CN102698009A - Medicine composition for treating migraine and preparation method thereof - Google Patents
Medicine composition for treating migraine and preparation method thereof Download PDFInfo
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- CN102698009A CN102698009A CN2012101514361A CN201210151436A CN102698009A CN 102698009 A CN102698009 A CN 102698009A CN 2012101514361 A CN2012101514361 A CN 2012101514361A CN 201210151436 A CN201210151436 A CN 201210151436A CN 102698009 A CN102698009 A CN 102698009A
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Abstract
The invention discloses a medicine composition for treating migraine. The medicine composition comprises the following raw materials by weight parts: 20-40 parts of ligusticum chuanxiong, 20-40 parts of asarum sieboldii, 20-40 parts of radix angelicae dahuricae, 20-40 parts of white peony root, 10-20 parts of saposhnicovia divaricata, 10-20 parts of herba ephedra, 10-20 parts of pinellia ternate, 10-20 parts of notopterygium root, 10-20 parts of rhizoma corydalis and 10-20 parts of radix glycyrrhizae. The medicine composition for treating migraine provided by the invention is good in treating effect, low in toxic and side effects and convenient in preparation method, thereby being fitting for clinical application.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition of treating migraine.
Background technology
Migraine is a kind of because the cephalagia that vasomotor dysfunction causes.The cyclicity cephalagia can be arranged repeatedly clinically, feel sick, vomit, keep in dark place, symptom such as giddy, pathogenesis is a blood vessel outside the local intracranial that on the heredodiathesis basis, forms, to the paroxysmal abnormal response of nerve-body fluid regulatory mechanism.
Though some Western medicine such as 5-hydroxytryptamine receptor agonist, Ergota amine medicine, NSAID and opium analgesics are being obtained bigger progress aspect the acute attack of alleviation migraine; Light, moderate migraine there is certain analgesic effect; But only be symptomatic treatment; Can not effect a radical cure, and these symptomatic treatments are not all effective to all migraine patients.And the frequent person that shows effect is as often taking analgesic, and effect can also can be brought serious toxic and side effects worse and worse, and is especially very big to lesions of liver and kidney, and is prone to produce medicine according to patience.
Chinese medicine has special advantages aspect the treatment migraine abundant theory and practice experience being arranged, and has potential advantage and wide development prospect.
Summary of the invention
Goal of the invention:, the invention provides a kind of pharmaceutical composition of treating migraine and preparation method thereof in order to solve the defective that medication effect is poor, toxic and side effects is big of existing treatment migraine.
Technical scheme: in order solving the problems of the technologies described above, to the invention provides a kind of pharmaceutical composition of treating migraine, to comprise Rhizoma Chuanxiong 20-40 weight portion; Herba Asari 20-40 weight portion, Radix Angelicae Dahuricae 20-40 weight portion, Radix Paeoniae Alba 20-40 weight portion; Windproof 10-20 weight portion, Herba Ephedrae 10-20 weight portion, Rhizoma Pinelliae 10-20 weight portion; Rhizoma Et Radix Notopterygii 10-20 weight portion, Rhizoma Corydalis 10-20 weight portion, Radix Glycyrrhizae 10-20 weight portion.
Pharmaceutical composition provided by the invention, preferred: as to comprise Rhizoma Chuanxiong 30 weight portions, Herba Asari 30 weight portions, the Radix Angelicae Dahuricae 30 weight portions; The Radix Paeoniae Alba 30 weight portions, windproof 15 weight portions, Herba Ephedrae 15 weight portions, the Rhizoma Pinelliae 15 weight portions; Rhizoma Et Radix Notopterygii 15 weight portions, Rhizoma Corydalis 15 weight portions, Radix Glycyrrhizae 15 weight portions.
The present invention also provides a kind of preparation of drug combination method of treating migraine, may further comprise the steps:
(1) takes by weighing Herba Cistanches 20-40 weight portion, Radix Astragali 20-40 weight portion, Radix Salviae Miltiorrhizae 20-40 weight portion, Herba Epimedii 20-40 weight portion, Radix Polygalae 20-40 weight portion, Rhizoma Chuanxiong 10-20 weight portion, Fructus Alpiniae Oxyphyllae 10-20 weight portion, Radix Angelicae Sinensis 10-20 weight portion, Rhizoma Atractylodis Macrocephalae 10-20 weight portion, Poria 10-20 weight portion respectively, get the mixed material medicine;
(2) with said mixed material medicine decocte with water twice, for the first time amount of water be mixed material medicine gross weight 3-5 doubly, decoct and extract 1h; For the second time amount of water be mixed material medicine gross weight 2-3 doubly, decoct and extract 30min, all filter after each the decoction; Merge filtrating twice; Concentrating under reduced pressure gets extractum, is the pharmaceutical composition of said treatment migraine.
