CN102709705B - MRI (magnetic resonance imaging) magnetic signal enhancement device - Google Patents
MRI (magnetic resonance imaging) magnetic signal enhancement device Download PDFInfo
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- CN102709705B CN102709705B CN201210128222.2A CN201210128222A CN102709705B CN 102709705 B CN102709705 B CN 102709705B CN 201210128222 A CN201210128222 A CN 201210128222A CN 102709705 B CN102709705 B CN 102709705B
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Abstract
The invention provides an MRI (magnetic resonance imaging) magnetic signal enhancement device arranged between a portion to be detected and a magnetic signal receiving coil of an MRI device. The MRI magnetic signal enhancement device comprises a housing and at least one tier of negative permeability metamaterial arranged in the housing. The negative permeability metamaterial is specially designed low-frequency negative permeability metamaterial. When permeability of the negative permeability metamaterial in the MRI magnetic signal enhancement device is negative and resonance frequency and MRI working frequency are consistent, the negative permeability metamaterial responds to the receiving coil of the MRI device, magnetic signals of the receiving coil are enhanced, and imaging quality of an MRI system is further improved. In addition, the imaging quality of the MRI system is improved, and accordingly the receiving coil of the MRI device need not cling to the portion to be detected, and comfort in using the MRI device is increased.
Description
Technical field
The present invention relates to MRI field, relate to a kind of MRI magnetic signal enhancement device particularly.
Background technology
The principle of nulcear magnetic resonance (NMR) (MRI) imaging system utilizes coil to remove the radio wave pulses energy detecting nuclear spin absorption and launch, and this coil, as receiving coil, is being gone back simultaneously as transmitting coil sometimes.Under the help of radio wave pulses energy, Magnetic resonance imaging scanner can a very little point in position patient body, then determines that this is the tissue of which kind of type.Magnetic resonance imaging machine device adopts the radio frequency pulse specific to hydrogen atom.The body region that will check is aimed in System guides pulse, and causes the proton uptake in this region to make them with the energy needed for different directions rotation or precession.This is NMR imaging device " resonance " part.Radio frequency pulse forces their (refer to unnecessary in each 1,000,000 proton a pair or two to unmatched proton) to rotate according to specific direction under characteristic frequency.The characteristic frequency causing resonance is called as Rameau that frequency, and this value draws according to wanting the magnetic field intensity of the particular organization of imaging and main field to calculate.Radio frequency pulse utilizes a coil to provide usually, and this coil is called transmitting coil.The receiving coil of existing magnetic resonance imaging device must quite near-earth close to detected part, to obtain the magnetic signal discharged by detected part.Definition and the main field strength of MRI imaging device are proportionate, and main magnetic field magnet system is the major part of MRI imaging device, and in order to promote the image quality of MRI imaging system, generally need to change whole MRI imaging device, cost is very high.
Meta Materials refers to some artificial composite structures with the extraordinary physical property not available for natural material or composite material.By the structurally ordered design on the key physical yardstick of material, the restriction of some apparent natural law can be broken through, thus obtain the meta-materials function exceeding the intrinsic common character of nature.The character of Meta Materials and function mainly come from the structure of its inside but not form their material.At present, the geometry of existing metal man-made microstructure is the open annular of " work " font or similar " recessed " font as shown in Figure 1, but this structure all can not realize magnetic permeability μ and be significantly less than 0 or make meta-material resonant frequency reduce, isotropism can not be realized, only has the metal man-made microstructure by design with special geometric figure, just can make this artificial electromagnetic material in special frequency channel, reach magnetic permeability μ value and be less than 0, and there is lower resonance frequency.
At present, international community has large quantifier elimination to magnetic permeability aspect, research wherein for positive magnetic permeability has been tending towards ripe, research for negative-magnetic-permeability meta-material is the focus of research both at home and abroad now, negative magnetoconductivity has quantum polarization, polarization can be produced to incident wave, therefore sphere of action is very large, as the mr imaging technique in medical imaging field, negative magnetic-inductive capacity material can strengthen electromagnetic imaging effect, negative magnetic-inductive capacity material also plays an important role in lens research in addition, at engineering field, magnetic permeability all refers to relative permeability usually, for absolute permeability μ and the magnetic constant μ of material
0the ratio of (also known as permeability of vacuum), μ
r=μ/μ
0, dimensionless number.Usually " relatively " two word and symbol subscript r be all removed.Magnetic permeability is when representing that material is subject to magnetizing field H effect, the increase (μ > 1) of inner true magnetic field relative to H or the degree of minimizing (μ < 1).So far, in the already present material of the nature found, μ is generally greater than 0.
