CN102696632A - Bactericidal composition containing (E,E,E)-N-methyl-2-[((((1-methyl-3-(2,6-dichlorophenyl)-2-propenyl) imino)oxygen)methyl)phenyl]-2-methoxyl imino acetamide - Google Patents
Bactericidal composition containing (E,E,E)-N-methyl-2-[((((1-methyl-3-(2,6-dichlorophenyl)-2-propenyl) imino)oxygen)methyl)phenyl]-2-methoxyl imino acetamide Download PDFInfo
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Abstract
The invention discloses a bactericidal composition containing (E,E,E)-N-methyl-2-[((((1-methyl-3-(2,6-dichlorophenyl)-2-propenyl) imino)oxygen)methyl)phenyl]-2-methoxyl imino acetamide. The active ingredients of the bactericidal composition comprises a first active ingredient of (E,E,E)-N-methyl-2-[((((1-methyl-3-(2,6-dichlorophenyl)-2-propenyl) imino)oxygen)methyl)phenyl]-2-methoxyl imino acetamide and second active ingredients which are selected from rice blast-controlling bactericides of isotianil, fenhexamid, fthalide and Tebufloquin, and the weight ratio of the first active ingredient to the second active ingredients is 1:20-20:1. The bactericidal composition can be prepared into agriculturally accepted water dispersible granules, wettable powder, suspending agents, suspending seed coating formulations and granules. The bactericidal composition has reasonable components and a good bactericidal effect and is low in cost, and the activity and the bactericidal effect of the bactericidal composition are not equal to the simple superposition of the activity of all components; and compared with the presently used single preparation, the bactericidal composition achieves an obvious insecticidal effect as well as obvious synergistic action, does not cause any pollution to crop, has high safety and meets the safety requirements of pesticide formulations. The bactericidal composition has an obvious controlling effect on rice blast.
Description
Technical field
The present invention relates to a kind of bactericidal composition that contains alkene oxime amine; Contain alkene oxime amine as first active component particularly a kind of comprising; Be selected from the different metsulfovax, ring propionyl bacterium amine, Rabcide, Tebufloquin of control rice blast bactericide bactericidal composition, belong to technical field of compounded pesticide as second active component.
Background technology
Alkene oxime amine, chemical name: (E, E, E)-N-methyl-2-[((((1-methyl-3-(2, the 6-dichlorophenyl)-2-acrylic) imino group) oxygen base) methyl) phenyl]-2-methoxyimino acetic amide.Alkene oxime amine is the methoxy acrylic bactericide by Shenyang Chemical Engineering Inst's exploitation, has unique mechanism of action, and it brings into play bacteriostasis through its mitochondrial respiratory of electronics transmission inhibition that pins between cytochrome b and the c1.Its fungicidal spectrum is wide, active high, can be used for preventing and treating plurality of plant diseases such as wheat rust, wheat powdery mildew, rice sheath blight disease, false smut, powdery mildew of cucumber, cucumber downy mildew, downy mildew of garpe, alternaria leaf spot of apple, apple mildew, sigatoka, early blight of tomato, pear scab, powdery mildew of strawberry, rust of sunflower.Although this bactericide mechanism of action is unique, pathogen is also very fast to the speed that it produces resistance, and use cost is high, promotes the use of so limited the large tracts of land of alkene oxime amine.
Rice blast is one of important disease of paddy rice, can cause the underproduction significantly, the underproduction 40%～50% when serious, even No kernels or seeds are gathered, as in a year of scarcity.All there is generation in each rice district, the world.Introduce several pesticide species that can be used for preventing and treating rice blast below:
Different metsulfovax, English common name isotianil, chemical name: 3,4-two chloro-N-(2-cyano-phenyl)-5-isothiazole formamide are the isothiazole carboxamides that the common research and development of Bayer and Sumitomo Chemical are used for preventing and treating rice blast.Characteristics are that it does not produce direct antibacterial action to pathogen, but through exciting the natural immunology defense of paddy rice self to rice blast, reach the purpose of opposing rice blast.
Ring propionyl bacterium amine, English common name fenhexamid is a kind of acid amide fungicides, belongs to interior suction, protective fungicide.Different with existing bactericide, no bactericidal activity does not suppress the growth of pathogen mycelia.Be mainly used in rice field control rice blast.
Rabcide has another name called rabcide, English common name fthalide, and chemical name: 4,5,6, the 7-Rabcide.Being the organochlorine bactericide, is the foliage spray protectant, has impermeabilisation and disturbs melanin biosynthesis effect, is mainly used in control rice blast.
Tebufloquin (test code number OK-02, SN4524); Chemical name: 6-tert-butyl-8-fluoro-2; 3-dimethyl-4-quinolyl acetate; Be by the quinoline bactericide of Meiji Pharmaceutial Ltd.'s exploitation, mainly rice blast and banded sclerotial blight had extraordinary preventive effect, also can be used for the control of soybean and vegetable disease.
