CN102698194B - 治疗慢性肝炎茵陈中药口服液及制备方法 - Google Patents
治疗慢性肝炎茵陈中药口服液及制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗慢性肝炎茵陈中药口服液，是由下列重量份的中药原料制备而成：茵陈100-260份、白术100份、土茯苓50-100份、黄芪50-100份、郁金100-200份、枳实100-200份、炙甘草30-50份，六腑以通为顺，诸药共奏通腑泄下退黄之功。本发明中药口服液健脾益气，通腑泄下退黄，标本兼治、扶正不滞邪、祛邪不伤正的作用，成本低，疗效持久，值得临床推广应用。
Description
技术领域
本发明涉及一种中药制品，尤其涉及一种用于治疗慢性肝炎茵陈中药口服液及其制备方法。
背景技术
慢性肝炎是指由不同病因引起的，病程至少持续超过6个月以上的肝脏坏死和炎症，如感染肝炎病毒（乙肝病毒，丙肝病毒），长期饮酒，服用肝毒性药物等。临床上可有相应的症状、体征和肝生化检查异常，也可以无明显临床症状，仅有肝组织的坏死和炎症。病程呈波动性或持续进行性，如不进行适当的治疗，部分患者可进展为肝硬化。临床上经常见到隐匿性肝硬化患者，在出现肝硬化之前，没有感觉到明显不适，也没有进行常规的体检，在不知不觉中逐步发展成为肝硬化；偶有患者出现恶心，腹胀、黄疸，尿色深，但依据症状不能判断出慢性肝炎的严重程度，慢性肝炎重度及慢性重型肝炎：当患者尿色进行性加深，皮肤巩膜黄染进行性加深，乏力食欲下降越来越明显时，提示病情恶化，尤其需要警惕慢性重型肝炎的发生，慢性重型肝炎是肝衰竭的表现，可表现为高度乏力，高度腹胀，高度黄疸以及高度食欲不振，可出现低蛋白血症，腹水胸水，腹腔感染，凝血功能下降，上消化道出血，肝性脑病等，临床上死亡率较高，需要积极救治。西药治疗慢性肝炎疾病用药存在弊病是副作用大，对患者有很大的伤害，而中医中草药己被世界公认是不可缺人类医药珍贵的宝库，采用中医中药的手段来治疗慢性肝炎疾病，是一极待开发的渠道，中医药具有药性平和，适用范围广等特点，作为慢性肝炎疾病治疗方面有其独到的效果。
发明内容
本发明的目的是提供一种疗效持久，并无毒无副作用，标本兼治，成本低的治疗慢性肝炎茵陈中药口服液及制备方法。
为实现上述目的，本发明是通过以下技术方案实现的：
治疗慢性肝炎茵陈中药口服液，是由下列重量份的中药原料制备而成：
茵陈100-260份、白术100份、土茯苓50-100份、黄芪50-100份、郁金100-200份、枳实100-200份、炙甘草30-50份。
所述的治疗慢性肝炎茵陈中药口服液，是由下列重量份的中药原料制备而成：
茵陈260份、白术100份、土茯苓100份、黄芪100份、郁金200份、枳实200份、炙甘草50份。
所述的治疗慢性肝炎茵陈中药口服液的制备方法，具体步骤如下
取茵陈260份、白术100份、土茯苓100份、黄芪100份、郁金200份、枳实200份、炙甘草50份，用水煎煮二次，每次用水量为药材重量的8-10倍量，煎煮二次，每次l-2小时，滤过，滤液浓缩成在60-65℃测相对密度为1．10-1．25的清膏，加乙醇至使含乙醇量为60％，搅匀，静置24小时，滤过，取滤液回收乙醇，浓缩成含固体重量65-67％的浸膏，加入蔗糖20％、炼蜜12％、防腐剂1-3％，原液灌封，辐照灭菌，包装成品，制成口服液，即得。
用法与用量：口服本发明药物每次20毫升，每日3次，饭后半小时，3个月为一个疗程。
本发明的中药原料中，茵陈：苦、甘、温，归脾、胃经，补气健脾、燥湿利水、止汗、安胎；白术：苦、甘，温，入脾经、胃经，燥湿健脾、补脾益不足、固表利水安胎；土茯苓：甘、淡、平，归肝、胃、脾经，解毒、除湿、利关节；黄芪：甘、微温，归脾、肺经，补气升阳、益卫固表、托毒生肌、利水消肿；郁金：辛、苦、凉，归心、肝、胆经，芳香透达、可升可降、具有行气活血、疏肝解郁、清心开窍、清热凉血的功效，枳实：苦、辛、微寒，归脾、胃、大肠经，破气消积、化痰除痞；甘草：甘、平，归心、脾、肺、胃经，补脾益气、润肺止咳、清热解毒、缓解止痛、缓和药性；六腑以通为顺，诸药共奏通腑泄下退黄之功。本发明中药口服液健脾益气，通腑泄下退黄，标本兼治、扶正不滞邪、祛邪不伤正的作用，成本低，疗效持久，值得临床推广应用。
具体实施方式
实施例l：
中药原料：茵陈260份、白术100份、土茯苓100份、黄芪100份、郁金200份、枳实200份、炙甘草50份。