Summary of the invention
Technical problem to be solved by this invention is: provide a kind of MRI magnetic signal enhancement device, this MRI magnetic signal enhancement device is negative-magnetic-permeability meta-material, the image quality of Contrast-enhanced MRI imaging device, simultaneously, the image quality of MRI imaging device strengthens, the receiving coil of MRI imaging device can be made near detected part, the comfortableness that MRI imaging device uses need not to be increased.
The present invention is the technical scheme realizing goal of the invention employing: provide a kind of MRI magnetic signal enhancement device, MRI magnetic signal enhancement device is arranged between the magnetic signal receiving coil of detected part and MRI imaging device, at least one deck negative-magnetic-permeability meta-material that MRI magnetic signal enhancement device comprises shell and arranges in the enclosure, negative-magnetic-permeability meta-material comprises substrate and is fixed on the man-made microstructure layer on substrate, the multiple man-made microstructure of periodic array arrangement on man-made microstructure layer, man-made microstructure is made up of four identical man-made microstructure unit, arbitrary man-made microstructure unit is around same rotating shaft half-twist, 180 °, overlap with other three artificial microstructure units respectively after 270 °, man-made microstructure unit is formed the concave-shaped openings resonant ring of multinest by the mode of multiple coiling by a wires.
Preferably, Meta Materials is laminated by two-layer substrate is alternate with three layers of man-made microstructure layer.
Preferably, the position of man-made microstructure unit is one to one, and man-made microstructure unit opening direction is, the opening direction of two outer man-made microstructure unit is identical, and intermediate layer man-made microstructure unit is contrary with the opening direction of outer man-made microstructure unit.
Preferably, substrate is FR-4 organic polymer substrate or ceramic substrate.
Preferably, the thickness of substrate is 0.10-0.30mm.
Preferably, metal wire live width 0.05-0.15mm.
Preferably, metal wire distance between centers of tracks 0.05-0.15mm.
Preferably, metal wire line thickness 0.015-0.020mm.
Preferably, man-made microstructure is of a size of 30mm × 30mm.
Preferably, metal wire winding turns is greater than 2.
The invention has the beneficial effects as follows: a kind of MRI magnetic signal enhancement device is provided, MRI magnetic signal enhancement device utilizes the magnetic permeability of negative-magnetic-permeability meta-material for this characteristic negative, reach the effect that signal strengthens, make MRI imaging device imaging effect better, simultaneously, MRI equipment image quality strengthens, and the receiving coil of MRI equipment can be made near detected part, need not to increase the comfortableness of MRI equipment use.
Accompanying drawing explanation
Fig. 1, prior art negative-magnetic-permeability meta-material man-made microstructure schematic diagram;
Fig. 2, MRI magnetic signal enhancement device schematic diagram;
Fig. 3, negative-magnetic-permeability meta-material man-made microstructure cell schematics of the present invention;
Fig. 4, Fig. 3 man-made microstructure unit opening direction schematic diagram;
Fig. 5, negative-magnetic-permeability meta-material structural representation of the present invention;
The right view of Fig. 6, Fig. 5;
Fig. 7, negative-magnetic-permeability meta-material man-made microstructure schematic diagram of the present invention;
Fig. 8, man-made microstructure unit polar coordinates schematic diagram;
Fig. 9, prior art negative-magnetic-permeability meta-material simulated effect schematic diagram;
Figure 10, negative-magnetic-permeability meta-material simulated effect schematic diagram of the present invention;
The in vitro coronal-plane effect contrast figure of Figure 11, MRI animal;
In figure, 10 negative-magnetic-permeability meta-materials, 12 shells, 1 man-made microstructure unit opening part, a, b, c man-made microstructure layer, d, e substrate.
Embodiment
Below in conjunction with drawings and Examples, the present invention is described in detail.
Figure 1 shows that the open annular man-made microstructure of similar " recessed " of the prior art font, the man-made microstructure of this shape can make Meta Materials magnetic permeability be negative, but the resonance frequency reaching negative magnetoconductivity is higher, shown in negative-magnetic-permeability meta-material technology simulated effect schematic diagram as existing in Fig. 9, it is that negative resonance frequency is more than 350MHz that above-mentioned man-made microstructure shape reaches magnetic permeability.