Although alkene oxime amine is a kind of disinfectant use in agriculture of high-efficiency broad spectrum, it is as methoxy acrylic ester compounds, and the mechanism of action is single, and germ is reused in the field for a long time can produce resistance, cause preventive effect to reduce, and use cost is high.Exist resistance risk after the different metsulfovax of the bactericide of above-mentioned several control rice blast, ring propionyl bacterium amine, Rabcide, the Tebufloquin listing.The inventor finds through test; The alkene oxime amine that the mechanism of action is different is bactericide compounded with the control rice blast, has obvious synergistic effect, can significantly improve control efficiency, the minimizing dosage of treatment, protection; Reduce the control cost, high to crop safety.
Summary of the invention
The object of the present invention is to provide a kind of component reasonable, synergistic effect is remarkable, and bactericidal effect is good, and drug cost is low, to the agricultural bactericidal composition of crop safety.
Another object of the present invention is to provide the application of above-mentioned composition on the control rice blast.
In order to overcome the defective of existing single preparation, technical scheme of the present invention is to solve like this:
A) the first active component alkene oxime amine;
B) second active component is selected from different metsulfovax, ring propionyl bacterium amine, Rabcide, the Tebufloquin of control rice blast bactericide;
The weight ratio of first active component and second active component is 1:20～20:1, is preferably 1:10-10:1, and more preferably 1:5～5:1 most preferably is 1:2～2:1.
The cumulant of first active component and second active component is 5%～90% of a said composition total weight, is preferably 8%～75%.
The preparation formulation that bactericidal composition of the present invention can be prepared according to method known in those skilled in the art is water dispersible granules, wetting powder, suspending agent, suspension seed-coating agent, granule.
For water dispersible granules, those skilled in the art are familiar with the use corresponding adjuvants and accomplish the present invention very much.In dispersant such as polycarboxylate, lignosulfonates, the alkylnaphthalene sulfonate one or more; In wetting agent such as alkyl sulfate, alkylsulfonate, the naphthalene sulfonate one or more; In disintegrant such as ammonium sulfate, urea, sucrose, the glucose one or more; In binding agent such as diatomite, corn starch, PVA, carboxymethyl (ethyl) cellulose family one or more; Filler such as diatomite, kaolin, white carbon, fine particle calcium carbonate, talcum powder, attapulgite, potter's clay one or more.
To wetting powder, spendable auxiliary agent has: in dispersant such as polycarboxylate, lignosulfonates, the alkylnaphthalene sulfonate one or more; In wetting agent such as alkyl sulfate, alkylsulfonate, the naphthalene sulfonate one or more; Filler such as ammonium sulfate, urea, sucrose, glucose, diatomite, kaolin, white carbon, fine particle calcium carbonate, talcum powder, attapulgite, potter's clay one or more.
To suspending agent, spendable auxiliary agent has: among dispersant such as polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate (dispersing agent NNO), the TERSPERSE 2020 (U.S. Huntsman Corporation produces, the alkyl naphthalene sulfonic acid salt) one or more; Alkyl phenol formaldehyde resin polyoxyethylene ether), farming breast 2201, this dish-60# (common name: Span60), Tween-60 # (common name: the polyoxyethylene sorbitan stearate), agricultural newborn 1601# (common name: triphen ethyl-phenol polyoxyethylene polyoxypropylene block polymer), among the TERSPERSE 4894 (U.S. Huntsman Corporation product) one or more emulsifier such as Nongru-700 # (common name:; Among wetting agent such as alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphate, alkylphenol-polyethenoxy base ether phosphate, phenethyl phenol polyethenoxy base ether phosphate, alkyl sulfate, alkylsulfonate, naphthalene sulfonate, the TERSPERSE 2500 (U.S. Huntsman Corporation product) one or more; In thickener such as xanthans, polyvinyl alcohol, bentonite, the aluminium-magnesium silicate one or more; In preservative such as formaldehyde, benzoic acid, the Sodium Benzoate one or more; Antifoaming agent such as organic silicon defoamer; In antifreezing agent such as ethylene glycol, propane diols, glycerine, urea, inorganic salts such as the sodium chloride one or more; Water is deionized water.
