CN102698119B - Perioperative mouth cleaning nursing drug and preparation method thereof - Google Patents
Perioperative mouth cleaning nursing drug and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a perioperative mouth cleaning nursing drug for preventing postoperative respiratory tract infection and a preparation method thereof. The perioperative mouth cleaning nursing drug is characterized by being prepared from the following medicinal raw materials in proportion by weight: fructus arctii, pterospermum leaf, dried tangerine or orange peel, paeonia suffruticosa, semen arecae, rhizoma anemarrhenae, radix scrophulariae, rhizoma acori talarinowii, honeysuckle, pinellia ternate, bamboo shavings, gypsum, prepared radix licorice and clamshell powder. The preparation method comprises the following steps: 1, extracting volatile oil from fructus arctii, pterospermum leaf, dried tangerine or orange peel, paeonia suffruticosa, semen arecae, rhizoma anemarrhenae, radix scrophulariae, rhizoma acori talarinowii and honeysuckle for later use; 2, decocting pinellia ternate, bamboo shavings, gypsum, prepared radix licorice and clamshell powder with water twice, and mixing the decoctions; 3, filtering the decoctions, carrying out ultrafiltration to obtain ultrafiltrate; and 4, spraying the mixed volatile oil into the ultrafiltrate, mixing evenly, disinfecting and subpackaging. Proved by clinical experiments, the perioperative mouth cleaning nursing drug prepared by the preparation method according to the formula can achieve the function of reducing respiratory tract infection when used for oral cavity nursing before and after an operation, has good palatable feeling, thus being worthy of clinical application and popularization.
Description
Technical field
The present invention relates to medical care, be specifically related to clean mouthful of nursing medicine of peri-operation period use and preparation method thereof.
Background technology
Respiratory tract infection is common complication after operation, a statistics as Heling etc. shows: after the surgical operation intubate rate of respiratory infection up to 17.0%, this during with surgery anesthesia tracheal intubation, operation technique cause diaphragmatic function damage, respiratory function decline, the postoperative inferior factor of having a low resistance relevant.Especially general anesthesia or comatose patient because cough and swallowing reflex weaken or disappear, and are detained respiratory secretions, and the probability of generation respiratory tract infection is higher.The oral cavity as the door of various bacterial invasions, is to cause organism infection, especially the major reason of respiratory tract infection.
The mouth care of peri-operation period is all generally that before art, routine is brushed teeth at present, and postoperative adopts traditional oral care method, namely uses inside, cotton balls wiping oral cavity.This kind oral care method, the pre-operative patients oral mucosa is generally all intact, brushes teeth in the preoperative and can only the physics cleaning remove the part noxious bacteria, and often break because the reasons such as anesthetic intubate cause oral mucosa after surgery, carry out conventional mouth care, relatively poor to the cleaning effect in oral cavity.Clinical mouth care mouthwash solution commonly used has: normal saline, a Bei Shi solution, 1% ~ 3% hydrogenperoxide steam generator, 0.08% metronidazole solution, though they have certain cleaning oral cavity, the effect such as antibacterial, but selectivity, unicity due to bacteriostasis, effectively the complication such as prevention of oral infections occurs, not good enough to the counteract oral malodour texts, taste, mouthfeel are not good enough yet, have simultaneously certain side effect, make some patients were be reluctant to accept and impact effect.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of effect certainly, and the clean mouth that the acceptant peri-operation period of patient uses is nursed medicine and preparation method thereof.
The technical scheme that the present invention solves its technical problem is: the clean mouthful of nursing medicine that a kind of peri-operation period uses, it is characterized in that being made by the crude drug of following weight proportion: 10 ~ 30 parts of Fructus Arctiis, 6 ~ 12 parts of Folium Pterospermi Heterophyllis, 3 ~ 10 parts of the Rhizoma Pinelliaes, 6 ~ 12 parts of Caulis Bambusae In Taenia, 3 ~ 10 parts of Semen Arecaes, 6 ~ 12 parts, Gypsum Fibrosum, 6 ~ 12 parts of Pericarpium Citri Reticulataes, 6 ~ 12 parts of Rhizoma Alismatis, 6 ~ 12 parts of Cortex Moutans, 9 ~ 15 parts of the Rhizoma Anemarrhenaes, 3 ~ 10 parts of Radix Glycyrrhizae Preparatas, 15 ~ 30 parts of Radix Scrophulariaes, 15 ~ 30 parts of Flos Loniceraes, 3 ~ 9 parts of Rhizoma Acori Graminei, 10 ~ 25 parts of Pulvis concha Anodonta seu Cristaria.