Fig. 2 is MRI magnetic signal enhancement device schematic diagram, and MRI magnetic signal enhancement device of the present invention comprises shell 12 and is arranged at least one deck negative-magnetic-permeability meta-material 10 in shell 12.Should be appreciated that shell 12 of the present invention plays the effect of support, protection internal layer negative-magnetic-permeability meta-material 10, at some privileged sites of measurement, during as leg, neck, conformal design can be carried out to shell 12, be convenient to user and use according to specific needs.If there is two-layer above negative-magnetic-permeability meta-material 10 shell 12 inside, can be coaxial parallel fixing by it.
Fig. 3 shows the artificial microstructure unit schematic diagram of the present invention, and the artificial microstructure unit of the present invention is the concave-shaped openings resonant ring being formed multinest by a wires by the mode of multiple coiling.1 is the opening part of artificial microstructure unit, it can thus be appreciated that, its opening direction upwards, see Fig. 4, four artificial microstructure units ringwise equidistantly array arrangement at substrate d, e surface, the position of man-made microstructure unit is one to one, man-made microstructure unit opening direction is, the opening direction of two outer man-made microstructure unit is identical, intermediate layer man-made microstructure unit is contrary with the opening direction of outer man-made microstructure unit, form man-made microstructure, see Fig. 7, multiple man-made microstructure cyclic array is arranged in substrate d, e surface, form man-made microstructure layer a, b, c, substrate d, e and man-made microstructure layer a, b, the alternate stacked composition negative-magnetic-permeability meta-material 10 of c, see Fig. 5.
Should be appreciated that multiple man-made microstructure is periodic arrangement on the surface of substrate d, e, as shown in Figure 6, rectangular array is arranged, namely with an x direction be row, with perpendicular to the y direction in x direction be row arrange, and each line space, each column pitch are respectively equal, and even line space equals column pitch.Preferred line space, column pitch are not more than 1/4th of the wavelength of the incident electromagnetic wave that will respond, the i.e. electromagnetic wave of such as operational environment to be wavelength be λ, Meta Materials is needed to be present negative magnetoconductivity to this electromagnetic electromagnetic property, when then designing man-made microstructure, above-mentioned line space, column pitch are selected to be not more than quarter-wave, be preferably 1/10th wavelength.
Should be appreciated that the metal wire material of man-made microstructure of the present invention is copper cash, silver-colored line, or even gold thread.Metal wire live width 0.05-0.15mm, metal wire distance between centers of tracks 0.05-0.15mm, metal wire line thickness 0.015-0.020mm, metal wire winding turns is greater than 2, and man-made microstructure is of a size of 30mm × 30mm.
Should be appreciated that a circle herein, refer to as shown in Figure 8, any of the ring-shaped inner part surrounded with split ring resonator is polar limit O
e, from limit O in split ring resonator two distal point
enear distal point line is to the extreme this polar pole axis, and getting is positive direction counterclockwise, then use polar coordinates (ρ successively along the every bit on split ring resonator
e, θ) represent, every one 360 degree is a circle, until reach split ring resonator from another distal point away from limit.
Should be appreciated that substrate d, e are FR-4 organic polymer substrate or ceramic substrate, the thickness of substrate d, e is 0.10-0.30mm.
Figure 10 is negative-magnetic-permeability meta-material simulated effect schematic diagram of the present invention, the simulation software that simulation software and Fig. 9 use is CST MICROWAVE STUDIO 2010, simulation parameter is: copper cash selected by metal wire, copper cash live width 0.1mm, copper cash distance between centers of tracks 0.1mm, copper cash line thickness 0.018mm, substrate is FR-4 epoxy resin base plate, thickness 0.018mm, man-made microstructure size 30mm × 30mm, from simulation result, it is that the resonance frequency of-1 is at below 10MHz that negative-magnetic-permeability meta-material of the present invention realizes magnetic permeability, compared with prior art, greatly reduce the resonance frequency of negative-magnetic-permeability meta-material.
Based on above-mentioned low resonant frequency negative-magnetic-permeability meta-material, make MRI magnetic signal enhancement device as shown in Figure 2, between the receiving coil that this magnetic signal enhance device is placed in MRI equipment and user, when the negative-magnetic-permeability meta-material in MRI magnetic signal enhancement device is when magnetic permeability is for bearing, and resonance frequency identical with MRI operating frequency when, the receiving coil of negative-magnetic-permeability meta-material and MRI equipment produces and responds, and strengthens the magnetic signal of receiving coil, and then the image quality of Contrast-enhanced MRI system.