To suspension seed-coating agent; Spendable auxiliary agent has: binding agent such as polysaccharose macromolecular compound (soluble starch, polypropylene graft copolymer, xanthan gum, microorganism mucilage), cellulose derivatives (hydroxypropyl methylcellulose, sodium carboxymethylcellulose, ethyl cellulose), seaweeds such as sodium alginate, agar; Rosin, paraffin, gelatin, pectin; The water-soluble composite of polyvinyl alcohol, polyethylene glycol, polyvinyl acetate, polyacrylamide, polyvinylpyrrolidone and polyhydric alcohol polymer, in the inorganic binder (aluminium-magnesium silicate, clay, waterglass, gypsum) one or more; Among dispersant such as polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate, the TERSPERSE 2020 one or more; The sorbitan monostearate APEO), among the agricultural newborn 1601#, TERSPERSE 4894 one or more emulsifier such as Nongru-700 #, farming breast 2201, this dish-60#, emulsifier T-60 (common name:; Among wetting agent such as alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphate, alkylphenol-polyethenoxy base ether phosphate, phenethyl phenol polyethenoxy base ether phosphate, alkyl sulfate, alkylsulfonate, naphthalene sulfonate, the TERSPERSE 2500 one or more; In thickener such as xanthans, polyvinyl alcohol, the bentonite one or more; In preservative such as formaldehyde, benzoic acid, the Sodium Benzoate one or more; Antifoaming agent such as organic silicon defoamer; In antifreezing agent such as ethylene glycol, propane diols, glycerine, urea, inorganic salts such as the sodium chloride one or more; Water is deionized water.
To granule, spendable auxiliary agent has: carrier such as clay, kaolin, talcum, calcium carbonate, diatomite, corn starch, alumina silicate etc.; In dispersant such as polycarboxylate, lignosulfonates, the alkylnaphthalene sulfonate one or more; In wetting agent such as alkyl sulfate, alkylsulfonate, the naphthalene sulfonate one or more; In adhesive such as polyvinyl alcohol, dextrin, the polyvinylpyrrolidone one or more.
Component of the present invention is reasonable, and treatment adds protective effect, and bactericidal effect is good, and drug cost is low, and its active and bactericidal effect is not the simple superposition of each composition activity, but significant synergistic effect is arranged, and is good to crop safety, meets the security requirement of pesticidal preparations.The present invention has the better prevention effect to rice blast.
Embodiment
In order to prevent and treat the rice blast in the agricultural production; The inventor has carried out mutual composite synergy research with alkene oxime amine and different metsulfovax, ring propionyl bacterium amine, Rabcide, Tebufloquin; Different according to the medicament mechanism of action, adopt pot-culture method and mycelial growth rate method to carry out toxicity test respectively.
Pot-culture method:
Alkene oxime amine and different metsulfovax or ring propionyl bacterium amine this method of employing that is mixed.Supplying the examination germ is wild sensitive rice Pyricularia oryzae Pyricularia oryzae Cav. bacterial strain, and supplying to study thing is paddy rice sense rice blast kind, and every basin sowing is 20 after the vernalization, selects 10 strains, 3 leaves, the 1 heart stage paddy rice seedling that wherein growing way is consistent subsequent use.To test with pathogen and on the suitable culture base, cultivate, after waiting to produce spore, wash spore, and, process the suspension that concentration is 1 * 105 spore/milliliter with 2 layers～4 layers filtered through gauze with sterile water, subsequent use.The medicament for preparing is diluted with water to 1mg/L, 2mg/L, 4mg/L, 8mg/L, 5 concentration of 16mg/L.Soup is evenly sprayed in the blade face to all wetting, treat behind the soup natural air drying subsequent use.Every processing 1 basin repeats for 4 times, and establishes the processing that only contains solvent and surfactant and do not contain effective composition and make blank.Use the spore suspension spray inoculation, inoculate after 3 days in chemicals treatment.Moving to after the inoculation preserves moisture under (relative moisture keeps the blade face dewfall to be arranged, 25 ℃～26 ℃ of temperature more than 95%) dark condition in the humidistat cultivates 24 h.Under 25 ℃～26 ℃, the condition of 12h alternation of light and darkness (intensity of illumination 20000 Lux), relative moisture 85%～90%, cultivated 7 days then.Treat that the sick leaf rate of blank reaches 50% when above, the incidence of strain blade is put in order in the classification investigation, and classification and statistical method are:
0 grade: whole strain is anosis;
1 grade: brown some scab occur;
3 grades: typical spindle scab occurs, lesion area accounts for whole below 5% of leaf area;
5 grades: typical scab, lesion area account for 6%～25% of whole leaf area;
7 grades: typical scab, lesion area account for 26%～50% of whole leaf area;
9 grades: typical scab, lesion area account for whole more than 50% of leaf area.
Disease index=[Σ (the sick numbers of sheets at different levels * relative level numerical value)/investigate total number of sheets * 9] * 100%
Control efficiency (%)=[(contrast disease index-processing disease index)/contrast disease index] * 100
The EC of each medicament is obtained in linear regression analysis between the probit value through preventive effect and the logarithm value of series concentration
50Value with the co-toxicity coefficient (CTC) of the abundant method calculating of Sun Yun mixture, is estimated the activity of confession reagent agent to germ with this.
The co-toxicity coefficient of complex preparation (CTC)>=120 shows as synergistic effect; CTC≤80 show as antagonism; 80＜CTC＜120 show as summation action.