Chinese medicine of the present invention is that the raw material by following optimum weight part proportioning is prepared from: 20 parts of Fructus Arctiis, 10 parts of Folium Pterospermi Heterophyllis, 6 parts of the Rhizoma Pinelliaes, 10 parts of Caulis Bambusae In Taenia, 6 parts of Semen Arecaes, 10 parts, Gypsum Fibrosum, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Rhizoma Alismatis, 10 parts of Cortex Moutans, 12 parts of the Rhizoma Anemarrhenaes, 6 parts of Radix Glycyrrhizae Preparatas, 20 parts of Radix Scrophulariaes, 20 parts of Flos Loniceraes, 6 parts of Rhizoma Acori Graminei, 20 parts of Pulvis concha Anodonta seu Cristaria.
Chinese medicinal preparation method of the present invention can comprise the following steps:
(1) coarse powder after Fructus Arctii, Folium Pterospermi Heterophylli, Pericarpium Citri Reticulatae, Cortex Moutan, Semen Arecae, the Rhizoma Anemarrhenae, Radix Scrophulariae, Rhizoma Acori Graminei, Flos Lonicerae pulverizing is extracted volatile oil with vapor distillation respectively, and mixing for standby use after collecting;
(2) Rhizoma Pinelliae, Caulis Bambusae In Taenia, Gypsum Fibrosum, Rhizoma Alismatis, Radix Glycyrrhizae Preparata, Pulvis concha Anodonta seu Cristaria mixing are added 5 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction;
(3) with after gained decocting liquid filtration in step 2, carry out ultrafiltration with micropore filtering film, get ultrafiltrate;
(4) gained mixed volatilization oil in step 1 is sprayed in step 3 gained ultrafiltrate mixing, sterilization, packing.
Wherein said: Fructus Arctii is the mature fruit of feverfew Fructus Arctii Arctium lappa L..Nature and flavor are hot, bitter, and are cold.Enter lung, stomach warp.But the merit dispelling wind and heat pathogens, expelling phlegm for arresting cough, heat-clearing and toxic substances removing.
Folium Pterospermi Heterophylli is the leaf of Sterculiaceae plant Folium potentillae velutinae (Radix Potentillae Fulgentis) tree Pterospermum heterophyllum Hance or Radix Pterospermi lanceaefolii Pterospermum lanceaefolium Roxb..Nature and flavor are sweet; Light; Tepor.Return liver; Spleen channel.But merit promoting blood circulation and hemostasis.
The Rhizoma Pinelliae is the tuber of aroid Rhizoma Pinelliae Pinellia ternata (Thunb.) Breit., and nature and flavor are hot, temperature.Return spleen, stomach, lung meridian.But the merit drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.
Caulis Bambusae In Taenia is the dry intermediate layer of the stem stalk of grass bambusa breviflora Munro Bambusa tuldoides Munro, major part allusion quotation bamboo Sinocalamus beecheyanus (Munro) Mc-Clure var. pubescens P.F.Li or phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle Phyllostachys nigra (Lodd.) Munro var. henonis (Mitf.) Stapf ex Rendle.Nature and flavor are sweet, are slightly cold.Attach to the lung and stomach meridians.But the merit removing heat-phlegm relieves restlessness and prevents vomiting.
Semen Arecae is the dry mature seed of babassu Semen Arecae Areca catechu L..Nature and flavor are bitter, hot, temperature.Return stomach, large intestine channel.But the merit killing insect and eliminating accumulation, sending down the abnormal ascending QI, row water, preventing the attack (or recurrence) of malaria.
