 1 and the second man-made microstructure 2, animal in vitro (detected part 103) is placed between MRI magnetic signal enhancement device 101 and receiving coil 102, other conditions are constant, record animal in vitro coronal-plane design sketch more clear, bright, the muscle that animal is in vitro, bone texture is more clear, its average gray value is 32.41, standard deviation value is 46.72, see Figure 11.
It can thus be appreciated that the average gray value of the in vitro coronal-plane design sketch of animal adds 46.72% than without MRI magnetic signal enhancement device, and standard deviation value adds 51%.The image quality of MRI imaging device improves greatly, and the image quality of MRI imaging device improves, and can make the receiving coil 102 of MRI imaging device need not near detected part, comfortableness when Contrast-enhanced MRI imaging device uses.
Above-described embodiment in the present invention has only done exemplary description, and those skilled in the art can carry out various amendment to the present invention without departing from the spirit and scope of the present invention after reading present patent application.
Claims (10)
1. a MRI magnetic signal enhancement device, it is characterized in that, at least one deck negative-magnetic-permeability meta-material that described MRI magnetic signal enhancement device comprises shell and arranges in the enclosure, described negative-magnetic-permeability meta-material comprises the first man-made microstructure and the second man-made microstructure that substrate and multiple cyclic array are arranged in substrate two sides, described first man-made microstructure is connected by a metallic vias with the second man-made microstructure, described first man-made microstructure and the second man-made microstructure are square torus, described square torus winding turns is 3 circles, described first man-made microstructure and the second man-made microstructure are of a size of 19.5mm × 19.5mm, described first man-made microstructure and described second man-made microstructure press row-column arrangement, and line space and column pitch are not more than 1/4th of the wavelength of the incident electromagnetic wave that will respond respectively, described substrate is placed with the magnetic signal receiving coil of two sides perpendicular to MRI imaging device of described first man-made microstructure and the second man-made microstructure, the resonance frequency of described negative-magnetic-permeability meta-material and the magnetic signal operating frequency of MRI imaging device close.
2. MRI magnetic signal enhancement device according to claim 1, is characterized in that, MRI magnetic signal enhancement device is of a size of 300mm × 300mm.
3. MRI magnetic signal enhancement device according to claim 1, is characterized in that, the field intensity of described MRI imaging device is 1.5T.
4. MRI magnetic signal enhancement device according to claim 3, is characterized in that, the live width of described first man-made microstructure and the second man-made microstructure is 0.50-1.50mm.
5. MRI magnetic signal enhancement device according to claim 3, is characterized in that, the distance between centers of tracks of described first man-made microstructure and the second man-made microstructure is 0.50-1.50mm.
6. MRI magnetic signal enhancement device according to claim 1, is characterized in that, the line thickness of described first man-made microstructure and the second man-made microstructure is 0.50-1.50mm.
7. MRI magnetic signal enhancement device according to claim 1, is characterized in that, described substrate comprises first substrate and second substrate, and first substrate and second substrate are FR-4 organic polymer substrate or ceramic substrate.
8. MRI magnetic signal enhancement device according to claim 7, is characterized in that, first substrate thickness is 0.15-0.20mm.
9. MRI magnetic signal enhancement device according to claim 7, is characterized in that, second substrate thickness is 0.05-0.10mm.
10. MRI magnetic signal enhancement device according to claim 1, is characterized in that, the aperture of described metallic vias is 0.05-0.90mm.
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| GB2363845A (en) * | 2000-06-21 | 2002-01-09 | Marconi Caswell Ltd | Focussing RF flux |
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| US20110204891A1 (en) * | 2009-06-25 | 2011-08-25 | Lockheed Martin Corporation | Direct magnetic imaging apparatus and method |
| CN102349831A (en) * | 2011-09-08 | 2012-02-15 | 浙江大学 | Superlens based on artificial electromagnetic structure in nuclear magnetic resonance imaging |
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| GB2363845A (en) * | 2000-06-21 | 2002-01-09 | Marconi Caswell Ltd | Focussing RF flux |
Non-Patent Citations (3)
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| Metamaterial transmission lines based on broad-side coupled spiral resonators;F. Aznar等;《Electronics Letters》;20070426;第43卷(第9期);正文第1栏第18-39行及图1.b * |
| Proposal of cylindrical rolled-up metamaterial lenses for magnetic resonance imaging application and preliminary experimental demonstration;Y. Xie等;《Progress in Electromagnetic Research》;20120331;第124卷;全文 * |
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