The mycelial growth rate method:
Alkene oxime amine and Rabcide or Tebufloquin are mixed and adopt this method.Subjects is Pyricularia oryzae (Pyriculariagrisea).Former medicine is mixed with the test medicine that needs, and test method is with reference to " the agricultural industry criteria NY/T1156.2-2006 of the People's Republic of China (PRC) ".At first single agent and each Mixed Pharmacy are provided with 5 variable concentrations gradients (0.25 mg/L, 0.5 mg/L, 1 mg/L, 2 mg/L, 4 mg/L).If the clear water contrast repeats 3 times.Adopt the mycelial growth rate method,, under aseptic condition, use diameter to be the 5mm card punch, cut the bacterium cake, the bacterium cake is connected on the culture medium flat plate of different drug concentrations, put in 26 ℃ of incubators and cultivate 72h with transfer needle from colony edge with cultured pathogen; The inspection colony diameter calculates the percentage that each chemicals treatment suppresses mycelial growth, and the EC of each medicament is obtained in the linear regression analysis between the probit value through inhibiting rate and the logarithm value of series concentration
50Value with the co-toxicity coefficient (CTC) of the abundant method calculating of Sun Yun mixture, is estimated the activity of confession reagent agent to germ with this.
The co-toxicity coefficient of complex preparation (CTC)>=120 shows as synergistic effect; CTC≤80 show as antagonism; 80＜CTC＜120 show as summation action.
Toxicity Determination result shows: a kind of among alkene oxime amine and different metsulfovax, ring propionyl bacterium amine, Rabcide, the Tebufloquin is that 1:20～20:1 uses with rice blast fungus is had virulence preferably with the weight ratio, and significant synergistic effect is all arranged.
Below in conjunction with FORMULATION EXAMPLE and biological Examples content of the present invention is described further.
FORMULATION EXAMPLE 1
Take by weighing 6% alkene oxime amine, 60% different metsulfovax, 4% Morwet D-425 (alkyl naphthalene sulfonic acid condensation polymer sodium salt, Akzo Nobel N.V. produces), 3% dispersing agent NNO, 2% Nekal BX, 2% K-12 (lauryl sodium sulfate), 2% corn starch, 2% sucrose, kaolin adds to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule is promptly mixed, ultra micro comminution by gas stream, mixing, granulation step are produced the different metsulfovax water dispersible granules of 66% alkene oxime amine.
FORMULATION EXAMPLE 2
Take by weighing 25% alkene oxime amine, 25% ring propionyl bacterium amine, 4% TERSPERSE 2700,2% dispersing agent NNO, 2% Nekal BX (nekal), 2%K-12,3% corn starch, 5% ammonium sulfate, attapulgite adds to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule is promptly mixed, ultra micro comminution by gas stream, mixing, granulation step are produced 50% alkene oxime amine ring propionyl bacterium amine water dispersible granules.
FORMULATION EXAMPLE 3
Take by weighing 15% alkene oxime amine, 75% Rabcide, 1% TERSPERSE 2700,1% dispersing agent NNO (alkylnaphthalene sulfonate formaldehyde condensation products), 1% Nekal BX, 1%K-12,1% carboxymethyl cellulose, diatomite adds to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule is promptly mixed, ultra micro comminution by gas stream, mixing, granulation step are produced 90% alkene oxime amine Rabcide water dispersible granules.
FORMULATION EXAMPLE 4
Take by weighing 50% alkene oxime amine, 2.5%Tebufloquin, 3% TERSPERSE 2700,3% dispersing agent NNO, 2% Nekal BX, 2%K-12,1% carboxymethyl cellulose, 5% urea, diatomite adds to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule is promptly mixed, ultra micro comminution by gas stream, mixing, granulation step are produced 52.5% alkene oxime amine Tebufloquin water dispersible granules.
FORMULATION EXAMPLE 5
Take by weighing 3% alkene oxime amine, 60% different metsulfovax, 5% calcium lignosulfonate, 2% Nekal BX, 2%K-12,5% white carbon black, kaolin and add to 100% weight portion.Above-mentioned raw materials makes the different metsulfovax wetting powder of 63% alkene oxime amine through mixing behind the comminution by gas stream.
FORMULATION EXAMPLE 6
Take by weighing 5% alkene oxime amine, 70% ring propionyl bacterium amine, 4% calcium lignosulfonate, 3% TERSPERSE 2700 (polycarboxylate, U.S. Huntsman Corporation produces), 2% Nekal BX, 2%K-12,3% white carbon black, fine particle calcium carbonate and add to 100% weight portion.Above-mentioned raw materials makes 75% alkene oxime amine ring propionyl bacterium amine wetting powder through mixing behind the comminution by gas stream.