Gypsum Fibrosum is monoclinic calcium sulfate Ore.Nature and flavor are hot, sweet, Great Cold.Enter lung, stomach warp.But the merit clearing away heat-fire, the convergence granulation promoting.
Pericarpium Citri Reticulatae is the dry mature skin of rutaceae orange Citrus reticulata Blanco and variety thereof.Nature and flavor are bitter, hot, temperature.Return lung, spleen channel.But the merit regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.
Rhizoma Alismatis is the dry tuber of Notes On Alism At Aceae Rhizoma Alismatis Alisma orientalis (Sam.) Juzep..Nature and flavor are sweet, and are cold.Return kidney, urinary bladder channel.But the merit diuresis, clearing away damp-heat.
Cortex Moutan is the root bark of ranunculaceae peony Paeonia suffruticosa Andr..Nature and flavor are hot, bitter, are slightly cold.Enter the heart, liver, kidney channel.But the merit clearing away heat and cooling blood, promoting blood circulation to remove blood stasis.
The Rhizoma Anemarrhenae is the rhizome of liliaceous plant Rhizoma Anemarrhenae Anemarrhena asphodeloides Bunge..Nature and flavor are bitter, and are cold.Enter lung, stomach, kidney channel.But the merit clearing away heat-fire, nourishing kidney is moisturized.
Radix Glycyrrhizae Preparata is concocted through processing for the dry root of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L. and is formed.Nature and flavor are sweet, and are flat.GUIXIN, lung, spleen, stomach warp.But the merit invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
Radix Scrophulariae is the root of goatweed Radix Scrophulariae Scrophularia ningpoensisHemsl..Nature and flavor are bitter, salty, and are cold.Enter spleen, stomach, kidney channel.But merit heat clearing away YIN nourishing, eliminating fire and detoxication.
Flos Lonicerae is the dry flower of caprifoliaceae plant Radix Ophiopogonis Lonicera japonica Thunb., Flos Lonicerae Lonicera hypoglauca Miq., Flos Lonicerae (hair calyx Radix Ophiopogonis) Lonicera confusa DC. or hair style Radix Ophiopogonis Lonicera dasystyla Rehd. or the flower that band is just opened.Nature and flavor are sweet, and are cold.Enter lung, stomach, the heart, spleen channel.But the merit heat-clearing and toxic substances removing, wind-heat dissipating.
Rhizoma Acori Graminei is the dry rhizome of acorus gramineus araceae plant Acorus tatarinowii Schott.Nature and flavor are hot, bitter, temperature.GUIXIN, stomach warp.But merit removing dampness appetizing, the eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.
Pulvis concha Anodonta seu Cristaria is Unionidae animal cristaria plicata Crostaroa plicata(Leach), hydriopsis cumingii Hyriopsis cumingii(Lea) and anodonta woodiana pacifica Anodonta woodiana(Lea) etc. the powder made of the shell of fresh water production.Salty in the mouth; Cold in nature.Return lung; Kidney; Liver Channel.But merit heat clearing away; Dampness removing reduces phlegm; Softening the hard mass.
Composition principle: the postoperative Abwehrkraft des Koepers is low, and mouth, pharynx, nose bacterial isolates are many, take gram-negative bacteria as main, are the main sources of iatrogenic Bacteria infecting respiratory, operate by invasive, bring the pars oralis pharyngis antibacterial into respiratory tract during as tracheal intubation.But, due to the friction of tracheal intubation and bite-block, cause the local ulcer of oral mucosa, erosion; A large amount of antibiotic are used and are easily caused dysbacteriosis in addition, encouraged the abnormal breeding of oral cavity bacterium, cause oral secretion not swallow, remain in and become vegetative culture medium in the oral cavity, thereby make some intraoral special conditioned pathogens enter trachea, also can cause respiratory tract infection.The multiformity of pathogenic bacterium makes single inhibiting-bacteria preparation be difficult to reach the best preventive infectious effect.From the Chinese point of view, oral cavity flora causes the pathogenesis of postoperative respiratory tract infection to be to steam on postoperative heart spleen intrinsic heat, the part is damp and hot, fire-toxin is entangled with, meet in ailment said due to cold or exposure and close the bottom of heart, the heat-transformation of reducing phlegm in entering, therefore answer dispelling wind, heat clearing away, dampness, side of the present invention gets Fructus Arctii, Flos Lonicerae heat-clearing and toxic substances removing, dispelling wind and heat pathogens; Gypsum Fibrosum, Rhizoma Anemarrhenae clearing away heat-fire, the detoxifcation of Radix Scrophulariae heat clearing away YIN nourishing; The Rhizoma Pinelliae, Pericarpium Citri Reticulatae drying dampness to eliminate phlegm, Caulis Bambusae In Taenia removing heat-phlegm, Rhizoma Alismatis clearing away damp-heat, Rhizoma Acori Graminei removing dampness; The Semen Arecae parasite killing; Pulvis concha Anodonta seu Cristaria removing heat-phlegm softening the hard mass; Gypsum Fibrosum convergence granulation promoting; The Cortex Moutan clearing away heat and cooling blood is invigorated blood circulation; And the Folium Pterospermi Heterophylli promoting blood circulation and hemostasis; Radix Glycyrrhizae Preparata and medicine.