Beneficial effect: the medicine composite for curing of treatment migraine provided by the invention is effective, toxic and side effects is little, and is cheap, method for preparing is easy, is suitable for clinical practice.
The specific embodiment
According to following embodiment, can understand the present invention better.Yet, those skilled in the art will readily understand that the described concrete material proportion of embodiment, process conditions and result thereof only are used to explain the present invention, and the present invention that should also can not limit in claims to be described in detail.
Embodiment 1: the pharmaceutical composition 1 of treatment migraine.
Prescription: Rhizoma Chuanxiong 300g, Herba Asari 300g, Radix Angelicae Dahuricae 300g, Radix Paeoniae Alba 300g, windproof 300g, Herba Ephedrae 150g, Rhizoma Pinelliae 150g, Rhizoma Et Radix Notopterygii 150g, Rhizoma Corydalis 150g, Radix Glycyrrhizae 150g.
Method for preparing:
Take by weighing Rhizoma Chuanxiong 300g, Herba Asari 300g, Radix Angelicae Dahuricae 300g, Radix Paeoniae Alba 300g, windproof 300g, Herba Ephedrae 150g, Rhizoma Pinelliae 150g, Rhizoma Et Radix Notopterygii 150g, Rhizoma Corydalis 150g, Radix Glycyrrhizae 150g respectively, get the mixed material medicine;
With said mixed material medicine decocte with water twice, add water 9L for the first time and decoct extraction 1h, add water 5.6L decoction for the second time and extract 30min; All filter after each the decoction, merge filtrating twice, concentrating under reduced pressure; Get extractum, be the pharmaceutical composition 1 of said treatment migraine.
Embodiment 2: the pharmaceutical composition 2 of treatment migraine.
Prescription: Rhizoma Chuanxiong 400g, Herba Asari 400g, Radix Angelicae Dahuricae 200g, Radix Paeoniae Alba 200g, windproof 200g, Herba Ephedrae 200g, Rhizoma Pinelliae 200g, Rhizoma Et Radix Notopterygii 200g, Rhizoma Corydalis 100g, Radix Glycyrrhizae 100g.
Method for preparing:
Take by weighing Rhizoma Chuanxiong 400g, Herba Asari 400g, Radix Angelicae Dahuricae 200g, Radix Paeoniae Alba 200g, windproof 200g, Herba Ephedrae 200g, Rhizoma Pinelliae 200g, Rhizoma Et Radix Notopterygii 200g, Rhizoma Corydalis 100g, Radix Glycyrrhizae 100g respectively, get the mixed material medicine;
With said mixed material medicine decocte with water twice, add water 6.6L for the first time and decoct extraction 1h, add water 4.4L decoction for the second time and extract 30min; All filter after each the decoction, merge filtrating twice, concentrating under reduced pressure; Get extractum, be the pharmaceutical composition 2 of said treatment migraine.
Embodiment 3: the pharmaceutical composition 3 of treatment migraine.
Prescription: Rhizoma Chuanxiong 200g, Herba Asari 200g, Radix Angelicae Dahuricae 400g, Radix Paeoniae Alba 400g, windproof 400g, Herba Ephedrae 100g, Rhizoma Pinelliae 100g, Rhizoma Et Radix Notopterygii 100g, Rhizoma Corydalis 200g, Radix Glycyrrhizae 200g.
Method for preparing:
Take by weighing Rhizoma Chuanxiong 200g, Herba Asari 200g, Radix Angelicae Dahuricae 400g, Radix Paeoniae Alba 400g, windproof 400g, Herba Ephedrae 100g, Rhizoma Pinelliae 100g, Rhizoma Et Radix Notopterygii 100g, Rhizoma Corydalis 200g, Radix Glycyrrhizae 200g respectively, get the mixed material medicine;
With said mixed material medicine decocte with water twice, add water 11.5L for the first time and decoct extraction 1h, add water 6.9L decoction for the second time and extract 30min; All filter after each the decoction, merge filtrating twice, concentrating under reduced pressure; Get extractum, be the pharmaceutical composition 3 of said treatment migraine.
Embodiment 4: the evaluating drug effect of the pharmaceutical composition of treatment migraine; Influence to nitroglycerin rat number of times difficult to tackle.
1, laboratory animal and modeling
60 of regular grade SD rats, male and female half and half, body weight 200-230g; Be divided into 6 groups after weighing at random, 10 every group; Be respectively: the blank group, model control group, positive controls, the present invention treat migraine pharmaceutical composition 1 high, medium and low dose groups.