FORMULATION EXAMPLE 7
Take by weighing 15% alkene oxime amine, 30% Rabcide, 2% calcium lignosulfonate, 2% dispersing agent NNO, 1% Nekal BX, 1%K-12, attapulgite and add to 100% weight portion.Above-mentioned raw materials makes 45% alkene oxime amine Rabcide wetting powder through mixing behind the comminution by gas stream.
FORMULATION EXAMPLE 8
Take by weighing 50% alkene oxime amine, 5%Tebufloquin, 4% calcium lignosulfonate, 4% dispersing agent NNO, 2% Nekal BX, 2%K-12,3% white carbon black, attapulgite and add to 100% weight portion.Above-mentioned raw materials makes 55% alkene oxime amine Tebufloquin wetting powder through mixing behind the comminution by gas stream.
FORMULATION EXAMPLE 9
Take by weighing 6% alkene oxime amine, 30% different metsulfovax, 4%TERSPERSE 4894 (U.S. Huntsman Corporation product), 1.5%TERSPERSE 2500 (U.S. Huntsman Corporation product), 2%TERSPERSE 2020 (U.S. Huntsman Corporation product), 1% aluminium-magnesium silicate, 0.2% xanthans, 5% ethylene glycol, 0.5% formaldehyde, 0.5% silicone defoaming agent (trade name: s-29 Nanjing "four news" (new ideas applied chemistry article company produces), deionized water adds to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making the different metsulfovax suspending agent of 36% alkene oxime amine behind the sand mill sand milling.
FORMULATION EXAMPLE 10
Take by weighing 7% alkene oxime amine, 28% ring propionyl bacterium amine, 5%TERSPERSE 4894,2%TERSPERSE 2500,3%TERSPERSE 2020,0.2% xanthans, 5% propane diols, 0.5% benzoic acid, 0.5% silicone defoaming agent, deionized water and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 35% alkene oxime amine ring propionyl bacterium amine suspending agent behind the sand mill sand milling.
FORMULATION EXAMPLE 11
Take by weighing 30% alkene oxime amine, 10% Rabcide, 2%TERSPERSE 2020,2% this dish-60#, 2% Tween-60 #, 1%TERSPERSE 2500,0.5% white carbon, 0.3% xanthans, 5% ethylene glycol, 0.5% benzoic acid, 0.5% silicone defoaming agent, deionized water and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 40% alkene oxime amine Rabcide suspending agent behind the sand mill sand milling.
FORMULATION EXAMPLE 12
Take by weighing 20% alkene oxime amine, 10%Tebufloquin, 1%TERSPERSE 2020,3% agricultural newborn 1601#, 2% agricultural newborn 2201#, 1%TERSPERSE 2500,0.3% xanthans, 5% ethylene glycol, 0.5% formaldehyde, 0.5% silicone defoaming agent, deionized water and add to 100% weight portion.High speed shear is disperseed 30min, with making 30% alkene oxime amine Tebufloquin suspending agent behind the sand mill sand milling.
FORMULATION EXAMPLE 13
Take by weighing 20% alkene oxime amine, 5% different metsulfovax, 1%TERSPERSE 2700,1%TERSPERSE 2500,3% TERSPERSE 4894,5.0% polyvinylpyrrolidone, 0.2% xanthans, 5% ethylene glycol, 0.3% benzoic acid, 0.5% silicone defoaming agent deionized water adds to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making the different metsulfovax suspension seed-coating agent of 25% alkene oxime amine behind the sand mill sand milling.
FORMULATION EXAMPLE 14
Take by weighing 8% alkene oxime amine, 24% ring propionyl bacterium amine, 3%TERSPERSE 4894,2%TERSPERSE 2500,1%TERSPERSE 2020,4.0% hydroxypropyl methylcellulose, 0.5% bentonite, 5% ethylene glycol, 0.3% Sodium Benzoate, 0.5% silicone defoaming agent deionized water and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 32% alkene oxime amine ring propionyl bacterium amine suspension seed-coating agent behind the sand mill sand milling.
FORMULATION EXAMPLE 15
Take by weighing 6% alkene oxime amine, 2% Rabcide, 1%TERSPERSE 2700,1%TERSPERSE 2500,3% TERSPERSE 4894,5.0% polyvinylpyrrolidone, 0.2% xanthans, 5% ethylene glycol, 0.3% benzoic acid, 0.5% silicone defoaming agent deionized water adds to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 8% alkene oxime amine Rabcide suspension seed-coating agent behind the sand mill sand milling.
FORMULATION EXAMPLE 16
Take by weighing 2% alkene oxime amine, 3%Tebufloquin, 3%TERSPERSE 4894,2%TERSPERSE 2500,1%TERSPERSE 2020,6.0% hydroxypropyl methylcellulose, 0.5% bentonite, 5% ethylene glycol, 0.3% Sodium Benzoate, 0.5% silicone defoaming agent deionized water and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 5% alkene oxime amine Tebufloquin suspension seed-coating agent behind the sand mill sand milling.