Compared with prior art, the present invention has the following feature that has:
1, reasonable recipe, except dispelling wind, heat clearing away, dampness, can also killing pests and suppressing bacteria, increase local blood circulation, reduce the oral cavity inflammatory reaction;
2, be aided with warm medicine in one cold and cool medicine, avoided the bitter cold gas that injures one's stomach;
3, preparation carries out differentiated treatment according to the medicine taste, has avoided the bitterness impact of individual drug, and has taked the ultrafiltration preparation, has reduced residue content in medicine, reduces the discomfort of taste mouthfeel.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: 10 parts of Fructus Arctiis, 6 parts of Folium Pterospermi Heterophyllis, 3 parts of the Rhizoma Pinelliaes, 6 parts of Caulis Bambusae In Taenia, 3 parts of Semen Arecaes, 6 parts, Gypsum Fibrosum, 6 parts of Pericarpium Citri Reticulataes, 6 parts of Rhizoma Alismatis, 6 parts of Cortex Moutans, 9 parts of the Rhizoma Anemarrhenaes, 3 parts of Radix Glycyrrhizae Preparatas, 15 parts of Radix Scrophulariaes, 15 parts of Flos Loniceraes, 3 parts of Rhizoma Acori Graminei, 10 parts of Pulvis concha Anodonta seu Cristaria.
Embodiment 2, the crude drug weight proportion: 20 parts of Fructus Arctiis, 10 parts of Folium Pterospermi Heterophyllis, 6 parts of the Rhizoma Pinelliaes, 10 parts of Caulis Bambusae In Taenia, 6 parts of Semen Arecaes, 10 parts, Gypsum Fibrosum, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Rhizoma Alismatis, 10 parts of Cortex Moutans, 12 parts of the Rhizoma Anemarrhenaes, 6 parts of Radix Glycyrrhizae Preparatas, 20 parts of Radix Scrophulariaes, 20 parts of Flos Loniceraes, 6 parts of Rhizoma Acori Graminei, 20 parts of Pulvis concha Anodonta seu Cristaria.
Embodiment 3, crude drug weight proportion: 30 parts of Fructus Arctiis, 12 parts of Folium Pterospermi Heterophyllis, 10 parts of the Rhizoma Pinelliaes, 12 parts of Caulis Bambusae In Taenia, 10 parts of Semen Arecaes, 12 parts, Gypsum Fibrosum, 12 parts of Pericarpium Citri Reticulataes, 12 parts of Rhizoma Alismatis, 12 parts of Cortex Moutans, 15 parts of the Rhizoma Anemarrhenaes, 10 parts of Radix Glycyrrhizae Preparatas, 30 parts of Radix Scrophulariaes, 30 parts of Flos Loniceraes, 9 parts of Rhizoma Acori Graminei, 25 parts of Pulvis concha Anodonta seu Cristaria.