Blank group rat skin lower injection normal saline 1.0mL/kg; All the other group rat skin lower injection Nitro-Bid 9.5mg/kg set up experimental Nerve in Migraine Model, and ears are rubescent, forelimb is frequently scratched one's head to occur, climb the uncomfortable symptom of hints model animal head such as cage increased frequency is the successful index of modeling.
2, experiment medicine
Positive control drug: the Sumatriptan Succinate sheet, produce by Simcere Pharmaceutical Co., Ltd., be made into the solution of 0.45mg/mL with deionized water.
Treatment migraine pharmaceutical composition 1: the migrainous pharmaceutical composition of treatment by embodiment 1 preparation is mixed with the 25mg/ml suspension with deionized water.
Treatment migraine pharmaceutical composition 2: the migrainous pharmaceutical composition of treatment by embodiment 2 preparations is mixed with the 25mg/ml suspension with deionized water.
Treatment migraine pharmaceutical composition 3: the antineoplastic pharmaceutical compositions by embodiment 3 preparations is mixed with the 25mg/ml suspension with deionized water.
3, experimental technique and result
Blank group and model group are irritated stomach distilled water 1.0mL/kg; All the other groups are used the relative medicine gastric infusion respectively, and number of times that (30min, 60min, 90min) forelimb is scratched one's head in symptom time of occurrence difficult to tackle and the unit interval section after the observation administration and appearance difficult to tackle and the time of alleviating, the gained result sees table 1.
The influence of table 1 pair nitroglycerin Migraine Rats number of times difficult to tackle
Wherein high dose group, middle dose groups, low dose group are compared with model control group, and significant difference P < 0.01 is arranged.
The influence of the appearance difficult to tackle of table 2 pair nitroglycerin Migraine Rats, remission time
Wherein high dose group, middle dose groups, low dose group are compared with model control group, and significant difference P < 0.01 is arranged.
The result of table 1 and table 2 shows that high, medium and low three dose groups of the present invention all can significantly reduce the rat migraine frequency difficult to tackle due to the nitroglycerin, compare with model control group, have significant difference.
Embodiment 5: clinical research
1, case is selected
Adopt the present invention to treat the medicine composite for curing migraineur of migraine, treatment selects 100 examples to have the migraine patient altogether, male 37 examples, and women 63 examples, the age is in 15-81 year, 57 years old mean age.
The medicine of taking this method preparation is after one week, and the recovery from illness patient of clinical symptoms complete obiteration is 51 people, and cure rate is 51%.The produce effects patient that clinical symptoms disappears basically is 39 people, and obvious effective rate is 39%.Effective patient that clinical symptoms partly disappears is 9 people, and total effective rate is 8%, and clinical symptoms does not have 1 people that has of improvement, and total inefficiency is 1%.Continue medication, after three weeks of medication, the recovery from illness patient of clinical symptoms complete obiteration has 85 people, and cure rate is 85%, and clinical symptoms disappears basically has 13 people, and clinical symptoms has 2 people of improvement.In therapeutic process, do not see obvious adverse effect and toxic and side effects, do not find the phenomenon of liver,kidney,spleen, stomach upset.
2., model case
The Wang, woman, 59 years old, the Guo Zhuan of Jurong City people from town.The patient often has a headache, and is main with forehead and right side temple, gives oral somedon.Through after six months, the headache sx, pain is taken the present invention and is treated migrainous medicine after two weeks unbearably sometimes, and the patient has a headache and obviously alleviates, and symptom is clearly better, after one month the after treatment, the clinical symptoms complete obiteration.
Liu, woman, 37 years old, Jurong City Flos Jasmini Nudiflori people from town.Cause is quarreled with neighbours, and the side severe headache that happens suddenly with nausea and vomiting, is shed tears, has a stuffy nose and had a toothache, having a headache is non-pulsation, repeatedly outbreak in the set time.Take the present invention and treat migrainous medicine after two weeks, patient's symptom is clearly better, adhere to one month after treatment after, the clinical symptoms complete obiteration.
Money, man, 73 years old, Jurong City white rabbit people from town.Patient's migraine before 3 years increases the weight of recently, and forehead and right side head be dull pain everyday almost, companion's vomiting, and numbness of hands and feet continues half a day to one day, and the sleep back takes a turn for the better, and goes to too much home hospitalize, DeGrain, the state of an illness is not felt any better.Take the present invention and treat migraine remedy after one month, symptom obviously alleviates, and after adhering to treating three months, does not reaccess so far.