FORMULATION EXAMPLE 17
Take by weighing 5% alkene oxime amine, 10% different metsulfovax, 3% sodium lignin sulfonate, 2% neopelex, 3% polyvinyl alcohol, kaolin and add to 100% weight portion.Mentioned component is added water mediate, use and pinch out comminutor and pinch out and is shaped, afterwards particle is used fluid-bed drying, adjust particle size, make the different metsulfovax granule of 15% alkene oxime amine.
FORMULATION EXAMPLE 18
Take by weighing 7.5% alkene oxime amine, 7.5% ring propionyl bacterium amine, 2% sodium lignin sulfonate, 3% TERSPERSE 2700,3% polyvinylpyrrolidone, clay adds to 100% weight portion.Above-mentioned raw materials is mediated through mixing and water adding, uses to pinch out comminutor and pinch out and is shaped, afterwards particle is used fluid-bed drying, adjusts particle size, makes 15% alkene oxime amine ring propionyl bacterium amine granule.
FORMULATION EXAMPLE 19
Take by weighing 7% alkene oxime amine, 14% Rabcide, 2% neopelex, 3% dispersing agent NNO, 3% polyvinylpyrrolidone, kaolin and add to 100% weight portion.Above-mentioned raw materials is mediated through mixing and water adding, uses to pinch out comminutor and pinch out and is shaped, afterwards particle is used fluid-bed drying, adjusts particle size, makes 21% alkene oxime amine ring propionyl bacterium amine granule.
FORMULATION EXAMPLE 20
Take by weighing 15% alkene oxime amine, 5% Tebufloquin, 3% lauryl sodium sulfate, 3% dispersing agent NNO, 4% dextrin, diatomite and add to 100% weight portion.Above-mentioned raw materials is mediated through mixing and water adding, uses to pinch out comminutor and pinch out and is shaped, afterwards particle is used fluid-bed drying, adjusts particle size, makes 20% alkene oxime amine Tebufloquin granule.
Biological Examples 1: control rice blast field trial (spraying)
2011 in Shaanxi Province Hanzhong City has carried out FORMULATION EXAMPLE 9 (the different metsulfovax suspending agent of 36% alkene oxime amine), FORMULATION EXAMPLE 2 (50% alkene oxime amine ring propionyl bacterium amine water dispersible granules), FORMULATION EXAMPLE 7 (45% alkene oxime amine Rabcide wetting powder), FORMULATION EXAMPLE 12 (30% alkene oxime amine Tebufloquin suspending agent) control rice blast field trial, verify that this medicament is to the control efficiency of rice blast, effective dose and to the safety of paddy rice.Trial crops is a paddy rice, and controlling object is rice blast (Pyricularia oryzae Cav.).Test is located at the Hanzhong City Hantai District, and test medicine and dosage see table 5 for details.Other establishes blank, and every processing 4 times repeats, every sub-district area 30 ㎡, and totally 72 sub-districts, district's group is arranged at random.Adopt conventional spray-on process, mu dispenser liquid 50kg evenly sprays the paddy rice complete stool.Altogether dispenser is 2 times, paddy rice booting latter stage and each dispenser of full heading time 1 time.
Investigation and statistical method:
Investigation in 14 days after the 2nd dispenser, investigation method is 5 samplings in every sub-district, every some investigation 50 fringes, grade scale is following:
0 grade: anosis;
1 grade: every fringe loss is (morbidity of indivedual branch stalk) below 5%;
3 grades: every fringe loss 6%-20% (branch stalk morbidity about 1/3);
5 grades: every fringe loss 21%-50% (fringe neck or main shaft morbidity, grain half is flat);
7 grades: every fringe loss 51%-70% (morbidity of fringe neck, most of shrivelled kernel);
9 grades: every fringe loss 71%-100% (morbidity of fringe neck causes dead ears).
Refer to calculate preventive effect according to disease.Behind each spray medicine behind the 1st day and the medicine some days, each handled the influence to paddy rice to observe medicament.
Disease index=[Σ (sick spike numbers at different levels * relative level numerical value)/investigate total spike number * 9] * 100%
Control efficiency (%)=[(contrast disease index-processing disease index)/contrast disease index] * 100.
Field test results shows: 1800 times, 2000 times, 2200 times of the different metsulfovax suspending agents of 36% alkene oxime amine; 4000 times, 4200 times, 4400 times of 50% alkene oxime amine ring propionyl bacterium amine water dispersible granules; 2200 times, 2400 times, 2600 times of 45% alkene oxime amine Rabcide wetting powders; 3200 times, 3400 times, 3600 times of 30% alkene oxime amine Tebufloquin suspending agents; Rice blast is had than remarkable prevention effect, obviously be superior to 1000 times of 10% alkene oxime amine missible oil, 1000 times of 30% different metsulfovax suspending agents, 20% 1000 times of ring propionyl bacterium amine amine suspending agents, 1000 times of 50% Rabcide wetting powders, 1000 times of control efficiency of 10%Tebufloquin suspending agent rice blast.