Chinese medicine of the present invention can be prepared from by following method:
(1) coarse powder after Fructus Arctii, Folium Pterospermi Heterophylli, Pericarpium Citri Reticulatae, Cortex Moutan, Semen Arecae, the Rhizoma Anemarrhenae, Radix Scrophulariae, Rhizoma Acori Graminei, Flos Lonicerae pulverizing is extracted volatile oil with vapor distillation respectively, and mixing for standby use after collecting;
(2) Rhizoma Pinelliae, Caulis Bambusae In Taenia, Gypsum Fibrosum, Rhizoma Alismatis, Radix Glycyrrhizae Preparata, Pulvis concha Anodonta seu Cristaria mixing are added 5 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction;
(3) with after gained decocting liquid filtration in step 2, carry out ultrafiltration with micropore filtering film, get ultrafiltrate;
(4) gained mixed volatilization oil in step 1 is sprayed in step 3 gained ultrafiltrate mixing, sterilization, packing.
Wherein the ultrafiltration technology condition can for: the microporous filter membrane aperture is 0.05mm, and transmembrane pressure is 0.05MPa, and temperature is room temperature.
Effective combination of said medicine is coordinated mutually, effectively reach the purpose of peri-operation period mouth care, and patient adaptability is better.The above results is the clinical data sufficient proof, and interrelated data is as follows, and wherein drugs uses and is crude drug weight proportion and preparation method in embodiment 2.
1 object and method.
1.1 object: the Patients Undergoing Elective Surgery of 100 customary general anesthesia intubate.By single even numbers random packet, odd number is treatment group 50 examples, male 29 examples, female's 21 examples, 21 ~ 71 years old age, average 50.8 years old with the patient.Intestinal resection 19 examples wherein, enterodialysis 10 examples, partial gastrectomy 13 examples, gastric perforation cleaning kposthesis 8 examples.Even numbers is matched group 50 examples, male 28 examples, female's 22 examples, 24 ~ 72 years old age, average 51.5 years old.Intestinal resection 20 examples wherein, enterodialysis 10 examples, partial gastrectomy 12 examples, gastric perforation cleaning kposthesis 8 examples.The situations such as two groups of sexes, age, kinds of Diseases, type of surgery, smoking relatively, difference not statistically significant (P〉0.05) has comparability.All use disposable intubate thing in two groups of arts, the anesthesia procedure person is same people, equal intubate success.
1.2 method: the clean mouthful of nursing medicine that the crude drug weight proportion in the treatment group use embodiment of the present invention 2 and preparation method are prepared, matched group uses Dobell's solution (a Bei Shi solution).Two groups all in the preoperative, postoperative all carries out mouth care, every day 2 times.The cotton balls scouring method that the oral cavity cleaning method is introduced according to " Fundamental Nursing " is carried out.Its operating procedure is: advise patient's head to raise 30 °, dehisce to send " " sound with abundant exposure bottleneck throat, use throat swab gently on wiping patient's upper lower gum, tongue, Sublingual, lingual surface, both sides palatine arches, buccal, pharyngeal, wipe and rapidly swab is inserted jam-pack in culture tube afterwards, then gargle with warm water.Clean successively tooth outside, inner face, occlusal surface, buccal, hard palate, lingual surface and Sublingual, until clean.Finish assess patient mouth comfort after mouth care, i.e. note in scouring process observing the patient have or not choke cough, feel sick, the situation generation such as vomiting.
1.3 observation index.
1.3.1 mouth comfort evaluation: adopt Organoleptic method, with integer integration record, 0=is without sense of discomfort, the slight unhappy mouthfeel of 1=, and the unhappy mouthfeel of 2=moderate, 3=is strongly uncomfortable, and 4=refuse use.
1.3.2 throat swab is cultivated: before art, postoperative dipped in normal saline with the sterile cotton swab respectively on the 1st day, dab patient both sides pharyngeal recess, taking-up is placed in sterilizing test tubes, send Bacteriology Room to do cultivation.
1.3.3 observe two groups of patient's pharyngalgia, situation and transference cure time appears in the symptom of coughing, cough up phlegm.
1.4 statistical analysis SPSS 13.0 carries out statistical analysis.Measurement data adopts mean ± standard deviation to carry out descriptive statistics, and the variation before and after treatment adopts rank test and t check to compare, and enumeration data adopts frequency, constituent ratio to carry out descriptive statistics.