制法：取茵陈260份、白术100份、土茯苓100份、黄芪100份、郁金200份、枳实200份、炙甘草50份，用水煎煮二次，每次用水量为药材重量的8-10倍量，煎煮二次，每次l-2小时，滤过，滤液浓缩成在60-65℃测相对密度为1．10-1．25的清膏，加乙醇至使含乙醇量为60％，搅匀，静置24小时，滤过，取滤液回收乙醇，浓缩成含固体重量65-67％的浸膏，加入蔗糖20％、炼蜜12％、防腐剂1-3％，原液灌封，辐照灭菌，包装成品，制成口服液，即得。
实施例2：
中药原料：茵陈180份、白术100份、土茯苓75份、黄芪75份、郁金150份、枳实150份、炙甘草40份。
制法：取茵陈180份、白术100份、土茯苓75份、黄芪75份、郁金150份、枳实150份、炙甘草40份，用水煎煮二次，每次用水量为药材重量的8-10倍量，煎煮二次，每次l-2小时，滤过，滤液浓缩成在60-65℃测相对密度为1．10-1．25的清膏，加乙醇至使含乙醇量为60％，搅匀，静置24小时，滤过，取滤液回收乙醇，浓缩成含固体重量65-67％的浸膏，加入蔗糖20％、炼蜜12％、防腐剂1-3％，原液灌封，辐照灭菌，包装成品，制成口服液，即得。
实施例3：
中药原料：茵陈100份、白术100份、土茯苓50份、黄芪50份、郁金100份、枳实100份、炙甘草30份。
制法：取茵陈100份、白术100份、土茯苓50份、黄芪50份、郁金100份、枳实100份、炙甘草30份，用水煎煮二次，每次用水量为药材重量的8-10倍量，煎煮二次，每次l-2小时，滤过，滤液浓缩成在60-65℃测相对密度为1．10-1．25的清膏，加乙醇至使含乙醇量为60％，搅匀，静置24小时，滤过，取滤液回收乙醇，浓缩成含固体重量65-67％的浸膏，加入蔗糖20％、炼蜜12％、防腐剂1-3％，原液灌封，辐照灭菌，包装成品，制成口服液，即得。
实施例4：
1）临床资料：慢性肝炎26例，男10例，女16例，年龄20-45岁。
本发明以中医慢性肝炎为例，经25例临床观察。选择中医诊断慢性肝炎为标准：疲乏无力、食欲不振、腹胀、大便稀溏、容易出汗、舌淡苔薄、脉缓；脸色黝黑、有肝面容；肝区隐痛；肝纤维化严重；肝功能转氨酶持续不正常，其它指标如血浆白蛋白、血总胆红素等不合格。如上症状，即可确诊。
在确诊观察对象中，男10例，女16例，无其它严重疾病，年龄20-45岁。
2）疗效判定：
显效：乏力缓解，身上有劲；纳差、腹胀、肝区隐痛缓解，肝区舒适；肝面容有所改观，脸色变得白皙；肝纤维化检查缓解明显。
有效：乏力解决，身上有劲，腹胀、纳差、肝面容有所缓解。
无效：病症无变化。
3）治疗方法：口服本发明实施例1每次20毫升，每日3次，饭后半小时，3个月为一个疗程。
4）治疗结果：患者服用本发明实施例1中药口服液，1个月后症状即有缓解，服用3个月后，症状明显改善。临床实验的26人，其中显效15人，有效10人，无效1人，总有效率96.1％。
实施例5：
典型病例：关某，35岁，男，患慢性肝炎1年烦躁、口渴、便秘、尿赤，服用该发明1个月后症状即有缓解，服用3个月后，症状明显改善，三个疗程后检查肝功能正常，自觉症状消失。
实施例6：
典型病例：高某，47岁，女，患慢性肝炎2年，烦躁、口渴、便秘、尿赤，服用该发明1个月后症状即有缓解，服用3个月后，症状明显改善，三个疗程后检查肝功能正常，自觉症状消失。
Claims (1)
1.一种治疗慢性肝炎茵陈中药口服液的制备方法，其特征在于：具体步骤如下
取茵陈180份、白术100份、土茯苓75份、黄芪75份、郁金150份、枳实150份、炙甘草40份，用水煎煮二次，每次用水量为药材重量的8-10倍量，煎煮二次，每次l-2小时，滤过，滤液浓缩成在60-65℃测相对密度为1．10-1．25的清膏，加乙醇至使含乙醇量为60％，搅匀，静置24小时，滤过，取滤液回收乙醇，浓缩成含固体重量65-67％的浸膏，加入蔗糖20％、炼蜜12％、防腐剂1-3％，原液灌封，辐照灭菌，包装成品，制成口服液，即得。
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Non-Patent Citations (3)
| Title |
|---|
| 张兆旺.口服液.《中药药剂学》.中国中医药出版社,2003,第159页. * |
| 杨颖林.浅谈肝炎中医治疗原则.《光明中医》.1999,第14卷(第82期),第15-16页. |
| 浅谈肝炎中医治疗原则;杨颖林;《光明中医》;19990331;第14卷(第82期);第15-16页 * |
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