To the security survey of paddy rice, to observe in some days behind the 1st day and the medicine behind the spray medicine, each test is handled not to be had the poisoning phenomenon to paddy rice and takes place.
After result of the test shows that alkene oxime amine and different metsulfovax, ring propionyl bacterium amine, Rabcide, Tebufloquin are mixed; Obviously improved control efficiency to rice blast; Having reduced dosage and drug cost, to paddy growth safety, is the desirable medicament of control rice blast.
Biological Examples 2: control rice blast field trial (seed dressing)
2011 in Shaanxi Province the Ankang City Hanbin District has carried out FORMULATION EXAMPLE 13 (the different metsulfovax suspension seed-coating agent of 25% alkene oxime amine), FORMULATION EXAMPLE 14 (32% alkene oxime amine ring propionyl bacterium amine suspension seed-coating agent), FORMULATION EXAMPLE 15 (8% alkene oxime amine Rabcide suspension seed-coating agent), FORMULATION EXAMPLE 16 (5% alkene oxime amine Tebufloquin suspension seed-coating agent) control rice blast field trial.Test medicine and dosage see table 6 for details.Other establishes the clear water blank, and every processing repeats for 4 times, area sub-district, sub-district area 20 ㎡, and district's group is arranged at random.Each chemicals treatment is calculated dosing and is converted the water yield in the ratio of 1.6 hydrargyrum oxydatum crudum liquid processing double centner seed.Handle the back sowing in rice paddy seed.
Investigation and statistical method are investigated 2 times altogether, and respectively at rice seedling and the investigation of fringe phase, 5 points are investigated in every sub-district, every 20 strain (fringe), and diseased plant (fringe) rate of sub-district rice blast is respectively handled in investigation, calculates preventive effect.Each handles the influence to paddy rice to observe medicament at each crucial growing stage of paddy rice.
Diseased plant rate (%)=(the morbidity strain number/total strain number of investigation) * 100
Control efficiency (%)=[(check plot diseased plant rate-treatment region diseased plant rate)/check plot diseased plant rate] * 100.
Field test results shows; The different metsulfovax suspension seed-coating agent of 25% alkene oxime amine, 32% alkene oxime amine ring propionyl bacterium amine suspension seed-coating agent, 8% alkene oxime amine Rabcide suspension seed-coating agent, 5% alkene oxime amine Tebufloquin suspension seed-coating agent are pressed dosage Rice seeds treated in the table 6 respectively to rice blast; Rice seedling and the rice blast of fringe phase all there is good preventive effect; Especially it is remarkable to control seedling stage rice blast effect, to the control of also need spraying of later stage rice blast.The preventive effect of these several kinds of mixture preparations obviously is superior to the preventive effect of 5 kinds of single agent such as 10% alkene oxime amine suspension seed-coating agent, 10% different metsulfovax suspension seed-coating agent to rice blast.
To the security survey of paddy rice, handle the rice seedling rate and be higher than blank about 2%, growing also is better than blank, shows that medicament is to paddy growth safety, no poisoning.
After result of the test shows that alkene oxime amine and different metsulfovax, ring propionyl bacterium amine, Rabcide, Tebufloquin are mixed; Through the chemicals treatment rice paddy seed; Obviously improved control efficiency to rice blast; Having reduced dosage and drug cost, to paddy growth safety, is the desirable medicament of control rice blast.
Biological Examples 3: control rice blast field trial (spreading fertilizer over the fields granule)
2011 in Shaanxi Province the Ankang City Hanyin County carried out FORMULATION EXAMPLE 17 (the different metsulfovax granule of 15% alkene oxime amine), FORMULATION EXAMPLE 18 (15% alkene oxime amine ring propionyl bacterium amine particle), FORMULATION EXAMPLE 19 (21% alkene oxime amine Rabcide granule), FORMULATION EXAMPLE 20 (20% alkene oxime amine Tebuf loquin granule) control rice blast field trial.Test medicine and dosage see table 7 for details.Other establishes blank, and every processing repeats for 4 times, area sub-district, sub-district area 20 ㎡, and the ridge is built in the minizone, single single the filling, district's group is arranged at random.Each medicament is mixed fine sand 10Kg by a design mu consumption and is spread fertilizer over the fields, in rice transplanting phase and each dispenser in booting stage once.
Investigation and statistical method are investigated 2 times altogether, and respectively at investigation in 21 days after each dispenser, 5 points are investigated in every sub-district, every 20 strain (fringe), and diseased plant (fringe) rate of sub-district rice blast is respectively handled in investigation, calculates preventive effect.Each handles the influence to paddy rice to observe medicament at each crucial growing stage of paddy rice.