2 results.
2.1 mouth comfort relatively: two groups of scorings are compared, and treatment group (1.23 ± 0.86) obviously is better than matched group (1.9l ± 1.34), P＜0.05.
2.2 two groups of pharynx examination the positive, pharyngalgia, the incidence rates of coughing, cough up phlegm compare: treatment group pharynx examination the positive, pharyngalgia, the incidence rate of coughing, cough up phlegm are more all lower than matched group, and difference has statistical significance (P＜0.05).See the following form.
| Group | Number of cases | Pharynx examination is positive | Pharyngalgia | Cough | Cough up phlegm |
| Treatment group | 50 | 12（24%） | 14（28%） | 13（26%） | 9（18%） |
| Matched group | 50 | 17（34%） | 19（38%） | 18（36%） | 11（22%） |
2.3 two groups of pharyngalgia, the extinction times of coughing, cough up phlegm are relatively: the treatment group pharyngalgia, transference cure time (14.45 ± 0.75d coughs, coughs up phlegm, 8.38 ± 0.58 d, 8.25 ± 1.55 d) early than matched group (18.45 ± 0.54 d, 11.37 ± 0.65 d, 11.28 ± 1.54 d), difference has statistical significance (P＜0.05).
3. conclusion.
The clean mouthful of nursing medicine that the prompting of this result of study, the prepared peri-operation period of prescription of the present invention and preparation method are used is used for the effect that the perioperatively mouth care can reduce respiratory tract infection, and agreeable to the taste sense well, and clinic is used, promoted.
Claims (2)
1. nurse medicine for clean mouthful of a peri-operation period use, it is characterized in that being made by the crude drug of following weight proportion: 10 ~ 30 parts of Fructus Arctiis, 6 ~ 12 parts of Folium Pterospermi Heterophyllis, 3 ~ 10 parts of the Rhizoma Pinelliaes, 6 ~ 12 parts of Caulis Bambusae In Taenia, 3 ~ 10 parts of Semen Arecaes, 6 ~ 12 parts, Gypsum Fibrosum, 6 ~ 12 parts of Pericarpium Citri Reticulataes, 6 ~ 12 parts of Rhizoma Alismatis, 6 ~ 12 parts of Cortex Moutans, 9 ~ 15 parts of the Rhizoma Anemarrhenaes, 3 ~ 10 parts of Radix Glycyrrhizae Preparatas, 15 ~ 30 parts of Radix Scrophulariaes, 15 ~ 30 parts of Flos Loniceraes, 3 ~ 9 parts of Rhizoma Acori Graminei, 10 ~ 25 parts of Pulvis concha Anodonta seu Cristaria.
2. clean mouthful of nursing medicine of a kind of peri-operation period use according to claim 1, is characterized in that being made by the crude drug of following weight proportion: 20 parts of Fructus Arctiis, 10 parts of Folium Pterospermi Heterophyllis, 6 parts of the Rhizoma Pinelliaes, 10 parts of Caulis Bambusae In Taenia, 6 parts of Semen Arecaes, 10 parts, Gypsum Fibrosum, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Rhizoma Alismatis, 10 parts of Cortex Moutans, 12 parts of the Rhizoma Anemarrhenaes, 6 parts of Radix Glycyrrhizae Preparatas, 20 parts of Radix Scrophulariaes, 20 parts of Flos Loniceraes, 6 parts of Rhizoma Acori Graminei, 20 parts of Pulvis concha Anodonta seu Cristaria.
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| CN104825898A (en) * | 2015-05-28 | 2015-08-12 | 梁志刚 | Preparation method of drug for relieving bleeding of elder people after tooth extraction |
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| CN1895585A (en) * | 2006-06-28 | 2007-01-17 | 陈江 | Breath freshening beverage |
| CN101085089A (en) * | 2007-06-29 | 2007-12-12 | 李文 | Gargle medicine for treating stomatocase |
| CN101391011A (en) * | 2008-11-03 | 2009-03-25 | 朱惠芬 | Pure Chinese herbal medicine gargle water for treating oral inflammation |
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