As shown in figure 11, left figure is the in vitro coronal-plane effect contrast figure of animal not adding MRI magnetic signal enhancement device, in figure, animal is the fresh in vitro leg of pork in vitro, right figure is the image that the same leg of pork uses identical MRI equipment after adding MRI magnetic signal enhancement device of the present invention, known by contrasting, after adding MRI magnetic signal enhancement device, the in vitro muscle of animal, bone texture display more clear, image is brighter, and MRI imaging effect significantly improves, and is convenient to doctor and diagnoses.Meanwhile, the image quality of Contrast-enhanced MRI system, can make the receiving coil of MRI equipment near detected part, need not increase the comfortableness of MRI equipment use.
Above-described embodiment in the present invention has only done exemplary description, and those skilled in the art can carry out various amendment to the present invention without departing from the spirit and scope of the present invention after reading present patent application.
Claims (8)
1. a MRI magnetic signal enhancement device, it is characterized in that, described MRI magnetic signal enhancement device is arranged between the magnetic signal receiving coil of detected part and MRI imaging device, at least one deck negative-magnetic-permeability meta-material that described MRI magnetic signal enhancement device comprises shell and arranges in the enclosure, described negative-magnetic-permeability meta-material comprises two-layer substrate and is fixed on the three layer man-made microstructure layer being laminated alternate with substrate on substrate, the multiple man-made microstructure of periodic array arrangement on described man-made microstructure layer, described man-made microstructure is made up of four identical man-made microstructure unit, arbitrary man-made microstructure unit is around same rotating shaft half-twist, 180 °, overlap with other three artificial microstructure units respectively after 270 °, described man-made microstructure unit is formed the concave-shaped openings resonant ring of multinest by the mode of multiple coiling by a wires,
The position of the man-made microstructure unit of adjacent layer is one to one, described man-made microstructure unit opening direction is: the opening direction of two outer man-made microstructure unit is identical, and intermediate layer man-made microstructure unit is contrary with the opening direction of outer man-made microstructure unit.
2. MRI magnetic signal enhancement device according to claim 1, is characterized in that, described substrate is FR-4 organic polymer substrate or ceramic substrate.
3. MRI magnetic signal enhancement device according to claim 1, is characterized in that, the thickness of described substrate is 0.10-0.30mm.
4. MRI magnetic signal enhancement device according to claim 1, is characterized in that, described metal wire live width 0.05-0.15mm.
5. MRI magnetic signal enhancement device according to claim 1, is characterized in that, described metal wire distance between centers of tracks 0.05-0.15mm.
6. MRI magnetic signal enhancement device according to claim 1, is characterized in that, described metal wire line thickness 0.015-0.020mm.
7. MRI magnetic signal enhancement device according to claim 1, is characterized in that, described man-made microstructure is of a size of 30mm × 30mm.
8. MRI magnetic signal enhancement device according to claim 1, is characterized in that, described metal wire winding turns is greater than 2.
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| CN104409865A (en) * | 2014-11-27 | 2015-03-11 | 骆柳春 | MRI magnetic signal enhancing component |
| CN104459585A (en) * | 2014-11-27 | 2015-03-25 | 骆柳春 | Magnetic signal enhancement device used for magnetic resonance imaging |
| CN104409863A (en) * | 2014-11-27 | 2015-03-11 | 骆柳春 | MRI magnetic signal enhancing device |
| CN104409866A (en) * | 2014-11-27 | 2015-03-11 | 骆柳春 | Magnetic signal enhancement device |
| RU2601373C1 (en) * | 2015-07-03 | 2016-11-10 | федеральное государственное автономное образовательное учреждение высшего образования "Санкт-Петербургский национальный исследовательский университет информационных технологий, механики и оптики" (Университет ИТМО) | Magnetic resonance tomographic scanner |
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| WO2005029633A1 (en) * | 2003-09-25 | 2005-03-31 | Universitat Autonoma De Barcelona | Filters and antennas for microwaves and millimetre waves, based on open-loop resonators and planar transmission lines |
| CN102204008A (en) * | 2008-08-22 | 2011-09-28 | 杜克大学 | Metamaterials for surfaces and waveguides |
| CN101667680A (en) * | 2009-08-31 | 2010-03-10 | 深圳市启汉科技有限公司 | Monopole radio frequency antenna |
| CN102074777A (en) * | 2011-01-05 | 2011-05-25 | 华东师范大学 | Micro-strip rectangular double annular circular-seam resonator-based frequency selectivity surface structure |
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