Diseased plant rate (%)=(the morbidity strain number/total strain number of investigation) * 100
Control efficiency (%)=[(check plot diseased plant rate-treatment region diseased plant rate)/check plot diseased plant rate] * 100.
Field test results shows; The different metsulfovax granule of 15% alkene oxime amine 500g/ mu, 15% alkene oxime amine ring propionyl bacterium amine granule 600g/ mu, 21% alkene oxime amine Rabcide granule 500g/ mu, 20% alkene oxime amine Tebufloquin granule 400g/ mu; Respectively spread fertilizer over the fields once in rice transplanting phase and booting stage; Rice seedling and the rice blast of fringe phase all there are preventive effect preferably, obviously are superior to the preventive effect (table 7) of 5 kinds of single agent such as 10% alkene oxime amine granule, 10% different metsulfovax granule rice blast.
To the security survey of paddy rice, each test is handled paddy growth safety, no poisoning.
Result of the test is processed granule and is spread fertilizer over the fields control rice blast after showing that alkene oxime amine and different metsulfovax, ring propionyl bacterium amine, Rabcide, Tebufloquin are mixed, and drug effect is obvious; Dispenser is easy; Saving manpower, to paddy growth safety, is the desirable medicament of control rice blast.
In sum; Composition of the present invention is to adopt two kinds of active component compound schemes, and its activity and bactericidal effect are not the simple superposition of each composition activity, compare with existing single preparation; Except that having significant bactericidal effect; And significant synergistic effect is arranged, and good to crop safety, meet the security requirement of pesticidal preparations.
Claims (8)
1. bactericidal composition that contains alkene oxime amine is characterized in that comprising:
A) the first active component alkene oxime amine;
B) second active component is selected from different metsulfovax, ring propionyl bacterium amine, Rabcide, the Tebufloquin of control rice blast bactericide;
The weight ratio of first active component and second active component is 1:20～20:1.
2. according to the said bactericidal composition that contains alkene oxime amine of claim 1, it is characterized in that: the weight ratio of first active component and second active component is 1:10～10:1.
3. according to the said bactericidal composition that contains alkene oxime amine of claim 1, it is characterized in that: the weight ratio of first active component and second active component is 1:5～5:1.
4. according to the said bactericidal composition that contains alkene oxime amine of claim 1, it is characterized in that: the weight ratio of first active component and second active component is 1:2～2:1.
5. according to the said bactericidal composition that contains alkene oxime amine of claim 1, it is characterized in that: the cumulant of first active component and second active component is 5%～90% of a said composition total weight.
6. according to the said bactericidal composition that contains alkene oxime amine of claim 5, it is characterized in that: the cumulant of first active component and second active component is 8%～75% of a said composition total weight.
7. according to the said bactericidal composition that contains alkene oxime amine of claim 1, it is characterized in that: said combination dosage form is water dispersible granules, wetting powder, suspending agent, suspension seed-coating agent, granule.
8. the said application of bactericidal composition on the control rice blast that contains alkene oxime amine of claim 1.
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| CN104255727A (en) * | 2014-09-19 | 2015-01-07 | 浙江省化工研究院有限公司 | ZJ4042 and fenaminstrobin containing insecticidal and disease-preventing composition and seed coating |
| CN104904720A (en) * | 2014-03-11 | 2015-09-16 | 浙江省化工研究院有限公司 | Sterilization composition containing ZJ5337 and methoxy acrylic ester sterilization agent |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101911946A (en) * | 2010-08-24 | 2010-12-15 | 河北省农林科学院植物保护研究所 | Complex bactericide for mainly treating grey mould disease, early blight and powdery mildew |
| CN102172240A (en) * | 2011-03-01 | 2011-09-07 | 陕西西大华特科技实业有限公司 | Bactericidal composition containing benziothiazolinone and methoxyl acrylic ester type bactericides |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101911946A (en) * | 2010-08-24 | 2010-12-15 | 河北省农林科学院植物保护研究所 | Complex bactericide for mainly treating grey mould disease, early blight and powdery mildew |
| CN102172240A (en) * | 2011-03-01 | 2011-09-07 | 陕西西大华特科技实业有限公司 | Bactericidal composition containing benziothiazolinone and methoxyl acrylic ester type bactericides |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104904720A (en) * | 2014-03-11 | 2015-09-16 | 浙江省化工研究院有限公司 | Sterilization composition containing ZJ5337 and methoxy acrylic ester sterilization agent |
| CN104904720B (en) * | 2014-03-11 | 2017-08-08 | 浙江省化工研究院有限公司 | A kind of bactericidal composition containing ZJ5337 and methoxy acrylic bactericide |
| CN104255727A (en) * | 2014-09-19 | 2015-01-07 | 浙江省化工研究院有限公司 | ZJ4042 and fenaminstrobin containing insecticidal and disease-preventing composition and seed coating |
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