Claims (3)
1. a pharmaceutical composition of treating migraine is characterized in that: comprise Rhizoma Chuanxiong 20-40 weight portion, Herba Asari 20-40 weight portion; Radix Angelicae Dahuricae 20-40 weight portion, Radix Paeoniae Alba 20-40 weight portion, windproof 10-20 weight portion; Herba Ephedrae 10-20 weight portion, Rhizoma Pinelliae 10-20 weight portion, Rhizoma Et Radix Notopterygii 10-20 weight portion; Rhizoma Corydalis 10-20 weight portion, Radix Glycyrrhizae 10-20 weight portion.
2. a kind of pharmaceutical composition of treating migraine according to claim 1 is characterized in that: comprise Rhizoma Chuanxiong 30 weight portions, Herba Asari 30 weight portions; The Radix Angelicae Dahuricae 30 weight portions, the Radix Paeoniae Alba 30 weight portions, windproof 15 weight portions; Herba Ephedrae 15 weight portions, the Rhizoma Pinelliae 15 weight portions, Rhizoma Et Radix Notopterygii 15 weight portions; Rhizoma Corydalis 15 weight portions, Radix Glycyrrhizae 15 weight portions.
3. the preparation of drug combination method of the described treatment migraine of claim 1 is characterized in that: may further comprise the steps:
(1) takes by weighing Herba Cistanches 20-40 weight portion, Radix Astragali 20-40 weight portion, Radix Salviae Miltiorrhizae 20-40 weight portion, Herba Epimedii 20-40 weight portion, Radix Polygalae 20-40 weight portion, Rhizoma Chuanxiong 10-20 weight portion, Fructus Alpiniae Oxyphyllae 10-20 weight portion, Radix Angelicae Sinensis 10-20 weight portion, Rhizoma Atractylodis Macrocephalae 10-20 weight portion, Poria 10-20 weight portion respectively, get the mixed material medicine;
(2) with said mixed material medicine decocte with water twice, for the first time amount of water be mixed material medicine gross weight 3-5 doubly, decoct and extract 1h; For the second time amount of water be mixed material medicine gross weight 2-3 doubly, decoct and extract 30min, all filter after each the decoction; Merge filtrating twice; Concentrating under reduced pressure gets extractum, is the pharmaceutical composition of said treatment migraine.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101514361A CN102698009A (en) | 2012-05-16 | 2012-05-16 | Medicine composition for treating migraine and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012101514361A CN102698009A (en) | 2012-05-16 | 2012-05-16 | Medicine composition for treating migraine and preparation method thereof |
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| CN102698009A true CN102698009A (en) | 2012-10-03 |
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| CN2012101514361A Pending CN102698009A (en) | 2012-05-16 | 2012-05-16 | Medicine composition for treating migraine and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105343409A (en) * | 2014-08-21 | 2016-02-24 | 李新民 | Formula for treating migraine |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1895438A (en) * | 2006-06-21 | 2007-01-17 | 三九医药股份有限公司 | Chinese-medicinal composition for treating cephalagia and its preparation |
| CN1931276A (en) * | 2005-10-08 | 2007-03-21 | 周小明 | Headache treating Chinese medicine composition and its prepn process |
| CN101129503A (en) * | 2007-09-13 | 2008-02-27 | 尹克华 | Traditional Chinese medicine for treating headache due to congealing cold |
| CN102225166A (en) * | 2011-06-02 | 2011-10-26 | 长治市郊区黄碾镇中心卫生院 | Medicament for treating prosopalgia and preparation method thereof |
-
2012
- 2012-05-16 CN CN2012101514361A patent/CN102698009A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1931276A (en) * | 2005-10-08 | 2007-03-21 | 周小明 | Headache treating Chinese medicine composition and its prepn process |
| CN1895438A (en) * | 2006-06-21 | 2007-01-17 | 三九医药股份有限公司 | Chinese-medicinal composition for treating cephalagia and its preparation |
| CN101129503A (en) * | 2007-09-13 | 2008-02-27 | 尹克华 | Traditional Chinese medicine for treating headache due to congealing cold |
| CN102225166A (en) * | 2011-06-02 | 2011-10-26 | 长治市郊区黄碾镇中心卫生院 | Medicament for treating prosopalgia and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 何永田 等: "《偏头痛的中医治疗概况》", 《长春中医学院学报》, vol. 11, no. 49, 30 September 1995 (1995-09-30) * |
| 周世明等: "中药治疗血管性头痛47例", 《陕西中医》, no. 07, 5 July 1990 (1990-07-05) * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105343409A (en) * | 2014-08-21 | 2016-02-24 | 李新民 | Formula for treating migraine |
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Application publication date: 20121003 |